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BIOCELL 2022年第12期46卷 2525-2530页

作者： monica SAVIO VALENTINA MINOIA PAOLA FULGHIERI LUCIA ANNA STIVALA VIRGINIE SOTTILE Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： Resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene

Vascular complications of pancreatitis

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World Journal of Clinical Cases 2022年第22期10卷 7665-7673页

作者： M Ammar Kalas monica Leon Luis Omar Chavez Eduardo Canalizo Salim Surani Department of Medicine Texas Tech University Health CenterEl PasoTX 79905United States Department of General Surgery Centro Medico ABCCiudad de Mexico 01120Mexico Department of Medicine Texas A&M UniversityBryanTX 77807United States

More than 200000 hospital admissions happen per year for acute pancreatitis and more than 50000 for chronic pancreatitis in the United States of *** pancreatitis accounts for 20%-30%of the ***-quarter of the patients with pancreatitis develop vascular complications,which carries a high *** mini-review will address these complications that can help primary care physicians and hospitalists in managing their patients effectively.

关键词： Acute pancreatitis Vascular complications Gastrointestinal bleeding Pseudoaneurysm Hemosuccus pancreaticus Pancreas

Classification of osteogenesis imperfecta:Importance for prophylaxis and genetic counseling

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World Journal of Clinical Cases 2023年第12期11卷 2604-2620页

作者： monica-Cristina Panzaru Andreea Florea Lavinia Caba Eusebiu Vlad Gorduza Department of Medical Genetics Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Department of Medical Genetics-Medical Genetics resident “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania

Osteogenesis imperfecta(OI)is a genetically heterogeneous monogenic disease characterized by decreased bone mass,bone fragility,and recurrent *** phenotypic spectrum varies considerably ranging from prenatal fractures with lethal outcomes to mild forms with few fractures and normal *** basic mechanism is a collagen-related defect,not only in synthesis but also in folding,processing,bone mineralization,or osteoblast *** recent years,great progress has been made in identifying new genes and molecular mechanisms underlying *** this context,the classification of OI has been revised several times and different types are *** Sillence classification,based on clinical and radiological characteristics,is currently used as a grading of clinical *** on the metabolic pathway,the functional classification allows identifying regulatory elements and targeting specific therapeutic *** classification has the advantage of identifying the inheritance pattern,an essential element for genetic counseling and *** genotype-phenotype correlations may sometimes be challenging,genetic diagnosis allows a personalized management strategy,accurate family planning,and pregnancy management decisions including options for mode of delivery,or early antenatal OI *** research on molecular pathways and pathogenic variants involved could lead to the development of genotype-based therapeutic *** narrative review summarizes our current understanding of genes,molecular mechanisms involved in OI,classifications,and their utility in prophylaxis.

关键词： Osteogenesis imperfecta Heterogeneity Classification Molecular mechanism Genetic counseling Prophylaxis

Comparison of intraocular pressure readings with Perkins,Tonopen,iCare 200,and iCare Home to manometry in cadaveric eyes

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2022-2027页

作者： monica K Ertel Leonard K Seibold Jennifer L Patnaik Malik Y Kahook Department of Ophthalmology University of ColoradoUC Health Sue Anschutz-Rodgers Eye CenterAuroraColorado 80045USA

AIM:To compare intraocular pressure(IOP)readings obtained with Perkins tonometry,i Care Home,i Care 200,and Tonopen to IOP readings obtained with the manometer of a perfusion system to assess the accuracy and reproducibility of each method of tonometry at set ***:The IOP of human cadaveric eyes(n=2)was measured using a manometer inserted into the eye through the optic *** measurements were obtained using a Perkins tonometer,i Care Home,i Care 200,and *** measurements were compared to set point IOP measurements of a manometer to determine accuracy and reproducibility of each ***:Mean IOP readings obtained with the Perkins tonometer compared to manometer readings demonstrated a difference of-1.0±5.0 mm Hg(P=0.45),indicating a lower reading on average than manometery although not *** IOP difference between iCare 200 and manometer was 5.3±2.2 mm Hg(P<0.0001).Mean difference in IOP between iCare Home and manometer was 3.5±2.4 mm Hg(P=0.0004).Mean IOP difference compared to manometer was 4.6±4.0 mm Hg for the Tonopen(P<0.0001).IOP measurements obtained with the Perkins tonometer demonstrated a standard deviation of 5.0 mm Hg while the Tonopen measurements demonstrated a 4.0 mm Hg standard *** comparison,iCare 200 and iCare Home demonstrated 2.2 and 2.4 mm Hg standard deviation,***:Applanation tonometry produces more accurate IOP readings than rebound tonometry or Tonopen,however it demonstrates greater variability than the other forms of *** tonometry is more reproducible but tends to over-estimate IOP.

关键词： intraocular pressure ocular tonometry manometry

Effectiveness of lukewarm water compress on reduction of breast pain and breast engorgement among post-cesarean section mothers

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中西医结合护理杂志(英文) 2023年第3期5卷 167-172页

作者： Soni CHAUHAN Kumari NUTAN monica AGRAWAL Surya Kant TIWARI Nursing Tutor Yatharth Nursing College and Paramedical InstituteChandauliUttar PradeshIndia Institute of Nursing King George’s Medical UniversityLucknowUttar PradeshIndia Professor Cum Vice-Principal M.V.P.Samaj’s Institute of Nursing EducationNashikMaharashtraIndia Department of Obstetrics and Gynecology King George’s Medical UniversityLucknowUttar PradeshIndia

Objective:The study aimed to assess the effectiveness of lukewarm water compress on breast pain and breast engorgement among post-cesarean primiparous *** and Methods:This quasi-experimental posttest-only design was conducted with 60 post-cesarean section primiparous mothers between October 2018 and January 2019.A simple random sampling technique was used to allocate 30 participants to both experimental and control *** experimental group received lukewarm water compress using a sponge cloth for 20 min twice a day on the second,third,and fourth postnatal *** control group received routine hospital *** pain and engorgement were assessed using the Visual Analog Pain Scale and Breast Engorgement Assessment Scale on the third,fourth,and fifth postnatal ***:Significant differences were observed between the experimental and control groups on day 1 and day 3 in terms of breast pain and engorgement scores among post-cesarean section mothers(P0.05).Conclusion:Lukewarm water compress is effective in reducing breast pain and engorgement in post-cesarean primiparous *** research can include randomized controlled trials to evaluate the effectiveness of different therapies in treating breast pain and engorgement.

关键词： Effectiveness lukewarm water compress post-cesarean section postnatal posttest only primiparous

Analysis of an event study using the Fama–French five‑factor model:teaching approaches including spreadsheets and the R programming language

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Financial Innovation 2023年第1期9卷 2042-2075页

作者： monica Martinez‑Blasco Vanessa Serrano Francesc Prior Jordi Cuadros IQS School of Management-Universitat Ramon Llull Via Augusta 39008017 BarcelonaSpain IQS School of Engineering-Universitat Ramon Llull Via Augusta 39008017 BarcelonaSpain

The current financial education framework has an increasing need to introduce tools that facilitate the application of theoretical models to real-world data and ***,only a limited number of free tools are available for this *** this lack of tools,the present study provides two approaches to facilitate the implementa-tion of an event *** first approach consists of a set of MS Excel files based on the Fama–French five-factor model,which allows the application of the event study methodology in a semi-automatic *** second approach is an open-source R-programmed tool through which results can be obtained in the context of an event study without the need for programming *** tool widens the calculus possibilities provided by the first approach and offers the option to apply not only the Fama–French five-factor model but also other models that are common in the finan-cial *** is a user-friendly tool that enables reproducibility of the analysis and ensures that the calculations are free of manipulation *** approaches are freely available and ready-to-use.

关键词： Event study Fama–French five-factor model Financial education Teaching innovation Spreadsheet R programming language

Revisiting mechanisms of resistance to immunotherapies in metastatic clear-cell renal-cell carcinoma

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Cancer Drug Resistance 2023年第2期6卷 314-326页

作者： monica Sheila Chatwal Jad Chahoud Philippe E.Spiess Department of Genitourinary Oncology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612USA

Renal-cell carcinoma(RCC)remains a leading cause of cancer-related mortality *** newer therapeutic combinations of immune checkpoint inhibitors and targeted therapies have greatly improved outcomes,resistance to these therapies is becoming a challenge for long-term *** of resistance have been explored in a variety of solid tumors,including *** upon our review of the current literature on the mechanisms of resistance to immunotherapies for the management of metastatic clear-cell renal cell carcinomas(mccRCC),the ensuing conclusions have been made:The management of mccRCC has progressed substantially with the advent of checkpoint inhibitors and targeted oral therapies,alone and/or in ***,innate or developed resistance to these therapies remains an ongoing challenge,particularly to immune checkpoint inhibitors(ICIs).Several of the known mechanisms of resistance have been well defined,but recent progression in cellular therapies helps to expand the armamentarium of potential combination options that may overcome these modes of resistance and improve long-term disease control and survival for an otherwise dismal *** the ensuing review and update of the literature on the mechanisms of resistance to immunotherapies in mccRCC,we have revisited the known resistance mechanisms of immunotherapies in metastatic clear-cell RCC and explored ongoing and future strategies to overcome them.

关键词： Metastatic clear-cell renal-cell carcinoma immune therapy checkpoint inhibitor resistance chimeric antigen receptor T-cell therapy

Smart cities from low cost to expensive solutions under an optimal analysis

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Financial Innovation 2023年第1期9卷 1660-1693页

作者： Romeo‑Victor Ionescu monica Laura Zlati Valentin‑Marian Antohi Dunarea de Jos University 111thDomneasca Street800201 GalatiRomania Dunarea de Jos University Nicolae BalcescuStreetNo.59‑61800001 GalatiRomania Department of Finance Accounting and Economic TheoryTransylvania UniversityBrasovRomania

This scientific approach mainly aims to develop a smart city/smart community concept to objectively evaluate the progress of these organizational forms in relation to other classical/traditional forms of city *** elaborated model allowed the construction of the dashboard of access actions in the smart city/smart community category on two levels of financial effort correlated with the effect on the sustainable development of smart *** validity of the proposed model and our approach was supported by the complex statistical analysis performed in this *** research concluded that low-cost solutions are the most effective in supporting smart urban *** should be followed by the other category of solutions,which implies more significant financial and managerial efforts as well as a higher rate of welfare growth for urban *** main outcomes of this research include modelling solutions related to smart city development at a low-cost level and identifying the sensitivity elements that maximize the growth *** implications of this research are to provide viable alternatives based on smart city development opportunities with medium and long-term effects on urban communities,economic sustainability,and translation into urban development *** study’s results are useful for all administrations ready for change that want the rapid implementation of the measures with beneficial effects on the community or which,through a strategic vision,aim to connect to the European objectives of sustainable growth and social welfare for ***,this study is a tool for defining and implementing smart public policies at the urban level.

关键词： IoT Smart city Smart economy Sustainability Urban development

Is the combination of immunotherapy with conventional chemotherapy the key to increase the efficacy of colorectal cancer treatment?

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 251-267页

作者： Jonadab E Olguin monica G Mendoza-Rodriguez C Angel Sanchez-Barrera Luis I Terrazas Laboratorio Nacional en Salud Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-degenerativasFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC) is among the most prevalent and deadly neoplasms worldwide. According to GLOBOCAN predictions, its incidence will increase from 1.15 million CRC cases in 2020 to 1.92 million cases in 2040. Therefore, a better understanding of the mechanisms involved in CRC development is necessary to improve strategies focused on reducing the incidence, prevalence,and mortality of this oncological pathology. Surgery, chemotherapy, and radiotherapy are the main strategies for treating CRC. The conventional chemotherapeutic agent utilized throughout the last four decades is 5-fluorouracil, notwithstanding its low efficiency as a single therapy. In contrast, combining 5-fluorouracil therapy with leucovorin and oxaliplatin or irinotecan increases its efficiency. However, these treatments have limited and temporary solutions and aggressive side effects. Additionally, most patients treated with these regimens develop drug resistance, which leads to disease progression. The immune response is considered a hallmark of cancer;thus, the use of new strategies and methodologies involving immune molecules, cells, and transcription factors has been suggested for CRC patients diagnosed in stages Ⅲ and Ⅳ. Despite the critical advances in immunotherapy, the development and impact of immune checkpoint inhibitors on CRC is still under investigation because less than 25% of CRC patients display an increased 5-year survival. The causes of CRC are diverse and include modifiable environmental factors(smoking, diet, obesity, and alcoholism), individual genetic mutations, and inflammation-associated bowel diseases. Due to these diverse causes, the solutions likely cannot be generalized. Interestingly, new strategies, such as single-cell multiomics, proteomics, genomics, flow cytometry, and massive sequencing for tumor microenvironment analysis, are beginning to clarify the way forward. Thus,the individual mechanisms involved in developing the CRC microenvironment, their causes, and t

关键词： Colorectal cancer Immunotherapy checkpoint inhibitors Chemotherapy Immunotherapy Immune response