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Adiponectin as a therapeutic target for diabetic foot ulcer

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World Journal of Diabetes 2023年第6期14卷 758-782页

作者： Mona Mohamed Ibrahim Abdalla Jaiprakash Mohanraj Sushela Devi Somanath Department of Physiology Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Biochemistry Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Microbiology School of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

The global burden of diabetic foot ulcers(DFUs)is a significant public health concern,affecting millions of people worldwide.These wounds cause considerable suffering and have a high economic cost.Therefore,there is a need for effective strategies to prevent and treat DFUs.One promising therapeutic approach is the use of adiponectin,a hormone primarily produced and secreted by adipose tissue.Adiponectin has demonstrated anti-inflammatory and antiatherogenic properties,and researchers have suggested its potential therapeutic applications in the treatment of DFUs.Studies have indicated that adiponectin can inhibit the production of pro-inflammatory cytokines,increase the production of vascular endothelial growth factor,a key mediator of angiogenesis,and inhibit the activation of the intrinsic apoptotic pathway.Additionally,adiponectin has been found to possess antioxidant properties and impact glucose metabolism,the immune system,extracellular matrix remodeling,and nerve function.The objective of this review is to summarize the current state of research on the potential role of adiponectin in the treatment of DFUs and to identify areas where further research is needed in order to fully understand the effects of adiponectin on DFUs and to establish its safety and efficacy as a treatment for DFUs in the clinical setting.This will provide a deeper understanding of the underlying mechanisms of DFUs that can aid in the development of new and more effective treatment strategies.

关键词： Diabetic foot ulcer Adiponectin Anti-inflammatory Adipose tissue Antioxidants Wound healing

Serum resistin and the risk for hepatocellular carcinoma in diabetic patients

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World Journal of Gastroenterology 2023年第27期29卷 4271-4288页

作者： Mona Mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Hepatocellular carcinoma(HCC),the predominant type of liver cancer,is a major contributor to cancer-related fatalities across the globe.Diabetes has been identified as a significant risk factor for HCC,with recent research indicating that the hormone resistin could be involved in the onset and advancement of HCC in diabetic individuals.Resistin is a hormone that is known to be involved in inflammation and insulin resistance.Patients with HCC have been observed to exhibit increased resistin levels,which could be correlated with more severe disease stages and unfavourable prognoses.Nevertheless,the exact processes through which resistin influences the development and progression of HCC in diabetic patients remain unclear.This article aims to examine the existing literature on the possible use of resistin levels as a biomarker for HCC development and monitoring.Furthermore,it reviews the possible pathways of HCC initiation due to elevated resistin and offers new perspectives on comprehending the fundamen-tal mechanisms of HCC in diabetic patients.Gaining a better understanding of these processes may yield valuable insights into HCC’s development and progression,as well as identify possible avenues for prevention and therapy.

关键词： Hepatocellular carcinoma Resistin Insulin resistance Obesity Diabetes Liver cancer

Role of visfatin in obesity-induced insulin resistance

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World Journal of Clinical Cases 2022年第30期10卷 10840-10851页

作者： Mona Mohamed Ibrahim Abdalla Physiology Department Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Bukit JalilMalaysia

The growing worldwide burden of insulin resistance(IR) emphasizes the importance of early identification for improved management.Obesity,particularly visceral obesity,has been a key contributing factor in the development of IR.The obesity-associated chronic inflammatory state contributes to the development of obesity-related comorbidities,including IR.Adipocytokines,which are released by adipose tissue,have been investigated as possible indicators of IR.Visfatin was one of the adipocytokines that attracted attention due to its insulinmimetic activity.It is released from a variety of sources,including visceral fat and macrophages,and it influences glucose metabolism and increases inflammation.The relationship between visfatin and IR in obesity is debatable.As a result,the purpose of this review was to better understand the role of visfatin in glucose homeostasis and to review the literature on the association between visfatin levels and IR,cardiovascular diseases,and renal diseases in obesity.

关键词： Homeostatic model assessment for insulin resistance Insulin resistance Obesity Visfatin pre-B cell colony enhancing factor Nicotinamide phosphoribosyl-transferase enzyme Diabetes Adipocytokines

Salivary resistin level and its association with insulin resistance in obese individuals

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World Journal of Diabetes 2021年第9期12卷 1507-1517页

作者： Mona Mohamed Ibrahim Abdalla Human Biology Department School of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

The escalating global burden of type 2 diabetes mellitus necessitates the implementation of strategies that are both more reliable and faster in order to improve the early identification of insulin resistance(IR)in high-risk groups,including overweight and obese individuals.The use of salivary biomarkers offers a promising alternative to serum collection because it is safer,more comfortable,and less painful to obtain saliva samples.As obesity is the foremost contributory factor in IR development,the adipocytokines such as leptin,adiponectin,resistin,and visfatin secreted from the adipose tissue have been studied as potential reliable biomarkers for IR.Measurement of salivary adipokines as predictors for IR has attracted widespread attention because of the strong correlation between their blood and salivary concentrations.One of the adipokines that is closely related to IR is resistin.However,there are conflicting findings on resistin’s potential role as an etiological link between obesity and IR and the reliability of measuring salivary resistin as a biomarker for IR.Hence this study reviewed the available evidence on the potential use of salivary resistin as a biomarker for IR in order to attempt to gain a better understanding of the role of resistin in the development of IR in obese individuals.

关键词： Homeostatic model assessment of insulin resistance Insulin resistance Obesity Salivary resistin Diabetes Adipocytokines

Association of Blastocystis hominis with colorectal cancer:A systematic review of in vitro and in vivo evidences

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 734-745页

作者： Vinoth Kumarasamy Wahib Mohammed Atroosh Deepa Anbazhagan Mona Mohamed Ibrahim Abdalla Meram Azzani Department of Microbiology and Parasitology Faculty of MedicineBioscience and NursingMAHSA UniversityJenjarom 42610SelangorMalaysia Department of Preclinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanKajang 43000SelangorMalaysia Department of Parasitology Faculty of MedicineUniversiti MalayaKuala Lumpur 50603Wilayah PersekutuanMalaysia Department of Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversity of AdenAden 00Yemen Human Biology Department International Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia Department of Community Medicine Faculty of MedicineBioscience and NursingMAHSA UniversityJenjarom 42610SelangorMalaysia

BACKGROUND Recently,there have been several findings that showed intestinal colonisation of Blastocystis hominis(Blastocystis)as a risk factor to the worsening of colorectal cancer(CRC).However,studies have shown controversial results in the pathogenicity of Blastocystis.AIM To review systematically the evidence available on the association between CRC and Blastocystis and the prevalence of Blastocystis in CRC patients and to investigate cytopathic and immunological effects of Blastocystis in in vitro and in vivo studies.METHODS PRISMA guidelines were utilised in conducting this systematic review.Original articles published before February 2,2020 were included.PubMed,Science Direct,Scopus and Google scholar databases were searched.Manual searching was carried out to find articles missed during the online search.RESULTS Out of 12 studies selected for this systematic review,seven studies confirmed the prevalence of Blastocystis and found it to be between 2%-28%in CRC patients,whereby subtype 1 and subtype 3 were predominantly seen.A total of four studies employing in vitro human colorectal carcinoma cell line study models showed significant cytopathic and immunological effects of Blastocystis.In addition,one in vivo experimental animal model study showed that there was a significant effect of infection with Blastocystis on exacerbation of colorectal carcinogenesis.CONCLUSION Blastocystis is a commonly identified microorganism in CRC patients.These studies have provided supportive data that Blastocystis could exacerbate existing CRC via alteration in host immune response and increased oxidative damage.Future studies of CRC and Blastocystis should attempt to determine the various stages of CRC that are most likely to be associated with Blastocystis and its relationship with other intestinal bacteria.

关键词： Blastocystis hominis Colorectal cancer Cytopathic effect Immunological effect

Childhood asthma biomarkers including zinc: An exploratory crosssectional study

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World Journal of Clinical Pediatrics 2024年第1期13卷 31-40页

作者： Hoda Atef Abdelsattar ibrahim mona Mohsen Boles Salep Aziz Hanna Dina Mahmoud Khaled mohamed Abdelhamid El-Khashab Pediatric Clinical Nutrition Unit Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Pediatrics Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Clinical Pathology Faculty of MedicineCairo UniversityCairo 12613Egypt

BACKGROUND Childhood bronchial asthma(BA)is a chronic inflammatory respiratory disease.Nutritional conditions,including zinc deficiency,can affect such allergic disorders.AIM To outline the difference in serum zinc levels between asthmatic children and healthy controls.METHODS A cross-sectional study was carried out at Children’s Hospital,Cairo University,investigating serum zinc levels in children with BA(n=40)and healthy children(n=21).Other markers included serum ferritin,iron,hemoglobin(Hb),and immunoglobulin E(IgE)levels.Independent t-tests and Mann-Whinny tests were used for comparisons.The Kruskal-Wallis test was applied to compare serum ferritin and IgE levels with regard to asthma severity.Spearman's rank correlation was performed to explore the relationship between serum ferritin levels and both iron and Hb levels in asthmatic children.RESULTS Children with BA had higher levels of zinc,yet the difference was not significant(P=0.115).Serum ferritin and IgE levels were significantly higher in asthmatic children(P=0.006 and 0.001,respectively),yet their levels did not differ significantly by severity(P=0.623 and 0.126,respectively).There was a nonsignificant weak correlation between serum ferritin levels and both serum iron and Hb levels.CONCLUSION Serum zinc levels do not seem to differ between asthmatic children and healthy children.Serum ferritin levels may be a marker of asthma control.Serum IgE levels are not markers of asthma severity.

关键词： Children Asthma Zinc Ferritin

Preliminary Assessment of Goat Piroplasmosis in Benadir Region, Somalia

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Open Journal of Veterinary Medicine 2013年第6期3卷 273-276页

作者： Ahmed Abdulkadir Hassan abdalla mohamed ibrahim Rabab Haroon mohamed Hussein Haji Aden Jazeera Quarantine Mogadishu Somalia

Haemoparasites are major-constraints on livestock production in tropical and sub-tropical countries. This study was conducted during 2012-2013 to determine the prevalence of blood parasites in goats of small-holders in Benadir region, Somalia and update epidemiological data that had already lost during the civil war in the country. A total of 100 blood samples were collected from goat in Wadajir (47 goat) and Dharkeynley (53 goat) districts, using venipuncture of jugular vein. The samples were examined for the presence of blood parasites using light microscopy. Some ticks when presented in the sampled animals—were also collected for tick identification. Analysis of blood smears revealed 100% samples positive for blood parasites. Out of these cases, 22 samples (22%) were harboring single infection of Babesia spp. and 14 samples (14%) were having single infection of Theileria spp. Interestingly the Remaining 64 blood samples (64%) showed mixed infection of Babesia spp. with Theileria spp. Rhipicephalus evertsi (72.84%), Rhipicephalus pulchellus (34.57%), Amblyomma lepidum (3.70%) and Hyalomma rufipes (1.23%) were identified from the investigated goats. In conclusion, the findings of this study indicated that, the prevalence of tick and tick-borne diseases were considered to be high in Benadir region of Somalia. A further area wide in-depth study is recommended in the country.

关键词： Piroplasmosis T&TBDs Goat Benadir Region Somalia

Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients

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World Journal of Hepatology 2016年第32期8卷 1392-1401页

作者： Mahmoud Khattab mohamed Amin Sakr mohamed Abdel Fattah Youssef Mousa Elwy Soliman Ashraf Breedy mona Fathi Salwa Gaber Ahmed Altaweil Ashraf Osman Ahmed Hassouna ibrahim Motawea Department of Internal Medicine Minia University Department of Tropical Medicine Ain Shams University Department of Clinical Pathology Ain Shams University Department of Pathology Minia University Department of Pathology Ain Shams University Department of Clinical Pathology Minia University Department of Cardiothoracic Surgery Ain Shams University

AIM To investigate the diagnostic ability of a non-invasive biological marker to predict liver fibrosis in hepatitis C genotype 4 patients with high accuracy.METHODS A cohort of 332 patients infected with hepatitis C genotype 4 was included in this cross-sectional study. Fasting plasma glucose, insulin, C-peptide, and angiotensinconverting enzyme serum levels were measured. Insulin resistance was mathematically calculated using the homeostasis model of insulin resistance(HOMA-IR).RESULTS Fibrosis stages were distributed based on Metavir score as follows: F0 = 43, F1 = 136, F2 = 64, F3 = 45 and F4 = 44. Statistical analysis relied upon reclassification of fibrosis stages into mild fibrosis(F0-F) = 179, moderate fibrosis(F2) = 64, and advanced fibrosis(F3-F4) = 89. Univariate analysis indicated that age, log aspartate amino transaminase, log HOMA-IR and log platelet count were independent predictors of liver fibrosis stage(P < 0.0001). A stepwise multivariate discriminant functional analysis was used to drive a discriminative model for liver fibrosis. Our index used cut-off values of ≥ 0.86 and ≤-0.31 to diagnose advanced and mild fibrosis, respectively, with receiving operating characteristics of 0.91 and 0.88, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and positive likelihood ratio were: 73%, 91%, 75%, 90% and 8.0 respectively for advanced fibrosis, and 67%, 88%, 84%, 70% and 4.9, respectively, for mild fibrosis.CONCLUSION Our predictive model is easily available and reproducible, and predicted liver fibrosis with acceptable accuracy.

关键词：肝纤维变性胰岛素抵抗 Aspartate 氨基的 transaminase 血小板年龄

The First Report on Sero-Prevalence of Toxoplasma gondii in Working Horses and Donkeys in the Sudan

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Journal of Life Sciences 2013年第12期7卷 1284-1287页

作者： Shadia mohamed Ahmed abdalla mohamed ibrahim Nabaa Kamal Alshafie Rabab Haroun Mohammed Ahmed Ali Ismail Tamador Elkhansa Elnour Angara College of Veterinary Medicine University of Bahri Khartoum 11111 Sudan College of Veterinary Medicine Sudan University of Science and Technology (SUST) Khartoum 11111 Sudan College of Science and Technology of Animal Production Sudan University of Science and Technology (SUST) Khartoum 11111Sudan

A serological survey of Toxoplasma gondii was conducted using LAT (Latex Agglutination Test) on 205 sera collected from working horses and donkeys in Khartoum State, Sudan. The overall sero-prevalence of the investigated equines was 32.7%. Antibodies to T. gondii were found in 38% of 100 horses and 27.6% of 105 donkeys. The titers were 1 2 (4 heads), 1 4 (11 heads), 1 8 (13 heads), 1 16 (17 heads), 1 32 (5 heads), 1 64 (10 donkeys) and 1 128 (7 donkeys). Neither the area nor animal species showed significant differences between the investigated groups. However, age was reported to show significant (P < 0.05) effect on equine toxoplasmosis in the Sudan. This is the first report on equine toxoplasmosis in the Sudan.

关键词：血清学调查弓形虫病苏丹阳性反应驴乳胶凝集试验动物种类弓形体病