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Ocular Changes in Egyptian Children on Regular Hemodialysis

International Journal of Clinical Medicine 2019年第6期10卷 353-362页

作者： Somaya mohamed Abd El-Ghany Manal Abd El-Salam mona mohamed farag Ola Ali El-Ashwah Department of Pediatrics Faculty of Medicine Al-Azhar University Cairo Egypt Department of Ophthalmology Faculty of Medicine Al-Azhar University Cairo Egypt

Background: Chronic Kidney disease (CKD) may cause ocular disorders for many reasons such as uraemia, haemodialysis and hypertension. Aim: To study the ocular changes in a group of Egyptian children with chronic kidney disease on regular hemodialysis. Subjects and Methods: This cross-sectional comparative study was conducted on 30 children on regular hemodialysis and another 30 age and sex-matched healthy children as controls. Their ages ranged from 4 to 17 years. Complete ophthalmological examination including;visual acuity and refraction, anterior segment examination, intraocular pressure (IOP), fundus examination and colored photography were assessed in the same line with routine laboratory investigations for children on regular hemodialysis and their controls. The relation of ocular disorders with related clinical and biochemical variables was measured statistically. Results: The most common eye abnormalities recorded were decreased visual acuity in Lt eye (73.3%) and Rt eye (60%), followed by corneal & conjunctiva calcification were (16.7%) and (13.3%) respectively and fundal changes (13.3%) of the study population. A significant positive relation was found between fundal changes particularly tortuous blood vessel abnormalities with the duration of hemodialysis and serum creatinine level. Conclusion: Ocular abnormalities are common than expected in children on regular hemodialysis. Visual acuity disorder is the major ocular abnormalities recorded in those patients. Regular ophthalmologic assessment is recommended in children to prevent longer-term visual complications.

关键词： Hemodialysis Children Ocular Changes

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Corneal sensitivity,ocular surface health and tear film stability after punctal plug therapy of aqueous deficient dry eye

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1598-1607页

作者： Azza mohamed Ahmed Said mona Elsayed farag Tarek mohamed Abdulla Othman Ali Othman Ziko Wesam mohamed Osman Ophthalmology Department Faculty of MedicineAin Shams University Pathology Department Faculty of MedicineAin Shams University

AIM： To evaluate the effect of punctal occlusion using thermosensitive（smart plug） versus silicone plug for management of aqueous deficient dry eye on cornea sensitivity, ocular surface health and tear film ***： A comparative prospective interventiona case study included 45 patients with bilateral severe form of aqueous deficient dry eye. In each patient, the smar plug was inserted in the lower punctum of the right eye which was considered as study group 1 and silicone plug was inserted in the lower punctum of the left eye o the same patient which was considered as study group2. All patients were subjected to careful history taking and questionnaire for subjective assessment of severity of symptoms. Corneal sensitivity, corneal fluorescein rose bengal staining, Schirmer＇s I test, tear film break up time and conjunctival impression cytology were performed pre and 1, 3 and 6mo post plug ***： A statistically significant improvement in subjective and objective manifestations occurred following treatment with both types of plugs（P 〈0.01）The thermosensitive plug caused significant overal improvement, decrease in frequency of application o tear substitutes and improvement of conjunctiva impression cytology parameters in the inserted side（P 〈0.01）. Canaliculitis was reported in two eyes（4.4% following punctal occlusion using thermosensitive plug（study group 1）. Spontaneous plug loss occurred in 21eyes（46.6%） in the silicone plug group（study group 2）.CONCLUSION： Improvement of subjective and objective manifestations of aqueous deficient dry eye occurs following punctal plug occlusion. Thermosensitive plug has good patient＇s compliance with fewer complications and lower rates of loss compared to the silicone plug.

关键词： conjunctival impression cytology comealsensitivity corneal fluorescein staining dry eye syndrome Schirmer's test silicone plug thermosensitive smart plug

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Revolutionizing diabetic retinopathy screening and management:The role of artificial intelligence and machine learning

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World Journal of Clinical Cases 2025年第5期13卷 1-12页

作者： mona mohamed Ibrahim Abdalla Jaiprakash Mohanraj Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetic retinopathy(DR)remains a leading cause of vision impairment and blindness among individuals with diabetes,necessitating innovative approaches to screening and *** editorial explores the transformative potential of artificial intelligence(AI)and machine learning(ML)in revolutionizing DR *** and ML technologies have demonstrated remarkable advancements in enhancing the accuracy,efficiency,and accessibility of DR screening,helping to overcome barriers to early *** technologies leverage vast datasets to identify patterns and predict disease progression with unprecedented precision,enabling clinicians to make more informed ***,AI-driven solutions hold promise in personalizing management strategies for DR,incorpo-rating predictive analytics to tailor interventions and optimize treatment *** automating routine tasks,AI can reduce the burden on healthcare providers,allowing for a more focused allocation of resources towards complex patient *** review aims to evaluate the current advancements and applic-ations of AI and ML in DR screening,and to discuss the potential of these techno-logies in developing personalized management strategies,ultimately aiming to improve patient outcomes and reduce the global burden of *** integration of AI and ML in DR care represents a paradigm shift,offering a glimpse into the future of ophthalmic healthcare.

关键词： Diabetic retinopathy Artificial intelligence Machine learning Screening Management Predictive analytics Personalized medicine

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Role of visfatin in obesity-induced insulin resistance

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World Journal of Clinical Cases 2022年第30期10卷 10840-10851页

作者： mona mohamed Ibrahim Abdalla Physiology Department Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Bukit JalilMalaysia

The growing worldwide burden of insulin resistance(IR) emphasizes the importance of early identification for improved ***,particularly visceral obesity,has been a key contributing factor in the development of *** obesity-associated chronic inflammatory state contributes to the development of obesity-related comorbidities,including ***,which are released by adipose tissue,have been investigated as possible indicators of *** was one of the adipocytokines that attracted attention due to its insulinmimetic *** is released from a variety of sources,including visceral fat and macrophages,and it influences glucose metabolism and increases *** relationship between visfatin and IR in obesity is *** a result,the purpose of this review was to better understand the role of visfatin in glucose homeostasis and to review the literature on the association between visfatin levels and IR,cardiovascular diseases,and renal diseases in obesity.

关键词： Homeostatic model assessment for insulin resistance Insulin resistance Obesity Visfatin pre-B cell colony enhancing factor Nicotinamide phosphoribosyl-transferase enzyme Diabetes Adipocytokines

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Advancing diabetes management: Exploring pancreatic beta-cell restoration’s potential and challenges

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World Journal of Gastroenterology 2024年第40期30卷 4339-4353页

作者： mona mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus,characterized by chronic hyperglycemia due to insulin deficiency or resistance,poses a significant global health *** to its pathogenesis is the dysfunction or loss of pancreatic beta cells,which are res-ponsible for insulin *** advances in beta-cell regeneration research offer promising strategies for diabetes treatment,aiming to restore endogenous insulin production and achieve glycemic *** review explores the physiological basis of beta-cell function,recent scientific advan-cements,and the challenges in translating these findings into clinical *** highlights key developments in stem cell therapy,gene editing technologies,and the identification of novel regenerative *** the potential,the field faces hurdles such as ensuring the safety and long-term efficacy of regen-erative therapies,ethical concerns around stem cell use,and the complexity of beta-cell differentiation and *** review highlights the importance of interdisciplinary collaboration,increased funding,the need for patient-centered approaches and the integration of new treatments into comprehensive care strategies to overcome these *** continued research and collab-oration,beta-cell regeneration holds the potential to revolutionize diabetes care,turning a chronic condition into a manageable or even curable disease.

关键词： Diabetes therapies Beta cell regeneration Regenerative medicine Stem cell therapy Gene editing Molecular therapeutics

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Serum resistin and the risk for hepatocellular carcinoma in diabetic patients

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World Journal of Gastroenterology 2023年第27期29卷 4271-4288页

作者： mona mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Hepatocellular carcinoma(HCC),the predominant type of liver cancer,is a major contributor to cancer-related fatalities across the *** has been identified as a significant risk factor for HCC,with recent research indicating that the hormone resistin could be involved in the onset and advancement of HCC in diabetic *** is a hormone that is known to be involved in inflammation and insulin *** with HCC have been observed to exhibit increased resistin levels,which could be correlated with more severe disease stages and unfavourable ***,the exact processes through which resistin influences the development and progression of HCC in diabetic patients remain *** article aims to examine the existing literature on the possible use of resistin levels as a biomarker for HCC development and ***,it reviews the possible pathways of HCC initiation due to elevated resistin and offers new perspectives on comprehending the fundamen-tal mechanisms of HCC in diabetic *** a better understanding of these processes may yield valuable insights into HCC’s development and progression,as well as identify possible avenues for prevention and therapy.

关键词： Hepatocellular carcinoma Resistin Insulin resistance Obesity Diabetes Liver cancer

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Enteric neuropathy in diabetes:Implications for gastrointestinal function

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World Journal of Gastroenterology 2024年第22期30卷 2852-2865页

作者： mona mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes,commonly known for its metabolic effects,also critically affects the enteric nervous system(ENS),which is essential in regulating gastrointestinal(GI)motility,secretion,and *** development of diabetes-induced enteric neuropathy can lead to various GI dysfunctions,such as gastroparesis and irregular bowel habits,primarily due to disruptions in the function of neuronal and glial cells within the ENS,as well as oxidative stress and *** editorial explores the pathophysiological mechanisms underlying the development of enteric neuropathy in diabetic ***,it discusses the latest advances in diagnostic approaches,emphasizing the need for early detection and intervention to mitigate GI complications in diabetic *** editorial also reviews current and emerging therapeutic strategies,focusing on pharmacological treatments,dietary management,and potential neuromodulatory ***,this editorial highlights the necessity of a multidisciplinary approach in managing enteric neuropathy in diabetes,aiming to enhance patient quality of life and address a frequently overlooked complication of this widespread disease.

关键词： Diabetic neuropathy Gastrointestinal Insulin resistance Diabetes Enteric nervous system Enteric neuropathy

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Salivary resistin level and its association with insulin resistance in obese individuals

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World Journal of Diabetes 2021年第9期12卷 1507-1517页

作者： mona mohamed Ibrahim Abdalla Human Biology Department School of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

The escalating global burden of type 2 diabetes mellitus necessitates the implementation of strategies that are both more reliable and faster in order to improve the early identification of insulin resistance(IR)in high-risk groups,including overweight and obese *** use of salivary biomarkers offers a promising alternative to serum collection because it is safer,more comfortable,and less painful to obtain saliva *** obesity is the foremost contributory factor in IR development,the adipocytokines such as leptin,adiponectin,resistin,and visfatin secreted from the adipose tissue have been studied as potential reliable biomarkers for *** of salivary adipokines as predictors for IR has attracted widespread attention because of the strong correlation between their blood and salivary *** of the adipokines that is closely related to IR is ***,there are conflicting findings on resistin’s potential role as an etiological link between obesity and IR and the reliability of measuring salivary resistin as a biomarker for *** this study reviewed the available evidence on the potential use of salivary resistin as a biomarker for IR in order to attempt to gain a better understanding of the role of resistin in the development of IR in obese individuals.

关键词： Homeostatic model assessment of insulin resistance Insulin resistance Obesity Salivary resistin Diabetes Adipocytokines

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Insulin resistance as the molecular link between diabetes and Alzheimer's disease

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World Journal of Diabetes 2024年第7期15卷 1430-1447页

作者： mona mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence *** studies have indicated a possible link between DM and an increased risk of developing ***,while primarily known for its role in regulating blood sugar,also plays a vital role in protecting brain *** resistance(IR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's *** insulin signalling becomes dysfunctional,it can negatively affect various brain functions,making individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein *** research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to *** review aims to explore the relationship between DM and AD,with a focus on the role of *** also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target *** IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关键词： Alzheimer's disease Insulin resistance Obesity Dementia Diabetes Metabolic syndrome

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Adiponectin as a therapeutic target for diabetic foot ulcer

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World Journal of Diabetes 2023年第6期14卷 758-782页

作者： mona mohamed Ibrahim Abdalla Jaiprakash Mohanraj Sushela Devi Somanath Department of Physiology Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Biochemistry Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Microbiology School of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

The global burden of diabetic foot ulcers(DFUs)is a significant public health concern,affecting millions of people *** wounds cause considerable suffering and have a high economic ***,there is a need for effective strategies to prevent and treat *** promising therapeutic approach is the use of adiponectin,a hormone primarily produced and secreted by adipose *** has demonstrated anti-inflammatory and antiatherogenic properties,and researchers have suggested its potential therapeutic applications in the treatment of *** have indicated that adiponectin can inhibit the production of pro-inflammatory cytokines,increase the production of vascular endothelial growth factor,a key mediator of angiogenesis,and inhibit the activation of the intrinsic apoptotic ***,adiponectin has been found to possess antioxidant properties and impact glucose metabolism,the immune system,extracellular matrix remodeling,and nerve *** objective of this review is to summarize the current state of research on the potential role of adiponectin in the treatment of DFUs and to identify areas where further research is needed in order to fully understand the effects of adiponectin on DFUs and to establish its safety and efficacy as a treatment for DFUs in the clinical *** will provide a deeper understanding of the underlying mechanisms of DFUs that can aid in the development of new and more effective treatment strategies.

关键词： Diabetic foot ulcer Adiponectin Anti-inflammatory Adipose tissue Antioxidants Wound healing

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