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Journal of Cancer Therapy 2011年第5期2卷 646-653页

作者： Amel Abd Allah Hashim Mahmoud Youns Ahmed Abd Al-rahman Soltan Sahar Abd El-mohsen Ali 不详

Bladder carcinoma is the foremost oncologic problem among males in Egypt. Here, we evaluated the possible diagnostic value of the urinary Nuclear Matrix Protein-22 “NMP-22” and Telomerase Reverse Transcriptase “hTERT” among histological subtypes of bladder cancer. 120 males with non-muscle invasive bladder cancer, 21 non malignant bladder conditions and 21 healthy volunteers were included in this study. Estimation of hTERT and NMP-22 was done by PCR-ELISA and ELISA, respectively, from voided urine and results were compared to those of urine cytology. Results showed that urinary hTERT and NMP-22 were significantly higher in all cancer patients compared to control group. NMP-22 was able to discriminate between transitional cell bladder carcinoma “TCC” patients and squamous cell bladder carcinoma “SqCC” ones. Both markers succeded to discriminate between some transitional cell bladder carcinoma grades. Additionally, hTERT discriminated between some Tumor stages in both TCC and SqCC. Our results demonstrated that urinary hTERT and NMP-22 could be efficient urinary markers for the differential diagnosis of bladder cancer.

关键词： Bladder Cancer Urinary Markers NMP-22 hTERT

Cost-effectiveness of remdesivir for the treatment of hospitalized patients with COVID-19:a systematic review

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Infectious Diseases of Poverty 2023年第2期12卷 112-112页

作者： Aziz Rezapour Zahra Behroozi Mostafa Nasirzadeh mohsen Rezaeian Mohammad Barzegar Mahsa Tashakori-Miyanroudi Abdollah Sayyad Aghdas Souresrafil Health Management and Economics Research Center Health Management Research InstituteIran University of Medical SciencesTehranIran Physiology Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKermanIran Department of Health Education and Health Promotion School of HealthOccupational Environment Research CenterRafsanjan University of Medical SciencesRafsanjanIran Department of Epidemiology and Biostatistics School of MedicineOccupational Environment Research CenterRafsanjan University of Medical SciencesRafsanjanIran Department of English Language Teaching School of Health Management and Information SciencesIran University of Medical SciencesTehranIran Psychiatry and Behavioral Sciences Research Center Addiction InstituteMazandaran University of Medical SciencesSariIran Department of Health Services and Health Promotion School of HealthOccupational Environment Research CenterRafsanjan University of Medical SciencesRafsanjanIran

Background Remdesivir is being studied and used to treat coronavirus disease 2019(COVID-19).This study aimed to systematically identify,critically evaluate,and summarize the findings of the studies on the cost-effectiveness of remdesivir in the treatment of hospitalized patients with *** In this systematic review,PubMed,EMBASE,Web of Science,SCOPUS,and the Cochrane Library were searched for studies published between 2019 and *** included all full economic evaluations of remdesivir for the treatment of hospitalized patients with *** were summarized in a structured and narrative *** Out of 616 articles obtained in this literature search,12 studies were included in the final *** mean score of the Quality of Health Economic Studies(QHES)for the studies was 87.66(high quality).All studies were conducted in high-income countries(eight studies in the USA and one study in England),except for three studies from middle-to-high-income countries(China,South Africa,and Turkey).Six studies conducted their economic analysis in terms of a health system perspective;five studies conducted their economic analysis from a payer perspective;three studies from the perspective of a health care *** results of five studies showed that remdesivir was cost-effective compared to standard ***,the therapeutic strategy of combining remdesivir with baricitinib was cost-effective compared to remdesivir *** Based on the results of the present study,remdesivir appears to be cost-effective in comparison with the standard of care in China,Turkey,and South *** conducted in the United States show conflicting results,and combining remdesivir with baricitinib is cost-effective compared with remdesivir ***,the cost-effectiveness of remdesivir in low-income countries remains ***,more studies in different countries are required to determine the cost-effectiveness of this drug.

关键词： Cost-effectiveness Remdesivir COVID-19 SARS-CoV-2

Acute middle ear Aspergillus niger infection in a patient with Stevens-Johnson syndrome: a case report

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Journal of Acute Disease 2019年第4期8卷 170-172页

作者： Keyvan Kiakojuri Mojtaba Taghizadeh Armaki Ramazan Rajabnia Abazar Pournajaf mohsen Karami Saeid Mahdavi Omran Department of Ear Noseand ThroatSchool of MedicineRoohani HospitalBabol University of Medical SciencesBabolIran Infectious Diseases and Tropical Medicine Research Center Health Research CenterBabol University of Medical SciencesBabolIran Department of Medical Parasitology and Mycology School of MedicineBabol University of Medical SciencesBabolIran Infectious Diseases and Tropical Medicine Research Center Health Research CenterBabol University of Medical SciencesBabolIran Department of Microbiology School of MedicineBabol University of Medical SciencesBabolIran

Rationale: Stevens-Johnson syndrome is a disorder mostly attributed to drug use, which can cause different skin problems. Patient concerns: A 31-year-old woman presented with severe pain and pounding in the left ear. Diagnosis: Fluconazole-induced Stevens-Johnson syndrome with fungal infection in ear. Intervention: Surgical and systemic antibiotic therapy. Outcomes: The patient recovered and resumed her normal life. Lessons: The prescription of fluconazole for patients with underlying conditions should be done with caution.

关键词： Stevens-Johnson syndrome Fluconazole Otomycosis

Peroxidative Activity in Patients with Skin Basal Cell Carcinoma

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Journal of Cancer Therapy 2013年第6期4卷 38-42页

作者： Hoda Rahmani mohsen Korani Mohamad Reza Sarasgani Hamid Reza Fathi Pedram N. Mohamadpoor Department of Biochemistry Tehran University of Medical Sciences Tehran Iran Department of Dermatology Tehran University of Medical Sciences Tehran Iran Department of Plastic Reconstructive and Aesthetic Surgery Tehran University of Medical Sci- ences Tehran Iran

Oxidative status assessment is an initial step in tumor related studies. To the best of our knowledge, this is the first study considering oxidative activity of both serum and tissue specimens in human basal cell carcinoma (BCC), which is the most common tumor in the world. Concentration of Malondialdehide (MDA) in human basal cell carcinoma (BCC) and individually matched normal skin tissue were examined with spectrophotometery method. Fresh normal and cancerous skin paired tissue was obtained from 60 patients who underwent curative BCC resection at one center in Tehran (Razi hospital). Serum Concentration of Malondialdehide (MDA) in these patients and 55 normal subjects were also measured. MDA level in cancerous tissue of patients with skin BCC (1.0 ± 0.14 ng/g) was significantly (p = 0.001) higher than normal neighboring skin tissue (0.3 ± 0.07 ng/g). A remarkable (Not significant, P = 0.18) increase was found in the serum MDA level in patients with skin BCC (8.0 ± 2.3 ng/ml) in comparison with the control subjects (7.3 ± 2.9 ng/ml). A significant positive correlation (r = 0.276, p = 0.03) was found between Serum MDA and skin tissue MDA for non-affected skin tissue (normal neighboring skin), whereas no significant correlation (p > 0.05) was found for cancerous tissue. Cut-point of 5.2 ng/ml of serum MDA concentration showed a screening sensitivity of 95%. There is an active oxidative process in BCC lesions. Serum MDA concentration can be used either as a screening test or a predictor for tissue MDA concentration.

关键词： Malondialdehyde Skin Cancer Screening Oxidative Stress Basal Cell Carcinoma

可变扩压器叶片对压比8.0离心压气机性能影响的研究

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可变扩压器叶片对压比8.0离心压气机性能影响的研究

作者：莫森（Seyed mohsen Ebrahimi Doabsari）清华大学

学位级别：硕士

离心压气机具有体积小、压比高的优点。在实际应用中,要求离心压气机在提供高压比的同时,能够保持高效率和宽广的工作范围。这对于离心压气机研究是个不小的挑战,因为随着压比升高,压气机的效率和工作范围不可避免地会降低。可变扩压器... 详细信息

离心压气机具有体积小、压比高的优点。在实际应用中,要求离心压气机在提供高压比的同时,能够保持高效率和宽广的工作范围。这对于离心压气机研究是个不小的挑战,因为随着压比升高,压气机的效率和工作范围不可避免地会降低。可变扩压器叶片是一种有效的解决方法,它不仅可以拓宽压气机的工作范围,而且可以通过改善扩压器和叶轮的匹配来提高效率,尤其是在非设计转速。因此,本文研究了变几何扩压器对高压比离心压气机性能和工作范围的影响。研究对象为压比8.0的跨音速带有叶扩压器的离心压气机。数值计算采用NUMECA FINE/Turbo的EURANUS求解器求解三维粘性定常雷诺平均N-S方程。空间和时间离散分别采用Jameson中心差分格式和四阶Runge-Kutta时间推进方法。湍流模型采用一方程Spalart-Allmaras模型。网格划分采用分块形式,并对网格质量和可靠性进行了验证。然后,对不同工况下的不同扩压器叶片角度下的扩压器与叶轮的匹配进行了研究,分析了叶轮和扩压器部件性能的变化规律。研究发现,通过调节扩压器来改善部件匹配,在非设计转速可以提高效率4.5%。通过对可变扩压器叶片在不同转速和不同工况下的拓稳机理研究发现,在+6到-6度范围内调节扩压器叶片在压比5.0和6.0时,可拓宽压气机工作范围30%,压气机喘振线和堵塞线均有所拓宽。通过研究叶轮性能和叶轮出口流场,对扩压器和叶轮之间的相互作用进行了研究。研究发现,当压气机流量一定时,调整扩压器叶片角不影响叶轮的性能。通过调节扩压器叶片,可以驱使叶轮工作在非常宽广流量范围。该方法可作为一种研究宽流量范围内叶轮特性的通用方法。最后,讨论了叶轮前缘攻角与叶尖流动分离的关系。发现在叶轮特性上存在临界流量,低于该流量时,过大的叶轮前缘入射攻角会导致叶尖区域的流动分离。

关键词：高压比离心压气机燃气轮机增压器变几何扩压器

Nonlinear frequency conversion in optical nanoantennas and metasurfaces:materials evolution and fabrication

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Opto-Electronic Advances 2018年第10期1卷 1-12页

作者： mohsen Rahmani Giuseppe Leo Igal Brener Anatoly V. Zayats Stefan A. Maier Costantino De Angelis Hoe Tan Valerio Flavio Gili Fouad Karouta Rupert Oulton Kaushal Vora Mykhaylo Lysevych Isabelle Staude Lei Xu Andrey E. Miroshnichenko Chennupati Jagadish Dragomir N. Neshev Research School of Physics and Engineering The Australian National University Canberra ACT 2601 Australia Matériaux et Phénomènes Quantiques Université Paris Diderot-Sorbonne Paris Cité 10 rue A. Domon et L. Duquet 75013 Paris France Center for Integrated Nanotechnologies Sandia National Laboratories Albuquerque New Mexico 87185 United States Department of Physics King’s College London Strand London WC2R 2LS United Kingdom The Blackett Laboratory Department of Physics Imperial College London London SW7 2AZ United Kingdom Chair in Hybrid Nanosystems Nano Institute Munich Fakultat für Physik Ludwig-Maximilians-Universitat München München Germany Deptartment of Information Engineering Universitàdegli Studi di Brescia and INO-CNR Via Branze 38 25123 Brescia Italy Institute of Applied Physics Abbe Center of Photonics Friedrich Schiller University Jena 07745 Jena Germany School of Engineering and Information Technology University of New South Wales Canberra ACT 2600 Australia

Nonlinear frequency conversion is one of the most fundamental processes in nonlinear *** has a wide range of applications in our daily lives,including novel light sources,sensing,and information *** is usually assumed that nonlinear frequency conversion requires large crystals that gradually accumulate a strong ***,the large size of nonlinear crystals is not compatible with the miniaturisation of modern photonic and optoelectronic ***,shrinking the nonlinear structures down to the nanoscale,while keeping favourable conversion efficiencies,is of great importance for future photonics *** the last decade,researchers have studied the strategies for enhancing the nonlinear efficiencies at the nanoscale,*** employing different nonlinear materials,resonant couplings and hybridization *** this paper,we provide a compact review of the nanomaterials-based efforts,ranging from metal to dielectric and semiconductor nanostructures,including their relevant nanofabrication techniques.

关键词： nonlinear nanophotonics metallic nanoantennas dielectric nanoantennas III-V semiconductor nanoantenna nanofabrication

Optically invariant InGaN nanowire light-emitting diodes on flexible substrates under mechanical manipulation

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npj Flexible Electronics 2019年第1期3卷 120-125页

作者： mohsen Asad Renjie Wang Yong-Ho Ra Pranav Gavirneni Zetian Mi William S.Wong Department of Electrical and Computer Engineering University of WaterlooWaterlooON N2L 3G1Canada Waterloo Institute for Nanotechnology University of WaterlooWaterlooON N2L 3G1Canada Department of Electrical and Computer Engineering McGill UniversityMontrealQC H3A 0E9Canada Department of Electrical and Computer Engineering University of MichiganAnn ArborMI 48109USA

The integration of GaN-based light-emitting diodes(LEDs)onto flexible platforms provides opportunities for conformal lighting,wearable electronics,and bendable *** this technology may enhance the functionality of the light source,the development of flexible GaN LEDs suffers from performance degradation,when mechanical bending is applied during operation.A unique approach to eliminate the degradation employs dot-in-wire structures,using cylindrical light-emitting heterostructures that protrude above the flexible platform,separating the active light-emitting region from the bending ***,we demonstrate the optical enhancement of nanowire light emitters by changing the geometric orientation within a 1×1 mm^(2) array of nanowires on a flexible platform through bending of the substrate *** flexible structures were achieved by transferring GaN nanowire LEDs from sapphire substrates onto flexible polyethylene terephthalate(PET)using a“paste-and-cut”integration *** I–V characteristics of the nanowire LEDs showed negligible change after integration onto the PET,with a turn-on voltage of 2.5 V and a forward current of 400μA at 4 V.A significant advantage for the nanowire devices on PET was demonstrated by tilting the LEDs through substrate bending that increased the electroluminescence(EL)intensity,while the I–V characteristics and the EL peak position remained *** finite-element analysis and three-dimensional finite-difference time-domain modeling,it was determined that tilting the protruding devices changed the effective distance between the structures,enhancing their electromagnetic coupling to increase light output without affecting the electrical properties or peak emission wavelength of the LEDs.

关键词： diodes sapphire light

Facies Analysis, Depositional Environment of the Lower Permian Deposits of Chili Formation in Kalmard Block, Eastern Central Iran (Darin Section)

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Open Journal of Geology 2015年第8期5卷 539-551页

作者： Javad Shahraki Mohammad Javad Javdan Seyed Mahmood Pahlavan Hashemi mohsen Jami Mahdiyeh Nastooh Seyed Mohammad Kalvandi Department of Geology Zahedan Branch Islamic Azad University Zahedan Iran

Early Permian deposits in north of Kalmard region recognize with formal group of Khan;they have various features in the different place. This group includes four different formations from lower to the upper part: Chili, Sartakht and Hermez. These formations consist of carbonate rocks. Chili Formation has 104 m, thickness in Darin section and consists of limestone with intermediates of shale and marland sandstone. Lower boundary of this formation is disconformable with Gachal formation. The upper boundary is separated by unconformity from the upper part Sartakht formation according to the lithological characters and microscopic studies, cause identifications of beach, intertidal, open and semi-restricted lagoon, shoals and bar and open marine sub-environ- ments for the Chili Formation. Vertical changes of microfacies and depth changes curve show much more thickness of shoals and bar microfacies, and little thickness of open and semi-re- stricted lagoon and open marine microfacies. Deposits of Chili Formation in Darin section deposited in the gentle gradient Homoclinal ramp in the south of Paleotethys Ocean. Two depositional sequences have been identified in this formation, based on recognized Fusulinid, show age of Sakmarian, which has adaptation with Lower Absaroka III.

关键词： Kalmard Area Chili Formation Depositional Environment Darinsection Paleotethys Sartakht Gachal

Efficient Approach for Monitoring and Controlling Water Parameters Utilizing Integrated Treatment Based on WSNs

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Wireless Sensor Network 2019年第4期11卷 47-66页

作者： Tarek Srour Ayman Haggag mohsen A. M. El-Bendary Mostafa Eltokhy Atef E. Abouelazm Department of Electronics Technology Faculty of Industrial Education Helwan University Cairo Egypt Faculty of Electronics Engineering Menofia University Cairo Egypt

Research works of Wireless Sensor Networks (WSNs) applications and its constraints solutions occupy wide area around the world and attract many researchers. In this paper, an important one of environmental WSN applications is presented that is the water monitoring applications. An efficient approach for monitoring and controlling water parameters in real-time is implemented utilizing merging between WSN and designed simple workstation. For implementation simplicity, two water parameters (pH and temperature) are monitored and controlled in the proposed approach. Most of past work of water monitoring presented different proposed monitoring scenarios for different water parameters only. This research work utilizes the concept of interactive WSN nodes. The interactive nodes interact with the monitored water parameters to control its value. In the base station, the collected data is analyzed and the real-time value of the monitored parameters appears on the designed Graphic User Interface (GUI). The GUI is designed using the Matlab program. Through the GUI, the operator can switch the control between automatic and manual. ZigBee module is used for implementing the wireless communications between the nodes and the workstation. Due to the cost and simplicity, two sensors only are used in the proposed approach. Different real-time experiments are performed to test and measure the effectiveness and performance of the presented approach. These experiments reveal that the presented approach is effective for water treatment and efficient more than the past proposed water monitoring scenarios.

关键词： Environmental Monitoring Water Quality Interactive WSN WSNs Applications Interactive Sensing Real-Time

A toolkit of thread-based microfluidics,sensors,and electronics for 3D tissue embedding for medical diagnostics

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Microsystems & Nanoengineering 2016年第1期2卷 163-172页

作者： Pooria Mostafalu mohsen Akbari Kyle A.Alberti Qiaobing Xu Ali Khademhosseini Sameer R.Sonkusale Nano Lab Department of Electrical and Computer EngineeringTufts UniversityMedfordMA 02155USA Biomaterials Innovation Research Center Division of Biomedical EngineeringDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of TechnologyCambridgeMA 02139USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115USA Laboratory for Innovation in MicroEngineering(LiME) Department of Mechanical EngineeringUniversity of VictoriaVictoriaBC V8P 2C5USA Department of Biomedical Engineering Tufts UniversityMedfordMA 02155USA Department of Physics King Abdulaziz UniversityJeddah 21589Saudi Arabia

Threads,traditionally used in the apparel industry,have recently emerged as a promising material for the creation of tissue constructs and biomedical implants for organ replacement and *** wicking property and flexibility of threads also make them promising candidates for the creation of three-dimensional(3D)microfluidic *** this paper,we report on thread-based microfluidic networks that interface intimately with biological tissues in three *** have also developed a suite of physical and chemical sensors integrated with microfluidic networks to monitor physiochemical tissue properties,all made from thread,for direct integration with tissues toward the realization of a thread-based diagnostic device(TDD)*** physical and chemical sensors are fabricated from nanomaterial-infused conductive threads and are connected to electronic circuitry using thread-based flexible interconnects for readout,signal conditioning,and wireless *** demonstrate the suite of integrated sensors,we utilized TDD platforms to measure strain,as well as gastric and subcutaneous pH in vitro and in vivo.

关键词： thread diagnostics 3D microfluidics implantable devices wearable devices flexible sensors flexible electronics pH sensor strain sensor glucose sensor