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Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules

Regenerative Biomaterials 2015年第1期2卷 31-45页

作者： Lingling Tian molamma p.prabhakaran Seeram Ramakrishna Mechanical Engineering Faculty of EngineeringNational University of Singapore2 Engineering Drive 3Singapore 117576 Nanoscience and Nanotechnology Initiative National University of Singapore2 Engineering Drive 3Singapore 117576

Nerve diseases including acute injury such as peripheral nerve injury(pNI),spinal cord injury(SCI)and traumatic brain injury(TBI),and chronic disease like neurodegeneration disease can cause various function disorders of nervous system,such as those relating to memory and voluntary *** nerve diseases produce great burden for individual families and the society,for which a lot of efforts have been *** pathways represent a unidirectional and aligned architecture allowing systematic axonal development within the *** a traumatic injury,the intricate architecture suffers disruption leading to inhibition of growth and loss of *** to limited capacity of the body to regenerate axonal pathways,it is desirable to have biomimetic approach that has the capacity to graft a bridge across the lesion while providing optimal mechanical and biochemical cues for tissue *** for central nervous system injury,one more extra precondition is compulsory:creating a less inhibitory surrounding for axonal *** is a cost-effective and straightforward technique to fabricate extracellular matrix(ECM)-like nanofibrous structures,with various fibrous forms such as random fibers,aligned fibers,3D fibrous scaffold and core-shell fibers from a variety of *** diversity and versatility of electrospinning technique,together with functionalizing cues such as neurotrophins,ECM-based proteins and conductive polymers,have gained considerable success for the nerve tissue *** are convinced that in the future the stem cell therapy with the support of functionalized electrospun nerve scaffolds could be a promising therapy to cure nerve diseases.

关键词： electrospinning nerve tissue engineering nanofibers functionalized scaffolds

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Structural properties of scaffolds:Crucial parameters towards stem cells differentiation

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World Journal of Stem Cells 2015年第4期7卷 728-744页

作者： Laleh Ghasemi-Mobarakeh molamma p.prabhakaran Lingling Tian Elham Shamirzaei-Jeshvaghani Leila Dehghani Seeram Ramakrishna Department of Textile Engineering Isfahan University of Technology Department of Mechanical Engineering Faculty of Engineering2 Engineering Drive 3National University of Singapore Department of Medical Science Islamic Azad University Najafabad Branch Isfahan Neurosciences Research Center AlZ ahra Hospital Isfahan University of Medical Sciences

Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciencesfor regeneration of damaged tissues. Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. Here, we focus on the recent reports that investigated the various aspects of scaffolds including the materials used for scaffold fabrication, surface modification of scaffolds, topography and mechanical properties of scaffolds towards stem cells differentiation effect. We will present a more detailed overview on the effect of mechanical properties of scaffolds on stem cells fate.

关键词： Stem cells Tissue engineering Differentiation Mechanical properties Surface modification Topography

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