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Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 249-256页

作者： Wan Suriyani Wan-Ibrahim Norzila Ismail Siti Farhanah mohd-Salleh Aidy Irman Yajid Michael Pak-KaiWong mohd nizam Md hashim Department of Pharmacology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Surgery School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Objective:To determine the anti-proliferative activity of Abrus precatorius(***)leaf extracts and their effect on cell ***:*** leaves were extracted successively with hexane,ethyl acetate and methanol by Soxhlet *** extract was prepared by decoction at 50 ℃.Extracts of *** leaves were used to treat selected cancer and normal cell lines for72 ***,3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide assay was performed to determine cell *** of cell cycle arrest,apoptosis assay and apoptosis protein expressions were determined by flow ***:Methanolic extract of *** leaves showed the lowest IC50 on MDA-MB-231 cells at(26.40±5.40)μg/*** cytometry analysis revealed that cell arrest occurred at G0/G1 phase and the apoptosis assay showed the occurrence of early apoptosis at 48 h in MDAMB-231 cells treated with methanolic extract of *** *** extract of *** leaves induced apoptosis by upregulation of Bax,p53 and caspase-3 and downregulation of ***:Methanolic extract of A precatorius leaves promotes MDA-MB-231 cell death by inducing cell cycle arrest and apoptosis possibly via the mitochondrial-related pathway.

关键词： Abrus precatorius MDA-MB-231 Apoptosis Cell cycle Breast cancer

Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 659-665页

作者： Husna Syakirah Ab Rahman Wan Suriyani Wan-Ibrahim Norzila Ismail Tuan Nadrah Naim Tuan Ismail Siti Farhanah mohd-Salleh Michael Pak-Kai Wong mohd Ridzuan Abdul Samad mohd nizam Md hashim Department of Surgery School of Medical Sciences Universiti Sains Malaysia Department of Pharmacology School of Medical Sciences Universiti Sains Malaysia School of Dental Sciences Universiti Sains Malaysia

Objective: To identify the phytochemical compounds from Annona muricata(A. muricata) and to determine their in vitro anti-proliferative activities against breast cancer cells, MCF7 and MDA-MB-231. Methods: A. muricata leaves were successively extracted by soxhlet method using n-hexane, ethyl acetate and methanol, and decocted with water. Each extract was analysed by gas chromatography mass spectrometry(GCMS) and characterized with Wiley and NIST library searches. Anti-proliferative activity of each extract was evaluated on MCF7 and MDA-MB-231 breast cancer cells using MTT assay. Results: The GCMS analysis of different solvent extracts of A. muricata leaves showed presence of different chemical groups of compounds such as steroids, terpenoids, phenolic compounds, sugars, sugars alcohol and others including vitamin E. Ethyl acetate leaves extract exhibited the lowest IC_(50) value on the MDA-MB-231 breast cancer cell and n-hexane leaves extract showed the the lowest IC_(50) value on the MCF-7 breast cancer cell. Conclusion: Steroids and phenolic compounds were the main phytocompound groups identified from all A. muricata leaves extracts. The antiproliferative activity of n-hexane and ethyl acetate extract towards breast cancer MCF7 and MDA-MB-231 respectively might be due to the presence of biologically active compounds in the extracts, hence, providing some scientific evidences of the effectiveness of its traditional usages.

关键词： Annona muricata GCMS Anti-proliferative Breast cancer Graviola

A Multidisciplinary Approach in Management of Breast Cancer: Case Study and Literature Reviews

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Journal of Cancer Therapy 2013年第7期4卷 7-11页

作者： Andee Dzulkarnaen Zakaria Nur Farhana Abd Salam Wan Zainira Wan Zain mohd nizam hashim School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia

The diagnosis of breast cancer can cause a significant anxiety in someone’s life. The care of the breast cancer patient requires in many centres. The care of breast cancer patient is undertaken as a joint venture between the surgeon, medical oncologist, radiotherapist, pathologist and allied health professionals such as the clinical nurse specialist as well as counsellors. This is a case of a 39-years-old Malay woman presented to HUSM with a history of ulcerating breast lump with bloody pus discharge on the right breast. An initial mammogram study showed lesion suspicious of malignancy, and histopathological examination was consistent with invasive ductal carcinoma. She received neoadjuvant chemotherapy before proceeding to right modified radical mastectomy with axillary clearance and immediate chest wall reconstruction. Detailed discussion on the diagnosis, treatment, surgical intervention and progress of the patient with reference to available literature reviews are presented.

关键词： Breast Cancer Multidisciplinary Approach Reconstructive Surgery

Exploring Nutritional Compositions,Volatile Compounds,Health Benefits,Emerging Processing Technologies,and Potential Food Products of Glutinous Rice:A Review

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Rice science 2024年第3期31卷 251-268页

作者： Maimunah mohd ALI Norhashila hashim Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600SelangorMalaysia Department of Biological and Agricultural Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia SMART Farming Technology Research Centre Faculty of EngineeringUniversiti Putra MalaysiaUPM Serdang 43400SelangorMalaysia Innovation Center for Confectionary Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM Bangi 43600Selangor Darul EhsanMalaysia

Glutinous rice(Oryza sativa ***)stands out as one of the most popular rice varieties globally,amidst thousands of rice *** increasing popularity is attributed to its rich nutritional compositions and health *** review aims to summarize the nutritional compositions,volatile compounds,and health benefits of glutinous ***,in-depth studies are necessary to explore the utilization of glutinous rice in enhancing processing technologies and developing new food *** rice has been shown to possess numerous health benefits,including antioxidant activity,bioactive compounds,anti-cancer properties,anti-inflammatory effects,anti-diabetic potential,and cholesterol-lowering *** its nutritional compositions,the major volatile compounds identified in glutinous rice could serve as a functional food for human *** processing technologies related to glutinous rice are elaborated to improve the latest developments for incorporating them into various food products.

关键词： glutinous rice health benefit volatile compound nutritional composition processing technology

Can the Bass innovation diffusion model describe adsorption breakthrough curves of pharmaceutical contaminants?

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Green Chemical Engineering 2024年第2期5卷 145-149页

作者： Khim Hoong Chu mohd Ali hashim Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia

*** Fixed bed adsorption is a widely used separation process in the chemical industry for the processing of liquids and *** performance of fixed bed adsorption systems is often evaluated by analyzing the breakthrough curves,which represent the variation of the solute concentration in the effluent stream as a function of time or bed volume.

关键词： adsorption breakthrough curves

Dye-tolerant marine Acinetobacter baumannii-mediated biodegradation of reactive red

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Water Science and Engineering 2018年第4期11卷 265-275页

作者： Sneha Unnikrishnan mohd hashim Khan Karthikeyan Ramalingam School of Life Sciences B.S.Abdur Rahman Crescent Institute of Science and Technology

The objective of this study was to isolate a potent dye-degrading microbe that can be used to reduce the pollution caused by industrial *** red 198 is an extensively used textile dye and is a major environmental pollutant in water bodies. In this study, a bacterial strain was isolated from sea sediments and identified as Acinetobacter baumannii with 16S rRNA sequencing. The isolated bacteria were immobilized in calcium alginate and decolorization studies were carried out to determine the optimum pH, temperature, dye concentration, inoculum volume,and static/agitated condition using the one factor at a time(OFAT) approach. The Box-Behnken design, a type of response surface methodology,was adopted to improve the degradation efficiency. At 37℃ using an inoculum volume of six beads, 96.20% decolorization was observed in 500 mg/L of reactive red 198 after 72 h. Dye degradation was confirmed with UV-visible spectroscopy and Fourier-transform infrared(FTIR)spectroscopy studies of the dye and degraded metabolites. Microbial toxicity studies using Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and phytotoxicity studies using Vigna radiata proved that the toxicity of the dye was significantly reduced after degradation. We can conclude that the isolated A. baumannii strain is an efficient dye-degrading microbe that can be used to reduce the pollution caused by industrial dyes.

关键词： Immobilization Box-Behnken design Response surface methodology Microbial toxicity Dye degradation

Modeling sprawl of unauthorized development using geospatial technology: case study in Kuantan district, Malaysia

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International Journal of Digital Earth 2011年第3期4卷 223-238页

作者： Mazlan hashim Norzailawati mohd Noor Maged Marghany Institute of Geospatial Science&Technology(INSTEG) Faculty of Geoinformation Sciences and EngineeringUniversiti Teknologi Malaysia81300 UTM SkudaiJohor BahruMalaysia

The paper explores a framework combining remote sensing and GIS-cellular automata(CA)concepts aimed at improving the modeling of unauthorized land use *** sensing data have been used in urban modeling and analysis,the use of high-resolution remote sensing data in assessing unauthorized development is quite *** work has demonstrated systematic combination utilization of geospatial analyses tools to acquire a new level of information to enable urban modeling and sprawl analysis in assisting urban sustainable *** this study,Kuantan city,Malaysia was selected in simulation of the unauthorized land use with CA concept for a period of 15 years(20002015),with main input time-series land use observation from 1995 to *** 2000 and 2005 land use input was also used as calibrated and test assessment of the *** results show excellent agreement between in-situ changes of the unauthorized land use classes and the corresponding simulated classes within the same *** conclusion,CA model can lead to new levels of understanding of how urban areas grow and change as in view of digital earth aspiration.

关键词： cellular automata sprawl remote sensing GIS urban simulation

Low-energy X-ray attenuation characteristics of Rhizophora ***

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Nuclear Science and Techniques 2021年第3期32卷 11-29页

作者： Damilola Oluwafemi Samson Ahmad Shukri mohd Zubir Mat Jafri Rokiah hashim mohd Zahri Abdul Aziz Sylvester Jande Gemanam mohd Fahmi mohd Yusof School of Physics Universiti Sains Malaysia11800 GelugorPenangMalaysia School of Industrial Technology Universiti Sains Malaysia11800 GelugorPenangMalaysia Advanced Medical and Dental Institute Universiti Sains Malaysia13200 BertamPenangMalaysia School of Health Sciences Universiti Sains Malaysia16150 Kota BharuKelantanMalaysia

Photon absorption parameters such as mass attenuation coefficients(μ_m),molar extinction coefficients(ε),total molecular(σ_(t,m)),atomic(σ_(t,a))and electronic(σ_(t,el))cross sections,half-value layers(X_(1/2)),tenth-value layers(X_(1/10)),mean free paths(λ),effective atomic numbers(Z_(eff)),and effective electron densities(N_(el))were estimated for defatted soy flour(DSF),soy protein concentrate(SPC),and soy protein isolate(SPI)-based Rhizophora *** composites substituted with 10 wt%sodium hydroxide(NaOH)and 0,5,10,and 15 wt%itaconic acid polyamidoamine-epichlorohydrin(IA-PAE)*** composition was assessed using ultrahigh-resolution field emission scanning electron microscopy-energy dispersive X-ray spectrometry(UHR-FESEM-EDX).The interaction parameters were evaluated for K_(α1)photons at16.59,17.46,21.21,and 25.26 keV,employing a low-energy germanium(LEGe)detector system and an~(241)Amγ-ray source.X-ray diffraction characterization revealed an amorphous phase in the developed particleboard *** DSF15',SPC15',and SPI15'exhibited the highest values ofμ_m,ε,σ_(t,m),Zeff,and N_(el)among all of the studied particleboard samples,within the range of measured photon *** addition,all of the modified samples exhibited lower X_(1/2),X_(1/10),λ,σ_(t,a),andσ_(t,el)than the unmodified samples,with DSF-,SPC-,and SPI/NaOH/Rhizophora spp./IA-PAE(15 wt%),indicating insignificant *** current results of the particleboard samples'analysis can be useful for medical radiation applications and shielding research.

关键词： Photon interaction parameters Shielding DSF–SPC–SPI Particleboards NaOH/IA-PAE

Biosynthesized Persicaria odorata-silver nanoparticles supported zeolite Y as biocompatible antibacterial agent against Cutibacterium acnes

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Particuology 2024年第10期93卷 1-10页

作者： Muhammad Hariz Asraf Nik Ahmad nizam Nik Malek Muhammad Redza mohd Radzi Hendra Susanto Department of Biosciences Faculty of ScienceUniversiti Teknologi Malaysia81310SkudaiJohorMalaysia Centre for Sustainable Nanomaterials(CSNano) Ibnu Sina Institute for Scientific and Industrial Research(ISI-SIR)Universiti Teknologi Malaysia81310UTMJohorMalaysia Department of Biology Faculty of Mathematics and Natural SciencesUniversitas Negeri MalangIndonesia

Conventionally synthesized silver nanoparticles(AgNP)imposed an alarming effect on the environment and caused toxicity to ***,the use of zeolite(zeoY)as a support system could increase its biocompatibility and reduce its ***,green synthesis of AgNP using Persicaria odorata leaves extract supported on zeolite Y has been prepared by an in situ synthesis *** phytochemical compounds in the optimized leaf extract concentration of 1%and volume of 0.9 mL reduced the silver ions to AgNP within the zeolite Y *** observation revealed the incorporation of AgNP in the zeolite Y(average size:18.51 nm).The release of AgNP exhibited antibacterial activity on *** at a concentration lower than 1 g L^(−1) which is also dependent on the ***-zeoY promoted cell proliferation in vitro and it has a non-irritating effect when tested in the in vivo skin irritation model.

关键词： Silver nanoparticles Biosynthesis Zeolite Antibacterial Biocompatible

Mesoscale surface circulation and variability of Southern Indian Ocean derived by combining satellite altimetry and drifter observations

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Acta Oceanologica Sinica 2015年第9期34卷 12-22页

作者： BENNY N.Peter SHENBAKAVALLI Ranjan MAZLAN hashim mohd Nadzri Reba mohd Razali Mahmud Department of Coastal and Offshore Engineering School of Ocean Engineering and Underwater TechnologyKerala University of Fisheries and Ocean Studies Department of Geomatic Engineering Faculty of Geoinformation and Real EstateUniversity of Technology Malaysia Institute of Geospatial Science & Technology Faculty of Geoinformation and Real EstateUniversity of Technology Malaysia

High resoultion Eulerian mean velocity field has been derived by combining the satellite tracked surface drifter data with satellite altimetry and ocean surface winds. The drifter data used in this study includes Argos and surface drifter data from Global Drifter Program. Maps of Sea Level Anomaly （MSLA） weekly files with a resolution of （1/3）° in both Latitude and Longitude for the period 1993-2012 have been used. The Ekman current is computed using ocean surface mean wind fields from scatterometers onboard ERS 1/2, Quikscat and ASCAT. The derived mean velocity field exhibits the broad flow of Antarctic Circumpolar Current with speeds up to 0.6 m/s. Anomalous field is quite significant in the western part between 20~ and 40~E and in the eastern part between 80~E and 100~E with velocity anomaly up to 0.3 m/s. The estimated mean flow pattern well agrees with the dynamic topography derived from in-situ observations. Also, the derived velocity field is consistent with the in-situ ADCP current measurements. Eddy kinetic energy illustrates an increasing trend during 1993-2008 and is in phase coherence with the Southern Annular Mode by three month lag. Periodic modulations are found in the eddy kinetic energy due the low frequency Antarctic Circumpolar Wave propagation.

关键词： Antarctic Ocean circulation satellite altimetry eddy kinetic energy Southern Indian Ocean antarctic circumpolar wave