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Prognostic non-invasive biomarkers for all-cause mortality in nonalcoholic fatty liver disease:A systematic review and meta-analysis

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World Journal of Hepatology 2022年第5期14卷 1025-1037页

作者： Nicole Cianci mohsan subhani Trevor Hill Amardeep Khanna Dong Zheng Abhishek Sheth Colin Crooks Guruprasad P Aithal NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust and University of OxfordOxford OX39DUUnited Kingdom Nottingham Digestive Diseases NIHR Biomedical Research Centre and the University of Nottingham Nottingham NG72UHUnited Kingdom King’s Liver Transplant Unit King's College HospitalLondon SE59RSUnited Kingdom NIHR Biomedical Research Center Freeman Hospital and Newcastle UniversityNewcastle upon Tyne NE77DNUnited Kingdom Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152GWUnited Kingdom School of Medicine Queen Mary University LondonLondon E14NSUnited Kingdom

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)represents a growing public health concern,with patients having higher risk of morbidity and *** has a considerably high prevalence in the general population,estimated 20%-40%in Europe,and is asymptomatic until late in the disease *** is therefore important to identify and validate tools that predict hard outcomes such as mortality for use in clinical practice in risk-stratifying NAFLD *** To evaluate available evidence on the use of non-invasive test(s)as prognostic factors for mortality in *** We performed electronic searches of Medline and EMBASE(Ovid)until 7^(th)January 2021 of studies in NAFLD *** markers included serum biomarkers,non-invasive scoring systems,and non-invasive *** population included all spectrums of disease severity,including NAFLD and non-alcoholic steatohepatitis(NASH).Outcomes included all-cause,and cardiovascular *** non-invasive tests were synthesised in a narrative systematic ***,we conducted a meta-analysis of non-invasive scoring systems for predicting all-cause and cardiovascular mortality,calculating pooled hazard ratios and 95%confidence(STATA 16.1).RESULTS Database searches identified 2850 studies-24 were included.16 studies reported non-invasive scoring systems,10 studies reported individual biomarkers,and 1 study reported imaging modalities.4 studies on non-invasive scoring systems(6324 participants)had data available for inclusion in the *** non-invasive scoring system that performed best at predicting all-cause mortality was NAFLD fibrosis score(NFS)[pHR 3.07(1.62-5.83)],followed by fibrosis-4 index[pHR 3.06(1.54-6.07)],BARD[pHR 2.87(1.27-6.46)],and AST to platelet ratio index[pHR 1.90(1.32-2.73)].NFS was also prognostic of cardiovascular-related mortality[pHR 3.09(1.78-5.34)].CONCLUSION This study reaffirms that non-invasive scoring systems,especially NFS,are reliable prognostic mark

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Biomarkers Non-invasive Prognosis Mortality

Impact of Some Agronomic Practices on Paddy Field Soil Health Under Varied Ecological Conditions: I. Influence of Soil Moisture

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Pedosphere 2001年第2期11卷 39-48页

作者： A.subhani LIAOMIN 等 NaturalResourcesScienceDepartment CollegeofEnvironmentalandResourcesSciencesZhejiangUniversityHangzhou310029（China） NaturalResourcesScienceDepartment CollegeofEnvironmentalandResourcesSciencesZheji

The effects of individual and combined additions of urea (100 μg N g-1 soil) and insecticide (triazophos at field rate, FR) under different moisture levels of air-dried soil (AD), 50% of water-holding capacity (WHC), 100% WHC and flooded soil (FS) on some selected soil properties in a paddy field soil were examined in a laboratory incubation study. The results indicated that after 21-day incubation at 25℃, the different moisture levels led to significant changes in the parameters studied. Flooding of soil with distilled water significantly increased the electron transport system (ETS) /dehydrogenase activity and phenol contents of the soil compared to the other moisture levels, while protein and phospholipids behaved differently at varied moisture levels with or without the addition of urea and/or triazophos. Increased ETS activity was observed with N addition at higher moisture levels while insecticide incorporation decreased it at all moisture levels as compared to the control (moisture only). The phenol contents slightly decreased and increased with N and insecticide applications, respectively. The soil protein contents were found to be unaffected among all the soil treatments at all moisture levels. However, among different moisture levels, reduced quantities of proteins were estimated at 50% WHC, suggesting more N-mineralization. Lower quantities of soil biomass phospholipids, among all treatments, were recorded at higher moisture levels (100% WHC and FS) than at the lower levels. An overall slight enhancement in phospholipid contents with N and small reduction with insecticide addition, respectively, was noticed against the untreated soil. The toxicity of fertilizer and insecticide decreased as the soil moisture contents increased, suggesting rapid degradation of agrochemicals.

关键词： electron transport system (ETS) activity moisture total phenol protein phospholipids

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Comparative Study on Various Strength Parameters of Structural Elements Made from Cross-Laminated Timber

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Journal of Renewable Materials 2022年第6期10卷 1575-1606页

作者： Mohammad Anwar-Us-Saadat Janeshka Goonewardena Bidur Kafle Mahmud Ashraf Mahbube subhani School of Engineering Technology-Civil Melbourne PolytechnicEpping3076Australia School of Engineering Deakin UniversityWaurn Ponds3216Australia

Cross laminated timber(CLT)is an innovative and environment friendly engineered timber product with superior structural *** offers strong resistance against both in-plane and out-of-plane ***,it is widely used as floors,roofs or wall *** experimental research on CLT under various loading conditions has been done in the recent *** article presents a comprehensive review of various design methods to determine basic mechanical properties such as tension,compression and rolling shear strength of CLT with primary focus on Norway *** relevant experimental data available from existing literature were collated and consequently been used to evaluate the performance of various methods to design CLT *** comparison revealed that different methods show considerable variance in predicting the capacity of CLT panels due to the variation in timber species,which affects the corresponding mechanical properties of the *** addition to species,rolling shear properties can also vary considerably depending on the type of experimental technique used for testing.A predictive model has also been proposed to correlate rolling shear strength obtained from shear analogy method to that obtained using planar shear.

关键词： Cross-laminated timber mass timber mechanical strength rolling shear strength planar shear test short span bending test

Anti-solvent engineering for efficient semitransparent CH3NH3PbBr3 perovskite solar cells for greenhouse applications

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Journal of Energy Chemistry 2019年第7期28卷 12-19页

作者： Waqas Siddique subhani Kai Wang Minyong Du Xiuli Wang Ningyi Yuan Jianning Ding Shengzhong(Frank)Liu Dalian National Laboratory for Clean Energy iChEMDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of the Chinese Academy of Sciences Beijing 100039China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710119ShaanxiChina Jiangsu Key Laboratory for Photovoltaic Engineering and Science Changzhou UniversityChangzhou 213164.Jiangsu.China

With ideal combination of benefits that selectively converts high photon energy spectrum into electricity while transmitting low energy photo ns for photos yn thesis,the CH3NH3PbBr3 perovskite solar cell(BPSC)is a promising candidate for efficient greenhouse based building integrated photovoltaic(BIPV)***,the efficiency of BPSCs is still much lower than their theoretical *** general,interface band alignment is regarded as the vital factor of the BPSCs whereas only few reports on enhancing perovskite film *** this work,highly efficient BPSCs were fabricated by improving the crystallization process of CH3NH3PbBr3 with the assistance of anti-solvents.A new anti-solvent of diphenyl ether(DPE)was developed for its strong interaction with the solvents in the perovskite precursor *** using the anti-solvent of DPE,trap-state density of the CH3NH3PbBr3 film is reduced and the electron lifetime is enhanced along with the large-grain crystals compared with the samples from conventional anti-solvent of *** preliminary optimization,the efficiencies of typical and semitransparent BPSCs are improved to as high as 9.54%and 7.51%,*** absorption measurement demonstrates that the cell without metal electrode shows 80%transparency in the wavelength range of 550-1000 nm that is perfect for greenhouse *** that the cell absorbs light in the blue spectrum before 550 nm,it offers very high solar cell efficiency with only 17.8%of total photons,while over 60%of total photons can transm让through for photosynthesis if a transparent electrode can be obtained such as indium doped SnO2.

关键词： CH3NH3PbBr3 Semitransparent perovskite solar cell Anti-solvent Greenhouse

Effects of Some Management Practices on Electron Transport System (ETS) Activity in Paddy Soil

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Pedosphere 2000年第3期10卷 257-264页

作者： A．subhani LIAOMIN 等 NaturalResourcesScienceDept. CollegeofNaturalResourcesandEnvironmentalSciencesZhejiangUniversityHangzhou310029China NaturalResourcesScienceDept. CollegeofNaturalResourcesandEnvi

Electron transport system (ETS ) / dehydrogenase activity in a paddy field soil was measured under a variety of incubation conditions using the reduction of 2- (p-iodophenyl- 3- (p-nitrophenyl ) -5- phellyl tetrazolium chloride (INT) to iodonitrotetrazolium formazan (INTF). The results exhibited a high positive correlation between the ETS activity and the incubation temperature and soil moisture. Dehydrogenase/ETS activity displayed a negative correlation with insecticide concentrations, and the activity affected adversely as the concentration of the insecticide increased. The higher doses, 5 and 10 field rates (1 field rate ~ 1500 mL ha-1), of insecticide significantly inhibited ETS activity, while lower rates failed to produce any significant reducing effect. Inorganic N (as urea) of concentrations from 0 to 100 ug N g-1 soil showed a positive response to ETS activity. However, at concentrations of 200 and 400 ug N g-1, the activity was reduced significantly.

关键词： electron transport system (ETS) activity insecticide moisture nitrogen temperature

Combined Effect of Nutrient and Pest Management on Soil Ecological Quality in Hybrid Rice Double-Cropping System

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Pedosphere 2003年第2期13卷 129-138页

作者： A.subhani Natural Resources Science Department College of Environmental and Resources Sciences Zhejiang Univer-sity

The mineral fertilizers (NPK) and pesticide, including herbicides, insecticides and fungicides, were applied alone or in combination and the soil sampling was done at different growth stages during the crop cycle to study the changes in soil organic matter, microbial biomass and their activity parameters in a paddy soil with different nutrient and pest management practices in a hybrid rice double-cropping system. A consistent increase in the electron transport system (ETS) activity was measured during the different crop growth stages of rice. The use of fertilizers (NPK) alone or with pesticides increased ETS activity, while a decline of ETS activity was noticed with pesticides alone as compared with the control. Nearly an increasing trend in soil phenol content was observed with the progression of crop growth stages, while the usage of pesticides alone caused maximum increments in the soil phenol content. The soil protein content was found nearly stable with fertilizers and/or pesticides application at various growth stages in both crops taken. But notable changes were noticed at different growth stages probably because of fluctuations in moisture and temperature at particular stages, which might have their effects on N mineralization. Marked depletions in the phospholipid content were found with the advancement of crop growth stages, while the incorporation of fertilizers and/or pesticides also produced slight changes, in which a higher decline was noticed with pesticide application alone compared with the control.

关键词： electron transport system (ETS) hybrid rice phenol phospholipid protein

Analysis of insecticide thiacloprid by ion chromatography combined with online photochemical derivatisation and fluorescence detection in water samples

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Chinese Chemical Letters 2014年第3期25卷 415-418页

作者： Qamar subhani Zhong-Ping Huang Zuo-Yi Zhu Lu-Ye Liu Yan Zhu Department of Chemistry Xixi CampusZhejiang University Thermofisher Scientific

This study describes a novel application of ion chromatography coupled with post-column photochemically induced fluorimetry derivatisation in alkaline medium and fluorescence detection （IC-hv-FD） for the determination of neonicotinoid pesticide, thiacloprid. In an aqueous medium, this compound showed fluorescence with an excitation maximum at 236 nm and an emission maximum at 353 nm. The 10 mmol/L NaOH with 10% （v/v） acetonitrile solution pumped at flow rate of 1.0 mL/min was used for the chromatographic elution to isocratically separate thiacloprid on an Ion Pac~＇ AS 11 （250 mm x 4 mm i.d; 13 p^m particle size, Dionex） anion-exchange column. The linear concentration range of application was 0.04-10.0 mg]L, with a relative standard deviation （RSD, n = 7） of 1.7% （for a level of 2.0 mg/L） and detection limit （LOD, SiN = 3） of 9.9 p^g]L. The procedure was applied with satisfactory results to the analysis of thiacloprid in ground and lake water samples. Pesticide average spiked recoveries ran^ed between 95.5% and 114.0%.

关键词： ThiaclopridPhotochemical derivatisationFluorescenceIon chromatography

Investigating the impact of Glyoxal retrieval from MAX-DOAS observations during haze and non-haze conditions in Beijing

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Journal of Environmental Sciences 2019年第6期31卷 296-305页

作者： Zeeshan Javed Cheng Liu Muhammad Fahim Khokhar Chengzhi Xing Wei Tan Muhammad Ahmed subhani Abdul Rehman Aimon Tanvir School of Earth and Space Sciences University of Science and Technology of China Center for Excellence in Regional Atmospheric Environment Institute of Urban Environment Chinese Academy of Sciences Key Lab of Environmental Optics & Technology Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Anhui Province Key Laboratory of Polar Environment and Global Change USTC Institute of Environmental Sciences and Engineering National University of Sciences and Technology

This study presents the Multi Axis Differential Optical Absorption Spectroscopy(MAXDOAS) measurements for Glyoxal(CHOCHO) in Beijing, China(39.95°N, 116.32°E). CHOCHO is the smallest compound of di-carbonyl group. As a primary sink of CHOCHO, its photolysis with NOx(oxides of nitrogen) results in the production of tropospheric ozone. Therefore,the focus of CHOCHO DOAS measurements is increasing in trend. We did the measurements from 09 May 2017 to 09 September 2017. The study was conducted to compare different retrieval settings in order to reveal best DOAS fit settings for CHOCHO;furthermore, effect of haze and non-haze days on CHOCHO concentration was *** root mean square of residual and Differential Slant Column density(dSCD) error was reduced when measurements were done with lower wavelength limit around 432–438 nm and upper intervals around 455–460 nm. Thus, lower wavelength intervals around432–438 nm and upper intervals around 457–460 nm were best for the retrieval of dSCDs for CHOCHO. Meteorological conditions like haze or non-haze days did not have significant effect on DOAS fit parameters. The CHOCHO vertical column densities range from 1.33 E +14 to 9.77 E + 14 molecules/cm2 during the study period with average of 6.16 E +14 molecules/cm2. The results indicated that during haze days CHOCHO concentration was higher because of lower rate of photolysis and atmospheric oxidation potential. Our results did not show any significant weekend effect on CHOCHO atmospheric concentration.

关键词： Glyoxal DOAS Retrieval settings Photolysis Haze days

Corrosion behavior of coating with plasma sprayed 8YSZ on the surface of carbon steel

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Journal of Rare Earths 2012年第6期30卷 592-598页

作者：刘扬佳范习之曾水冰王盈邹兵林古立建陈小龙 Zuhair subhani Khan 杨道武曹学强 Department of Chemical and Biological Engineering Changsha University of Science and Technology State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences

The corrosion behavior of plasma sprayed 8YSZ （ZrO2 stabilized by 8 wt.% Y2O3） coating on the surface of carbon steel in seawater was investigated. The electrochemical impedance spectroscopy was used as a non-destructive evaluation technique to monitor the protection properties of the coating when it was immersed in seawater, and corrosion products were characterized by scanning electron microscopy, energy dispersive spectrometry and X-ray photoelectron spectroscopy. The results indicated that three time constants were obtained dur ing the initial immersion period, and then a new time constant appeared due to the formation of rust layer, which was corresponding to the corrosion process. Corrosion products were formed on the coating surface as well as inside the coating, and the crystalline composition of the rust layer mainly consisted of γ-FeOOH.

关键词： thermal barrier coating carbon steel corrosion behavior electrochemical impedance spectroscopy rare earths