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A review of microbial laccase production and activity toward different biotechnological applications

Systems Microbiology and Biomanufacturing 2023年第4期3卷 533-551页

作者： monalisa mahuri Manish Paul Hrudayanath Thatoi Department of Biotechnology Maharaja Sriram Chandra Bhanjadeo UniversitySriram Chandra ViharTakatpurBaripadaOdisha 757003India

Laccases are versatile enzymes that belong to the multi-copper oxidase *** enzyme has several biotechnological applications because of its ablilty to oxidize a wide range of phenolic and non-phenolic ***,their large-scale applicability in bioremediation and water treatment is hindered by high salt content and extreme pH values of the polluted media which also affects the stability,recovery and recycling of *** from some bacteria,laccase is abundantly present in several lignin-degrading white-rot fungi ***,Deuteromycetes,and ***,lac-case has been employed in the development of biosensors as a medical diagnostic tool,biofuel cells,and in bioremediation purpose to remove herbicides,pesticides,and some toxic chemicals from the ***,most of the enzymes including laccase are normally unstable and susceptible to lose their activity over *** might be avoided by maintaining the activity and lengthening the enzyme's lifespan through the use of appropriate immobilization *** potential of laccase immobilized biocathodes for dye decolorization in microbial fuel cells has recently been *** laccase nanoparticles have potential uses as biocatalyst in the bioremediation of *** addition,advanced research considering microbial laccase has been conducted for its heterologous expression along with in silico protein engineering to attain maximum enzyme activity which can be potentially applied in different biotechnological *** related to laccase also implied that this enzyme can be used as suitable catalyst for the production of promising anti-cancer drugs and even as a significant ingredient in cosmetics.

关键词： Microbial laccase Laccase activity Membrane immobilization Heterologous expression In silico protein engineering Bioremediation

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Improvement of saccharification of native grass,Pennisetum *** cellulase from isolated Aspergillus fumigatus for bioethanol production:an insight into in silico molecular modelling,docking and dynamics studies

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Systems Microbiology and Biomanufacturing 2023年第3期3卷 394-413页

作者： Hrudayanath Thatoi Sonali Mohapatra Manish Paul Sandesh Behera monalisa mahuri Department of Biotechnology Maharaja Sriram Chandra Bhanja Deo UniversityBaripada 757003OdishaIndia Department of Biotechnology Odisha University of Technology and ResearchBiju Patnaik University of TechnologyKalinga NagarGhatikiaBhubaneswar 751003OdishaIndia

Lignocellulosic grass biomass is potential substrate for economical and sustainable bioethanol ***,the processing cost of bioethanol that majorly includes the hydrolysis of cellulose by cellulases is still a major concern for its industrial ***,knowledge on the sequence to the structural study of cellulase enzyme with consideration of its catalytic region can give important information for effective enzyme engineering and consequently towards enhanced bioethanol production from Pennisetum ***,in this study,sequence conservativeness of different cellulosic site among a group of endoglucanase family of cellulase from previously isolated Aspergillus species has been ***,comparative molecular modeling of the endoglucanase from eight different Aspergillus species including Aspergillus fumigatus was conducted and the obtained structures revealed a high degree of difference in their conformational *** from InterProScan revealed that the modeled endoglucanase has similar types of domains and share homology with protein family,such as glycoside hydrolase family-61 and fungal cellulose binding ***,molecular docking and interaction studies demonstrated the presence of residues in the endoglucanase of *** ***20,His88,Asp96,Ala99,Ser100,Ser101,His102,His169,Glu170,Arg173,Glu178,and Tyr218 that are responsible in forming the substrate *** interesting molecular phenomenon,i.e.,catalytic promiscuity has been noted for all the substrate bound complexes of *** endoglucanase which also depicts the degree of ligand binding efficacy of the studied *** molecular interaction study,binding energy analysis and molecular dynamics simulation,demonstrated that heteromeric substrate XylGlc3 is more strongly interacting with the receptor ***,the present findings revealed that important amino acid residues can help in increasing the specificity of endoglucanase from A.

关键词： Endoglucanase Aspergillus fumigatus Homology modeling Molecular docking Catalytic promiscuity Molecular dynamics simulation

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