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Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1175-1186页

作者： Azza A.Matloub Hadeer A.Aglan Sahar Salah Mohamed el Souda mona elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed Pharmacognosy Department National Research Centre Hormones Department National Research Centre Chemistry of Natural Compounds Department National Research Centre Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group) National Research Centre Therapeutical Chemistry Department National Research Centre Laboratory of Immune and Biomarkers for Infection the Center of Excellence for Advanced SciencesNational Research Centre

Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical ***:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,*** polysaccharide extracts(20 mg/kg *** 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were ***:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,*** polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC ***,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),*** bioactive polysaccharides in HCC induced rats improved the humoral immune *** photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological ***,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/***,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic ***:The pronounced antitumor activi

关键词： Jania rubens Pterocladia capillacea Enteromorpha intestinalis Polysaccharide-protein complexes Anti-tumor activity Anti-angiogenesis

Molecular design and applications of a nanostructure green Tripodal surface active ionic liquid in enhanced oil recovery: Interfacial tension reduction, wettability alteration, and emulsification

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Petroleum Science 2023年第6期20卷 3530-3539页

作者： mona Kharazi Javad Saien Morteza Torabi Mohammad Ali Zolfigol Faculty of Chemistry and Petroleum Science Bu–Ali Sina UniversityHamedan***Iran

Surface active ionic liquids (SAILs) are considered as prominent materials in enhanced oil recovery thanks to their high interfacial activity. This study reports the preparation and applications of a nanostructure Tripodal imidazolium SAIL as an environmentally-friendly substitute to the conventional surfactants. The product has a star-like molecular structure centered by a triazine spacer, namely [(C_(4)im)_(3)TA][Cl_(3)], prepared by a one-step synthesis method and characterized with FT-IR, NMR, XRD, and SEM analysis methods. The interfacial tension of the system was decreased to about 78% at critical micelle concentration of less than 0.08 mol·dm^(−3). Increasing temperature, from 298.2 to 323.2 K, improved this capability. The solid surface wettability was changed from oil-wet to water-wet and 80% and 77% stable emulsions of crude oil–aqueous solutions were created after one day and one week, respectively. Compared to the Gemini kind homologous SAILs, the superior effects of the Tripodal SAIL were revealed and attributed to the strong hydrophobic branches in the molecule. The Frumkin adsorption isotherm precisely reproduced the generated IFT data, and accordingly, the adsorption and thermodynamic parameters were determined.

关键词： Tripodal ionic liquids Green materials Enhanced oil recovery Interfacial tension Wettability Emulsification

Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions

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World Journal of Gastroenterology 2018年第11期24卷 1228-1238页

作者： Abdel-Rahman N Zekri Somaya el Deeb Abeer A Bahnassy Abeer M Badr mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam el-dien Shimaa Rabah Assmaa Abd elkader Molecular Virology and Immunology Unit Department of Cancer BiologyNational Cancer InstituteCairo University Department of Zoology Faculty of ScienceCairo University Department of Pathology National Cancer InstituteCairo University Medical Biochemistry and Molecular Biology Department of Cancer BiologyNational Cancer InstituteCairo University Department of Hepatology and Tropical Medicine Faculty of MedicineCairo University Department of Biochemistry Misr University for Science and Technology

AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic *** Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow *** levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by *** Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P el was not significantly changed among other *** p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P ely) in HCC *** was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P elation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P ell as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P elopment and progression of HCC.

关键词： Hepatocellular carcinoma Hepatitis C virus NKG2D CD40 interleukin-2 interleukin-10 myeloid dendritic cells plasmacytoid cells natural killer cell Cytokines

Reconstruction of incidence reporting rate for SARS-CoV-2 Delta variant of COVID-19 pandemic in the US

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Infectious Disease Modelling 2024年第1期9卷 70-83页

作者： Alexandra Smirnova mona Baroonian Department of Mathematics&Statistics Georgia State UniversityAtlantaUSA

In recent years,advanced regularization techniques have emerged as a powerful tool aimed at stable estimation of infectious disease parameters that are crucial for future projections,prevention,and *** other system parameters,i.e.,incubation and recovery rates,the case reporting rate,Ψ,and the time-dependent effective reproduction number,R_(e)t,are directly influenced by a large number of factors making it impossible to pre-estimate these parameters in any meaningful *** this study,we propose a novel iteratively-regularized trust-region optimization algorithm,combined with SuSvIuIvRD compartmental model,for stable reconstruction ofΨand R_(e)t from reported epidemic data on vaccination percentages,incidence cases,and daily *** innovative regularization procedure exploits(and takes full advantage of)a unique structure of the Jacobian and Hessian approximation for the nonlinear observation *** proposed inversion method is thoroughly tested with synthetic and real SARS-CoV-2 Delta variant data for different regions in the United States of America from July 9,2021,to November 25,*** study shows that case reporting rate during the Delta wave of COVID-19 pandemic in the US is between 12%and 37%,with most states being in the range from 15%to 25%.This confirms earlier accounts on considerable under-reporting of COVID-19 cases due to the impact of”silent spreaders”and the limitations of testing.

关键词： Epidemiology Incidence reporting rate Compartmental model Transmission dynamic Regularization algorithm

Investigation of a mutual interaction force at different pressure amplitudes in sulfuric acid

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Chinese Physics B 2011年第8期20卷 454-459页

作者： Nastaran Rezaee Rasoul Sadighi-Bonabi mona Mirheydari Homa Ebrahimi Department of Physics Sharif University of Technology11365-91TehranIran Department of Physics Islamic Azad University Central Tehran BranchTehranIran

This paper investiages the secondary Bjerknes force for two oscillating bubbles in various pressure amplitudes in a concentration of 95% sulfuric acid. The equilibrium radii of the bubbles are assumed to be smaller than 10 μm at a frequency of 37 kHz in various strong driving acoustical fields around 2.0 bars （1 bar=10^5 Pa）. The secondary Bjerknes force is investigated in uncoupled and coupled states between the bubbles, with regard to the quasi-adiabatic model for the bubble interior. It finds that the value of the secondary Bjerknes force depends on the driven pressure of sulfuric acid and its amount would be increased by liquid pressure amplitude enhancement. The results show that the repulsion area of the interaction force would be increased by increasing the driven pressure because of nonlinear oscillation of bubbles.

关键词： multi-bubble sonoluminescence secondary Bjerknes force coupled and uncoupled state,nonlinear oscillation

Salivary resistin level and its association with insulin resistance in obese individuals

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World Journal of Diabetes 2021年第9期12卷 1507-1517页

作者： mona Mohamed Ibrahim Abdalla Human Biology Department School of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

The escalating global burden of type 2 diabetes mellitus necessitates the implementation of strategies that are both more reliable and faster in order to improve the early identification of insulin resistance(IR)in high-risk groups,including overweight and obese *** use of salivary biomarkers offers a promising alternative to serum collection because it is safer,more comfortable,and less painful to obtain saliva *** obesity is the foremost contributory factor in IR development,the adipocytokines such as leptin,adiponectin,resistin,and visfatin secreted from the adipose tissue have been studied as potential reliable biomarkers for *** of salivary adipokines as predictors for IR has attracted widespread attention because of the strong correlation between their blood and salivary *** of the adipokines that is closely related to IR is ***,there are conflicting findings on resistin’s potential role as an etiological link between obesity and IR and the reliability of measuring salivary resistin as a biomarker for *** this study reviewed the available evidence on the potential use of salivary resistin as a biomarker for IR in order to attempt to gain a better understanding of the role of resistin in the development of IR in obese individuals.

关键词： Homeostatic model assessment of insulin resistance Insulin resistance Obesity Salivary resistin Diabetes Adipocytokines

Degradation of polyacrylamide (PAM) and methane production by mesophilic and thermophilic anaerobic digestion: Effect of temperature and concentration

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Frontiers of Environmental Science & Engineering 2020年第6期14卷 75-85页

作者： mona Akbar Muhammad Farooq Saleem Khan Ling Qian Hui Wang State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Sino-Japan Friendship Center for Environmental Protection Beijing 100029China

Polyacrylamide(PAM)is generally employed in wastewater treatment processes such as sludge dewatering and therefore exists in the ***,it degrades slowly and can deteriorate methane yield during anaerobic digestion(AD).The impact or fate of PAM in AD under thermophilic conditions is still *** study mainly focuses on PAM degradation and enhanced methane production from PAM-added sludge during 15 days of thermophilic(55°C)AD compared to mesophilic(35°C)*** and PAM dose from 10 to 50 g/kg TSS were *** results showed that PAM degraded by 76%to 78%with acrylamide(AM)content of 0.2 to 3.3 mg/L in thermophilic ***,it degraded only 21%to 30%with AM content of 0.5 to 7.2 mg/L in mesophilic *** methane yield was almost 230 to 238.4 mL/g VSS on the 8th day in thermophilic AD but was 115.2 to 128.6 mL/g VSS in mesophilic *** investigation revealed that thermophilic AD with continuous stirring not only enhanced PAM degradation but also boosted the organics release from the sludge with added PAM and gave higher methane yield than mesophilic AD.

关键词： Polyacrylamide(PAM)degradation Acrylamide(AM) Mesophilic anaerobic digestion Thermophilic anaerobic digestion Methane production

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

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World Journal of Diabetes 2024年第7期15卷 1430-1447页

作者： mona Mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence *** studies have indicated a possible link between DM and an increased risk of developing ***,while primarily known for its role in regulating blood sugar,also plays a vital role in protecting brain *** resistance(IR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's *** insulin signalling becomes dysfunctional,it can negatively affect various brain functions,making individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein *** research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to *** review aims to explore the relationship between DM and AD,with a focus on the role of *** also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target *** IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关键词： Alzheimer's disease Insulin resistance Obesity Dementia Diabetes Metabolic syndrome

Performance of OFDM System with Constant Amplitude Modulation

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Circuits and Systems 2013年第4期4卷 329-341页

作者： Waleed Saad Nawal el-Fishawy Sayed el-Rabaie mona Shokair Department of electronic and Communication Engineering Faculty of Electronic Engineering Minoufiya University Menouf Egypt

The Orthogonal Frequency Division Multiplexing (OFDM) technique has recently received considerable attention for wireless networks. Despite its advantages, it has a major drawback of its high Peak-to-Average Power Ratio (PAPR) value which affects the system efficiency and the cost. In this paper, a proposed system is discussed to achieve 0 dB PAPR value. It depends on a proposed block, called Constant Amplitude (CA) modulation. The whole characteristic mathematical analysis is presented for the proposed system. Additionally, the complexity evolution is explained. Afterwards, many MATLAB simulation programs are executed. Time and frequency domain behaviors are presented. Furthermore, in-band distortion introduced by the proposed CA modulation is calculated in terms of Error Vector Magnitude (EVM). Moreover, the proposed system outperforms the conventional one when compared in terms of PAPR, equalization, and BER under Additive White Gaussian Noise (AWGN) channel and multipath fading channels. In addition, the impact of the proposed scheme design parameter is studied.

关键词： OFDM Multipath Fading Channels PAPR BER Equalizer EVM