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Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model:Microarray analysis

World Journal of Gastroenterology 2021年第15期27卷 1616-1629页

作者： monia cecati Matteo Giulietti Alessandra Righetti Berina Sabanovic Francesco Piva Department of Specialistic Clinical and Odontostomatological Sciences Polytechnic University of MarcheAncona 60126Italy

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of death among cancers,it is characterized by poor prognosis and strong *** the PDAC microenvironment,stromal cells release different extracellular components,including *** CXCL12 is a chemokine promoting the communication between tumour and stromal *** different splicing isoforms of CXCL12 are known(α,β,γ,δ,ε,θ)but their role in PDAC has not yet been *** To investigate the specific role ofα,β,andγCXCL12 isoforms in PDAC *** We used hTERT-HPNE E6/E7/KRasG12D(Human Pancreatic Nestin-Expressing)cell line as a pancreatic pre-tumour model and exposed it to theα,β,andγCXCL12 *** altered expression profiles were assessed by microarray analyses and confirmed by Real-Time polymerase chain *** functional enrichment analyses have been performed by Enrichr tool to highlight Gene Ontology enriched *** addition,wound healing assays have been carried out to assess the phenotypic changes,in terms of migration ability,induced by theα,β,andγCXCL12 *** Microarray analysis of hTERT-HPNE cells treated with the three different CXCL12 isoforms highlighted that the expression of only a few genes was ***,theαandβisoforms showed an alteration in expression of different genes,whereasγisoform affected the expression of genes also common withαandβ***βisoform altered the expression of genes mainly involved in cell cycle *** addition,all isoforms affected the expression of genes assay confirmed that CXCL12 enhanced the migration ability of hTERT-HPNE *** the CXCL12 splicing isoforms,theγisoform showed higher induction of migration thanαandβ*** Our data suggests an involvement and different roles of CXCL12 isoforms in PDAC ***,more investigations are needed to confirm these preliminary observations.

关键词： CXCL12 Splicing isoforms Pancreatic cancer Microarray Migration Wound healing assay

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The Role of the Spatial Network in Urban Disaster Risk Variations:Reimagining the Notion of Spatial Vulnerability at the Urban Scale

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International Journal of Disaster Risk Science 2024年第3期15卷 303-316页

作者： monia Del Pinto Ksenia Chmutina Falli Palaiologou Lee Bosher School of Architecture Building and Civil Engineering Loughborough University School of Business University of Leicester

The notion of “spatial vulnerability” is present in most disaster studies with a strong geographical connotation and accordingly is adopted at all scales, including the urban. While enabling mapping and visualizing risk patterns at macroscales, this geocentric foundation fails to capture disaster risk dynamics associated with the urban spatial network—an element that plays a significant role in the everyday and emergency functioning of cities, enabling users' movement and interaction. Yet,urban vulnerability assessment overlooks this aspect and thus leaves urban disaster risk mechanisms partially *** study investigated the role of the network of urban public open spaces(UPOS) in the creation and progression of urban disaster risk in earthquake-prone settlements. Through a multimethod approach that integrates quantitative and qualitative methods and explores spatial configuration, planning policies, and practices of use of UPOS in everyday and emergency scenarios, our study demonstrated that UPOS configuration plays an active role in urban disaster risk. Urban public open spaces impact risk by influencing the exposure of pedestrians and their capacity for self-protection. The study further reconceptualized spatial vulnerability at the urban scale, as the fraction of vulnerability associated to the spatial network, highlighting the interplay of planning policies and spatial practices in its production and progression. Our findings make the notion of spatial vulnerability less ambiguous at the urban scale, by viewing the variable as an imbalance in capacities and exposure that generates spatially unsafe conditions. This refined conceptualization of spatial vulnerability becomes a lens for a more granular approach to urban disaster risk reduction and city planning by identifying and integrating sociospatial considerations.

关键词： Central Italy Earthquakes Pedestrian evacuation Space syntax Spatial vulnerability Urban disaster risk

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An Improved Deep Learning Framework for Automated Optic Disc Localization and Glaucoma Detection

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1429-1457页

作者： Hela Elmannai monia Hamdi Souham Meshoul Amel Ali Alhussan Manel Ayadi Amel Ksibi Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information System College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Glaucoma disease causes irreversible damage to the optical nerve and it has the potential to cause permanent loss of *** ranks as the second most prevalent cause of permanent *** glaucoma diagnosis requires a highly experienced specialist,costly equipment,and a lengthy wait *** automatic glaucoma detection,state-of-the-art glaucoma detection methods include a segmentation-based method to calculate the cup-to-disc *** methods include multi-label segmentation networks and learning-based methods and rely on hand-crafted *** the optic disc(OD)is one of the key features in retinal images for detecting retinal diseases,especially for glaucoma disease *** approach presented in this study is based on deep classifiers for OD segmentation and glaucoma ***,the optic disc detection process is based on object detection using a Mask Region-Based Convolutional Neural Network(Mask-RCNN).The OD detection task was validated using the Dice score,intersection over union,and accuracy *** OD region is then fed into the second stage for glaucoma ***,considering only the OD area for glaucoma detection will reduce the number of classification artifacts by limiting the assessment to the optic disc *** this task,VGG-16(Visual Geometry Group),Resnet-18(Residual Network),and Inception-v3 were pre-trained and *** also used the Support Vector Machine *** feature-based method uses region content features obtained by Histogram of Oriented Gradients(HOG)and Gabor *** final decision is based on weighted fusion.A comparison of the obtained results from all classification approaches is *** metrics including accuracy and ROC curve are compared for each classification *** novelty of this research project is the integration of automatic OD detection and glaucoma diagnosis in a global ***,the fusion-based decision system uses the g

关键词： Optic disc glaucoma fundus image deep learning

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Fluctuating Asymmetry of Elopes lacerta (Valenciennes, 1847) Otoliths in the Western African Waters

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Open Journal of Marine Science 2024年第3期14卷 41-62页

作者： Madel Floriane Adjibayo Houeto Marwa Mejri Malek Tazarki Marius Sounouvou Nicolas Andrialovanirina Meriem Ben Ghorbel Pierre Dossou-Yovo Abdellah Chalh Pierre Quignard monia Trabelsi Kélig Mahé Laboratory of Ecology Biology and Physiology of Aquatic Organisms Faculty of Sciences of Tunis University of Tunis El Manar Tunis Tunisia Institute of Mathematics and Physical Sciences University of Abomey-Calavi (UAC) Abomey-Calavi Benin IFREMER Unit HMMN Halieutic Resources Laboratory Boulogne-sur-Mer France Laboratory for Research into the Processing and Conservation of Fishery Products (LAREPROH) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Unit of Population Genetics and Biological Resources Faculty of Sciences of Tunis University of Tunis El Manar Tunis Tunisia Laboratoire dIchtyologie Universit Montpellier Montpellier France

The importance of this study lies in the in-depth exploration of the ecological diversity of otoliths in Elopes lacerta, based on the analysis of data from 260 individuals collected from various sites, including the Porto Novo lagoon, the Cotonou lagoon, Lake Nokou, and the Atlantic coast in southern Benin. The results highlight significant variations in otolith morphology, establishing relevant links with the biological parameters of the fish at each site. Exploration of the asymmetry between the right and left sides reveals notable distinctions between these two aspects. Analysis of otolith shape thus emerges as a valuable tool for discriminating between stocks and providing a better understanding of ecological variations. The local diversity observed highlights the crucial importance of implementing adaptive management strategies to ensure effective conservation of the species and its habitat.

关键词： Analysis Porto-Novo Lagoon Cotonou Lagoon Lake Nokoué Coast Atlantic

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An Efficient Three-Party Authenticated Key Exchange Procedure Using Chebyshev Chaotic Maps with Client Anonymity

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Computers, Materials & Continua 2023年第6期75卷 5337-5353页

作者： Akshaykumar Meshram monia Hadj Alouane-Turki N.M.Wazalwar Chandrashekhar Meshram Department of Applied Mathematics Yeshwantrao Chavan College of EngineeringNagpur441110MaharashtraIndia Department of Statistics Rashtrasant Tukadoji Maharaj Nagpur UniversityNagpur440033MaharashtraIndia Department of Computer Science College of Computer ScienceKing Khalid UniversityAbhaSaudi Arabia Department of Post Graduate Studies and Research in Mathematics Jaywanti Haksar Government Post-Graduate CollegeCollege of Chhindwara UniversityBetul460001Madhya PradeshIndia

Internet of Things(IoT)applications can be found in various industry areas,including critical infrastructure and healthcare,and IoT is one of several technological *** a result,tens of billions or possibly hundreds of billions of devices will be linked *** smart devices will be able to gather data,process it,and even come to decisions on their *** is the most essential thing in these *** IoT infrastructure,authenticated key exchange systems are crucial for preserving client and data privacy and guaranteeing the security of data-in-transit(e.g.,via client identification and provision of secure communication).It is still challenging to create secure,authenticated key exchange *** majority of the early authenticated key agreement procedure depended on computationally expensive and resource-intensive pairing,hashing,or modular exponentiation *** focus of this paper is to propose an efficient three-party authenticated key exchange procedure(AKEP)using Chebyshev chaotic maps with client anonymity that solves all the problems mentioned *** proposed three-party AKEP is protected from several *** proposed three-party AKEP can be used in practice for mobile communications and pervasive computing applications,according to statistical experiments and low processing *** protect client identification when transferring data over an insecure public network,our three-party AKEP may also offer client ***,the presented procedure offers better security features than the procedures currently available in the literature.

关键词： Client anonymity Chebyshev chaotic maps authenticated key exchange statistical experiment Galois fields

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Three siblings with gyrate atrophy of the choroid and retina:a case report

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2133-2135页

作者： Maamouri Rym Ferchichi Molka Ben Chehida Amel Hadj-Taieb Sameh Cheour monia Department of Ophthalmology Habib Thameur HospitalTunis 1069Tunisia Department of Pediatrics Rabta HospitalTunis 1007Tunisia Laboratory of Biochemistry Rabta HospitalTunis 1007Tunisia University of Tunis El Manar Faculty of Medicine of Tunis 1068Tunisia

Dear Editor,We report the cases of three siblings with gyrate atrophy(GA)of the choroid and retina with foveoschisis,anterior subcapsular cataracts,and capsular bag *** is a rare autosomal recessive degenerative disorder of the choroid and *** one-third of all reported cases are from Finland where the incidence is estimated to be around 1:50000 whereas the theoretical global incidence is only 1:1500000[1].

关键词： atrophy cases cataract

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Robust Deep Transfer Learning Based Object Detection and Tracking Approach

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Intelligent Automation & Soft Computing 2023年第3期35卷 3613-3626页

作者： C.Narmadha T.Kavitha R.Poonguzhali V.Hamsadhwani Ranjan walia monia B.Jegajothi Electronics and Communication Engineering Periyar Maniammai Institute of Science&Technology(PMIST)Thanjavur613403India Department of Computer Science and Engineering Periyar Maniammai Institute of Science&TechnologyThanjavur613403India Department of Electrical and Electronics Engineering Periyar Maniammai Institute of Science and TechnologyThanjavur613403India Electrical Engineering Department Model Institute of Engineering&Technology(Autonomous)Jammu181122India Department of Computer Science and Engineering Shri Mata Vaishno Devi UniversityKatra182320India Center for Energy Research Chennai Institute of TechnologyChennai600069India

At present days,object detection and tracking concepts have gained more importance among researchers and business ***,deep learning(DL)approaches have been used for object tracking as it increases the perfor-mance and speed of the tracking *** paper presents a novel robust DL based object detection and tracking algorithm using Automated Image Anno-tation with ResNet based Faster regional convolutional neural network(R-CNN)named(AIA-FRCNN)*** AIA-RFRCNN method performs image anno-tation using a Discriminative Correlation Filter(DCF)with Channel and Spatial Reliability tracker(CSR)called DCF-CSRT *** AIA-RFRCNN model makes use of Faster RCNN as an object detector and tracker,which involves region proposal network(RPN)and Fast *** RPN is a full convolution network that concurrently predicts the bounding box and score of different *** RPN is a trained model used for the generation of the high-quality region proposals,which are utilized by Fast R-CNN for detection ***,Residual Network(ResNet 101)model is used as a shared convolutional neural network(CNN)for the generation of feature *** performance of the ResNet 101 model is further improved by the use of Adam optimizer,which tunes the hyperparameters namely learning rate,batch size,momentum,and weight ***,softmax layer is applied to classify the *** performance of the AIA-RFRCNN method has been assessed using a benchmark dataset and a detailed comparative analysis of the results takes *** outcome of the experiments indicated the superior characteristics of the AIA-RFRCNN model under diverse aspects.

关键词： Object detection tracking deep learning deep transfer learning image annotation

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An Efficient MPPT Tracking in Solar PV System with Smart Grid Enhancement Using CMCMAC Protocol

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Computer Systems Science & Engineering 2023年第11期47卷 2417-2437页

作者： B.Jegajothi Sundaram Arumugam Neeraj Kumar Shukla I.Kathir P.Yamunaa monia Digra Saveetha School of Engineering SIMATSChennai602105India Department of Electrical and Computer Engineering Navajo Technical UniversityCrown PointNMUSA Department of Electrical Engineering King Khalid UniversityAbhaSaudi Arabia Department of EEE V.S.B.Engineering CollegeTamilnaduIndia Department of Electrical Engineering Peri Institute of TechnologyTamilnaduIndia Department of CSE Model Institute of Engineering and TechnologyJammuIndia

Renewable energy sources like solar,wind,and hydro are becoming increasingly popular due to the fewer negative impacts they have on the ***,Since the production of renewable energy sources is still in the process of being created,photovoltaic(PV)systems are commonly utilized for installation situations that are acceptable,clean,and *** study presents an adaptive artificial intelligence approach that can be used for maximum power point tracking(MPPT)in solar systems with the help of an embedded *** adaptive method incorporates both the Whale Optimization Algorithm(WOA)and the Artificial Neural Network(ANN).The WOA was implemented to enhance the process of the ANN model’s training,and the ANN model was developed using the *** addition to this,the inverter circuit is connected to the smart grid system,and the strengthening of the smart grid is achieved through the implementation of the CMCMAC *** protocol prevents interference between customers and the organizations that provide their *** a protocol known as Cross-Layer Multi-Channel MAC(CMCMAC),the effect of interference is removed using the way that was ***,with the utilization of the ZIGBEE communication technology,bidirectional communication is made *** strategy that was suggested has been put into practice,and the results have shown that the PV system produces an output power of 73.32 KW and an efficiency of 98.72%.In addition to this,a built-in regulator is utilized to validate the proposed *** this paper,the results of various experiments are analyzed,and a comparison is made between the suggested WOA with the ANN controller approach and others,such as the Particle Swarm Optimization(PSO)based MPPT and the Cuckoo Search(CS)based *** examining the comparison findings,it was determined that the adaptive AI-based embedded controller was superior to the other alternatives.

关键词： DC/DC converter MPPT controller Artificial Neural Network(ANN)algorithm ZIGBEE communication CMCMAC protocol Smart Grid(SG)

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Two mitochondrial haplotypes in Pterochloroides persicae （Hemiptera： Aphididae： Lachninae） associated with different feeding sites

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Insect Science 2013年第5期20卷 637-642页

作者： Mdellel Lassaad David Martinez-Torres Ben Halima Kamel monia Hight Institute of Agronomy Chott Mariem 4042 Sousse Tunisia Institut Cavanilles de Biodiversitat i Biologia Evolutiva Universitat de Valencia Apdo. Correos 22085 46071 Valencia Spain

Pterochloroides persicae （Cholodkovsky） is an aphid species belonging to the subfamily Lachninae that uses different members of Rosaceae （specially Prunus spp.） as hosts. Partial sequences from the mitochondrial cytochrome c oxidase 1 （COI） and the nuclear long-wave opsin genes were obtained for approximately 100 P. persicae aphid individuals sampled from 34 colonies collected mainly in Tunisia and other Mediterranean locations. The variability found at the mitochondrial locus revealed the presence of two maternal haplotypes in the studied area that differed in a single nucleotide. The nuclear gene analyzed, however, failed to reveal any variability in this species. The variability found at the COI locus was related to the season of aphid sampling and with the site of feeding, with haplotype I mostly detected in samples collected in spring and summer on trunks and branches and haplotype II only detected in aphids collected in autumn on roots. The observed pattern of molecular variation suggests the presence of two clonal races of P. persicae coexisting in the studied area differentially adapted to conditions prevalent in the alternative seasons and/or to different feeding sites.

关键词： aphids COI Lachninae life cycle Pterochloroides variability

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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