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Genotypic characterization of Helicobacter pylori isolates among Egyptian patients with upper gastrointestinal diseases

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The Chinese-German Journal of Clinical Oncology 2012年第1期11卷 15-23页

作者： Abdel Hamid Hussein Ezzat mona Hamza Ali Eman Ahmed El-Seidi Iman Ezzat Wali Nagwa Abd El Rahman Sedky Sherif Medhat Mahmoud Naguib Department of Surgical Oncology National Cancer Institute Cairo University Laboratory Forensic Medicine Egyptian Ministry of Justice Medical Microbiology and Immunology Faculty of Medicine Cairo University Internal Medicine Faculty of Medicine Cairo University

Objective： Over 50% of the world populations are infected with Helicobacter pylori （H. pylori）. Most subjects are asymptomatic; however, in 1994, H. pylori has been categorized as group I carcinogen. The aim of the study was to investigate the relationship between H. pylori infection and gastric cancer. Methods： Thirty gastric cancer patients （GCs） and 30 gastritis patients were enrolled in the study. H. pylori was cultured on non-selective and selective medias, infection density was assessed by quantitative culture. Antibiotic sensitivity testing was performed. PCR was done for the H. pylori 16S rRNA gene in addition to cagA, vacA and iceA genes. Results： H. pylori could be cultured from 100% of specimens obtained from all patients. The density of H. pylori was higher in cancer cases than in gastritis patients. The 16S rRNA was detected in all GC patients （100%） while it was only detected in 70% of gastritis patients. The cagA gene was found in 53.3% vs 13.3% of GC and gastritis patients, respectively. The vacA gene was present in all GC patients （by at least one of its alleles） while it was only found in 33.3% of gastritis patients. The vacA slml combination was the most predominant genotype in GC patients, while m2 was the commonest allele in gastritis patients （10%）. The iceA gene was found in 86.7% vs 40% of GC and gastritis patients, respectively. Simultaneous presence of multiple H. pyiori strains was proved, both phenotypically and genotypically. Conclusion： The development of GC is linked to infection with H. pylori harboring certain virulence genes. Higher infection density of H. pylori was found in GC patients. Co-existence of more than one strain of H. pylori in the same patient occurs in both malignant and benign lesions.

关键词： Helicobacter pylori (H. pylori) pathogenesis virulence genes diagnosis infection density antibiotic resistance PCR

深圳市当代艺术馆与城市规划展览馆中国深圳(2007-2016)

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世界建筑导报 2016年第2期31卷 58-61页

作者：沃尔夫·狄·普瑞克斯 Quirin Krumbholz Jorg Hugo mona Bayr 无不详蓝天组建筑事务所蓝天组

深圳市当代艺术馆与城市规划展览馆（两馆）是深圳新市中心——福田区总体规划的重要组成部分。本项目包含了两个独立的但共享同一个建筑的机构,即当代艺术馆和城市规划展览馆,分别作为文化交汇之处以及建筑展览场所。大厅、多功能厅、... 详细信息

深圳市当代艺术馆与城市规划展览馆（两馆）是深圳新市中心——福田区总体规划的重要组成部分。本项目包含了两个独立的但共享同一个建筑的机构,即当代艺术馆和城市规划展览馆,分别作为文化交汇之处以及建筑展览场所。大厅、多功能厅、礼堂、会议室和服务区域将由两者共同使用。艺术馆和展览馆被设计成独立的个体,强调二者独特的功能和艺术要求,然而在建筑上两者却形成了一个整体,由一个多功能的立面环绕。

关键词：当代艺术馆中国深圳灯光设计艺术要求服务区域 exhibition 公共广场人能总体规划 visitors

Antidiabetic profiling of veramycins,polyketides accessible by biosynthesis,chemical synthesis and precursor-directed modification

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Organic Chemistry Frontiers 2022年第6期9卷 1604-1615页

作者： Denis Dardić Nils Böhringer Alberto Plaza Florian Zubeil Juliane Pohl Svenja Sommer Leo Padva Jonathan Becker Maria A.Patras mona-Katharina Bill Michael Kurz Luigi Toti Sven W.Görgens Sören M.M.Schuler AndréBillion Oliver Schwengers Paulus Wohlfart Alexander Goesmann Norbert Tennagels Andreas Vilcinskas Peter E.Hammann Till F.Schäberle Armin Bauer Fraunhofer Institute for Molecular Biology and Applied Ecology(IME) Branch for Bioresources35392 GießenGermany Justus-Liebig-University Gießen 35392 GießenGermany Sanofi-Aventis Deutschland GmbH R&D Integrated Drug Discovery65926 Frankfurt am MainGermany Sanofi-Aventis Deutschland GmbH R&D German Hub65926 Frankfurt am MainGermany German Center of Infection Research(DZIF) Partner Site Gießen-Marburg-Langen35392 GießenGermany

Seven new polyketides,termed veramycins,were isolated from a Streptomyces *** the Sanofi microbial strain collection along with their known congeners NFAT-133 and *** A,anα-pyrone congener of TM-123 and NFAT-133 showed an increased baseline deoxy-glucose uptake in the absence of insulin in a modified L6 rat skeletal muscle cell line(L6 GLUT4 AS160-like cells).In addition,both compounds slightly increased the sensitivity to insulin in this cell *** syntheses of NFAT-133,TM-123 and veramycin A were accomplished starting from a central building block,which bears the three contiguous stereogenic centers of this polyketide *** approach enables an efficient,selective and flexible access to all possible isomers of the stereotriad for further exploration of this series as a potential anti-diabetic lead structure as exemplified by the synthesis of an NFAT-133 ***,the corresponding biosynthetic gene cluster(BGC)was identified by genome sequencing and gene *** on feeding experiments,a biosynthetic pathway was proposed,which enabled access to new veramycin A analogs by precursor-directed biosynthesis.

关键词： synthesis directed isomers

阿克伦艺术博物馆美国俄亥俄州(2001-2007)

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世界建筑导报 2016年第2期31卷 78-81页

作者：沃尔夫.狄.普瑞克斯 tom wiscombe mona marbach roland halbe 无不详蓝天组建筑设计事务所

蓝天组通过阿克伦艺术博物馆展现了一种新的博物馆设计理念,即＂未来博物馆＂。博物馆的传统功能和城市空间共同形成了一座新型的文化中心,向参观者提供数字,模拟信息和体验。博物馆由三个部分组成：水晶体、美术馆和云顶。水晶体作为... 详细信息

蓝天组通过阿克伦艺术博物馆展现了一种新的博物馆设计理念,即＂未来博物馆＂。博物馆的传统功能和城市空间共同形成了一座新型的文化中心,向参观者提供数字,模拟信息和体验。博物馆由三个部分组成：水晶体、美术馆和云顶。水晶体作为博物馆的主入口,可作为一个指示方位的场所,并与新旧建筑物的公共功能区相连。它是一个大型、灵活的空间,可用于举办宴会、艺术节,或供外部机构和企业举办各种活动。美术馆内部是一个广阔的空间,柱体较少.

关键词：艺术博物馆阿克伦城市空间文化中心云顶主入口美国俄亥俄州模拟信息 heating 人造光源

Prevalence of occult hepatitis C in egyptian patients with non alcoholic fatty liver disease

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Open Journal of Internal Medicine 2011年第2期1卷 33-37页

作者： Yasmin Saad Soheir Zakaria Iman Ramzy Maissa El Raziky Olfat Shaker Wafaa elakel Mohamed Said mona Noseir Mai El-Daly Mohamed Abdel Hamid Gamal Esmat 不详

This study aim is to assess the prevalence of occult HCV infection among Egyptian patients with non alcoholic fatty liver disease (NAFLD) with elevated AST and ALT, and to correlate presence of occult HCV with severity of liver disease. Patients and Methods: After informed consent 27 patients with elevateed liver enzymes diagnosed as NAFLD were examined for demographic, clinical, laboratory data and Ultrasonography. Liver biopsy was done and tested for HCV RNA in tissue. Genotyping using RFLP analysis of PCR products in the 5’NCR was done for positive cases. Results: HCV RNA in tissue was positive in 11/27 patients (40.7%);genotype was 4a in all positive cases. AST and ALT values showed significantly lower values in occult HCV than the non HCV NAFLD group. Liver biopsy of studied patients showed no significant difference as regard inflammation and fibrosis according to METAVIR score. Conclusions: Occult HCV is highly prevalent among Egyptian NAFLD patients. It seems to induce a mild liver disease. Patients with elevated ALT and negative HCV RNA in sera might be investigated for tissue HCV RNA. Follow up is recommended for the occult HCV patients to monitor progression to overt disease.

关键词： Genotype 4 Liver Enzymes NAFLD Occult HCV

利用激光捕获显微分离技术和突变分析法检测肺癌病人痰细胞的K-ras和p53基因突变

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海峡预防医学杂志 2008年第6期14卷 1-2,14页

作者：郑奎城 Gao Wei-Min Keohavong Phouthone Mady Hussam Melhem mona 美国匹兹堡大学公共卫生学院日本国立琉球大学医学部福建省疾病预防控制中心福州350001

[目的]探索激光捕获显微分离技术在检测肺癌病人K-ras和p53基因突变的应用。[方法]以3种不同的基因突变分析法对20例患者的痰细胞进行基因突变分析:①以PCR+DGGE方法分析K-ras基因突变,以PCR+SSCP方法分析p53基因突变;②以PCR+MAE+DGGE... 详细信息

[目的]探索激光捕获显微分离技术在检测肺癌病人K-ras和p53基因突变的应用。[方法]以3种不同的基因突变分析法对20例患者的痰细胞进行基因突变分析:①以PCR+DGGE方法分析K-ras基因突变,以PCR+SSCP方法分析p53基因突变;②以PCR+MAE+DGGE方法分析K-ras基因突变;以PCR+MAE+SSCP方法分析p53基因突变;③以激光捕获显微分离技术和突变分析法检测肺癌病人痰细胞的K-ras和p53基因突变。[结果]在20例患者中,以现有的方法仅发现有15%(3/20)的基因突变,而激光捕获显微分离技术则发现有60%(12/20)的基因突变。[结论]激光捕获显微分离技术和突变分析法能高效灵敏检测肺癌病人痰细胞的K-ras和p53基因突变。

关键词：肺癌 K—ras和p53基因突变激光捕获显微分离技术突变分析法

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer

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Science China(Life Sciences) 2022年第11期65卷 2205-2217页

作者： Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss mona PTan Mathew A Cherian Erwei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineBreast Tumor CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Clinical Research Design Division Clinical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Medical Statistics School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Department of Breast Surgery the Second Affiliated HospitalShandong UniversityJinan 250033China Department of Breast Surgery Key Laboratory of Breast DiseasesThird Hospital of NanchangNanchang 330009China Department of Breast Surgery the First Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510120China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Experimental and Clinical Pharmacology University of MinnesotaMinneapolisMN 55455USA Department of Surgery College of MedicineUniversity of RzeszówRzeszów 35-959Poland Department of Radiation Oncology O’Neal Comprehensive Cancer CenterUniversity of Alabama at Birmingham School of MedicineBirminghamALUSA Laboratoty of Predictive Oncology Institut Paoli-CalmettesCentre de Recherche en Cancérologie de MarseilleINSERM UMR1068CNRS UMR725MarseilleFrance Department of Drug Development and Innovation(D3i) Institut CurieParis 75005France Comprehensive Cancer Center UOC di Oncologia MedicaFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168Italy Multidisciplinary Breast Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Breast Surgery Department of Surgical OncologyRoswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Surgery MD Anderson Cancer CenterHoustonTX 77030USA Department of Plastic and Reconstructive Surgery

Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,*** who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer.

关键词： hormone receptor-positive breast cancer micro RNA signature neoadjuvant chemotherapy dynamic contrast-enhanced magnetic resonance imaging nomogram

Intrinsic Bio-Enhancer Entities of <i>Fagonia cretica</i>for Synthesis of Silver Nanoparticles Involves Anti-Urease, Anti-Oxidant and Anti-Tyosinase Activity

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Advances in Bioscience and Biotechnology 2019年第12期10卷 455-468页

作者： Aqsa Yousaf Ayesha Zafar Muhammad Ali Snober mona Bukhary Yasmeen Manzoor Tuba Tariq Asma Saeed Muhammad Akram Faryal Bukhari Muhammad Abdullah Syeda Sadaf Zehra Shahbaz Gul Hassan Murtaza Hasan Department of Biochemistry and Biotechnology The Islamia University Bahawalpur Pakistan Department of Biological Sciences Gomal University Dera Ismail Khan Pakistan Department of Chemistry The Islamia University Bahawalpur Pakistan Cholistan Institute of Desert Studies (CIDS) The Islamia University Bahawalpur Pakistan Department of Botany The Islamia University Bahawalpur Pakistan College of Information Science and Engineering Zhongkai University of Agriculture and Engineering Guangzhou China

Objective: Evaluating the bio-reducing activity and various potential, annotates the biological entitties of Fagonia cretica. Method: By fractionating the crude extract with different ethanol-water fraction mixture. This substantiates the reduction potential for the biological synthesis of AgNPs, its antioxidant, anti-urease and anti-Tyrosinase activity. Results: UV-visible spectra confirm the bio-reducing potential for Ag NPs with the optimized 50% ethanol-water fraction mixture. Transmission electron microscopy (TEM) confirmed the round shaped AgNPs with an average size of 16 nm in optimized 50% fraction mixture. Further evaluating Ethanol-water fraction with 90% and 70% of plant extract showed more potentials for Anti-Tyrosinase and Anti-urease activity. Moreover, diluted 30% fraction exhibits two folds higher Anti-oxidant and Anti urease activity. Conclusion: Overall, this work showed that 50% Ethanol-water fraction has potentially active molecules (among all fractions) primarily involved in bio-reducing potential of Ag NPs and enzymatic assay while 90% mixture proved to be least active. This study suggested electing the optimum mixture fraction of 50% ethanol-water in order to screen the bioactive compounds and to inculcate their activity status for clinical trials.

关键词： Bioactivity Fagonia cretica Nanoparticles Enzymes Assay Bio Reducing Agent

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皇后街的柯南·道尔怎样和福尔摩斯亲密接触

城市地理 2021年第8期 18-25页

作者：鲁佳张鹏(图) 苏因(图) Gabriele Stravinskaite(图) mona Jain(图) Visual Stories(图) 不详

全世界的福尔摩斯迷去伦敦游玩,一定都会到位于贝克街221B的福尔摩斯博物馆去看他的“故居”。我也曾专程去过,这个“故居”做得非常逼真,最大程度地还原了我们心目中福尔摩斯的形象。但福尔摩斯毕竟是虚构的文学人物,这部风靡全球的侦... 详细信息

全世界的福尔摩斯迷去伦敦游玩,一定都会到位于贝克街221B的福尔摩斯博物馆去看他的“故居”。我也曾专程去过,这个“故居”做得非常逼真,最大程度地还原了我们心目中福尔摩斯的形象。但福尔摩斯毕竟是虚构的文学人物,这部风靡全球的侦探小说的作者柯南·道尔才是一个真实存在过的人。

关键词：柯南·道尔福尔摩斯侦探小说皇后街真实存在故居博物馆