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Is the urinary kidney injury molecule an optimum biomarker for early detection of obstructive nephropathy? An experimental study

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Current Urology 2024年第4期18卷 312-317页

作者： Ahmed S el-Hefnawy mona a el-hussiny Ahmed M.A Ibrahim Khadiga M Ali Mohammed A Atwa Nashwa Barakat Mohamed Alhefnawy Ahmed A Shokeir Urology Department Urology and Nephrology CenterFaculty of Med/c/neMansouraEgypt Clinical Pathology Department Faculty of MedicineMansouraEgypt Clinical Pathology Department Student HospitalMansouraEgypt Pathology Department Faculty of MedicineMansouraEgypt Research Laboratory Department Urology and Nephrology CenterMansoura UniversityMansouraEgypt Faculty of Medicine Benha UniversityBenhaEgypt

Objectives To evaluate the urinary kidney injury molecule-1(KIM-1)as a predictor for early detection of acute kidney injury in cases with obstructive nephropathy in an animal model and to correlate urinary KIM-1 with the progress of obstructive nephropathy on a histopathological *** and methods Three models of obstruction were induced in 90 male rats:unilateral partial ureteral obstruction with a normal contra-lateral kidney,with nephrectomy of a contralateral kidney(solitary kidney),and bilateral partial ureteral *** group was further divided into 2 subgroups;the sham-group(10 rats)and the disease group(20 rats).Serum creatinine,blood urea nitrogen,and urinary KIM-1 were collected on days 0,7,and *** were sacrificed on the 7th and 14th day for histopathological examination of the obstructed *** By the end of first week,there was a significant rise of all biomarker levels in all groups when compared with basal ***,biomarker levels at the 14th day were significantly higher than those obtained at the 7th *** urinary KIM-1 level was not detected in the baseline *** of urinary KIM-1 showed a significant rise in all models ranging from 22 to 85 fold at the 7th day and even higher levels at the 14th *** examination confirmed the presence of different forms of tubular *** Urinary KIM-1 is significantly elevated in obstructive *** an elevation might be advantageous in the early diagnosis and subsequent early intervention of cases with partial ureteral obstruction.

关键词： Biomarker Injury Kidney Kidney injury molecule Nephropathy Obstruction Uropathy

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Value of duplex doppler ultrasonography in non-invasive assessment of children with chronic liver disease

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World Journal of Gastroenterology 2010年第48期16卷 6139-6144页

作者： Mortada HF el-Shabrawi Maissa el-Raziky Maha Sheiba Hanaa M el-Karaksy mona el-Raziky Fetouh Hassanin Abeer Ramadan Department of Pediatrics Cairo University Department of Tropical Medicine Cairo University Department of Clinical Pharmacy Misr International University

AIM:To investigate the value of duplex Doppler ultrasonography (US) in the assessment of the hemodynamics of the portal and hepatic veins in a cohort of children with chronic liver disease (CLD) and to detect any relationship between the US changes,etiology and severity (or stage) of CLD. METHODS:We prospectively enrolled 25 children with biopsy-proven CLD. Thirteen had cirrhosis (aged 8.9 ± 2.0 years) and 12 had chronic hepatitis (aged 9.3 ± 2.3 years). Gray scale and color-coded duplex Doppler US were performed for all,as well as 30 healthy age and sex-matched controls. Findings were correlated with clinical,laboratory and histopathological characteristics. RESULTS:Prominent caudate lobe was detected in 100% of cirrhotics,but none of the chronic hepatitis or controls. Thickened lesser omentum and loss of the triphasic waveform of the hepatic vein were present in 69.2% and 53.8% of cirrhotics vs 33.3% and 8.3% of chronic hepatitis respectively. Portal vein flow velocity was significantly lower (P elation with both abnormal hepatic vein waveform and direction of portal blood flow; and a negative correlation with both hepatic and portal vein flow velocities. No correlation with the etiology of CLD could be detected. CONCLUSION:Duplex Doppler added to grayscale US can detect significant morphologic and portal hemodynamic changes that correlate with the severity (stage) of CLD,but not with etiology.

关键词： Chronic hepatitis Chronic liver disease Cirrhosis Doppler Grayscale Pediatrics Ultrasound

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Synthesis and Structure-Activity Relationships of Novel Neocryptolepine Derivatives

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Chemical Research in Chinese Universities 2017年第3期33卷 373-377页

作者： Ahmed A. el-GOKHA Nader M. BOSHTA mona K. ABO HUSSEIN Ibrahim el-T. el SAYED Chemistry Department Faculty of Science Menoufia University Shebin EI-Koam Menoufia Egypt Department of Pharmaceutical Chemistry Institute of Pharmaceutical Sciences Eberhard Karls Universitat Tubingen 72076 Tubingen Germany Pharmaceutical Institute Pharmaceutical Chemistry I University of Bonn 53121 Bonn Germany

Herein we reported the synthesis of a novel series of neocryptolepine（5-methyl-5H-indolo[2,3-b]quinoline） derivatives containing different substituents at Cll using methyl 1H-indole-3-carboxylate and N-methylaniline as starting material. The target 21 compounds were evaluated for their axltibacterial activity in vitro against gram-positive bacteria（B, subtilis and S. aureus） and gram-negative bacteria（E, coli and ***）. Almost all the tested compounds showed moderate to high activities against the four bacterial strains at the minimum inhibitory concentrations（MICs） of 1-10μg/mL. The obtained results suggest that part of the novel synthetic neocryptolepine derivatives exhibit significant antibacterial effect against all the tested organisms.

关键词： Neocryptolepine Indoloquinolme Antibacterial

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Training program for caregivers to prevent pressure ulcers among elderly residents at geriatric homes

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Frontiers of Nursing 2021年第3期8卷 249-259页

作者： Donia Atef Ibrahiem mona Mohamed Abd el-Maksoud Community Health Nursing Faculty of NursingHelwan UniversityCairo 11571Egypt

Objectives:Pressure ulcer(PU)is one of the most common problem among the bedridden elderly and has significantly more burden on elderly and *** study is aimed to evaluate the effects of the training program for caregivers to prevent PUs among elderly residents at geriatric ***:A quasi-experimental design was used to carry out the current study.A purposive sample comprised of all formal(39 nurses)or informal caregivers(39)and all immobilized elderly residents(35)who are found in all geriatric centers in Helwan district.A structured questionnaire was used to assess caregivers’socio-demographic characteristics,knowledge,attitude,and observational checklists for their practice for prevention of PU at pre-and posttest and during ***:After the training program,there were improvements in the level of knowledge,practice,and positive attitude of caregivers about PU prevention with a statistically significant difference between pre-,post-,and follow-up training programs(Pelderly caregivers’attitudes as well as practice for prevention could be important in reducing the burden of PU among the ***,conducting a training program for caregivers at different geriatric homes about caring skills for elders can prevent PU,and using spontaneous reposition is very effective to prevent PUs.

关键词： caregivers elderly residents geriatric homes pressure ulcers training program

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Beneficial effects of vincamine with thioctic acid and lutein on retinal and optic nerve functions in an opaque media

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1450-1455页

作者： mona Abdelkader Sameh Saleh Tharwat Mokbel Hossam Abouelkheir Ayman Abd el Ghafar Mansoura Ophthalmic Center Mansoura Medicine Hospital Faculty of Medicine Mansoura University

AIM: To detect whether the combination of vincamine, thioctic acid and lutein will improve the retina and optic nerve functions in cases of an opaque media with an optic nerve and/or a retinal defect or ***: Totally 2000 patients(2000 eyes) of corneal opacities with defects in the optic nerve or/and the retinal functions were studied. Every patient received three types of drugs: thioctic acid with cyanocobalamine, vincamine, and lutein. The drugs were given daily for 3-12 mo according to patient’s responses. Full field flash electroretinogram(ERG) and flash visual evoked potential(VEP) were done before treatment and at 1, 3, 6, and 12 mo sequentially. Patients were followed up for 12 ***: In the 2000 eyes, 1000 eyes had both moderate optic nerve and retinal function defects;and 840 eyes out of the 1000 improved with the medical treatment. Another 500 eyes out of the 2000 eyes had extinguished retinal function with normal optic nerve function and only 125 eyes of them improved. The 290 out of the 2000 eyes had severe defects in optic nerve with normal retinal function and 130 of them improved. Another 210 eyes have mild optic nerve and retinal function defects and 194 ***: The combination of vincamine, thioctic acid with cyanocobalamine, and lutein improved both retina and optic nerve functions mainly in mild and moderate defect than in severe cases.

关键词： retina optic nerve opaque media thioctic acid with cyanocobalamine vincamine lutein

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Synthesis,antimicrobial, antiquorum-sensing and cytotoxic activities of new series of benzothiazole derivatives

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Chinese Chemical Letters 2015年第12期26卷 1522-1528页

作者： Moustafa T.Gabr Nadia S.el-Gohary Eman R.el-Bendary Mohamed M.el-Kerdawy Nanting Ni mona I.Shaaban Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry Georgia State University Department of Microbiology Faculty of Pharmacy Mansoura University Department of Microbiology College of Pharmacy Taibah University

New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds4 a and 6j displayed promising activity against A. fumigatus 293. The same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum ATCC 12472, whereas compounds4 a, 6j and 6p showed moderate activity. The in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that all tested compounds have IC50 values 〉50 mmol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.

关键词： antibacterial moiety antifungal antimicrobial cytotoxic screened moderate substituent Candida albicans

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Assessing decontamination practices at a medical microbiology research laboratory

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Journal of Biosafety and Biosecurity 2022年第2期4卷 124-129页

作者： Merna M.Alfy Sherine B.el Sayed mona el-Shokry Medical Microbiology and Immunology Department Faculty of MedicineAin Shams UniversityCairoEgypt

To our knowledge,this is the first study to conduct an objective assessment of the routine decontamination practices at a medical microbiology research laboratory(MRL)a year after a biosafety training was provided to all laboratory *** March 28th and June 28th,2021,unobtrusive observations were carried out to identify-three high-touch surfaces at the MRL during different working *** was used to evaluate the effectiveness of the disinfectant used in the *** three high-touch surfaces were sampled before and after decontamination with 200 ppm of 5%sodium hypochlorite(household bleach)to quantify the microbial load and identify the types of organisms residing on the laboratory surfaces.A higher concentration(500 ppm)of 5%sodium hypochlorite was employed after refresher training was provided to housekeeping staff,and resampling of the three surfaces was carried out during a 4-week follow-up period using the same *** three high-touch surfaces identified were the two sides of the workbench(22%–24%)and the front surface of one incubator(14%).Anthracoid bacilli and Staphylococcus aureus were the most commonly found organisms on laboratory surfaces preintervention(100%and 89%,respectively)and post-intervention(56%and 44%,respectively).Other microorganisms detected included Salmonella spp.(27.7%),Proteus spp.(5.6%),Escherichia coli(5.6%),and Klebsiella spp.(33.3%).Employing a higher concentration(500 ppm)of sodium hypochlorite significantly(p<0.000)reduced the total aerobic colony count from an average of 15–250 cfu/cm2 to 10–60 cfu/cm^(2).This study demonstrated suboptimal decontamination practices at the MRL and the need to apply a higher concentration(500 ppm)of sodium hypochlorite to reduce the overall microbial *** also demonstrated the importance of quantitative assessment to monitor decontamination practices and ensure staff *** studies are needed to identify bacterial communities within the laboratory,which will

关键词： Biosafety Laboratory-acquired infection Sodium hypochlorite Environmental decontamination Bacterial contamination Egypt

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Prenatal exposure to the fluoride containing psychiatric drug fluoxetine and anti-oxidative alterations in the neonatal rat brain

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BIOCelL 2019年第2期43卷 65-71页

作者： RAMESA SHAFI BHAT AMINA el GEZEERY ABIR BEN BACHAN mona AWAD ALONAZI LEENA SALEH ALSUHAIBANI AFAF el-ANSARY Biochemistry Department College of ScienceKing Saud University Human Genetic Department Medical Research instituteAlexandria UniversityEgypt Central Laboratory Female Centre for Scientific and Medical StudiesKing Saud UniversitySaudi Arabia Medicinal Chemistry Department National Research CentreDokkiCairoEgypt

Fluoride is a key ingredient of many psychiatric drugs like fluoxetine(Prozac■Fluoxetine■).Pregnant women frequently use this drug as they suffer from depression and anxiety disorders during this *** is able to reach the fetus through the placenta and passes to the newborn through *** the present study,female Wistar rats were treated with 5,10,and 20 mg/L fluoxetine(containing 94% fluorides)from pregnancy day 10 to day *** delivery,the levels of the enzymatic antioxidants in the brain of their offspring at postnatal day 2 were *** results showed that,in all fluoxetine exposed groups compared with the control group,there was a significant decrease(P0.05)in the activity of malondialdehyde and creatine *** results suggest that fluoxetine may be a developmental neurotoxicant due to presence of fluoride hence must be used carefully during pregnancy.

关键词： Antidepressant Brain Neonate Prozac Oxidative stress

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Seismic Hazard Assessment of District Mansehra,Khyber Pakhtoonkhawa,Pakistan

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Acta Geologica Sinica(English Edition) 2014年第4期88卷 1157-1168页

作者： mona Lisa COMSATS Institute of Information Technology(CIIT) Islamabad PakistanDepartment of Earth SciencesQuaid-i-Azam University

The site of Mansehra is located seismically in an active regime, known as the Crystalline Nappe Zone and Hazara-Kashmir Syntaxis in NW Himalayas, Pakistan. Seismic Hazard Assessment （SHA） for the site has been carried out by considering the earthquake source zones, selection of appropriate attenuation equations, near fault effects and maximum potential magnitude estimation. The Mansehra Thrust, Oghi Fault, Banna Thrust, Balakot Shear Zone, Main Boundary Thrust, Panjal Thrust, Jhelum Fault and Muzaffarabad Fault and, further to the south, the Sanghargali, Nathiagali, and Thandiani Thrusts are the most critical tectonic features within the 50 km radius of Mansehra. Using the available instrumental seismological data from 1904 to 2007, SHA has been carried out. Other reactivated critical tectonic features in the area have been investigated. Among them the Balakot-Bagh fault, with the fault length of 120 km from Balakot to Poonch, has been considered as the most critical tectonic feature on the basis of geological/structural/seismological data. The potential earthquake of maximum magnitude 7.8 has been assigned to the Balakot-Bagh fault using four regression relations. The peak ground acceleration value of 0.25 g （10% probability of exceedance for 50 years） and 0.5 g has been calculated with the help of the attenuation equation using probabilistic and deterministic approaches.

关键词： Seismic Hazard Assessment Mansehra District NW Himalayas Pakistan Probabilistic and Deterministic Approaches Balakot-Bagh Fault

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High power density technologies for large generators and motors for marine applications with focus on electrical insulation challenges

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High Voltage 2020年第1期5卷 7-14页

作者： mona Ghassemi Department of electrical and Computer Engineering Virginia Tech1185 Perry Street644 Whittemore HallBlacksburgVA 24061USA

High power density generators and motors are envisaged in modern all-electric ships where electrical power for both propulsion and service loads is provided through a common electrical platform known as an integrated power *** recent high-power density technologies for generators and motors proposed for marine applications are reviewed,and the author focuses on their electrical insulation *** technologies are high-frequency(high-speed)generators(200–400 Hz),superconducting generators,and novel insulation materials and *** high-speed generators,high loss in magnetic materials may shorten its insulation ***,these generators should be designed to be cooled by water instead of *** superconducting generators,the most significant concern is the integrity of the insulation system over the large thermal excursion whenever the system is cycled between room temperature and operating *** novel insulation materials and systems section:(i)using mica paper tapes containing boron nitride filler in the binding resin of the glass backing insulation,developed by Toshiba and Von Roll,resulted in a 15%increase in the MVA of generators for the same slot dimensions and operating temperatures,(ii)GE developed an enhanced polyethylene glycol terephthalate-mica tape having superior voltageendurance characteristics,(iii)Isovolta has introduced a mica paper tape using a flat glass fibre backing material,called Powerfab,rather than the more common woven structure,leading to a 15%reduced mica tape,and(iv)adding novel nanocomposites as fillers to ground wall insulation,introduced by Siemens,is a promising technique towards more high power density ***,accelerated aging of insulation systems especially those in electrical rotating machines exposed to voltage pluses with high slew rates up to hundreds of kV/μs and high-repetition rates ranging from hundreds of kHz to MHz is *** voltage pulses are generated by wide bandga

关键词： power insulation electrical

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