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The medieval Persian manuscript of Afyunieh:the first individual treatise on the opium and addiction in history

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Journal of Integrative Medicine 2018年第2期16卷 77-83页

作者： Abdolali Moosavyzadeh Farzaneh Ghaffari Seyed Hamdollah Mosavat Arman Zargaran Azarakhsh Mokri Soghrat Faghihzadeh mohsen naseri Department of lranian Traditional Medicine Faculty of MedicineShahed UniversityTehran 33191-18651Iran School of Traditional Medicine Shahid Beheshti University of Medical SciencesTehran 15167-45811Iran Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical SciencesShiraz 71356-44144Iran Department of History of Medicine School of Traditional MedicineTehran University of Medical SciencesTehran 16687-53961Iran Psychiatry Department and National Center for Addiction Studies Tehran University of Medical SciencesTehran 14176-53761Iran Department of Biostatistics and Epiderniology Faculty of MedicineZanjan University of Medical SciencesZanjan 45371-38791Iran Traditional Medicine Clinical Trial Research Center Shahed UniversityTehran 14179-53836Iran

According to historical evidence, the abuse of opium has been reported all over the globe-specifically throughout Eastern nations-since the sixteenth century. Before that, opium had mostly been applied as medication. Reference has been made in traditional Persian medical literature to the method of cultivation, properties, side effects and toxicity. In sixteenth century Iran, during the reign of the Safavids, opium abuse began. It was from then that prominent Persian scholars started to think of solutions to this societal problem. One of the most famous scholars was Imad al-Din Mahmud ibn Mas＇ud Shirazi, who composed a book concerning addiction-Afyunieh, a comprehensive book on the topic of opium and all issues of opium. Furthermore, he recommended methods for reducing opium dose as well as substitution with other medications that had a narrower range of side effects, in order to eradicate dependency upon opium and opium-derived materials. This is most likely the first book that comprehensively addressed opium and discussed drug rehabilitation methodology, in traditional Persian medical literature. In this historical review, the authors have introduced the book Afyunieh, which presents methods for treating addiction to and giving up opium; the text comprises a synthesis of the author＇s opinions, professional experience and references to the work of other famous physicians.

关键词： Persian medicine Opium addiction Imad al-Din Mahmud

Periconceptional care and offspring health at birth and long term,from the perspective of Avicenna

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Journal of Integrative Medicine 2019年第2期17卷 80-86页

作者： Mohammad Ansaripour mohsen naseri Mohammad Mahdi Esfahani Iraj Nabipour Fatemeh Rakhshani Arman Zargaran Roya Kelishadi Department of Iranian Traditional Medicine Faculty of Medicine Shahed University Traditional Medicine Clinical Trial Research Center Shahed University Traditional Medicine Department Tehran University of Medical Sciences School of Iranian Traditional Medicine The Persian Gulf Biomedical Research Institute Bushehr University of Medical Sciences Health Education and Promotion Department Shahid Beheshti University of Medical Sciences School of Public Health Department of History of Medicine School of Traditional Medicine Tehran University of Medical Sciences Child Growth and Development Research Center Research Institute for Primordial Prevention of Noncommunicable Disease Isfahan University of Medical Sciences

Periconceptional care such as lifestyle plays an important impact role in offspring health. The aim of the present study was to clarify the perspective of Avicenna on periconceptional care. Avicenna(980–1037 A.D.) was one of the outstanding Persian physicians, who made great contributions to the field of medical sciences, in particular, obstetrics. In advance, Avicenna's book, Canon of Medicine, was considered to find his perspectives on periconceptional care. Then, his ideas and theories were compared to the current findings by searching the keywords in main indexing systems including PubMed/MEDLINE,Scopus and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. Current investigations show that gamete quality, pregnancy outcome, and offspring health at birth and long term depend on both parents' lifestyle in pre-and periconceptional period, as well as the intrauterine environment. Avicenna believed that seminal fluid, sperm, ovum, and developing conditions in utero were influenced by the stages of food digestion and the function of some *** the other hand, food digestion and function of the organs also depend on each parent's lifestyle and environmental factors. He mentioned 6 principles of healthy lifestyle: exercise, nutrition, sleep and awareness, excretion of body wastes and retention of necessary materials, psychic features, as well as air and climate. Thus, a multicomponent healthy lifestyle should be considered by parents of child-bearing age in an appropriate period before and in early pregnancy as well as elimination of any disorders in parents, to give birth to more healthy offspring.

关键词： Avicenna Epigenetic diseases Healthy lifestyle Offspring health Periconceptional care Persian medicine

Finger Printing and Quantitative Analysis of <i>Cuscuta chinensis</i>Flavonoid Contents from Different Hosts by RP-HPLC

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Food and Nutrition Sciences 2014年第10期5卷 914-921页

作者： Maryam Shekarchi Babak Mokhtari Kondori Homa Hajimehdipoor Leila Abdi mohsen naseri Mojgan Pourfarzib Gholamreza Amin Clinical Trial Research Center of Traditional Medicine Shahed University Tehran Iran Department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Department of Traditional Medicine Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Department of Traditional Medicine Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Food and Drug Control Laboratories and Food and Drug Laboratory Research Center MOH and ME Tehran Iran Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

Background: Cuscuta spp. known as dodders, have been used as traditional medicines in eastern and southern Asian countries for many disorders such as gastrointestinal, respiratory, endocrine, skin and neurological diseases (Drug of mania). Flavonoids are the main biologically active constituents in Cuscuta genus especially in C. chinensis. Our aim in this study was to identify and discriminate between C. chinensis samples which were collected from different hosts, by using the pattern recognition aided fingerprint analysis and comparison of the content of four major flavonoids (hyperoside, rutin, isorhamnetin, kaempferol). Material and methods: Samples were collected from nine different plants in the same time and place, dried, grinded and extracted with methanol (80%) by repeated maceration. Extractions were evaluated by high performance liquid chromatography analysis and fingerprinting. Results: Beside chromatographic fingerprint using similarity index, we compared the content of 4 major flavonoids (hyperoside, rutin, isorhamnetin, kaempferol) of C. chinensis samples on different hosts. Coclusion: The results showed that there were significant differences between the content of four major flavonoids of nine C. chinensis samples, but chromatographic fingerprint by similarity index of more than 0.88, showed that the sample consistency was similar. So, it was suggested that combination of chromatographic fingerprint and the content determination of major flavonoids could be used to evaluate the quality control of C. chinensis from different hosts.

关键词： Cuscuta chinensis Fingerprint Flavonoids Hosts Similarity

Cognitive-emotional feasibility of the effect of visual quality of building form on promoting the sense of place attachment(Case study:Cultural iconic buildings of Iran’s contemporary architecture)

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Frontiers of Architectural Research 2024年第1期13卷 37-56页

作者： Narmin Ariannia Negar naseri Mansour Yeganeh Digital Architecture and Artificial Intelligence Lab Department of ArchitectureTarbiat Modares UniversityTehranIran Architectural Design Modeling and Fabrication LabDepartment of ArchitectureTarbiat Modares UniversityTehranIran

The present research studies the relationship between place attachment and the perception of form’s visual quality in fifteen outstanding contemporary Iranian architectural cultural *** study puts forward the hypothesis that there is a correlation between the quality of building form and the sense of place attachment,in the sense that creating high visual quality through enhancing the quality of building form increases citizens’initial satisfaction with and subsequent attachment to the *** visual quality influences people’s experience of the environment and improves the quality of *** attachment highlights how people,on a personal level,recreate a sense of place for *** present study adopts the descriptive-analytical method as its theoretical framework and the survey as the empirical *** were developed using the Likert scale and distributed among experts and ordinary *** analysis using SPSS and the adoption of descriptive-analytical statistics,correlation analysis,and regression showed the relationship among the characteristics of *** results show a positive correlation between form and place attachment mediated through visual quality,and they are causal conditions for one *** addition,only some of the buildings under study evoke the same level of place attachment.

关键词： Visual preferences Environmental quality Environmental psychology Mental schemas Contemporary architecture

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伊朗传统医学治疗牙周疾病

亚太传统医药 2005年第4期1卷 60-64页

作者： Semyari Hassan naseri mohsen Shayegh Shojaoddyn Jalayer Nadery Noushin Aliasgari Rahime 伊朗王大学口腔系牙周专业伊朗王大学口腔系药理专业伊朗王大学口腔系假牙修复科伊朗王大学口腔系面部组织专业牙科医生

目的:牙周疾病非常普遍,尽管有各种特定的治疗方法,但我们始终面临治疗方法有限的问题。考虑到世界组织十分关注传统医学在医疗服务中的发展和应用,我们在一直考察研究伊朗传统医学中药物对牙周疾病的治疗作用。方法:此项研究是一个对... 详细信息

目的:牙周疾病非常普遍,尽管有各种特定的治疗方法,但我们始终面临治疗方法有限的问题。考虑到世界组织十分关注传统医学在医疗服务中的发展和应用,我们在一直考察研究伊朗传统医学中药物对牙周疾病的治疗作用。方法:此项研究是一个对有关方面书籍的综合论述,伊朗传统医学内容是经过对重量级作者如Avicenna和Alzahrawy所著的有价值的书籍修订,收集了各医学院校馆藏图书和医药公司的有关信息编辑而成,因为在伊朗传统医学中牙周疾病分成不同目类,对有关药物的研究也被分成8个大组63个题目。(1)缓解牙龈肿胀药物(2)治疗牙龈恶化药物(3)治疗口疮腐烂药物(4)治疗牙龈肥大药物(5)利于伤口康复药物(6)利于牙龈加固的药物(7)阻止牙龈出血的药物(8)防止牙齿松动药物。结果结论:伊朗传统医学在准确的观察和实践的基础上来描述和治疗牙周疾病的。在制药学、有效治疗方面、科学研究手段等领域,伊朗传统医学在以下几个方面可作为现代制药研究的重要资源:(1)纯天然资源(2)容易获得(3)相对比较安全。

关键词：补充医学替代医学草药传统治疗牙周疾病

Preferential solvation of pomalidomide,an anticancer compound,in some binary mixed solvents at 298.15 K

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Chinese Journal of Chemical Engineering 2020年第10期28卷 2626-2633页

作者： mohsen Padervand Shima naseri Hadi Chahiyan Boroujeni Department of Chemistry Faculty of ScienceUniversity of MaraghehMaraghehIran Department of Chemistry and Biology Farhangian Teacher Training UniversityMashhad BranchMashhadIran

Preferential solvation of pomalidomide(PMD)was explored in dimethyl sulfoxide(DMSO)-dimethylformamide(DMF),DMSO-tetrahydrofuran(THF),DMSO-methanol(Me OH),DMSO-isopropanol,DMSO-water,water-DMF,water-THF,water-Me OH,and water–isopropanol binary mixed solvents at 298.15 ***-Rose model was utilized to determine the electronic transition energies(ET)and other preferential solvation parameters,describing solute-solute and solute-solvent *** found thatλmaxsituation shifted with dielectric constant of the pure solvents *** to the obtained results,ETenhanced andλmaxshifted to the lower wavelengths as the percentage of DMSO decreased in the binary mixtures,remarking the important role of DMSO for stabilizing the excited state(π*)of PMD chromophore via efficient intermolecular solute-solvent *** addition,the aqueous binary systems showed an optimum point for the ETvalues as the percentage of water changed in the *** local mole fraction of the solvents in the cybotactic region was also estimated to describe the specific and non-specific interactions in the systems.

关键词： Pomalidomide Preferential solvation Bosch-Rose model Binary solvents

Anti-inflammatory, anti-oxidative and anti-apoptotic effects of Heracleum persicum L. extract on rats with gentamicin-induced nephrotoxicity

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Asian Pacific Journal of Tropical Biomedicine 2021年第2期11卷 47-58页

作者： mohsen Akbaribazm Nader Goodarzi mohsen Rahimi Leila naseri Mozafar Khazaei Students Research Committee Kermanshah University of Medical SciencesKermanshahIran Department of Basic Sciences and Pathobiology Faculty of Veterinary MedicineRazi UniversityKermanshahIran Department of Medical Parasitology and Mycology School of MedicineShahid Beheshti University of Medical SciencesTehranIran Fertility and Infertility Research Center Health Technology InstituteKermanshah University of Medical SciencesKermanshahIran

Objective:To evaluate the effect of Heracleum persicum *** gentamicin-induced nephrotoxicity in ***:Thirty-six Wistar rats were divided into 6 groups including control(normal saline),gentamicin(80 mg/kg/d for 10 d),Heracleum persicum(750 mg/kg/d),and gentamicin(10 d)+Heracleum persicum extract at three different doses(250,500,and 750 mg/kg/d for 40 d).Urine creatinine,urea,protein,and albumin levels were *** addition,serum urea,creatinine,sodium,potassium,cytokines(TNF-α,IL-1β,IL-6,and IL-10),glutathione peroxidase activity,total antioxidant capacity,kidney malondialdehyde,stereological parameters,and expressions of apoptosis-related genes(p53,Bax,Bcl-2,and caspase-3)were *** LD50 of Heracleum persicum extract was determined based on Lorke’s *** evaluation was also ***:In addition to decreased urine protein and albumin,and increased creatinine and urea,co-treatment with gentamicin and Heracleum persicum significantly reduced levels of creatinine and urea,and increased sodium and potassium in *** persicum treatment also improved stereological parameters and serum inflammatory *** was a significant increase in serum glutathione peroxidase activity and total antioxidant capacity as well as a reduction in malondialdehyde ***,treatment with Heracleum persicum extracts downregulated p53,caspase-3,and Bax and upregulated Bcl-2 *** histopathological evaluation,Heracleum persicum extracts showed protection against gentamicin-induced renal ***:Heracleum persicum exhibits protective effects against gentamicin-induced structural and functional renal impairments.

关键词： Kidney Heracleum persicum L. Gentamicin Stereology Apoptosis

Mononitration of phenol derivatives by guanidinium nitrate and silica sulfuric acid under mild conditions

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Chinese Chemical Letters 2011年第12期22卷 1431-1434页

作者： Arash Ghorbani-Choghamarani Hamid Goudarziafshar mohsen Nikoorazm Zahra naseri Department of Chemistry Faculty of ScienceIlain UniversityP.O.Box 69315516IlamIran

A mixture of guanidinium nitrate and silica sulfuric acid acts as mild and heterogeneous media for the efficient mono nitration of phenolic compounds in dichloromethane at room temperature.

关键词： Nitration Phenol Heterogeneous Guanidinium nitrate Silica sulfuric acid

Pharmacological and therapeutic properties of the Red Clover(Trifolium pratense L.):an overview of the new findings

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Journal of Traditional Chinese Medicine 2021年第4期41卷 642-649页

作者： mohsen Akbaribazm Fatemeh Khazaei Leila naseri Mona Pazhouhi Mohammad Zamanian Mozafar Khazaei Student Research Committee Kermanshah University of Medical SciencesKermanshah ***Iran Fertility and infertility research center Health Technology InstituteKermanshah University of Medical SciencesKermanshah ***Iran Seed and Plant Improvement Institute Agricultural ResearchEducationExtension OrganizationKaraj ***Iran

OBJECTIVE:To review beneficial effects of red clover(Trifolium pratense L.)on biological ***:A systematic review was carried out according tothe PRISMA *** Me SH keywords,385 articles were extracted from national and international databases(Pub Med,Science Direct,SID,and Google Scholar search engine)without time *** removing duplicates,80 articles were ***:Our findings revealed that the compositions of red clover promote anti-oxidant and anti-cancer ***,they exude beneficial effects on cardiovascular functionand improvesymptoms of ***,these compounds can regulate blood glucose and lipid *** effects of the herb on have also been investigated on various tissues including endometrium,breast,skin and reproductive ***:In recent studies,the anti-cancer effects of clover(Trifolium)extract co-administrated with standard drugs have been reportedin different cancers.

关键词： plants medicinal trifolium isoflavonoid antioxidants anti-cancer