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Nigella sativa protects against isoproterenol-induced myocardial infarction by alleviating oxidative stress,biochemical alterations and histological damage

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Asian Pacific Journal of Tropical Biomedicine 2017年第4期7卷 294-299页

作者： Md.Quamrul Hassan mohd.akhtar.sayeed ahmed Aftab Ahmad Abul Kalam Najmi Department of Pharmacology Faculty of PharmacyJamia Hamdard(Hamdard University) Department of Pharmacognosy Faculty of PharmacyJamia Hamdard(Hamdard University) Health Information Technology Department Jeddah Community CollegeKing Abdulaziz University

Objective: To evaluate the cardioprotective effect of Nigella sativa L.(***) in isoproterenol-induced myocardial infarction(MI).Methods: Groups were treated with different doses of ethanol extract of ***(EENS)and *** oil alone and along with enalapril for 28 *** was induced by subcutaneous administration of isoproterenol(85 mg/kg) in two consecutive *** of cardiac biomarkers and antioxidant enzymes such as creatine kinase–N-acetyl-L-cysteine, lactate dehydrogenase, aspartate aminotransferase, malondialdehyde, superoxide dismutase, reduced glutathione and catalase were evaluated along with gross histopathological ***: Isoproterenol(85 mg/kg) induced MI by causing the significant(P < 0.01)reduction in the activity of cardiac biomarkers(creatine kinase–N-acetyl-L-cysteine,lactate dehydrogenase, aspartate aminotransferase) and antioxidant markers(superoxide dismutase, catalase, glutathione) along with significant(P < 0.01) increase in the level of ***, histopathological evaluation also confirmed the isoproterenol-induced *** with EENS(800 mg/kg) and combination of EENS(800 mg/kg) with enalapril(1 mg/kg) significantly(P < 0.01) prevented the development of these alteration and restored activity of cardiac biomarkers as well as antioxidant markers almost near to normal *** evaluation of cardiac tissue further confirmed the restoration of biochemical ***: Experimental findings thus indicate that EENS(800 mg/kg) demonstrated cardioprotective effect against isoproterenol-induced MI by restoring cardiac biomarkers and antioxidant status.

关键词： Antioxidant Isoproterenol Myocardial necrosis Nigella sativa Oxidative stress

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Achieving Energy Efficiency in Wireless Sensor Networks Using Dynamic Channel Polling and Packet Concatenation

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China Communications 2021年第8期18卷 249-270页

作者： Shama Siddiqui Anwar ahmed Khan sayeed Ghani Department of Computer Science DHA Suffa UniversityKarachiPakistan Department of Computer Science Institute of Business AdministrationKarachiPakistan Department of Computer Science Sindh Institute of Management&TechnologyKarachiPakistan

There has been a significant interest of researchers to combine different schemes focused on optimizing energy performance while developing aMAC protocol for Wireless Sensor Networks(WSNs).In this paper,we propose to integrate two cross-layer schemes:dynamic channel polling and packet concatenation using a recent asynchronous MAC protocol“Adaptive&Dynamic Polling MAC”(ADPMAC).ADP-MAC dynamically selects the polling interval distribution based on characterization of incoming traffic patterns using Coefficient of variation(CV).Packet Concatenation(PC)refers to combining the individually generated data packets into a single super packet and sending it at the polling ***,the Block Acknowledgement(BA)scheme has been developed for ADP-MAC to work in conjunction with the packet *** proposed schemes have been implemented in Tiny-OS for Mica2 platform and Avrora emulator has been used for conducting *** results have revealed that the performance both in terms of energy&packet loss improves when ADP-MAC is used in conjunction with the additional features of PC&***,the proposed scheme has been compared with a stateof-art packet concatenation primitive PiP(Packet-in-Packet).It has been observed that ADP-MAC supersedes the performance of PiP in terms of PDR(Packet Delivery Ratio)due to better management of synchronization between source and sink.

关键词： energy efficiency concatenation dynamic polling

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Community microgrid:an approach towards positive energy community in an urban area of Dhaka,Bangladesh

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Clean Energy 2023年第4期7卷 926-939页

作者： Mohammad Zeyad S.M.Masum ahmed sayeed Hasan Dewan Mahnaaz Mahmud Energy and Technology Research Division Advanced BioinformaticsComputational Biology and Data Science LaboratoryBangladesh(ABCD LaboratoryBangladesh)House:24Road:01Block:BHalishaharChattogram 4226Bangladesh School of Engineering and Physical Sciences(EPS) Heriot-Watt UniversityCampus The AvenueEdinburghScotland EH144ASUK Department of Energy Engineering University of the Basque Country(UPV/EHU)Ingeniero Torres Quevedo Plaza1BilbaoBiscay 48013Spain Department of Electrical Electronic and Control EngineeringSchool of Industrial EngineeringUniversity of ExtremaduraCampus UniversitarioAv.de Elvass/nBadajozBadajoz 06006Spain Centre for Research on Geography ResourcesEnvironmentEnergy and Networks(Green)Bocconi UniversityVia Roentgen 1MilanoLombardy 20136Italy Control and Robotics(CORO) Ecole Centrale De Nantes1 Rue de la No?44300 NantesFrance

The pollution and toxic greenhouse gases produced by fossil fuel combustion are troubling as global energy demand continues to *** mitigate the consequences of global warming,a transition to sustainable energy sources is *** manuscript presents a feasible community microgrid design in Hazaribagh,Dhaka based on meteorological data that leads to photovoltaic installation on the rooftop of a local community *** study shows a microgrid design of a system with the lowest cost of energy and a large renewable fraction,which is analysed using the HOMER Pro *** real-time data,analysis of the system cost,cost of energy,renewable fraction,unmet load,energy purchased and energy sold is discussed.A suitable case for electrification is also identified and presented for the selected *** proposed case yields a cost of energy of$0.0357/kWh,which is 52%less than the current tariff rate,with a 70%renewable *** study will provide people in this community with more green energy at a lower cost;in addition,this designed microgrid sells additional energy to the grid to avoid possible power *** potential for a positive energy community is also investigated in terms of energy consumption and renewable output of the planned microgrid.

关键词： cost of energy microgrid positive energy community renewable fraction

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Grid-connected microgrid:design and feasibility analysis for a local community in Bangladesh

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Clean Energy 2022年第3期6卷 447-459页

作者： Dewan Mahnaaz Mahmud S.M.Masum ahmed sayeed Hasan Mohammad Zeyad Energy and Technology Research Division Advanced BioinformaticsComputational Biology and Data Science LaboratoryBangladesh Faculty of Engineering Erasmus Mundus Joint MSc in Smart Cities and Communities(SMACCs)University of Mons(UMONS)Belgium School of Engineering and Physical Sciences(EPS) Erasmus Mundus Joint MSc in Smart Cities and Communities(SMACCs)Heriot-Watt University(HWU)UK

Global demand for electricity is growing significantly in developing *** energy accounts for barely 3%of total energy consumption in *** of renewable energy,***,are increasingly being acknowledged as viable supply-side choices for *** article presents a grid-connected microgrid design based on meteorological data for a local community situated in Mohammadpur,*** study presents a feasible design of a system that gives the lowest cost of energy production and emissions that is evaluated using software named Hybrid Optimization Multiple Energy Resources(HOMER Pro).Comparison and assessment of the net present cost,cost of energy,operating cost and environmental emission for five different feasible microgrids are analysed concerning real-time ***,a suitable case is sorted out and proposed for the local community for *** proposed case offers a$0.0442/kWh cost of energy,which is~32%cheaper than the current rate with a 57.5%renewable fraction and a payback period of 16.86 *** of this local community will have access to considerably more clean energy at a lower price by this study;also this design could sell the excess energy to the grid to avoid frequent electricity outages.

关键词： renewable energy communities microgrid community energy photovoltaic batteries emission cost of energy

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Spatial distribution,source apportionment,and associated risks of trace metals (As,Pb,Cr,Cd,and Hg) from a subtropical river,Gomti,Bangladesh

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International Journal of Sediment Research 2022年第1期37卷 83-96页

作者： Abu sayeed Shafiuddin ahmed Mohammad Belal Hossain Saad Mohammad Omar Faruque Babu Moshiur Rahman Jun Sun Mohammad Shafiqul Islam Sarker Department of Fisheries and Marine Science Noakhali Science and Technology University School of Engineering and Built Environment Griffith University College of Marine and Environmental Sciences Tianjin University of Science and Technology Forensic Science Laboratory Rapid Action Battalions Headquarters

Sediment samples from the Gomti River basin were investigated to determine and evaluate trace metal concentrations,their biological effect,and potential ecological and human health risks for adults and *** mean concentrations of trace metals were organized in the descending order of mercury(Hg)(0.08 mg/kg)>chromium (Cr)(0.06 mg/kg)>lead (Pb)(0.05 mg/kg)>arsenic (As)(0.02 mg/kg)>cadmium (Cd)(0.01 mg/kg).The current study illustrated that metals were attributed to the area from natural sources and different anthropogenic sources especially from ***,the concentration levels were lower than the sediment quality guidelines (SQGs) based on the effect-range classifications of threshold effect concentration (TEC) and probable effect concentration (PEC).Therefore,the concentration of the elements showed no adverse biological effects on aquatic *** evaluated potential ecological risk index also revealed the low toxicity to the aquatic ***,the applied sediment quality indices,geo-accumulation index (Igeo),contamination factor (CF),and contamination severity index (CSI) suggested that the contamination levels of the elements were in the acceptable range,and the contamination had not notably impacted on the sediment *** risk index (HI) concerning age groups was significantly less than the threshold limit of 1 indicating that the contamination had no non-carcinogenic risk *** total carcinogenic risk (TCR) was less than a risk value of 1×***,the current study suggests that immediate remediation is not required due to an absence of alarming conditions in the study *** monitoring of the attribution of the metal elements should be done for the betterment of human and environmental health.

关键词： Trace metals Biological effects Ecological risk Human health risk Gomti river Bangladesh

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Resource Exhaustion Attack Detection Scheme for WLAN Using Artificial Neural Network

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Computers, Materials & Continua 2023年第3期74卷 5607-5623页

作者： Abdallah Elhigazi Abdallah Mosab Hamdan Shukor Abd Razak Fuad A.Ghalib Muzaffar Hamzah Suleman Khan Siddiq ahmed Babikir Ali Mutaz H.H.Khairi sayeed Salih Faculty of Engineering Future UniversityKhartoum 10553Sudan Faculty of Computing and Informatics Universiti Malaysia SabahKota Kinabalu88400Malaysia Information Assurance and Security Research School of ComputingUniversiti Teknologi MalaysiaJohor81310Malaysia School of Psychology and Computer Science University of Central LancashirePreston PR12HEUK Deaptement of Management Information Systems College of Administrative ScienceApplied Science UniversityAl Eker623Bahrain Deaptement of Information Technology College of Computer and Information SciencesKing Saud UniversityRiyadh11461Saudi Arabia

IEEE 802.11 Wi-Fi networks are prone to many denial of service(DoS)attacks due to vulnerabilities at the media access control(MAC)layer of the 802.11 *** to the data transmission nature of the wireless local area network(WLAN)through radio waves,its communication is exposed to the possibility of being attacked by illegitimate ***,the security design of the wireless structure is vulnerable to versatile *** example,the attacker can imitate genuine features,rendering classificationbased methods inaccurate in differentiating between real and false *** security standards have been proposed over the last decades to overcome many wireless network attacks,effectively detecting such attacks is crucial in today’s real-world *** paper presents a novel resource exhaustion attack detection scheme(READS)to detect resource exhaustion attacks *** proposed scheme can differentiate between the genuine and fake management frames in the early stages of the attack such that access points can effectively mitigate the consequences of the *** scheme is built through learning from clustered samples using artificial neural networks to identify the genuine and rogue resource exhaustion management frames effectively and efficiently in *** proposed scheme consists of four modules whichmake it capable to alleviates the attack impact more effectively than the related *** experimental results show the effectiveness of the proposed technique by gaining an 89.11%improvement compared to the existing works in terms of detection.

关键词： 802.11 media access control(MAC) wireless local area network(WLAN) artificial neural network denial-of-service(DoS)

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Treatment of chronic recurrent dislocation of temporomandibular joint by autologus blood injection

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Plastic and Aesthetic Research 2016年第1期3卷 121-125页

作者： Syed sayeed ahmed Md.Kalim Ansari Department of Oral and Maxillofacial Surgery Dr.Ziauddin Ahmed Dental CollegeAligarh Muslim UniversityAligarh 202002India

Aim:The aim of this study was to evaluate the efficacy of autologus blood injection in the management of recurrent temporomandibular joint(TMJ)***:A total of 11 patients,4 males,7 females,mean age of 58.6 years and suffering from recurrent dislocation of TMJ,were included in the *** all the patients the procedure included anesthesia-local or sedation,arthrocentesis which was followed by autologous blood injection in the upper joint *** peri-articular tissues were also infiltrated with autologous *** procedure advice included restricted mouth activity and liquid diet for a ***:The results indicate that success rate of treatment of recurrent dislocation of TMJ is 72.8%which can be considered as *** recurrence was noticed in 27.2%cases after one year follow ***:Autologus blood injection is an effective,simple,non-invasive,and safe procedure for treatment of recurrent dislocation of TMJ and can be performed on outpatient basis.

关键词： Subluxation recurrent dislocation arthrocentesis temporomandibular joint autologous blood

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Rational drug design,synthesis,and biological evaluation of novel N-(2-arylaminophenyl)-2,3-diphenylquinoxaline-6-sulfonamides as potential antimalarial,antifungal,and antibacterial agents

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Digital Chinese Medicine 2021年第4期4卷 290-304页

作者： ahmed Hassen Shntaif Sharuk Khan Ganesh Tapadiya Anand Chettupalli Shweta Saboo mohd sayeed Shaikh Falak Siddiqui Ramkoteswra Rao Amara College of Science for Women Babylon UniversityHillaBabil 00964Iraq MUPs College of Pharmacy(B Pharm) WashimMaharashtra 444506India Shreeyash Institute of Pharmaceutical Education and Research AurangabadMaharashtra 431010India Department of Pharmaceutical Sciences Center for NanomedicineAnurag UniversityHyderabad 501301India Government College of Pharmacy KaradMaharashtra 415124India Department of Pharmacy Shri Jagdishprasad Jhabarmal Tibrewala UniversityVidya NagariRajasthan 333001India

Objective Sulfanilamide,sulfadiazine,and dapsone were the first sulfonamides to be used to treat malaria by disrupting the folate biosynthesis process,which is essential for parasite ***,we aimed to synthesize novel N-(2-arylaminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide derivatives through a rational drug design *** All compounds were synthesized by the conventional method,and the products were characterized by spectral analysis(1 H NMR and mass spectrometry).The progression of the reaction was monitored using thin-layer chromatography(TLC).All the derivatives were analyzed for their effective binding mode in the allosteric site of the plasmodium cysteine protease *** and antifungal activities were determined using the broth dilution *** S6(N-(2-thiazol-4 yl)-acetyl-aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide and S9(N-(1 H-benzo[d]imidazol-2-yl)aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide formed five hydrogen bonds;S8(N-(2-1 H-imidazol-2 yl)aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide and S10(N-(1 H-benzo[d]imidazol-5-yl)aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide formed four hydrogen bonds with the allosteric site of the *** the docking scores and formation of hydrogen bonds with the target enzyme,the novel derivatives were processed for wet lab *** the newly synthesized derivatives were subjected to in vitro antimalarial,antifungal,and antibacterial *** the derivatives exhibited sufficient sensitivity to the Plasmodium falciparum strain compared to the ***,compounds S9 and S10 showed the most potent dual antimicrobial and antimalarial *** also exhibited powerful molecular interactions in molecular docking *** Based on the above results,it was concluded that N-(2-arylaminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide derivatives have excellent biological potential to act as antimalarial,antifungal,

关键词： Sulfonamides Antimalarials Antifungal Antibacterial Plasmodium cysteine protease falcipain-2 2,3-Diphenylquinoxaline-6-sulfonamide Plasmodium falciparum

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Genetic polymorphisms of GSTM1,GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 982-989页

作者： Mir Muhammad Nasir Uddin Maizbha Uddin ahmed Mohammad Safiqul Islam Mohammad Siddiqul Islam Muhammad Shahdaat Bin sayeed Yearul Kabir Abul Hasnat Department of Clinical Pharmacy and Pharmacology Faculty of PharmacyUniversity of Dhaka Department of Pharmacy Noakhali Science and Technology University Department of Biochemistry and Molecular Biology University of Dhaka

Objective:To verify possible associations between polymorphisms of glutathione S-transferase Mu(GSTM1),glutathione S-transferase θ(GSTT1) and glutathione S-transferase Pi(GSTP1)genes and susceptibility to lung ***:A total of 106 lung cancer patients and 116 controls were enrolled in a case-control *** GSTM1 and GSTT1 were analyzed using PCR while GSTP1 was analyzed using PCR-restriction fragment length *** of lung cancer was estimated as odds ratio at 95%confidence interval using unconditional logistic regression models adjusting for age,sex,and tobacco ***:GSTM1 null and GSTT1 null genotypes did not show a significant risk for developing lung cancer.A significandy elevated lung cancer risk was associated with GSTP1 heterozygous,mutant and combined heterozygous+mutant variants of *** classified by tobacco consumption status,no association with risk of lung cancer was found in case of tobacco smokers and nonsmokers carrying null and present genotypes of GSTM1 and GSTTL There is a three-fold(approximately) increase in the risk of lung cancer in case of both heterozygous(AG) and heterozygous+mutant homozygous(AG+GG) genotypes whereas there is an eightfold increase in risk of lung cancer in cases of GG with respect to AA genotype in ***:Carrying the GSTM1 and GSTT1 null genotype is not a risk factor for lung cancer and GSTP1Ile105 Val is associated with elevated risk of lung cancer.

关键词： Lung cancer Glutathione S-transferase Genetic polymorphism Smoking

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Life Style and Risk Behavior of Street Children in Bangladesh: A Health Perspective

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Health 2017年第4期9卷 577-591页

作者： Sajeda Chowdhury Abu sayeed Chowdhury KATM Ehsanul Huq Yasmin Jahan Rubana Chowdhury Toufiq ahmed Md Moshiur Rahman Institute of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Chemistry National University Dhaka Bangladesh Japan Advanced Institute of Science and Technology Nomi Ishikawa Japan

Background: Street children concern to millions of deprived boys and girls who have adopted the street as their residence. They grow up where tranquility and physical and emotional stability are frequently threatened. The purpose is to have an empathetic look into the lives of street children for identifying their health-related needs. Method: A cross sectional descriptive type of study was conducted among 125 street children between the ages 8 to 14 years who were available at different intercept points of Dhaka city, Bangladesh. The information was collected through face-to-face interview using a structured questionnaire. An attempt was made to relate their lifestyle, risk behavior and health impact upon the socio demographic characteristics. Result: According to the statement of street children, poverty (41%) is the main reason behind enforcing the children to stay and work on the street. They pass their leisure by playing games, roaming around by watching video/cinema but on the other side of the coin, they are frequently abused (80.8%) either physically or sexually. Regarding health, about 87.2% of street children were suffering from different type of diseases as accidental injury, skin infection, hepatitis, sexually transmitted diseases and warm infestation. Conclusion: A careful examination of the lives of these children will provide a clearer understanding of their disadvantageous life. A better diagnosis of the contributing factors will help to minimize the extent of the problems and also to develop innovative approaches and ensure a healthy lifestyle, protection and rehabilitation for those children.

关键词： Street Children Life Style Risk Behavior Bangladesh

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