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Esophago-gastro-duodenoscopy could be an important tool in the diagnostic dilemma inherent in perforated peptic ulcer: A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 82-84页

作者： Pankaj Prasoon Giridhar Hanumappa Devadasar Tun Aung Kyaw mohd.akthar ansari Mulky Damodar Kamath Chean Leung Chong Department of General Surgery Suri Seri Begawan HospitalKuala Belait Negara Brunei DarussalamBrunei

Acute abdomen is a common and sometimes dramatic clinical condition,which can be fatal if diagnosis is not made in *** peptic ulcer is a cause of an acute abdomen,which can be diagnosed by imaging ***,erect chest X-ray and CT scan may not always establish the *** we report a case of a patient with acute abdomen,where radiological imaging and CT scan were not able to provide a clear *** patient was diagnosed with perforated peptic ulcer by esophago-gastro-duodenoscopy,and underwent laparotomy to repair the anterior wall duodenal perforation with an omental *** endoscopic evaluation seems to be an essential tool for upper gastrointestinal evaluation in acute abdomen cases with inconclusive imaging results.

关键词： Perforated peptic ulcer Esophago-gastro-duodenoscopy Acute abdomen

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Analytical methods for nano-bio interface interactions

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Science China Chemistry 2016年第11期59卷 1467-1478页

作者： Jing Wang Waseem akthar Quershi Yiye Li Jianxun Xu Guangjun Nie CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology

Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.

关键词： engineered nanomaterial nano-bio interface nano-bio interaction analytical methods protein corona synchrotron radiation

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Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy ——a hypothesis

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 1041-1045页

作者： Kaviyarasi Renu V.G.Abilash P.B.Tirupathi Pichiah Thabassum akthar Syeda Sankarganesh Arunachalam School of Biosciences and Technology VIT University Department of Animal Science School of Life Sciences Bharathidasan University Department of Biotechnology Kalasalingam University

Diabetic cardiomyopathy is one of the life threatening complications of diabetes. A number of animal models are being used for studying diabetic cardiomyopathy. In laboratory animal models, induction of cardiomyopathy happens in two stages: first being the induction of diabetic condition and the second being the induction of cardiomyopathy by prolonging diabetic condition. It takes a longer time to develop diabetes with the limited success rate for development of cardiomyopathy. Adriamycin is an effective anticancer drug limited by its major side-effect cardiomyopathy. A number of features of Adriamycin treatment mimics diabetes. We postulate that Adriamycin-induced cardiomyopathy might be used as a model system to study diabetic cardiomyopathy in rodents since a number of features of both the cardiomyopathies overlap. Left ventricular hypertrophy, systolic and diastolic dysfunction, myofibrillar loss, and fibrosis are hallmarks of both of the cardiomyopathies. At the molecular level, calcium signaling, endoplasmic reticulum stress, advance glycation endproduct activation, mitochondrial dysfunction,inflammation, lipotoxicity and oxidative stress are similar in both the *** signature profile of both the cardiomyopathies shares commonalities. In conclusion,we suggest that Adriamycin induced cardiomyopathic animal model can be used for studying diabetic cardiomyopathy and would save time for researchers working on cardiomyopathy developed in rodent using the traditional method.

关键词： Cardiomyopathy Diabetes Animal model for cardiomyopathy Adriamycin Diabetic cardiomyopathy

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