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Natural sources, biosynthesis, biological functions, and molecular mechanisms of shikimic acid and its derivatives

Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 139-147页

作者： Gopalsamy Rajiv Gandhi Alan Bruno Silva Vasconcelos Poovathumkal James Antony monalisa martins montalvão Mariana Nobre Farias de Franca Varghese Edwin Hillary Stanislaus Antony Ceasar Dan Liu Division of Phytochemistry and Drug Design Department of BiosciencesRajagiri College of Social SciencesKalamaserryKochi 683104India Laboratory of Biology and Immunology of Cancer and Leishmania Department of MorphologyFederal University of SergipeSão Cristóvão 49100.000SergipeBrazil Nepal Jesuit Society Human Resource Development and Research CentreKathmandu 44600Nepal Postgraduate Program of Health Sciences Federal University of SergipeCampus Prof.João Cardoso NascimentoAracaju 49060.108SergipeBrazil Division of Plant Molecular Biology and Biotechnology Department of BiosciencesRajagiri College of Social SciencesKalamaserryKochi 683104India School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

Shikimic acid is a hydroaromatic compound possessing critical biological properties,such as antibacterial and antiviral *** review mainly focused on shikimic acid and its *** first briefly introduced the sources of shikimic acid and its derivatives and discussed their *** in vitro and in vivo studies indicate that shikimic acid and its derivatives exhibit diverse bioactivities,such as antioxidant,antiviral,anti-inflammatory,antibacterial,hypolipidemic,bone protective,skin protective,neuroprotective,and antidiabetic *** mainly focused on the related molecular ***,the wide range of bioactivities of shikimic acid and its derivatives indicate that a more detailed exploration of their potential for the prevention and treatment of certain diseases is warranted.

关键词： Natural products Shikimate Ginkgo biloba Neuroprotection Inflammation

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Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease:A systematic review

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1408-1428页

作者： Gopalsamy Rajiv Gandhi Thiruchenduran Mohana Kumaraswamy Athesh Varghese Edwin Hillary Alan Bruno Silva Vasconcelos Mariana Nobre Farias de Franca monalisa martins montalvão Stanislaus Antony Ceasar Gnanasekaran Jothi Gurunagarajan Sridharan Ricardo Queiroz Gurgel Baojun Xu Division of Phytochemistry and Drug Design Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Department of Biochemistry Meenakshi Ammal Dental College and Hospital(MAHER)Maduravoyal600095ChennaiTamil NaduIndia Department of Biochemistry Srimad Andavan Arts and Science College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirapalli620005Tamil NaduIndia Division of Plant Molecular Biology and Biotechnology Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Laboratory of Biology and Immunology of Cancer and Leishmania Department of MorphologyFederal University of SergipeSao CristovaoSergipeBrazil Postgraduate Program in Health Sciences(PPGCS) Federal University of Sergipe(UFS)Campus Prof.Joao Cardoso NascimentoAracajuCEP 49060.108SergipeBrazil Programme of Food Science and Technology Department of Life SciencesBNU-HKBU United International CollegeZhuhaiGuangdong519087China

This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules in managing inflammatory bowel disease(IBD).Specifically,the objective is to examine the impact of these substances on interleukins and other key inflammatory signaling *** articles published up to December 2022 were identified through a search of the PubMed,Scopus,Web of Science,and Embase *** search used keywords including“inflammatory bowel disease”,“medicinal plants”,“natural molecules”,“anti-inflammatory”,and“ulcerative colitis”,and identified 1,878 potentially relevant articles,of which 89 were included in this review after completion of the selection *** study provides preclinical data on natural products(NPs)that can potentially treat IBD,including ulcerative *** main actions of these NPs relate to their effects on nuclear factor kappa B(NF-κβ),the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway,the regulation of T helper 17/regulatory T cells balance,and oxidative *** ability of these NPs to inhibit intestinal inflammation appears to be dependent on lowering levels of the pro-inflammatory cytokines tumor necrosis factor-alpha(TNF-α),interleukin(IL)-1β,and IL-17,via the Jun N-terminal kinase(JNK)1,NF-κβ-p65,and STAT3 *** addition,NPs were shown to reduce oxidative stress and the severity of ulcerative colitis,as well as increase the activity of antioxidant *** actions suggest that NPs represent a promising treatment for IBD,and potentially have greater efficacy and safety than current treatments.

关键词： Crohn's disease Inflammation Interleukins oxidative stress Phytochemicals Ulcerative colitis

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