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A lead role for a“secondary”axonal injury response

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Neural Regeneration Research 2025年第2期20卷 469-470页

作者： Melissa A.Rudy Trent A.watkins Division of Neuroimmunology and Glial Biology Department of NeurologyUniversity of California at San FranciscoSan FranciscoCAUSA Development Disease Modelsand Therapeutics Graduate ProgramBaylor College of MedicineHoustonTXUSA

Stress signaling following axon injury stimulates a transcriptional program for regeneration that might be exploited to promote central nervous system ***,this stress response drives neuronal apoptosis in non-regenerative *** duality presents a quandary for the development of therapeutic interventions:manipulating stress signaling to enhance recovery of damaged neurons risks accelerating neurodegeneration or restricting regenerative *** dichotomy is well illustrated by the fates of retinal ganglion cells(RGCs)following optic nerve *** this central nervous system injury model,disruption of a stress-activated MAP kinase(MAPK)cascade blocks the extensive apoptosis of RGCs that occurs in wild-type mice(watkins et al.,2013;Welsbie et al.,2017).

关键词： injury axonal stress

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自制最好的石英钟

科技纵览 2024年第2期 18-20页

作者： Gavin watkins 不详

高级计时技术进入家庭。我一直对精准计时技术很感兴趣。现今,我们主要依赖互联网或者来自GPS卫星、广播电台的无线电波提供的计时。但我想要一个不依赖外界也可良好运行的计时时钟,而且一定要比一般的数字时钟或微控制器中使用的石英... 详细信息

高级计时技术进入家庭。我一直对精准计时技术很感兴趣。现今,我们主要依赖互联网或者来自GPS卫星、广播电台的无线电波提供的计时。但我想要一个不依赖外界也可良好运行的计时时钟,而且一定要比一般的数字时钟或微控制器中使用的石英晶体振荡器所提供的时间更准确,这些设备每天的时间偏差约1.7秒,一年的偏差超过10分钟。

关键词：石英晶体振荡器无线电波时间偏差数字时钟微控制器广播电台互联网 GPS卫星

Hybrid Short-term Load Forecasting Method Based on Empirical Wavelet Transform and Bidirectional Long Short-term Memory Neural Networks

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1216-1228页

作者： Xiaoyu Zhang Stefanie Kuenzel Nicolo Colombo Chris watkins School of Artificial Intelligence Anhui UniversityHefei 230601China Department of Electronic Engineering Royal HollowayUniversity of LondonEgham HillEgham TW20 OEXUK Department of Computer Science Royal HollowayUniversity of LondonEgham HillEgham TW200EXUK

Accurate short-term load forecasting is essential to modern power systems and smart grids. The utility can better implement demand-side management and operate power system stably with a reliable load forecasting system. The load demand contains a variety of different load components, and different loads operate with different frequencies. The conventional load forecasting methods, e.g., linear regression(LR), auto-regressive integrated moving average(ARIMA), deep neural network, ignore the frequency domain and can only use time-domain load demand as inputs. To make full use of both time-domain and frequency-domain features of the load demand, a load forecasting method based on hybrid empirical wavelet transform(EWT) and deep neural network is proposed in this paper. The proposed method first filters noises via wavelet-based denoising technique, and then decomposes the original load demand into several sub-layers to show the frequency features while the time-domain information is preserved as well. Then, a bidirectional long short-term memory(LSTM) method is trained for each sub-layer independently. In order to better tune the hyperparameters, a Bayesian hyperparameter optimization(BHO) algorithm is adopted in this paper. Three case studies are designed to evaluate the performance of the proposed *** the results, it is found that the proposed method improves the prediction accuracy compared with other load forecasting method.

关键词： Load forecasting empirical wavelet transform(EWT) recurrent neural network data denoising Bayesian hyperparameter optimization(BHO)

Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs

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Cancer Biology & Medicine 2017年第4期14卷 387-395页

作者： Sumadi Lukman Anwar Wahyu Wulaningsih Johnathan watkins PILAR Research Network Cambridgeshire CB1 2JD UK Division of Surgical Oncology Department of Surgery Faculty of Medicine Universitas Gadjah Mada Yogyakarta 55281 Indonesia Division of Hemato-Oncology Department of Internal Medicine Faculty of Medicine Universitas Gadjah Mada Yogyakarta 55281 Indonesia MRC Unit for Lifelong Nealth and Ageing University College London London WCIB 5JU UK Institute of Molecular and Mathematical Biomedicine King's College London London SE1 1UL UK

Objective:To determine the influence of the single nucleotide polymorphism(SNP)rs4245739 on the binding and expression of micro RNAs and subsequent MDM4 expression and the correlation of these factors with clinical determinants of ER-negative breast ***:Find Tar and miRanda were used to detect the manner in which potential micro RNAs are affected by the SNP rs4245739-flanking *** sequencing data for ER-negative breast cancer from The Cancer Genome Atlas(TCGA)were used to compare the expression of miR-184,miR-191,miR-193a,miR-378,and MDM4 in different rs4245739 ***:Comparison of ER-negative cancer patients with and without the expression of miR-191 as well as profile micro RNAs(miR-184,miR-191,miR-193a and miR-378 altogether)can differentiate the expression of MDM4 among different rs4245739 *** simple genotyping alone did not reveal significant clinical relationships,the combination of genotyping and micro RNA profiles was able to significantly differentiate individuals with larger tumor size and lower number of involved lymph nodes(P<0.05)in the risk group(A allele).Conclusions:We present two novel methods to analyze SNPs within 3′UTRs that use:(i)a single miRNA marker expression and(ii)an expression profile of miRNAs predicted to bind to the SNP *** demonstrate that the application of these two methods,in particular the miRNA profile approach,permits detection of new molecular and clinical features related to the rs4245739 variant in ER-negative breast cancer.

关键词： Rs4245739 ER-negative breast cancer MDM4 microRNA clinical relevance

A review of smartphones-based indoor positioning:Challenges and applications

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IET Cyber-Systems and Robotics 2021年第1期3卷 1-30页

作者： Khuong An Nguyen Zhiyuan Luo Guang Li Chris watkins School of Computing Engineering and MathematicsUniversity of BrightonBrightonUK Computer Science Department Royal HollowayUniversity of LondonEghamUK Institute of Cyber-Systems and Control Zhejiang UniversityHangzhouChina

The continual proliferation of mobile devices has encouraged much effort in using the smartphones for indoor *** article is dedicated to review the most recent and interesting smartphones-based indoor navigation systems,ranging from electromagnetic to inertia to visible light ones,with an emphasis on their unique challenges and potential realworld applications.A taxonomy of smartphone sensors will be introduced,which serves as the basis to categorise different positioning systems for reviewing.A set of criteria to be used for the evaluation purpose will be *** each sensor category,the most recent,interesting,and practical systems will be examined,with detailed discussion on the open research questions for the academics,and the practicality for the potential clients.

关键词： client smart taxonomy

The state and future of emergency medicine in Macedonia

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World Journal of Emergency Medicine 2016年第4期7卷 245-249页

作者： Bret Nicks Marko Spasov Christopher watkins Emergency Medicine Wake Forest Baptist Medical Center2nd Meads Hall Medical Center Blvd Clinic on Traumatology State University Hospital

BACKGROUND:Macedonia has universal public health care *** and emergency patient care is provided in different care environments based on the medical complaint and resource *** emergency medicine and well organized emergency departments(EDs) are an essential component of any developed health care system,emergency medicine as a specialty is relatively non-existent in *** RESOURCES:A system assessment regarding presence,availability and capacity of EDs was completed from 2013-2015,based upon assessments of 21 institutions providing emergency care and information provided by the Ministry of *** assessment establishes a benchmark from which to strategically identify,plan and implement the future of emergency medicine in ***:In general,emergency departments- defined by offering acute care 24 hours per day,7 days per week- were available at all general and university ***,care resources,emergency and acute care training,and patient care capacity vary greatly within the *** is limited uniformity in acute care approach and *** EDs are not organized as separate divisions run by a head medical doctor,nor are they staffed by specialists trained in emergency *** diagnostic and treatment capacities are insufficient or outdated by current international emergency medicine standards and frequently require patient transfer or admission prior to ***:Most of the surveyed hospitals are capable of providing essential diagnostic tests,but very few are able to do so at the point or time of *** emergency medical services(EMS) have improved system-wide,emergent care interventions by EMS and within all hospitals remain *** system-wide acute and emergency care improvements are forthcoming.

关键词： Emergency medicine Macedonia

Current Trend in Synthesis,Post-Synthetic Modifications and Biological Applications of Nanometal-Organic Frameworks(NMOFs)

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Chinese Journal of Chemistry 2019年第4期37卷 378-404页

作者： Ebenezer Baa Gary M.watkins Rui.W.Krause Derek.N.Tantohb Department of Chemistry Rhodes UniversityPO Box 94Grahamstown6140South Africa Department of Applied Chemistry University of JohannesburgPO Box 524Auckland Park2006South Africa

Since the early reports of MOFs and their interesting properties,research involving these materials has grown wide in scope and *** synthetic approaches have ensued in view of obtaining materials with optimised properties,the extensive scope of application spanning from energy,gas sorption,catalysis biological applications has meant exponentially evolved over the *** far-reaching synthetic and PSM approaches and porosity control possibilities have continued to serve as a motivation for research on these *** respect to the biological applications,MOFs have shown promise as good candidates in applicati ons involving drug delivery,BioMOFs,sensing,imaging amongst *** being a while away from successful entry into the market,observed results in sensing,drug delivery,and imaging put these materials on the spot light as candidates poised to usher in a revolution in *** this regard,this review article focuses current approaches in synthesis,post functionalization and biological applications of these materials with particular attention on drug delivery,imaging,sensing and BioMOFs.

关键词： Current Trend Post-Synthetic Modifications Nanometal-Organic Frameworks(NMOFs)

Study of wind towers with different funnels attached to in crease natural ventilation in an underground building

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Frontiers of Architectural Research 2020年第4期9卷 925-939页

作者： C.A.Varela-Boydo S.L.Moya R.watkins Tecnologico Nocional de Mexico Centro Nacional de Investisacion y Desorrollo TecnoldsicoInterior Internado Palmira s/nColonia PalmiraCuernavaca62490 MorelosMexico Kent School of Architecture&Planning University of KentUK

Finding ways to cool buildings by natural,passive techniques is crucial in the context of global *** centuries,wind towers(traditi onal win dcatchers)have been used in the Middle East for cooling *** this study,the use of funnels at the openings of wind towers for wind ingress and egress is proposed primarily to increase the mass flow captured by the wind *** use of funnels in the wind in gress openings in creases the inlet area,improving the capture of *** parallel,the use of funnels in the egress openings modifies the wake of the tower,which aims to ease the exit of the flow from inside the *** design configurations are presented,where the length and width of the funnels are changed and tested separately by computational fluid dynamics(CFD).Results of over 120 CFD simulations are presented and *** volumetric flow entering the wind towers in creases by 10.7% in several *** results in dicate that adding funnels to wind towers could positively in fluence their *** the dimensions of the funnels affects their efficacy and can increase or decrease the airflow entering the tower.

关键词： Wind towers Passive cooling Natural ventilation Funnels CFD Wind catchers

IT-Software SMEs in China, Technology Transfer from Universities and Entrepreneurship, a Successful Nexus？

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Frontiers of Business Research in China 2014年第1期8卷 18-48页

作者： Jianghong Cao M. John Foster Lorraine watkins-Mathys Kingston-Business School Kingston University Kingston Upon Thames KT2 7LB UK

Drawing on the empirical work of a broader study, this paper examines whether technology is being successfully transferred from universities to the IT-sottware SMEs present in China, and the effectiveness of entrepreneurship in effecting such transfers. A conceptual framework was generated to guide the investigation. Data were elicited using a detailed questionnaire which generated 53 usable responses; follow-up interviews with 17 of the 53 respondents; and four interviews with relevant government officials （civil servants from the Ministry of Science and Technology and state-owned banks）. There were three main fmdings. Chinese software SMEs tend to be reluctant to adopt new technologies from local tmiversities; there is a lack of common purpose between the parties; and entrepreneurs who did undertake such technology transfer felt the process was badly impeded by the lack of available finance, and expressed fears about poor protection of intellectual property rights in China. The majority of the sample firms acted opportunistically, taking advantage of the benefits offered under government schemes to earn rapid returns mainly using extant technologies. These conclusions suggest that the Chinese government＇s policies in this area of technology transfer have had only limited success.

关键词： entrepreneurship technology transfer universities IT-software,SME China