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The short form of the sUR1 and its functional implications in the damaged brain

Neural Regeneration Research 2022年第3期17卷 488-496页

作者： Iván Alquisiras-Burgos Javier Franco-Pérez moisés rubio-osornio Penélope Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio de Formación Reticular Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio Experimental de Enfermedades Neurodegenerativas Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico.

sulfonylurea receptor(sUR) belongs to the adenosine 5′-triphosphate(ATP)-binding cassette(ABC) transporter family;however,sUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the ***8 and Abcc9 genes code for the proteins sUR1 and sUR2,*** sUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other *** is well known that sUR1 assembles with Kir6.2 and TRPM4 to establish K_(ATP) channels and non-selective cation channels,***8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of sUR1 and sUR2,which have been detected by different experimental ***,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of sUR(-65 k Da).Identity of the sUR1 variants has not been clarified,and some authors have suggested that the shorter forms are ***,immunoprecipitation assays have shown that sUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the *** evidence confirms that the structure of the short forms of the sURs is fully functional and does not lose the ability to interact with the *** structural changes in short forms of sUR modify its affinity to ATP,regulation of its expression might represent an advantage in pathologies where ATP concentrations decrease and a therapeutic target to induce ***,the expression of sUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(*** stroke and epilepsy).In this review,we want to contribute to the knowledge of sUR1 complexity by analyzing evidence that shows the existence of short sUR1 variants and its possible implications in brain function.

关键词： brain edema epilepsy Parkinson's disease stroke sulfonylurea receptor 1 sUR1 traumatic brain injury TRPM4

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Lipschitz Algebras and Peripherally-multiplicative Maps

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Acta Mathematica sinica,English series 2008年第8期24卷 1233-1242页

作者： A.JIM■NEZ-VARGAs moisés VILLEGAs-VALLECILLOs Departamento de■lgebray Análisis Matemático Universidad de Almería04071AlmeríaSpain

Let X be a compact metric space and let Lip（X） be the Banach algebra of all scalar- valued Lipschitz functions on X, endowed with a natural norm. For each f ∈ Lip（X）, σπ（f） denotes the peripheral spectrum of f. We state that any map Φ from Lip（X） onto Lip（Y） which preserves multiplicatively the peripheral spectrum： σπ（Φ（f）Φ（g）） = σπ（fg）, A↓f, g ∈ Lip（X） is a weighted composition operator of the form Φ（f） = τ· （f °φ） for all f ∈ Lip（X）, where τ ： Y → {-1, 1} is a Lipschitz function and φ ： Y→ X is a Lipschitz homeomorphism. As a consequence of this result, any multiplicatively spectrum-preserving surjective map between Lip（X）-algebras is of the form above.

关键词： Lipschitz algebra peripherally-multiplicative map spectrum-preserving map peaking function peripheral spectrum

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Anthropogenic mineral generation and its potential resource supply:The case of niobium

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science China Earth sciences 2024年第8期67卷 2583-2591页

作者： Xianlai ZENG moisés Gómez Mahmoud BAKRY Yong GENG Jinhui LI school of Environment Tsinghua UniversityBeijing 100084China school of Environmental science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China school of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200030China

The strategy of carbon neutrality is reshaping the global landscape of resource flow and *** the final sink of geological minerals,the proliferated anthropogenic minerals,also called secondary resources,play an increasingly important role in resource supply *** is a critical metal that lacks full concern for its *** fundamental principle of niobium circularity is to recycle and maintain the material as close to the manufacturing process as *** we estimate the niobium-containing applications lost at their end-of-life,underscoring the imperative to minimize such ***,we elucidate the extraction processes for scrap and alloy quantities throughout the industry's *** from anticipated waste generated by the majority of niobium applications,a forecast indicates a potential loss of approximately 168 kt by 2090 in the absence of ***,with a recycling efficiency of 90%for niobium,the projected loss diminishes to approximately 16 *** delve into the significance of niobium's circular economy and explore various aspects that demand further investigation for a seamless transition from linear to circular practices.

关键词： Niobium Anthropogenic mineral Circular economy Recycling sustainability

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Together but not scrambled:A perspective on chaotic printing/bioprinting

Aggregate

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Aggregate 2024年第4期5卷 1-11页

作者： Grissel Trujillo-de santiago Mario moisés Alvarez Centro de Biotecnología-FEMsA Tecnologico de MonterreyMonterreyNuevo LeonMéxico Departamento de Ingeniería Mecatrónica y Eléctrica Escuela de Ingeniería y CienciasTecnologico de MonterreyMonterreyNuevo LeonMéxico

structures in nature are often multi-material,and their structures have aﬁne bal-ance between segregation and aggregation(mixed,but not scrambled)that provides *** fabrication,a technology that exploits the ability of chaotic advection to create predictable and reproducible multilayered structures,excels at producing materials where this balance can be achieved andﬁnely *** method is based on the use of chaotic mixing systems,which can produce constructs with highly organized internal micro-architecture in a simple and cost-effective *** manuscript provides a perspective on how chaotic printing can be a great enabler in the manufacture of advanced materials,including living *** printing may overcome many of the critical hurdles that are currently faced in man-ufacturing and biofabrication(e.g.,creating a wide array of interfaces,reaching high resolutions rapidly and at low cost,and producing densely vascularized tissues).The manuscript introduces the technology,explains how the idea originated,presents a timeline that provides a recapitulation of the milestones achieved so far,describes the main characteristics,advantages,limitations,and challenges of the technology,and concludes with future perspectives on the evolution and use of this versatile method.

关键词： advanced materials bioprinting chaotic bioprinting chaotic printing multilayered multimaterial

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A study of fire propagation in coal seam with numerical simulation of heat transfer and chemical reaction rate in mining field

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International Journal of Mining science and Technology 2019年第6期29卷 873-879页

作者： moisés Oswaldo Bustamante Rúa Alan José Daza Aragón Pablo Bustamante Baena National University of Colombia Cr 65 # 63 20 CIMEX Minerals Institute

spontaneous combustion of coal is a problem that affects the mining operation and generates environ-mental,economic,social and geotechnical *** phenomenon has been divided into two pro-cesses:ignition and *** propagation develops in coal seams because of a set of factors such as direction and wind speed,fracturing and *** this work,heat transfer and chemical kinetics are studied from conservation equations of energy and species,respectively,using the software COMsOL Multiphysics to simulate the propagation of fires in coal *** possible scenarios were analyzed that usually occur in the walls of the coal seams,such as fire focus and fire complete *** was found that the propagation kinetics of the fire changes depending on the temperature,the fractur-ing of rock mass and the area of fire *** temperature values lower than 300℃,there is con-sumption around 250 cm^3/h,values around 700℃,the consumption is 1500 cm^3/h,and for fires of 1200℃ have values of 3000 cm^3/*** on the speed of propagation can vary from 4 to 17cm/day,considering on the level and fracturing of the final wall of the open pit.

关键词： spontaneous combustion of coal Open pit mines simulation Heat transfer Chemical reaction COMsOL

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Complexity of adaptive testing in scenarios defined extensionally

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Frontiers of Computer science 2023年第3期17卷 11-28页

作者： Ismael RODRÍGUEZ David rubio Fernando rubio Dpto.sistemas Informáticos y Computación Facultad de InformáticaUniversidad Complutense de MadridMadrid 28040Spain Instituto de Tecnologías del Conocimiento Universidad Complutense de MadridMadrid 28040Spain Instituto de Biomecánica de Valencia.Universitat Politècnica de València València 46022Spain

In this paper,we consider a testing setting where the set of possible definitions of the Implementation Under Test(IUT),as well as the behavior of each of these definitions in all possible interactions,are extensionally defined,i.e.,on an element-by-element and case-by-case *** this setting,the problem of finding the minimum testing strategy such that collected observations will necessarily let us decide whether the IUT is correct or not(i.e.,whether it necessarily belongs to the set of possible correct definitions or not)is studied in four possible problem variants:with or without non-determinism;and with or without more than one possible definition in the sets of possible correct and incorrect *** computational complexity of these variants is studied,and properties such as PsPACE-completeness and Log-APX-hardness are identified.

关键词： formal testing adaptive testing computational complexity PsPACE-completeness approximation hardness

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Caving performance through the integration of microseismic activity and numerical modeling at DOZ-PT Freeport,Indonesia

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International Journal of Minerals,Metallurgy and Materials 2009年第1期16卷 1-6页

作者： rubio Enrique Napitupulu Daulat Mining Engineering Department Universidad de Chile Geotechnical Engineering Department PT Freeport IndonesiaTembagapuraIndonesia

This article describes an undergoing research at PT Freeport, Indonesia, in which the main goal is to use the microseismic information recorded as a result of mining to analyze cave propagation and stress performance on the actual production and fixed infrastructure. At the moment, several numerical experiments have been conducted to correlate the mining activity with the microseismic events using the data collected during year 2005 and 2006. As a result of the preliminary analysis a micro- and a macrocracking envelop were proposed on the basis of computation of stress behavior at the location of the events. stresses have been computed using standard elastic continuous boundary element models. The correlation between the average source radius and the stress performance has provided a method to propose a macrocracking criterion. several techniques have been tested to nucleate the microseismic activity around different geological features. This last attempt was aimed to look at potential overstresses induced over the undercut and extraction level drifts. A method was devised to integrate the microseismicity into a 3-dimensional ride distribution model. This model has shown to be very effective to quantify the overstress induced as a result of computing volumetric microseismicity density. The volumetric microseismic model showed to induce overstress up to 10 MPa over a period of two months. The future work will concentrate on the calibration of the integrated model with actual damage observations made at the current mining infrastructure.

关键词： microseism underground mining block caving stress distribution microcrack criterion

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Assessing the energy saving potential of using adaptive setpoint temperatures:The case study of a regional adaptive comfort model for Brazil in both the present and the future

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Building simulation 2024年第3期17卷 459-482页

作者： Daniel sánchez-García David Bienvenido-Huertas Carlos rubio-Bellido Ricardo Forgiarini Rupp Department of Electrical Engineering University Carlos III of MadridMadridSpain Department of Building simulation ZEROCEM SLSevilleSpain Department of Building Constructions University of GranadaGranadaSpain Department of Building Constructions II University of SevilleSevilleSpain section of Design for sustainability Department of Civil and Mechanical EngineeringTechnical University of DenmarkKgs.LyngbyDenmark

It has been found in recent years that using setpoint temperatures based on adaptive thermal comfort models is a successful method of energy *** studies using adaptive setpoint temperatures incorporate international models from AsHRAE standard 55 and *** study,however,has instead considered a regional Brazilian adaptive comfort *** study investigates the energy demand arising from the use of a local Brazilian comfort model in order to assess the energy implications from the use of the worldwide AsHRAE standard 55 adaptive model and various fixed setpoint *** of Brazil’s climate zones,full air-conditioning,mixed-mode building operating modes,present-day climate change scenarios,and future scenarios—specifically Representative Concentration Pathways(RCP)2.6,4.5,and 8.5 for the years 2050 and 2100—have all been taken into account in building energy *** use of adaptive setpoint temperatures based on the Brazilian local model considering mixed-mode has been found to significantly reduce energy consumption when compared to static setpoint temperatures(average energy-saving values ranging from 52%to 58%)and the AsHRAE 55 adaptive model(average values ranging from 15%to 21%).Considering climate change and the mixed-mode Brazilian model,the overall energy demand for the three groups of climatic zones(annual average outdoor temperatures≤21℃,>21 and≤25℃and>25℃)ranged between 2%decrease and 5%increase,4%and 27%increase,and 13%and 45%increase,*** is concluded as a consequence that setting setpoint temperatures based on the Brazilian local adaptive comfort model is a very efficient energy-saving method.

关键词： adaptive thermal comfort building energy simulation energy efficiency climate change adaptive setpoint temperatures local comfort mode

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On the singular Effects in the Relativistic Landau Levels in Graphene with a Disclination

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Communications in Theoretical Physics 2018年第12期69卷 817-822页

作者： Rosinildo F.do Nascimento Diego Cogollo Edilberto O.silva moisés Rojas Cleverson Filgueiras Instituto de Fisica Universidade Federal de UberlandiaUberlandiaMGBrasil Unidade Academica de Fisica Universidade Federal de Campina GrandePOB 1007158109-970Campina Grande-PB Brazil Departamento de Fisica Universidade Federal do Maranhao65085-580Sao Luis-MABrazil Departamento de Fisica Universidade Federal de LavrasCaixa Postal 303737200-000Lavras-MGBrazil

The effect of a pseudo Aharonov-Bohm(AB) magnetic field generated by a disclination on a two-dimensional electron gas in graphene is addressed in the continuum limit within the geometric approach. The influence of the coupling between the spinor fields and the singular conical curvature is investigated, which shows that singularities have pronounced impact in the Hall conductivity. Moreover, the degeneracy related to the Dirac valleys is broken for negative values of the angular momentum quantum numbers, ?, including ? ≡ 0. In this case, a Hall plateau develops at the null filling factor. Obtaining the Hall conductivity by summing over the positive and the negative ?′s, the null Landau level is recovered and the plateau at the null filling factor disappears. In any case, the standard plateaus, which are seen in a flat graphene are not obtained with these curvature and singular effects.

关键词： Landau Levels Hall conductivity Graphene Elastic deformations

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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