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Journal of Bioresources and Bioproducts 2020年第4期5卷 248-255页

作者： Siti Nuurul Hud Mohammad Azmin Najah Aliah binti mohd Hayat mohd shukri mat nor Faculty of Agro-Based Industry Universiti Malaysia Kelantan Jeli CampusLocked Bag 10017600 Jeli KelantanMalaysia Department of Research and Development Jeli Agricultural TechnologyPT7458 Kampung Gemang Baru17700 Ayer LanasJeli KelantanMalaysia

Agricultural wastes,including cocoa pod husk(waste from the chocolate industry)and sugarcane bagasse(waste from the sugar industry),are increasing day by *** development of food packaging biofilms from these two wastes could be beneficial to the environment and ***,this study was conducted to develop biodegradable plastic films by using cocoa pod husk and sugarcane *** and fibre were extracted from cocoa pod husk and sugar-cane bagasse,*** developed bioplastic films were divided into several concentration ratios of cellulose and fibre which are 100꞉0(100%cellulose),75꞉25(cellulose꞉fibre),50꞉50(cel-lulose꞉fibre),25꞉75(cellulose꞉fibre),and 0꞉100(100%fibre).The physicochemical properties for all bioplastic concentration ratios were determined in terms of sensory evaluation,drying time,moisture content,water absorption and water vapor *** the observation and anal-ysis of the physicochemical properties of bioplastic,we found that the most suitable bioplastic film for food packaging goes to the combination of 75%cellulose and 25%fibre bioplastic,as it demonstrated the lowest water absorption percentage and water vapor permeability.

关键词： Agricultural waste Cocoa pod husk Sugarcane bagasse Bioplastic film Water absorption Moisture content

The effect of nanosilica sizes in the presence of nonionic TX100 surfactant on CO_(2)foam flooding

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Petroleum Research 2022年第1期7卷 62-76页

作者： Suriatie mat Yusuf Radzuan Junin mohd Akhmal Muhamad Sidek Muhammad AManan mohd Fazril Irfan Ahmad Fuad mohd Zaidi Jaafar Effah Yahya nor Roslina Rosli Department of Petroleum Engineering School of Chemical and Energy EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310Johor BahruMalaysia Institute for Oil and Gas Universiti Teknologi Malaysia81310Johor BahruMalaysia School of Chemical Engineering College of EngineeringUniversiti Teknologi MARA40450 Shah AlamSelangorMalaysia

The aim of this research is to study the effect of hydrophilic silica nanoparticles,sizes as CO_(2) foam stabilizer in the presence of nonionic TX100 *** nanosilica sizes,15 and 70 nm,have been examined *** of TX100 on silica nanoparticles(nanosilica)was characterized by adsorption isotherm and surface tension measurement,while CO_(2) foams stability was quantified based on their foamability,foam stability,particle partitioning in the foams,and bubble *** show that direct contact of TX100 with nanosilica does altered the wettability of hydrophilic nanosilica surface,enable them to lengthen CO_(2) foams life at certain surfactant and nanoparticles *** 15 nm nanosilica,CO_(2) foam stability shows excellent performance at 0.1 and 0.5 wt%TX100 *** for 70 nm nanosilica,CO_(2) foam demonstrates longer lifetime at much lower TX100 concentration,0.01 wt%.Without the presence of TX100,CO_(2) foams exhibit undesirable lifetime performances for both nanosilica *** partitioning in CO_(2) foams structures demonstrate consistent relation with contact angle *** bubble sizes shows insignificant effect on CO_(2) foams *** the assists of nanosilica and TX100,enhanced oil recovery via CO_(2) foam injection succeeds in increasing oil production by 13e22%of original oil-in-place(OOIP).

关键词： Nanoparticle sizes Adsorption Nonionic surfactant TX100 surfactant Foamability CO_(2)foam stability CO_(2)foam flooding EOR

Screening the synergy of sodium dodecylbenzenesulfonate and carboxymethyl cellulose for surfactant-polymer flooding

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Petroleum Research 2022年第3期7卷 308-317页

作者： Suriatie mat Yusuf Radzuan Junin mohd Akhmal Muhamad Sidek Augustine Agi mohd Fazril Irfan Ahmad Fuad nor Roslina Rosli norazah Abd Rahman Effah Yahya nor Adilah Muhamad Soffian Wong Muhammad Hazim Mustaza Department of Petroleum Engineering School of Chemical and Energy EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310Johor BahruMalaysia Institute for Oil and Gas Universiti Teknologi Malaysia81310Johor BahruMalaysia School of Chemical Engineering College of EngineeringUniversiti Teknologi MARA40450Shah AlamSelangorMalaysia

Carboxymethyl cellulose(CMC)has emerged in oil and gas industries as a superior substitution to the conventional HPAM and xanthan gum(XG)for high viscosity polymer flooding *** this study,the combined effect of conventional surfactant,sodium dodecylbenzenesulfonate(SDBS)and CMC for potential surfactant-polymer(SP)flooding in enhanced oil recovery(EOR)has been ***,SDBS–CMC interaction and the functional groups present in CMC were appropriately *** presence of various C–O bonds signifies the existence of carboxymethyl group which greatly influence the rheological properties of CMC *** behaviour of SDBS–CMC was characterized by their viscosity,shear rate,solubilization,wettability,and surface *** flooding utilizing SDBS-CMC was performed and compared to commercial SDBS-XG SP *** results indicate several SDBS-CMC combinations are favourable for EOR *** viscosity shows direct relationship with CMC ***,at any given SDBS concentrations,significant increment was observed at 0.3 wt%and ***,the trend displayed inconclusive relation to SDBS *** of the SDBS-CMC combinations generate Winsor III emulsions particularly at CMC of 0.2 and 0.3 wt%,while Type II were observed in few *** CMC concentrations increased the contact angle,while gradual reductions were observed with SDBS *** gradual reduction in surface tension was highly influenced by the addition of CMC rather than SDBS.A novel combination of 0.3 wt%SDBS and 0.4 wt%CMC possessed an encouraging criterion in term of viscosity,solubilization,and surface tension reduction for EOR *** experiment from several SDBS-CMC combinations proved to recover additional oil ranging 16.4–20.2%of oil initially in place(OIIP).The trend in incremental oil recovery is similar to that of when utilising SDBS-XG.

关键词： Carboxymethyl cellulose Sodium dodecylbenzenesulfonate Enhanced oil recovery Surfactant-polymer flooding

Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine:A review

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Asian Pacific Journal of Tropical Medicine 2022年第1期15卷 7-16页

作者： Nur Ellene mat Luwi Suhana Ahmad Ahmad Suhaimi Nurfatihah Azlyna Asyikin nordin Maria Elena Sarmiento Armando Acosta mohd nor norazmi Vuk Uskoković Rohimah Mohamud Ramlah Kadir Department of Immunology School of Medical SciencesUniversiti Sains Malaysia16150 Kubang KerianKelantanMalaysia School of Health Sciences Universiti Sains Malaysia16150 Kubang KerianKelantanMalaysia Department of Mechanical Engineering San Diego State UniversityCampanile Dr.5500San Diego 921982CAUSA TardigradeNano LLC IrvineCA 92604USA

Liposomes are phospholipid bilayer vesicles,which are biocompatible,biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery *** this review,we discuss the prospect of using liposome technology in the development of a vaccine for *** remains an important health problem that requires the development of an effective vaccine,especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin(BCG)one developed 100 years *** review focuses on the different applications of liposomes toward achieving this *** liposomal formulations showing prospect in the research stage and in clinical trials are discussed.

关键词： Liposomes Tuberculosis vaccine Adjuvant Delivery system Tuberculosis

Low-energy X-ray attenuation characteristics of Rhizophora ***

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Nuclear Science and Techniques 2021年第3期32卷 11-29页

作者： Damilola Oluwafemi Samson Ahmad shukri mohd Zubir mat Jafri Rokiah Hashim mohd Zahri Abdul Aziz Sylvester Jande Gemanam mohd Fahmi mohd Yusof School of Physics Universiti Sains Malaysia11800 GelugorPenangMalaysia School of Industrial Technology Universiti Sains Malaysia11800 GelugorPenangMalaysia Advanced Medical and Dental Institute Universiti Sains Malaysia13200 BertamPenangMalaysia School of Health Sciences Universiti Sains Malaysia16150 Kota BharuKelantanMalaysia

Photon absorption parameters such as mass attenuation coefficients(μ_m),molar extinction coefficients(ε),total molecular(σ_(t,m)),atomic(σ_(t,a))and electronic(σ_(t,el))cross sections,half-value layers(X_(1/2)),tenth-value layers(X_(1/10)),mean free paths(λ),effective atomic numbers(Z_(eff)),and effective electron densities(N_(el))were estimated for defatted soy flour(DSF),soy protein concentrate(SPC),and soy protein isolate(SPI)-based Rhizophora *** composites substituted with 10 wt%sodium hydroxide(NaOH)and 0,5,10,and 15 wt%itaconic acid polyamidoamine-epichlorohydrin(IA-PAE)*** composition was assessed using ultrahigh-resolution field emission scanning electron microscopy-energy dispersive X-ray spectrometry(UHR-FESEM-EDX).The interaction parameters were evaluated for K_(α1)photons at16.59,17.46,21.21,and 25.26 keV,employing a low-energy germanium(LEGe)detector system and an~(241)Amγ-ray source.X-ray diffraction characterization revealed an amorphous phase in the developed particleboard *** DSF15',SPC15',and SPI15'exhibited the highest values ofμ_m,ε,σ_(t,m),Zeff,and N_(el)among all of the studied particleboard samples,within the range of measured photon *** addition,all of the modified samples exhibited lower X_(1/2),X_(1/10),λ,σ_(t,a),andσ_(t,el)than the unmodified samples,with DSF-,SPC-,and SPI/NaOH/Rhizophora spp./IA-PAE(15 wt%),indicating insignificant *** current results of the particleboard samples'analysis can be useful for medical radiation applications and shielding research.

关键词： Photon interaction parameters Shielding DSF–SPC–SPI Particleboards NaOH/IA-PAE

Role of toll like-receptor 2 in inflammatory activity of macrophage infected with a recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 333-339页

作者： nor Munirah Zakaria Rapeah Suppian norazmi mohd nor nor Fazila Che mat School of Health Sciences Health Campus Universiti Sains Malaysia

Objective: To investigate the role of toll-like receptor 2(TLR2) in inflammatory activity of macrophage infected with the recombinant Mycobacterium bovis bacillus Calmette-Guerin(rBCG). Methods: Mouse macrophage cell line J774 A.1 was infected with Mycobacterium bovis bacillus Calmette-Guerin(BCG) and rBCG cultures for 48 h in the presence or absence of 10 μg/mL of TLR2 inhibitor. Untreated macrophages were used as a negative control while lipopolysaccharide-stimulated macrophages were used as a positive control. The ability of the macrophage to engulf the BCG and rBCG in the absence or presence of TLR2 inhibitor was assessed using a phagocytic assay, while the production of inflammatory cytokines and nitric oxide by the infected macrophages was evaluated using ELISA and Griess reagent method, while the expression of the inducible nitric oxide synthase was determined using Western blot analysis. Results: The results showed that blocking TLR2 function reduced the phagocytic activity, nitric oxide production and proinflammatory cytokine secretion such as TNF-α, IL-1β and IL-12 p40 as well as inducible nitric oxide synthase expression in the infected macrophages. These data showed the importance of TLR2 in the activation of macrophages following BCG and r BCG infections. Conclusions: Through exploring the immunological mechanism which underlies the protection conferred by the candidate vaccine, this study will improve our understanding of the vaccine candidate's mechanism to protect the host from malaria infection.

关键词： Macrophages Mycobacterium bovis bacillus Calmette-Guerin Plasmodium falciparum Proinflammatory cytokine Toll-like receptor 2

Identifications of drug resistance mutations among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 73-76页

作者： Rozainanee mohd Zain Nabila Ibrahim Suriani Ismail Jeyanthi Suppiah nor Aziyah mat Rahim Ravindran Thayan Virology Unit Institute for Medical ResearchInfectious Disease Research CentreJalan Pahang50588Kuala LumpurMalaysia

Objective: To determine drug resistance mutations and the HIV-1 subtypes among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia,Methods: A total of 45 samples from four hospitals that provide HIV viral load services were subjected to the amplification of the protease and two third of reverse transcriptase regions of the pol gene by RT-PCR and Sanger sequencing,Drug resistance mutation(DRM) interpretation reports the presence of mutations related to protease inhibitors(PIs),Nucleoside reverse-transcriptase inhibitors(NRTI) and Non-nucleoside reverse-transcriptase inhibitors(NNRTI) based on analysis using Stanford HIV database program,Results: DRMs were identified in 35% of patients,among which 46.7% of them showed minor resistance to protease inhibitor with A71 V and L10 l were the commonest DRMs detected,About 21.4% and 50.0% of patients had mutations to NRTIs and NNRTIs,respectively,CRF01_AE was found to be the predominant HIV-1 subtype,Conclusions: These findings have served as an initial crucial data in determining the prevalence of transmitted HIV-1 drug resistance for the country,However,more samples from various parts of the country need to be accumulated and analyzed to provide overall HIV-1 drug resistance in the country.

关键词： HIV Resistance Malaysia Antiretroviral treatment naive

Proapoptotic activities of Oroxylum indicum leave extract in HeLa cells

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Asian Pacific Journal of Tropical Biomedicine 2019年第8期9卷 339-345页

作者： Nurul Hidayah Wahab Nur Afina mohd Din Yee Ying Lim Noor Izani Noor Jamil nor Fazila Che mat School of Health Sciences Health Campus Universiti Sains Malaysia

Objective: To examine the proapoptotic properties of Oroxylum indicum methanol extract on cervical cancer cells. Methods: Methylene blue assay was used to determine the IC50 value of the extract. Western blotting assays were done to analyze the expression of HPV oncoproteins (HPV18 E6 and E7) and apoptotic molecules (caspase-3 and caspase-8). Reverse transcriptase PCR assays were performed to determine genetic alteration of tumor suppressors p53 and pRb and apoptosis markers Fas and FasL. Enzyme-linked immunosorbent assay (ELISA) was done to determine the expression of cytokine levels (IL-6 and IL-12). Results: The determination of IC50 value indicated a higher anti-proliferative activity of the extract compared to cisplatin. After 24 hours of treatment, Western blot analysis showed that treated HeLa cells exhibited a significant down-regulation of HPV18 oncoproteins E6 and E7, and a significant induction of caspase-8 and caspase-3 activation level. Meanwhile, the mRNA expressions of p53, pRb, Fas and FasL were significantly upregulated in treated cells. Moreover, ELISA showed an increased IL-12 and decreased IL-6 production after Oroxylum indicum treatment. Conclusions: The methanol extract of Oroxylum indicum has an anti-proliferative activity and proapoptotic potential. It induces localized-immunity improvements by altering cytokine production in HPV-positive cervical cancer cells.

关键词： Oroxylum indicum Proapoptotic Anti-proliferative HeLa cells

Sharing experiences from a reference laboratory in the public health response for Ebola viral disease, MERS-CoV and H7N9 influenza virus investigations

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 199-200页

作者： T.S.Saraswathy Subramaniam Ravindran Thayan mohd Apandi Yusof Jeyanthi Suppiah Tengku Rogayah Tg Abd Rashid Zarina mohd Zawawi nor Aziyah mat Rahim Fauziah Kassim Rozainanee mohd Zain Zainah Saat Virology Unit Institute for Medical Research

The International Health Regulations was enforced in June 2007,emphasizing the obligation of State Parties to detect,report,and respond to public health emergencies[1].An effective public health response requires a coordinated laboratory response in the Ministry of Health(MOH)network with credible laboratories capable of providing accurate and reliable results in a timely manner to enable effective public health measures

关键词： obligation providing coordinated enable timely capable laboratories manner sequencing detecting

Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

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Neural Regeneration Research 2021年第3期16卷 482-488页

作者： Monica L.Acosta mohd N.mat nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green School of Optometry and Vision Science University of AucklandAucklandNew Zealand Faculty of Medicine Universiti Sultan Zainal AbidinTerengganuMalaysia Department of Ophthalmology University of AucklandAucklandNew Zealand Buchanan Ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand New Zealand National Eye Centre University of AucklandAucklandNew Zealand Centre for Brain Research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain Research New Zealand–Rangahau Roro Aotearoa AucklandNew Zealand

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of *** of these compounds are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,despite evidence of functional *** the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels,their function as channels and possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evidence implicating pannexins and connexins in disease,considering their homeostatic versus pathological roles,their contribution to excesive ATP release linked to disease onset and progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat