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Investigation of Iron Complex Formation of Anti-Hypertensive Drug: Methyldopa

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American Journal of Analytical Chemistry 2015年第6期6卷 551-558页

作者： Tehmina Fiaz Nasreen Fatima S. Zafar Abbas Zaidi Tanveer Abbas mohib R. Kazimi Department of Chemistry University of Karachi Karachi Pakistan Department of Microbiology University of Karachi Karachi Pakistan Department of Applied Chemistry and Chemical Technology University of Karachi Karachi Pakistan

The drug administered for any disease may play an unwanted function in biological system. They may have multiple counter effects, one of which is their interaction to bioactive metals. Iron is most common bio essential metal and is reported to interact with antihypertensive drug methyldopa. In the present study, above said complex is analyzed by UV-Visible spectrophotometry. Formation constant of the complex is calculated by using mole ratio method and single point statistical method which is in the range of 1010, values are also calculated which are independent of pH like formation constant. Absorbance maxima were found to be dependent on pH. At lower pH complex shows two broad bands centered at 430 nm and 730 nm. With the rise in pH later peak shifts toward lower wavelength, so 615 nm is selected for further studies. Molar extinction coefficient of the complex is explored by serial dilution method. At all wavelengths it increases with increase in pH. Mole ratio and slope ratio methods are used for exploring stoichiometry. Metal to ligand combining ratio in the complex is 1:2 at pH 4.0 and pH 4.5 while 1:3 at pH 5.0 and pH 5.5.

关键词： Iron Methyldopa Stoichiometry Formation Constant UV-Spectrophotometery

Influence of Cell Confluency on the Expression of the α4 Integrin Subunit of Retinal Pigment Epithelial Cells

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Advances in Biological Chemistry 2015年第2期5卷 73-82页

作者： Jean-Michel Bourget mohib Morcos Karine Zaniolo Sylvain L. Guérin Stéphanie Proulx Centre de recherche du CHU de Québec and Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX axe médecine régénératrice Hopital du Saint-Sacrement Québec Canada Département d’anatomie et de cytologie pathologiques CHU de Québec Hopital du Saint-Sacrement Québec Canada Département de biologie moléculaire biochimie médicale et pathologie Faculté de médecine Université Laval Québec Canada Département d’Ophtalmologie Faculté de médecine Université Laval Québec Canada

Integrins are a family of transmembrane glycoproteins that mediate cell-cell and cell-extracellular matrix interactions. The integrin α4 subunit is widely expressed by cells from the immune system and its expression by non-hematopoietic cells is scarce. In the present study, gene and protein expression of this integrin subunit was characterized in proliferating and quiescent human RPE cells. Immunofluorescent studies confirm that the α4 subunit is expressed in vitro by RPE cells, a result that has been validated by immunofluorescence and FACS analyses. The accumulation of the α4 integrin at cell-cell junctions in post-confluent RPE cell cultures negatively correlated with the level of expression of the mRNA transcript. Accordingly, transient transfection analyses reveal that the α4 promoter activity is considerably reduced when RPE cells form a confluent monolayer. Moreover, transfection of recombinant constructs bearing 5’-deletions of the α4 promoter segment allows the localization of strong negative regulatory elements on the -76 to -300 region of the α4 gene suggesting that its expression is intimately linked to the proliferative state of primary cultured RPE cells.

关键词： Retinal Pigment Epithelium Integrin Alpha 4 Subunit Cell Culture Confluency Promoter

Effect of Foliar Application of Micronutrients on Fruit Quality of Peach

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American Journal of Plant Sciences 2014年第9期5卷 1258-1264页

作者： Amjad Ali Sajida Perveen Syed Noor Muhammad Shah Zengqiang Zhang Fazli Wahid mohib Shah Shahida Bibi Abdul Majid College of Natural Resources and Environment Northwest A&F University Yangling China Department of Agriculture Chemistry Faculty of Agriculture Gomal University D.I. Khan Pakistan Department of Botany Abdul Wali Khan University Mardan Pakistan Department of Horticulture Faculty of Agriculture Gomal University D. I. Khan Pakistan Department of Weed Science University of Agriculture Pe-shawar Pakistan Soil and Environmental Sciences University of Agriculture Peshawar Pakistan

This experiment was conducted to study the effect of foliar spray of micronutrients on quality of peach fruits at Horticulture Farm, University of Agriculture Peshawar during 2010. The experiment was conducted in randomized complete design with six treatments and four replications on peach orchards (early grand). Our pre-treatment soil analysis showed silt loam soil class, alkaline and calcareous in nature and adequate in organic matter. The soil was deficient in P, Zn, Fe and B, whereas adequate in Mn and Cu. The fruit quality was evaluated and maximum fruit length, diameter and yield were noted in T6 (Zn + Cu + Fe + Mn + B). The juice pH decreased and the juice acidity increased in a linear fashion after foliar spray of micronutrients. The total soluble solids of fresh fruit juice ranged 7.01%-8.88% and vitamin C ranged from 4.80%-7.90% after foliar spray. So the foliar spray of micronutrients significantly (P ≤ 0.05) affected the quality of peach fruit.

关键词： Acidity Fruit Quality Micronutrients Peach Spray Vitamin C

Effects of Humic Acid and Crop Residues on Soil and Wheat Nitrogen Contents

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American Journal of Plant Sciences 2014年第9期5卷 1277-1284页

作者： Kashif Akhtar Syed Noor Muhammad Shah Amjad Ali Sajjad Zaheer Fazli Wahid Ahmad Khan mohib Shah Shahida Bibi Abdul Majid College of Natural Resources and Environment Northwest A&F University Yangling China Department of Agriculture Chemistry Faculty of Agriculture Gomal University D.I. Khan Pakistan Department of Agronomy Amir Muhammad Khan Campus Mardan University of Agriculture Peshawar Pakistan Department of Agronomy Faculty of Crop Production Sciences University of Agriculture Peshawar Pakistan Department of Botany Abdul Wali Khan University Mardan Pakistan Department of Horticulture Faculty of Agriculture Gomal University D.I. Khan Pakistan Department of Weed Science University of Agriculture Peshawar Pakistan Soil and Environmental Sciences University of Agriculture Peshawar Pakistan

This study was conducted with the aim of finding humic acid and crop residues effects on soil and wheat nitrogen at New Development Farm, University of Agriculture, Peshawar, Pakistan during winter 2009-2010. The experiment was laid out in RCB design having four replications. Different levels (1, 1.5, 2 and 2.5 kg ha-1) of Humic acid were applied at sowing time. Mungbean (5 tons ha-1), wheat straw (10 tons ha-1) and mungbean (2.5 tons ha-1) + wheat straw (5 tons ha-1) were incorporated 30 days before sowing. Our results showed higher mineral and total nitrogen (7.32 and 0.43, respectively) mg kg-1 in soil and also higher nitrogen in stem, leaves and grains (2.3, 4.6 and 21.1, respectively) mg kg-1 at maturity in those plots in which 2.5 kg ha-1 of humic acid was applied. Higher mineral and total nitrogen (7.04 and 0.5, respectively) mg kg-1 in soil and also higher nitrogen in leaves (5.5) mg kg-1 at pre-anthesis, while at maturity stage in stem, leaves and grain (5.5, 2.1, 4.2 and 20.8) g kg-1 was recorded in those plots in which 5 tons ha-1 mung bean was incorporated. Our experimental results suggest the use of 5 tons ha-1 of mungbean residues with 2.5 kg ha-1 of humic acid to improve soil fertility availability of more nitrogen in wheat plants to increase the crop yield and grains quality.

关键词： Anthesis Grain Maturity Soil Fertility Straw Mung Bean

GIS and Intra-Site Spatial Analyses: An Integrated Approach for Recording and Analyzing the Fossil Deposits at Casablanca Prehistoric Sites (Morocco)

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Journal of Geographic Information System 2011年第4期3卷 373-381页

作者： R. Gallotti A. mohib M. El Graoui F. Z. Sbihi-Alaoui J.-P. Raynal 不详

The Mio-Plio-Pleistocene sequence at Casablanca, covering the last six million years, is well known in scientific literature. The variability and the chronology of the Acheulian sequence is documented by systematic, modern and controlled investigations in various sites (Unit L and Hominid Cave at Thomas I Quarry, Rhinoceros Cave at Oulad Hamida 1 Quarry, Sidi Abderrahman Extension Quarry, Bear’s Cave and Cap Chatelier at Sidi Abderrahman Quarry) which have taken place within the framework of the Franco-Moroccan co-operative project “Casablanca”. In order to manage the excavation data and to explore the taphonomic nature of Unit L, Hominid Cave and Rhinoceros Cave, where research is still in progress, an approach combining a Geographic Information System (GIS) and spatial analysis techniques was developed, incorporating all existing information produced from previous excavations and recent surveys of the sites. The amalgamation of this data into a GIS has resulted in a digital database that allows the production of simultaneous or separate visualizations and analyses of the fossils, artifacts and geological materials within their original spatial contexts and also permits intra-site spatial analyses that allow a comprehensive investigation of the site formation processes.

关键词： Morocco Casablanca Prehistoric Archaeology GIS Intra-Site Spatial Analyses Site Formation Processes

*** database of clinical data and biological material for research on uveal melanoma

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Annals of Eye Science 2018年第1期 453-453页

作者： Solange Landreville Frédéric Mouriaux Patrick J.Rochette Christian Salesse mohib W.Morcos Claudine Bellerive Sylvain Guérin Centre de recherche du CHU de Québec-UniversitéLaval Hôpital du Saint-SacrementQuébecQCCanada Département d’ophtalmologie et d’ORL-CCF Facultéde médecineUniversitéLavalQuébecQCCanada Centre de recherche en organogénèse expérimentale de l’UniversitéLaval/LOEX QuébecQCCanada Département d'ophtalmologie Facultéde médecineUniversitéde Rennes 1RennesFrance Service d’ophtalmologie CHU de RennesRennesFrance

Background:Sharing biological material and clinical data from patients with uveal ***:Uveal melanoma is the most common intraocular malignancy in the adult *** uveal melanoma is primarily a sporadic cancer and familial cases are rare,it is difficult to prevent or detect *** effective treatment of ocular tumors,more than 50%of patients develop incurable liver metastases mainly in the 5-10 years following the detection of the primary *** cancer is relatively rare and the obtained biopsies are very *** 20 samples are taken each year in *** provincial infrastructure is made of biological material from donors with uveal melanoma and a large clinical *** tumor biopsies are used for culturing cell lines and the creation of a DNA/RNA library used for genomic and genetic ***:This infrastructure plays an important role in the achievement of various research programs for a better understanding of genetic and environmental factors involved in the development of melanoma and the spread of *** allows collaboration with other researchers at a provincial,national and international level in order to make progress in basic and clinical research on uveal ***:The biological material and clinical data of this infrastructure are available upon request to VHRN members whose research project was approved by the ethics committee of the institution.

关键词： Uveal melanoma tumor biopsies blood clinical data