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Circulating levels of advanced glycation end products in females with polycystic ovary syndrome:a meta-analysis

Reproductive and Developmental Medicine 2024年第2期8卷 93-100页

作者： Seyed Sobhan Bahreiny Akram Ahangarpour mojtaba aghaei Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Medical Basic Sciences Research Institute Physiology Research CenterDepartment of PhysiologySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Polycystic ovary syndrome(PCOS)is a common endocrine disorder characterized by a hormonal imbalance that affects females of reproductive *** association between advanced glycation end products(AGEs)and PCOS has attracted considerable attention in recent years,highlighting the potential of AGEs as biomarkers for this *** the present systematic review and meta-analysis,we aimed to examine the association between AGEs and PCOS,evaluate their potential as biomarkers,and improve our understanding of the pathophysiology of PCOS and its associated metabolic complications.A literature search was performed using various databases from January 2000 to March 2023 to identify relevant studies investigating the association between AGEs and *** effect estimates were calculated using standardized mean differences(SMD)with 95%confidence intervals(CIs).Sub-group and meta-regression analyses were performed to examine potential sources of *** meta-analysis included six studies with a total of 623 *** results revealed a significant increase in circulating AGE levels in females with PCOS compared to healthy females(SMD=2.35;95%CI:1.10-3.60;P<0.001).Significant heterogeneity was observed between the studies(I2=96.37%;P<0.001),indicating the presence of several factors influencing the ***-group analyses based on body mass index,age,and homeostatic model assessment for insulin resistance indicated differential effects of AGEs on specific *** systematic review and meta-analysis support the association between elevated AGE levels and PCOS,thereby suggesting the potential role of AGEs as biomarkers in PCOS.

关键词： Polycystic ovary syndrome PCOS Advanced glycation end products AGEs Biomarker Meta-analysis

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Exploring the relationship between ambient sulfur dioxide and semen quality parameters:A systematic review and meta-analysis

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Asian pacific Journal of Reproduction 2024年第1期13卷 12-21页

作者： Seyed Sobhan Bahreiny mojtaba aghaei Mohammad Reza Dabbagh Hamid Ghorbani Moslem Javidan Reza Mohammadpour Fard Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Medical Basic Sciences Research Institute Physiology Research CenterDepartment of PhysiologySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Biology Faculty of ScienceShahid Chamran University of AhvazAhvazIran Department of Immunology Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Objective:To investigate the relationship between ambient sulfur dioxide(SO2)exposure and semen quality ***:A systematic literature search was conducted to identify relevant studies investigating the association between SO2 exposure and semen quality *** search encompassed the timeframe from January 2000 to May 2023 and included electronic databases such as Web of Science,Google Scholar,PubMed,Cochrane,and *** effect estimates with 95%confidence intervals(CI)were calculated using percent changes(PC).The meta-analysis included seven studies with 6711 participants and 15087 semen ***:The results revealed a significant negative association between ambient SO2 exposure and certain semen quality *** particular,SO2 exposure was associated with a significant decrease in progressive motility(PC=0.032;95%CI:-0.063 to-0.001;P=0.044)and sperm concentration(PC=-0.020;95%CI:-0.036 to-0.005;P=0.012).However,no statistically significant associations were observed for total sperm count(PC=-0.038;95%CI:-0.079 to 0.003;P=0.070),seminal fluid volume(PC=-0.009;95%CI:-0.048 to-0.030;P=0.662)and sperm motility(PC=-0.17;95%CI:-0.363 to 0.022;P=0.830).In addition,the results of the subgroup analysis revealed specific variables that were associated with the decrease in relevant sperm ***:This systematic review and meta-analysis provides compelling evidence supporting a consistent negative association between exposure to ambient SO2 and semen quality parameters.

关键词： Semen quality Sulfur dioxide Ambient air pollution Meta-analysis

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Exploring the relationship between Hashimoto's thyroiditis and male fertility:A meta-analytic and meta-regression perspective on hormonal and seminal factors

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Asian pacific Journal of Reproduction 2024年第4期13卷 147-159页

作者： Seyed Sobhan Bahreiny mojtaba aghaei Mahdi Amraei Mohammad Reza Dabbagh Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Medical Basic Sciences Research Institute Physiology Research CenterDepartment of PhysiologySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Thalassemia&Hemoglobinopathy Research Center Health Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran USERN Office Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Biology Faculty of ScienceShahid Chamran University of AhvazAhvazIran

Objective:To explore the relationship between Hashimoto's autoimmune hypothyroidism(HT)and male fertility,focusing on hormonal and seminal ***:A systematic literature search was conducted across databases such as PubMed,Web of Science,EMBASE,Scopus,Cochrane,and Google Scholar,covering studies published from January 2000 to March *** investigating the impact of HT on semen quality parameters and reproductive hormones were *** effect estimates were calculated using standard mean difference(SMD)and 95%confidence intervals(CI).Results:A total of 8 studies with 8965 participants were *** significantly affected semen quality and reproductive hormone ***,there was a notable decrease in progressive morphology(SMD=-0.78;95%CI:-1.40 to-0.17;P=0.01)and sperm motility(SMD=-1.151;95%CI:-1.876 to-0.425;P=0.002).In addition,there were no significant changes in reproductive hormones,although there were elevated levels of luteinizing hormone(SMD=0.437;95%CI:0.000 to 0.874;P=0.050)and follicle-stimulating hormone(SMD=0.293;95%CI:-0.171 to 0.758;P=0.216),with a slight impact on testosterone levels(SMD=-1.143;95%CI:-2.487 to 0.200;P=0.095).Conclusions:This systematic review and meta-analysis provides robust evidence of the detrimental effects of HT on semen quality and reproductive hormones,underscoring the necessity for thorough evaluation and management of thyroid function in male infertility assessments.

关键词： Hashimoto thyroiditis Male fertility Semen quality Reproductive hormones Meta-analysis Meta-regression

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Case study of hydraulic fracturing in an offshore carbonate oil reservoir

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Petroleum Research 2022年第4期7卷 419-429页

作者： Mohammad Azad mojtaba Ghaedi Amir Farasat Hadi Parvizi Hamed aghaei Department of Petroleum Engineering School of Chemical and Petroleum EngineeringShiraz UniversityIran Iranian Offshore Oil Company TehranIran Petroxin Ltd LondonUnited Kingdom

Maximizing petroleum production while efficiently managing the operational costs is the oil and gas industry's primary goal which requires innovative engineering approaches and production-enhancing treatments such as hydraulic fracturing(HF).During the HF process,the injected fluid mixed with sands or proppants will create permanent fluid channels to drain more of the reservoir *** level of complexity and various constraints involved in real field treatments have made HF even more chal-lenging in layered carbonate reservoirs with the water drive mechanism.A prominent concern is the downward fracture growth to the oil/water contact zone that may cause unfavorable water cut *** fracture height confinement criterion necessitates optimization of fracture dimension *** height development is mainly a function of in-situ stress conditions and stress magnitude differences between geologic *** cases with a water table at the proximity of the wellbore,fracture height directly affects the operational *** paper demonstrates a practical step-by-step approach towards the design of hydraulic fracturing treatment in an offshore carbonate oil *** modeling process involves optimization of the location,number,and conductivity of the proposed ***-jection of high viscosity fluid causes a bi-wing vertical planar fracture to propagate perpendicular to the direction of minimum horizontal stress in the strike-slip faulting *** of the induced hydraulic fractures are also impacted by the amount and type of ***,as with this case study,the magnitude of vertical stress is in the same range as the maximum horizontal stress;the fracture height growth is the limiting *** LGR method is used to define fractures in the dynamic reservoir model which has been built based on a complete set of data ranging from the analyses of logs,core samples,and seismic details,to perform production forecasts and economic ev

关键词： Hydraulic fracture design Carbonate reservoirs Proppant selection Economic analysis Reservoir modeling

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Knowledge, attitude and practice of healthcare workers concerning Crimean-Congo hemorrhagic fever in Western Iran

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 546-550页

作者： mojtaba Salimi Abbas aghaei Afshar mojtaba Limoee Soraya Babakhani Omid Chatrabgoun Ahmad Ali Hanafi-Bojd Gidiglo Godwin Nutifafa Department of Medical Entomology & Vector Control School of Public HealthTehran University of Medical Sciences (TUMS) Department of Health Promotion and Network Expansion Health DeputyKermanshah University of Medical Sciences Leishmaniasis Research Center Kerman University of Medical Sciences Departments of Public Health and Health Research Center Kermanshah University of Medical Sciences Department of Mathematical Statistics and ProbabilityMalayer University Department of Medical Entomology & Vector Control School of Public HealthInternational CampusTehran University of Medical Sciences

Objective: To determine the knowledge, attitude and practice of healthcare workers in Kermanshah Province about Crimean-Congo hemorrhagic fever(CCHF).Methods: This study was conducted in 2014 on healthcare personnel in different job categories including physicians, nurses, midwives, laboratory staff and network health staff of Kermanshah Province by direct ***: A total of 367 respondents who had more than 5 years of experience in their jobs were interviewed. Among them 91% of physicians and nurses, 97% of midwives and health workers and 96% of laboratory staff stated that they had not been confronted with CCHF patients so far. Regarding knowledge, 76% of physicians, 78% of nurses, 77% of midwives and 58% of laboratory staff believed that the disease is remediable. Most of the interviewed participants stated that the disease pertains to people who are in close contact with domestic animals, but they did not consider their own occupations as one of the risk factors. More than 70% of the respondents believed that the disease may exist in the province or their work field. Generally, the knowledge about CCHF was inadequate, with nurses having the lowest level of ***: Knowledge of Kermanshah healthcare staff about CCHF was poor,especially nurses in a high risk job category. Therefore, it is necessary to conduct specific training programs for the disease identification, transmission, prevention, and treatment as well as the use of personal protection and safety devices.

关键词： Crimean-Congo hemorrhagic fever Healthcare worker Knowledge Iran

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Evaluating the effect of Myrtus communis on programmed cell death in hydatid cyst protoscolices

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1072-1076页

作者： mojtaba Shahnazi Abbas Azadmehr Moazzam Dosti Jondabeh Reza Hajiaghaee Reza Norian Hamidreza aghaei Mehrzad Saraei Mahmood Alipour Department of Parasitology Qazvin University of Medical SciencesQazvinIran Cellular&Molecular Research Institute Qazvin University of Medical SciencesQazvinIran Department of Immunology Qazvin University of Medical SciencesQazvinIran Department of Immunology Babol University of Medical SciencesBabolIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran Department of Microbiology Faculty of Veterinary MedicineUrmia UniversityUrmiaIran Department of Social Medicine Qazvin University of Medical SciencesQazvinIran

Objective: To evaluate the possible involvement of programmed cell death strategy in hydatid cyst protoscolices following treatment with Myrtus communis(M. communis) as an herbal ***: Protoscolices were aseptically collected from sheep liver hydatid cysts. Evaluating the effect of M. communis extract on programmed cell death and increased activity of caspases 3, 8, and 9 in hydatid cyst protoscolices was conducted by treating the protoscolices with different concentration(5, 50, and 100 mg/mL) of M. communis extract at37C and 5% CO2 for 4 h by using the Bradford test and ELISA commercial ***: The extract of M. communis at all concentrations led to initiation of programmed cell death in protoscolices and this effect, was only significant at 50 and 100 mg/mL concentrations, compared to the negative control(P < 0.05). Also, the activity of caspases3, 8, and 9 in hydatid cyst protoscolices, was shown that the extract at all 3 concentrations could only increase the activity of caspases 3 and 9. Moreover, a significant increase in the activity of caspase 3 was only observed at concentrations 50 and 100 mg/m L by 37.00%and 66.19% while a significant increase in the activity of caspase 9 at the same concentrations was observed by 20.89% and 63.67%, respectively(P < 0.05).Conclusions: The extract of M. communis at different concentrations could increase the activity of caspases 3 and 9 and caused programmed cell death in hydatid cyst protoscolices however, this effect was significant at high concentrations of the extract.

关键词：包虫 granulosus Protoscolex Myrtus communis 规划房间死亡 Caspase

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