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Methods of screening,monitoring and management of cardiac toxicity induced by chemotherapeutics

Chinese Chemical Letters 2022年第6期33卷 2773-2782页

作者： Humayra Afrin Christiancel Joseph Salazar mohsin kazi Syed Rizwan Ahamad Majed Alharbi Md Nurunnabi Environmental Science&Engineering University of Texas at El PasoEl PasoTX 79965United States Border Biomedical Research Center University of Texas at El PasoEl PasoTX 79965United States Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh 11451Kingdom of Saudi Arabia Central Laboratory Department of Pharmaceutical ChemistryCollege of PharmacyKing Saud UniversityRiyadh 11451Kingdom of Saudi Arabia Department of Biomedical Engineering University of Texas at El PasoEl PasoTX 79965United States Department of Pharmaceutical Sciences School of PharmacyUniversity of Texas at El PasoEl PasoTX 79902United States

Cardiac toxicity is one of the most common side effects of anticancer *** toxicity results dysfunction of heart including hypotension,heart failure,and even cause death in extreme *** potential risk of cardiotoxicity is a huge concern in chemotherapeutics mediated cancer *** individual with any pre-existing cardiac issues are excluded from clinical trials due to the potential risk of *** of the potential cardiotoxicity,there is an emerging need for alternatives of some very potent anticancer drugs(doxorubicin/DOX,5-fluorouracil/5 FU,trastuzumab).While a patient is being treated with anticancer drugs,early blood screening,biomarker detection,and careful monitoring of cardiac functions are necessary to be able to avoid any irreversible cardiac ***,early detection methodology to monitor cardiotoxicity in real-time,and a drug formulation that prevent interaction between drug and cardiac cell,seemingly have potential to mitigate the *** this review,we have summarized the cardiotoxicity of the most used anticancer drugs,their pathophysiology and some of the conventional and newer screening methods available to manage an individual patient in *** have also incorporated our perspective on how a rationale designing of biomolecules can be used to overcome the cardiotoxicity generated chemotherapeutics.

关键词： Cardiotoxicity Anticancer drug Chemotherapy Screening Biomarker

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Connective tissue growth factor expression hints at aggressive nature of colorectal cancer

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World Journal of Gastroenterology 2022年第5期28卷 547-569页

作者： Ishrat Parveiz Bhat Tahseen Bilal Rather Irfan Maqbool Gowhar Rashid Kulsum Akhtar Gulzar A Bhat Fazl Q Parray Besina Syed Ishrat Younas Khan mohsin kazi Muhammad D Hussain Mudassar Syed Department of Clinical Biochemistry Sher-I-Kashmir Institute of Medical SciencesSrinagar 190011Jammu and KashmirIndia Department of General Surgery Sher-I-Kashmir Institute of Medical SciencesSrinagar 190011Jammu and KashmirIndia Department of Pathology Sher-I-Kashmir Institute of Medical SciencesSrinagar 190011Jammu and KashmirIndia Department of Pharmaceutics College of PharmacyKing Saud UniversityPO Box 2457Riyadh 11451Saudi Arabia Department of Pharmaceutical and Biomedical Sciences California Health Sciences UniversityCaliforniaCA 93612United States

BACKGROUND Connective tissue growth factor(CTGF)is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling,inflammatory processes and fibrosis in various illnesses including *** To investigate the role of CTGF in colorectal cancer(CRC)progression and to compare the CTGF expression with different clinicopathological *** Real-time polymerase chain reaction,immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version *** CTGF expression levels in tumor specimens were significantly higher than their paired normal *** higher protein expression levels showed a significant association with smoking,staging,tumor grade,invasion depth,necrosis of tumor tissue,and both lymphovascular and perineural *** per the cox regression model and classification tree analysis,tumor-nodemetastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC *** analysis indicated that CTGF overexpression was associated with poorer overall and disease-free *** Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC *** findings support prior observations and thus CTGF may be a possible prognostic marker in CRC.

关键词： Connective tissue growth factor Quantitative real time polymerase chain reaction Immunohistochemistry Western blotting Colorectal cancer

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