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Anthrax lethal toxin and tumor necrosis factor-a synergize on intestinal epithelia to induce mouse death

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Protein & Cell 2024年第2期15卷 135-148页

作者： Xinhe Gao Teng Teng Yifei Liu Tingting Ai Rui Zhao Yilong Fu Peipei Zhang jiahuai han Yingying Zhang State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Research Unit of Cellular Stress of CAMS Xiang'an Hospital of Xiamen UniversityCancer Research Center of Xiamen UniversitySchool of MedicineFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Laboratory Animal Center Faculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China

Bacillus anthracis lethal toxin(LT)is a determinant of lethal *** function in myeloid cells is required for bacterial dissemination,and LT itself can directly trigger dysfunction of the cardiovascular *** interplay between LT and the host responses is important in the pathogenesis,but our knowledge on this interplay remains *** necrosis factor-a(TNF-a)is a pleiotropic pro-inflammatory cytokine induced by bacterial *** LT accumulates and cytokines,predominantly TNF,amass during *** infection,co-treatment of TNF+LT in mice was used to mimic in vivo conditions for LT to function in inflamed *** marrow transplantation and genetically engineered mice showed unexpectedly that the death of intestinal epithelial cells(IECs)rather than that of hematopoietic cells led to LT+TNF-induced *** of p38a mitogen-activated protein kinase(MAPK)signaling by LT in IECs promoted TNF-induced apoptosis and necroptosis of IECs,leading to intestinal damage and mouse ***,p38a inhibition by LT enhanced TNF-mediated cell death in human colon epithelial HT-29 *** intestinal damage is one of the leading causes of lethality in anthrax patients,the IEC damage caused by LT+TNF would most likely be a mechanism underneath this clinical manifestation and could be a target for interventions.

关键词： lethal toxin TNF p38a intestinal epithelial cell cell death

Enhancing Photovoltaic Performance of Nonfused-Ring Electron Acceptors via Asymmetric End-Group Engineering and Noncovalently Conformational Locks

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Chinese journal of Chemistry 2024年第5期42卷 485-490页

作者： Bo Liu Congqi Li Xiaobin Gu Yinghui han Zhixiang Wei Yunhao Cai Xin Zhang Hui Huang Yanping Huo School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhouGuangdong510006 China College of Materials Science and Opto-Electronic Technology & Center of Materials Science and Optoelectronics Engineering & CAS Center for Excellence in Topological Quantum Computation & CAS Key Laboratory of Vacuum Physics University of Chinese Academy of SciencesBeijing100049 China College Resources and Environment University of Chinese Academy of SciencesBeijing100049 China Center for Excellence in Nanoscience (CAS) & Key Laboratory of Nanosystem and Hierarchical Fabrication (CAS) National Center for Nanoscience and TechnologyBeijing100190 China

By employing the asymmetric end-group engineering,an asymmetric nonfused-ring electron acceptor(NFREA)was designed and *** with the symmetric analogs(NoCA-17 and NoCA-18),NoCA-19 possesses broader light absorption range,more coplanarπ-conjugated backbone,and appropriate crystallinity according to the experimental and theoretical *** organic solar cells based on j52:NoCA-19 exhibited a power conversion efficiency as high as 12.26%,which is much higher than those of j52:NoCA-17(9.50%)and j52:NoCA-18(11.77%),mainly due to more efficient exciton dissociation,better and balanced charge mobility,suppressed recombination loss,shorter charge extraction time,longer charge carrier lifetimes,and more favorable blend film *** findings demonstrate the great potential of asymmetric end-group engineering in exploring low-cost and high-performance NFREAs.

关键词： Organic solar cells Nonfused-ring electron acceptors Asymmetric end-group engineering Noncovalently conformational locks Low-cost acceptors

Interstitial carbon induces enriched Cu^(δ+) sites in Cu_(2)O nanoparticles to facilitate CO_(2) electroreduction to C_(2+) products

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Nano Research 2024年第8期17卷 7013-7019页

作者： Haoran Wang Rongbo Sun Peigen Liu Haohui Hu Chen Ling Xiao han Yi Shi Xusheng Zheng Geng Wu Xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Sinochem Holdings Co Ltd Xiongan New AreaHebei 071700China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China

The electrochemical CO_(2) reduction reaction(CO_(2)RR)holds significant promise in advancing carbon *** catalysts for the electrochemical CO_(2)RR to multi-carbon(C_(2+))products(e.g.,C_(2)H_(4))under industrial-level current density is urgently needed and ***,we report the Cu_(2)O nanoparticles doped with interstitial carbon atoms(denoted as C-Cu_(2)O NPs)for the conversion of CO_(2) to C_(2+)*** interstitial carbon promotes the C-Cu_(2)O NPs to possess abundant unsaturated Cu–O bonds,leading to a high-density Cu^(δ+)(0<δ<1)*** obtained C-Cu_(2)O NPs exhibited significant Faradic efficiency(FE)of C_(2+) products approaching 76.9%and a partial current density reaching 615.2 mA·cm^(–2)under an industrial-level current density of 800 mA·cm^(–2).Furthermore,the efficient electrosynthesis of C_(2)H_(4) achieved an FE of 57.4%with a partial current density of 459.2 mA·cm^(–2).In situ electrochemical attenuated total reflection Fourier transform infrared spectroscopy and in situ Raman spectroscopy analyses revealed that C-Cu_(2)O NPs stabilized the intermediate*CO and facilitated C–C coupling,leading to increased selectivity towards C_(2+) products.

关键词： CO_(2) electroreduction C-C coupling interstitial carbon *CO coverage industrial-level current density

Smooth muscle cell-specific genetic targeting by Myh11-driven Cre(ER)knockin mice

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Science China(Life Sciences) 2024年第10期67卷 2280-2282页

作者： Enci Wang Ximeng han Haixiao Wang Kathy O.Lui Bin Zhou Lixin Wang Department of Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Cardiology Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Pediatric Research Institute The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China Department of Chemical Pathology and Li Ka Shing Institute of Health SciencesPrince of Wales HospitalThe Chinese University of Hong KongHong Kong 999077China New Cornerstone Investigator Institute State Key Laboratory of Cell BiologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Department of Vascular Surgery(Xiamen) Zhongshan hospitalFudan UniversityXiamen 361015China

Dear editor,Site specific recombinases have been widely used for genome engineering in cardiovascular research(Fu et al.,2024;Huang et al.,2023;Xue et al.,2022).In particular,Cre is the most broadly used recombinase for cell type-specific lineage tracing and gene manipulation in *** smooth muscle cell(SMC)-specific targeting,several SMC promoters including Myh11(smooth muscle myosin heavy chain),Acta2(smooth muscle a-2 actin),and SM22a(Tagln)have been used to drive Cre or CreER.

关键词： cardiovascular manipulation

Tungsten separation behavior on preparation of high-purity cerium by combined vacuum gravity sedimentation-directional solidification

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journal of Rare Earths 2024年第6期42卷 1182-1186,I0007页

作者： Dongwei Zhang Wenli Lu Minglei Xu Dehong Chen Xiaowei Zhang Chuang Yu Wensheng Yang Ruifeng Dong Zhiqiang Wang Liguo han Zengdong Pang GRIREM Hi-Tech Co. Ltd.Langfang065201China National Engineering Research Center for Rare Earth China GRINM Group Co.Ltd.Beijing100088China GRIREM Advanced Materials Co. Ltd.Beijing100088China

In light of the difficult removal of harmful impurity tungsten(W)in Ce metal,in this paper a combined vacuum gravity sedimentation-directional solidification method was innovatively designed and the W separation behavior was *** reducing the electron beam power instantly and gradually at reduction rates of 1,3 and 5 kW/min,it is found that W is enriched at the bottom of ingots as the melt *** enrichment effect is much better than that of single purification method and the enrichment degree increases as the beam reduction rate decreases,attributed to the k0(W)>1 andρ(W)>ρ(Ce).Overall,the minimum content of W impurity can decrease from 630 to 0.1 ppm at the top of the ingot,and the purity of Ce increases from 99.932 wt%to 99.995 wt%by this combined ***,this paper provides a new method for the removal of high density and low evaporation coefficient impurities in low vapor pressure rare earth metals.

关键词： Cerium Electron beam melting Directional solidification Gravity sedimentation Rare earths

The actin motor protein OsMYA1 associates with OsExo70H1 and contributes to rice secretory defense by modulating OsSyp121 distribution

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journal of Integrative Plant Biology 2024年第9期66卷 2058-2075页

作者： Yuan‐Bao Li Chengyu Liu Ningning Shen Shuai Zhu Xianya Deng Zixuan Liu Li‐Bo han Dingzhong Tang State Key Laboratory of Ecological Control of Fujian‐Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of CropsPlant Immunity CenterFujian Agriculture and Forestry UniversityFuzhou 350002China College of Agriculture Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China School of Future Technology Fujian Agriculture and Forestry UniversityFuzhou 350002China

Magnaporthe oryzae(***)is a devastating hemibiotrophic *** biotrophic invasive hyphae(IH)are enclosed in the extrainvasive hyphal membrane produced by plant cells,thus generating a front line of the battlefield between the pathogen and the host *** plants,defense-related complexes such as proteins,callose-rich materials and vesicles,are directionally secreted to this interface to confer defense responses,but the underlying molecular mechanism is poorly *** this study,we found that a Myosin gene,Myosin A1(OsMYA1),contributed to rice *** OsMYA1 knockout mutant exhibited decreased resistance to *** ***1 localizes to the actin cytoskeleton and surrounds the IH of ***1 interacts with an exocyst subunit,OsExo70H1,and regulates its accumulation at the plasma membrane(PM)and pathogen–plant ***,OsExo70H1 interacted with the rice syntaxin of the plants121 protein(OsSyp121),and the distribution of OsSyp121 to the PM or the pathogen–plant interface was disrupted in both the OsMYA1 and OsExo70H1 ***,these results not only reveal a new function of OsMYA1 in rice blast resistance,but also uncover a molecular mechanism by which plants regulate defense against *** by OsMYA1-initiated vesicle secretory pathway,which originates from the actin cytoskeleton to the PM.

关键词： cytoskeleton plant defense mechanism rice blast vesicle delivery

Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEN You-qin han Yu-ying WEI Li-hui YAO Meng-ying FANG Yi WU Mei-zhu CHENG Ying Thomas j.Sferra LIU Hui-xin LI Li PENG jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (Phanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

Quantitative Applications of Weather Satellite Data for Nowcasting:Progress and Challenges

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journal of Meteorological Research 2024年第3期38卷 399-413页

作者： jun LI jing ZHENG Bo LI Min MIN Yanan LIU Chian-Yi LIU Zhenglong LI WPaul MENZEL Timothy j.SCHMIT john L.CINTINEO Scott LINDSTROM Scott BACHMEIER Yunheng XUE Yayu MA Di DI han LIN Innovation Centre for Fengyun Meteorological Satellite(FYSIC) National Satellite Meteorological CentreChina Meteorological AdministrationBeijing100081China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University and Southern Laboratory of Ocean Science and EngineeringZhuhai519082China Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai200241China Research Center for Environmental Changes Academia SinicaTaipei11529China Cooperative Institute for Meteorological Satellite Studies University of Wisconsin-MadisonMadisonWI53706USA Sensors and Calibration Branch STAR/NESDISMadisonWI53706USA Wuxi University Wuxi214105China School of Computer Science Chengdu University of Information TechnologyChengdu610225China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing210044China Key Laboratory of Spatial Data Mining and Information Sharing of Ministry of Education National and Local Joint Engineering Research Center of Satellite Geospatial Information TechnologyFuzhou UniversityFuzhou350108China

Monitoring and predicting highly localized weather events over a very short-term period,typically ranging from minutes to a few hours,are very important for decision makers and public *** these events usually relies on radar observations through monitoring and *** advanced high-resolution imaging and sounding observations from weather satellites,nowcasting can be enhanced by combining radar,satellite,and other data,while quantitative applications of those data for nowcasting are advanced through using machine learning *** applications include monitoring the location,impact area,intensity,water vapor,atmospheric instability,precipitation,physical properties,and optical properties of the severe storm at different stages(pre-convection,initiation,development,and decaying),identification of storm types(wind,snow,hail,etc.),and predicting the occurrence and evolution of the *** observations can provide information on the environmental characteristics in the preconvection stage and are very useful for situational awareness and storm *** paper provides an overview of recent progress on quantitative applications of satellite data in nowcasting and its challenges,and future perspectives are also addressed and discussed.

关键词： weather satellite quantitative applications nowcasting pre-convection

Activation of biomass-derived porous carbon for supercapacitors:A review

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Chinese Chemical Letters 2024年第7期35卷 121-138页

作者： Zixuan Guo Xiaoshuai han Chunmei Zhang Shuijian He Kunming Liu jiapeng Hu Weisen Yang Shaoju jian Shaohua jiang Gaigai Duan jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Institute of Materials Science and Devices Suzhou University of Science and TechnologySuzhou 215009China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China Fujian Provincial Key Laboratory of Eco-Industrial Green Technology Key Laboratory of Green Chemical Technology of Fujian Province UniversityCollege of Ecological and Resources EngineeringWuyi UniversityWuyishan 354300China

Due to the advantages of renewable,low pollution and wide distribution of biomass resources,it is selected as the electrode material for *** carbon-based electrode materials,specific surface area and pore structure have a great *** and summarizing the influence of activation on pore structure will greatly broaden this *** on the activation mechanism of activator,this paper summarizes the latest progress of biomass activation applied to supercapacitors,including traditional physical and chemical activation methods and non-traditional methods such as biological activation method,self-activation method,template assisted activation method and green activator ***,the challenges,strategies and prospects for the future development of biomass-derived carbon material activation are pointed *** summary,this review will help researchers choose appropriate strategies to design biomass-derived carbon electrode materials for supercapacitors,thereby promoting the application of biomass materials.

关键词： Biomass-derived Activation Pore structure Electrochemistry Supercapacitor