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Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 295-318页

作者： Ramón Cantero-Cid Karla Marina Montalbán-Hernández Jenny Guevara Alejandro Pascual-iglesias Elisa Pulido JoséCarlos Casalvilla Cristóbal Marcano Cristina Barragán serrano Jaime Valentín Gloria Cristina Bonel-Pérez JoséAvendaño-Ortiz Verónica Terrón Roberto Lozano-Rodríguez Alejandro Martín-Quirós Elvira Marín Eva Pena Laura Guerra-Pastrián Eduardo López-Collazo Luis Augusto Aguirre Tumor Immunology Laboratory The Innate Immune Response GroupHospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Digestive surgery service La Paz University HospitalMadrid 28046Spain Emergency Department and Emergent Pathology Research Group Hospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Pathologic Anatomy service Hospital La PazMadrid 28046Spain

BACKGROUND Colorectal cancer(CRC)accounts for 9.4%of overall cancer deaths,ranking second after lung *** the large number of factors tested to predict their outcome,most patients with similar variables show big differences in ***,right-sided CRC(RCRC)and left-sided CRC(LCRC)patients exhibit large differences in outcome after surgical intervention as assessed by preoperative blood leukocyte *** hypothesised that stronger indexes than circulating(blood)leukocyte ratios to predict RCRC and LCRC patient outcomes will result from combining both circulating and infiltrated(tumour/peritumour fixed tissues)concentrations of *** To seek variables involving leukocyte balances in peripheral blood and tumour tissues and to predict the outcome of CRC *** sixty-five patients diagnosed with colon adenocarcinoma by the Digestive surgery service of the La Paz University Hospital(Madrid,spain)were enrolled in this study:43 with RCRC and 22 with *** were followed-up from January 2017 to March 2021 to record overall survival(Os)and recurrence-free survival(RFs)after surgical *** concentrations in peripheral blood were determined by routine laboratory ***-fixed samples of tumour and peritumoural tissues were assessed for leukocyte concentrations by immunohistochemical detection of CD4,CD8,and CD14 marker *** of leukocyte concentration in blood and tissues were calculated and evaluated for their predictor values for Os and RFs with spearman correlations and Cox univariate and multivariate proportional hazards regression,followed by the calculation of the receiver-operating characteristic and area under the curve(AUC)and the determination of Youden’s optimal cutoff values for those variables that significantly correlated with either RCRC or LCRC patient *** patients from the cohort were randomly assigned to modelling and validation sets,and clinician-friendly nomogra

关键词： Left colorectal cancer Leukocyte ratios Prognostic variables Recurrence-free survival Right colorectal cancer Overall survival

西班牙阿斯图里亚斯中部地区室内222Rn浓度

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国际放射医学核医学杂志 1996年第6期20卷 44-44页

作者：ＩｇｌｅｓｉａｓＪＭＰ

西班牙阿斯图里亚斯中部地区室内２２２Ｒｎ浓度［英］／ＩｇｌｅｓｉａｓＪＭＰ…∥ＨｅａｌｔｈＰｈｙｓ．－１９９６，７０（５）．－６８９～６９４建筑物内２２２Ｒｎ的主要来源是地基土壤、建材及室外空气。当一个地区地壳内的２... 详细信息

西班牙阿斯图里亚斯中部地区室内２２２Ｒｎ浓度［英］／ＩｇｌｅｓｉａｓＪＭＰ…∥ＨｅａｌｔｈＰｈｙｓ．－１９９６，７０（５）．－６８９～６９４建筑物内２２２Ｒｎ的主要来源是地基土壤、建材及室外空气。当一个地区地壳内的２３８Ｕ浓度达到３６Ｂｑ／ｋｇ数量级...

关键词：阿斯图里亚斯 Rn 中部地区西班牙南欧

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用硫酸铁浸出预处理含金的砷黄铁矿精矿

新疆有色金属 1997年第4期20卷 59-64页

作者： N.iglesias F.CARRANZA 张登福

生物氧化可作为含金硫化矿的预处理方法、其药剂费用低,对环境保护也很有意义.然而,该法的动力学缓慢,反应时间长(几天甚至几周),因此操作费用很高.如果通过间接接触的方法进行生物氧化,并且将化学和生物两种作用有效地分成两个作业,则... 详细信息

生物氧化可作为含金硫化矿的预处理方法、其药剂费用低,对环境保护也很有意义.然而,该法的动力学缓慢,反应时间长(几天甚至几周),因此操作费用很高.如果通过间接接触的方法进行生物氧化,并且将化学和生物两种作用有效地分成两个作业,则其反应动力学将会得到改善,两个作业分别为:(1)用三价铁进行硫化物的化学反应;(2)所产生的二价铁的生物氧化(化学和生物作用).本文作为一种间接生物氧化的例子,采用将化学和生物两种作用分离的方法研究了砷黄铁矿精矿的硫酸铁浸出工艺.研究结果令人满意.通过用银作催化剂和采用适宜的高温作业,提高了化学氧化阶段(硫酸铁浸出)的动力学.已经证实,二价铁生物氧化(生物阶段)动力学的驱动作用增强了化学氧化阶段的反应,从而导致整个工艺过程的改善.

关键词：金矿砷黄铁矿硫酸铁浸出生物氧化

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Involvement of ethylene receptors in the salt tolerance response of Cucurbita pepo

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Horticulture Research 2021年第1期8卷 1058-1071页

作者： Gustavo Cebrian Jessica iglesias-Moya Alicia Garcia Javier MartInez Jonathan Romero Jose Javier Regalado Cecilia Martinez Juan Luis Valenzuela Manuel Jamilena Department of Biology and Geology Agri-food Campus of International Excellence(CeiA3)and Research Center CIAMBITALUniversity of Almeria04120 AlmeriaSpain

Abiotic stresses have a negative effect on crop production,affecting both vegetative and reproductive *** plays a relevant role in plant response to environmental stresses,but the specific contribution of ethylene biosynthesis and signalling components in the salt stress response differs between Arabidopsis and rice,the two most studied model *** this paper,we study the effect of three gain-of-function mutations affecting the ethylene receptors CpETR1B,CpETR1A,and CpETR2B of Cucurbita pepo on salt stress response during germination,seedling establishment,and subsequent vegetative growth of *** mutations all reduced ethylene sensitivity,but enhanced salt tolerance,during both germination and vegetative growth,demonstrating that the three ethylene receptors play a positive role in salt *** salt stress,etr1b,etr1a,and etr2b germinate earlier than WT,and the root and shoot growth rates of both seedlings and plants were less affected in mutant than in *** enhanced salt tolerance response of the etr2b plants was associated with a reduced accumulation of Na^(+)in shoots and leaves,as well as with a higher accumulation of compatible solutes,including proline and total carbohydrates,and antioxidant compounds,such as *** membrane monovalent cation transporters,including Na^(+)/H^(+)and K^(+)/H^(+)exchangers(NHXs),K^(+)efflux antiporters(KEAs),high-affinity K^(+)transporters(HKTs),and K^(+)uptake transporters(KUPs)were also highly upregulated by salt in etr2b in comparison with *** aggregate,these data indicate that the enhanced salt tolerance of the mutant is led by the induction of genes that exclude Na+in photosynthetic organs,while maintaining K^(+)/Na^(+)homoeostasis and osmotic *** the salt response of etr mutants occurs via the ethylene signalling pathway,our data show that ethylene is a negative regulator of salt tolerance during germination and vegetative ***,the higher upregulation

关键词： subsequent aggregate likely

Neuroinmunological response in HIV-associated Guillain-Barre syndrome: A case report

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World Journal of Neuroscience 2012年第1期2卷 32-35页

作者： Ivonne M. iglesias-González Alberto J. Dorta-Contreras Bárbara Padilla-Docal Maylin Victoria-Garcia Ricardo Junco-Calzadilla Faculty of Medical sciences “Dr Miguel Enríquez” Central Laboratory of Cerebrospinal Fluid (LABCEL) Havana Medical Sciences University Havana City Cuba Raúl Gómez García Hospital Havana City Cuba

Introduction: Human immunodeficiency virus infec- tion is associated with several different types of peripheral neuropathy: distal predominantly sensory axonal polyneuropathy, like Guillain Barre syndrome. Case presentation: A 55-year-old Caucasian woman with Human immunodeficiency virus infection, diag- nosed with Guillain Barre syndrome was studied. serum and CsF immunoglobulin G and Albumin levels were quantified by using an immunodiffusion technique. she had preceding viral symptoms. The clinical diagnosis of the illness in this patient was pa-resthesias or sensory loss, tendon reflexes. It was also observed cranial nerves abnormalities, acute mo- tor and sensory axonal neuropathy and ophthalmoplegia. The mean CD4 count was 367/mm3, CsF white blood cell 25 wbc/mm3. The serum sodium concentration was significantly low (133 mmol/L). she had a respiratory compromise as a result of their neuropa- thy and developed congestive heart failure and hy- potension and died of a cardiac arrest. The neuro-immunological response described by our patient was a blood/CsF barrier dysfunction without IgG intra-thecal synthesis. Conclusion: There is no doubt that this study is of great importance because will help clinicians increase their knowledge of the immune response in patients with this autoimmune disorder on the basis of this case report, in which, for first time, could be seen the neuroimmunological response through the reibergram in a patient with HIV- asso-ciated Guillain-Barre syndrome.

关键词： Guillain Barre Human Immunodeficiency Virus Neuroimmunological Response Blood/CsF

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAs detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht s.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.s. Acharya C. Adam Bourdarios L. Adamczyk s.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.s. Ahmed s. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy s. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali s. Ali s.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei s.P. Amor Dos santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders s.Y. Andrean A. Andreazza s. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal s.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin s. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai s. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos s. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten s. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay s. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-s. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAs Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAs Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAs *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAs JET QUARK GLUON TAGGING

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拉丁美洲从金融危机中吸取的惨痛教训

拉丁美洲研究 2005年第3期27卷 3-6+16-79页

作者：恩里克·伊格莱西亚斯 ,高静美洲开发银行拉美所行长

20世纪90年代以来,拉美地区多次发生金融危机,引起各国学者的广泛关注。美洲开发银行行长恩里克·伊格莱西亚斯先生是拉美著名经济学家,多年从事美洲开发银行领导工作,曾发表过大量相关文章和报告。2005年4月18日,应中国社会科学院拉丁... 详细信息

20世纪90年代以来,拉美地区多次发生金融危机,引起各国学者的广泛关注。美洲开发银行行长恩里克·伊格莱西亚斯先生是拉美著名经济学家,多年从事美洲开发银行领导工作,曾发表过大量相关文章和报告。2005年4月18日,应中国社会科学院拉丁美洲研究所邀请,恩里克·伊格莱西亚斯先生在拉美所做演讲,精辟地分析了拉美国家的金融危机及相关问题。现将其书面报告全文译出,并将问答内容加以整理,一并发表。

关键词：美元化银行储蓄伊格莱西亚斯支付体系储户道德风险金融财政金融美洲开发银行泛美开发银行金融危机金融风暴经济危机银行资本拉丁美洲

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“妈妈,我在看呢！”

世界科学 1982年第2期 44-45页

作者： Carlos iglesias Y.P.Pardillo 汤菊明

“耶稣,请你原谅他吧,尽管他是个坏人。我现在正用他的眼睛看……”这就是十一岁的小哈依曼的话。他刚从帕尔玛·台·马约尔卡的玛累·诺斯敦医院里出来。这种一般看起来似乎是不可能成功的手术——让一个生下来就瞎的孩子重见光明——... 详细信息

“耶稣,请你原谅他吧,尽管他是个坏人。我现在正用他的眼睛看……”这就是十一岁的小哈依曼的话。他刚从帕尔玛·台·马约尔卡的玛累·诺斯敦医院里出来。这种一般看起来似乎是不可能成功的手术——让一个生下来就瞎的孩子重见光明——使孩子的父母亲和动手术的医疗小组的人员足足担忧了二十天。

关键词：妈妈生下来父母亲

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卢拉回来了巴西下届总统会是他吗?

商业周刊（中文版） 2021年第6期 36-37页

作者： Andrew Rosati simone iglesias Marisa Wanzeller 牛小婧(译) 不详

初期民调结果并不明朗,大选.将呈现两极化争夺巴西政坛头把交椅的战斗可能会在两位政治生涯与被称为“洗车行动”(Operation Car Wash)的里程碑式反腐调查紧紧关联的人物之间展开,一位借反腐上位,另一位则被认为因反腐而葬送了前程。202... 详细信息

初期民调结果并不明朗,大选.将呈现两极化争夺巴西政坛头把交椅的战斗可能会在两位政治生涯与被称为“洗车行动”(Operation Car Wash)的里程碑式反腐调查紧紧关联的人物之间展开,一位借反腐上位,另一位则被认为因反腐而葬送了前程。2021年3月10日,巴西前总统路易斯·伊纳西奥·卢拉·达席尔瓦(Luiz Inacio Lula da silva)对这项反腐调查进行了抨击,他说自己是巴西历史上“500年不遇的司法大谎言的受害者”,之后他又剑指自己的主要竞争对手,谴责现任总统雅伊尔.博尔索纳罗(Jair Bolsonaro)让巴西遭受了新冠疫情和经济灾难。卢拉拒绝透露2022年是否会竞选总统。他对记者们表示:“这个问题以后再讨论。”

关键词：现任总统席尔瓦卢拉两极化政治生涯竞选总统反腐