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Cervical Cancer in Women with Inflammatory Pap Smears

Journal of Cancer Therapy 2014年第1期5卷 82-90页

作者： mongia achour Dorra Zeghal Center of Maternity and Neonatology Service of Gynecology and Obstetrics Tunis Tunisia IMEC (Immuno-Microbiology Environmental and Carcinogenesis) UNIT Faculty of Sciences Bizerta Tunisia

In spite of preventive measures such as Papanicolaou cervical cytological analysis and, more recently, vaccination against HPV infection, cancer of the uterine cervix continues to be one of the most frequent causes of mortality among women worldwide, particularly in developing countries. In this prospective study, sixty patients with inflammatory Pap smears had a colposcopy with directed biopsies. The average age of our patients was 42 years. Results showed that colposcopy is normal in 10% of women. It showed normal transformations, ectropion, a colpotis and polyp at 8.33%, 21.66%, 13.33% and 5% respectively. It was able to detect changes with Grade I atypical transformations (28.33%), and Grade II atypical transformations in 13.33% of cases. The biopsies were objectified dysplasia and carcinoma in 24.13% of cases with carcinoma in situ, micro invasive squamous cell carcinoma and invasive carcinoma glandular. Moreover, we detected HPV-specific antibodies in sera of these patients. Results showed that six patients (10%) showed a positive reactivity to at least one of the HPV-16 or HPV-18 antigens and sera showed different reactivity to the different antigens with the following percentages: 5%, 3%, 2%, 3% and 3% for L1 HPV-16, E6 HPV-16, E7 HPV-16, E6 HPV-18 and E7 HPV-18 respectively. Among patients having positive antibody response, 83.33% were cases of dysplasia and carcinoma. We concluded that the Pap smear, examination of key screening for cervical cancer, is a screening test without diagnostic value and more specifically any inflammatory Pap smear should be considered a positive test and led to further investigations. Moreover, colposcopy is an exam that is performed on an outpatient basis;it allows a detailed study of the cervix and reduces the negative rate of cytology. In addition, early detection of HPV antibodies could help the follow-up of patients.

关键词： Pap Smear Inflammatory Cervical Cancer Human Papillomavirus

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Fundamental investigations for lowering emissions and improving operability

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Propulsion and Power Research 2018年第3期7卷 197-204页

作者： Xiao Ren Xin Xue Kyle B.Brady Chih-Jen Sung Hukam C.mongia Department of Mechanical Engineering University of ConnecticutStorrsCT 06269USA National Research Council Air Force Research LaboratoryWPAFBOH 45433USA CSTI Associates LLCYardleyPA 19067USA

This paper first highlights recent developments in lean direct injection(LDI)combustion technology.In view of the needs and opportunities to lower emissions and expand the operability range of LDI,fundamental research has been undertaken to elucidate the effects of air swirler vane angle,air swirler rotation direction,and overall equivalence ratio on the LDI flow field and flame structure/response.Moreover,additional investigation has been conducted to understand the fundamental differences between representative LDI and airblast injectors in order to highlight the importance of the flare feature to LDI venturi geometry.The results of these fundamental studies are discussed to help identify possible areas for optimization to generic LDI designs that may improve individual swirler performance.

关键词： Gas turbine combustor Low emissions Lean direct injection Airblast injector Swirl-venturi configuration

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Lead Induced Oxidative Stress: Beneficial Effects of Kombucha Tea

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Biomedical and Environmental Sciences 2003年第3期16卷 276-282页

作者： P.DIPTI B.YOGESH A.K.KAIN T.PAULINE B.ANJU M.SAIRAM B.SINGH S.S.mongia G.ILAVAZHAGAN DEVENDRA KUMAR W.SELVAMURTHY Defence Institute of Physiology and Allied Sciences Lucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.IndiaDefence Institute of Physiology and Allied SciencesLucknow RoadTimarpurDelhi-110054.India

Objective To evaluate the effect of oral administration of Kombucha tea (K-tea) on lead induced oxidative stress. Methods Sprague Dawley rats were administered 1 mL of 3.8% lead acetate solution daily alone or in combination with K-tea orally for 45 d, and the antioxidant status and lipid peroxidation were evaluated. Results Oral administration of lead acetate to rats enhanced lipid peroxidation and release of creatine phosphokinase and decreased levels of reduced glutathione (GSH) and antioxidant enzymes (superoxide dismutase, SOD and glutathione peroxidase, GPx). Lead treatment did not alter humoral immunity, but inhibited DTH response when compared to the control. Lead administration also increased DNA fragmentation in liver. Oral administration of Kombucha tea to rats exposed to lead decreased lipid peroxidation and DNA damage with a concomitant increase in the reduced glutathione level and GPx activity. Kombucha tea supplementation relieved the lead induced immunosuppression to appreciable levels. Conclusion The results suggest that K-tea has potent antioxidant and immunomodulating properties.

关键词： Lead Oxidative stress Kombucha tea Antioxidant activity

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Mass Synthesis in Polyol of Tailored Zinc Oxide Nanoparticles for Photovoltaic Applications

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Journal of Surface Engineered Materials and Advanced Technology 2016年第1期6卷 1-10页

作者： mongia Hosni Ivaylo Hinkov Christian Ricolleau Thierry Pauporté Samir Farhat Noureddine Jouini Laboratoire des Sciences des Procé dé s et des Maté riaux CNRS LSPM-UPR Universit&eacute Paris 13 PRES Sorbonne-Paris-Cit&eacute Villetaneuse France Department of Chemical Engineering University of Chemical Technology and Metallurgy Sofia Bulgaria Laboratoire Maté riaux et Phé nomè nes Quantiques CNRS UMR Universit&eacute Paris Diderot Paris France Chimie ParisTech PSL Research University CNRS Institut de Recherche de Chimie Paris (IRCP) Paris France

Zinc oxide nanoparticles with different sizes and shapes have been synthesized in polyol using a bottom-up approach. We have studied the scale-up of the process to massively produce high quality nanoparticles of controlled size and shape. The scale-up strategy required the effective mixing of reagents using either axial or radial mixing configurations and was experimentally validated by comparing structural properties of particles obtained in a small and a large size reactor. In addition, the flow patterns in these reactors have been calculated using three-dimensional turbulent computational fluid dynamics (CFD) simulations. Our results indicate a strong connection between the flow patterns, as obtained by CFD simulations, and the size and shape of the particles. Actually, our pilot scale reactor allowed producing sample aliquots of ~50 grams with nanoparticle sizes ranging from 8 nm to 600 nm and aspect ratio varying from 1 (nanospheres) to 20 (nanorods). After their synthesis, these two nanoparticle classes have been tested as building blocks in D149-dye-sensitized solar cell (DSSC). The measured power conversion efficiency (PCE) was 4.66% for nanorods shaped particles and 4.21% for nanospheres. These values were significantly higher than the 3.90% PCE obtained with commercial Degussa VP20 ZnO nanoparticles.

关键词： Zinc Oxide Polyol Process Nanoparticles Scale-Up Strategy Dye-Sensitized Solar Cells

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Scale-Up of the Polyol Process for Nanomaterial Synthesis

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Journal of Materials Science and Chemical Engineering 2014年第9期2卷 1-11页

作者： Samir Farhat Nassima Ouar mongia Hosni Ivaylo Hinkov Silvana Mercone Frédéric Schoenstein Noureddine Jouini Département de Génie Chimique Université de Technologie Chimique et de Métallurgique 8 Boulevard St. Kliment Ohridski 1756 Sofia Bulgarie Laboratoire des Sciences des Procédés et des Matériaux CNRS LSPM-UPR 3407 Université Paris 13 PRES Sorbonne-Paris-Cité 99 Avenue J.-B. Clément 93430 Villetaneuse France

Two classes of inorganic materials such as metallic nanowires and metal oxides nanorods were synthesized using the polyol process and scaled-up to produce macroscopic quantities. Scale-up strategy was successfully built by performing the synthesis in a 15 cm diameter, 4.5 litersvolume cylindrical tank using a straight paddle impeller and a Rushton turbine. The actual yield of the synthesis is ~45 grams per batch for zinc oxide nanorods and ~20 grams per batch for cobalt nickel nanowires. Under the same rotation speed, the aspect ratio of the produced nanowires and nanorods using the Rushton turbine impeller with radial flow patterns has shown a lower aspect ratio, nanoparticle size and polydispersity. This is attributed to the increase of the local dissipated energy as spatially calculated by computational fluid dynamics (CFD) that is proposed to design, optimize and scale-up the polyol process.

关键词： CFD Simulation Polyol Process Nanomaterial Synthesis

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沙棘叶子提取物对白化病白鼠由铬诱导氧化胁迫的抗氧化活性评估

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陕西林业科技 2006年第1期30卷 90-94页

作者：郭海赵明 S.Geetha M.Sai Ram S.S.mongia Virendra Singh G.Ilavazhagan R.C.Sawhney 水利部沙棘开发管理中心北京100038 香港中文大学生物系生理联合科学预防研究所 H.P.农业大学

本研究报道沙棘(胡颓子科)对雄性白化病白鼠由铬诱导氧化胁迫的抗氧化活性。氧化胁迫通过对小白鼠进行强制性喂养30 d,以浓度为30 m g/kg的铬相对体重比例的重铬酸钾盐实现。铬促使体重下降,而却明显增加了器官与体重比例。铬处理明显... 详细信息

本研究报道沙棘(胡颓子科)对雄性白化病白鼠由铬诱导氧化胁迫的抗氧化活性。氧化胁迫通过对小白鼠进行强制性喂养30 d,以浓度为30 m g/kg的铬相对体重比例的重铬酸钾盐实现。铬促使体重下降,而却明显增加了器官与体重比例。铬处理明显减少了谷胱甘肽的降低,增加了丙二醛和肌氨酸磷酸激酶的水平;而且它还加强了血清中谷氨酸草酰乙酸转移酶和谷氨酸丙酮酸转移酶的浓度。用不同剂量的沙棘叶子提取物(乙醇提取)对保护铬元素诱导的氧化胁迫进行了评估,结果表明叶子提取物在浓度为100到250 m g/kg铬与体重比的情况下可以明显保护动物避免由铬所诱导的氧化伤害。

关键词：沙棘铬氧化胁迫抗氧化剂

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