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Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

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World Journal of Experimental Medicine 2024年第1期14卷 113-123页

作者： Suriati mohd Nasir Anis Farihan ismail Tuan Salwani Tuan ismail Wan Faiziah Wan Abdul Rahman Wan Amir Nizam Wan Ahmad Tengku Ahmad Damitri Al-Astani Tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Endocrinology Laboratory Department of Chemical PathologySchool of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Biomedicine Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Basic Medical Sciences Kuliyyah of MedicineInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia

BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney *** is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic ***,the effect of stingless bee honey(SBH)administration in relieving liver and kidney damage in diabetes has not been *** To investigate the effect of SBH administration on the kidney and liver of streptozotocin-induced(STZ;55 mg/kg)diabetic Sprague Dawley *** The rats were grouped as follows(n=6 per group):non-diabetic(ND),untreated diabetic(UNT),metformin-treated(MET),and SBH+metformin-treated(SBME)*** successful diabetic induction,ND and UNT rats were given normal saline,whereas the treatment groups received SBH(2.0 g/kg and/or metformin(250 mg/kg)for 12 *** biochemical parameters and histological changes using hematoxylin and eosin(H&E)and periodic acid–Schiff(PAS)staining were *** On H&E and PAS staining,the ND group showed normal architecture and cellularity of Bowman’s capsule and tubules,whereas the UNT and MET groups had an increased glomerular cellularity and thickened basement *** SBH-treated group showed a decrease in hydropic changes and mild cellularity of the glomerulus vs the ND group based on H&E staining,but the two were similar on PAS ***,the SBME-treated group had an increase in cellularity of the glomerulus on H&E staining,but it was comparable to the SBH and ND groups on PAS *** diabetic rats had tubular hydropic tubules,which were smaller than other *** fatty vacuole formation and dilated blood sinusoids in liver tissue were seen in the SBH ***,the UNT group had high glucose levels,which subsequently increased MDA levels,ultimately leading to liver *** treatment reduced this damage,as evidenced by having the lowest fasting glucose,serum alanine transaminase,aspartate transaminase,and alkaline phosphatase l

关键词： Diabetes Streptozotocin Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney

Neuroprotective effects of exogenous brain-derived neurotrophic factor on amyloid-beta 1-40-induced retinal degeneration

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Neural Regeneration Research 2023年第2期18卷 382-388页

作者： mohd Aizuddin mohd Lazaldin Igor Iezhitsa Renu Agarwal Puneet Agarwal Nafeeza mohd ismail Department of Biosciences Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia School of Medicine International Medical UniversityKuala LumpurMalaysia Department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgogradRussia Faculty of Medicine Universiti Teknologi MARASungai Buloh CampusSelangorMalaysia

Amyloid-beta(Aβ)-related alterations,similar to those found in the brains of patients with Alzheimer's disease,have been observed in the retina of patients with *** levels of brain-derived neurotrophic factor(BDNF)are believed to be associated with the neurotoxic effects of Aβ*** investigate the mechanism underlying the neuroprotective effects of BDNF on Aβ_(1-40)-induced retinal injury in Sprague-Dawley rats,we treated rats by intravitreal administration of phosphate-buffered saline(control),Aβ_(1-40)(5 nM),or Aβ_(1-40)(5 nM)combined with BDNF(1μg/mL).We found that intravitreal administration of Aβ_(1-40)induced retinal ganglion cell ***-Gold staining showed a significantly lower number of retinal ganglion cells in the Aβ_(1-40)group than in the control and BDNF *** the Aβ_(1-40)group,low number of RGCs was associated with increased caspase-3 expression and reduced TrkB and ERK1/2 *** abolished Aβ_(1-40)-induced increase in the expression of caspase-3 at the gene and protein levels in the retina and upregulated TrkB and ERK1/2 *** findings suggest that treatment with BDNF prevents RGC apoptosis induced by Aβ_(1-40)by activating the BDNF-TrkB signaling pathway in rats.

关键词： amyloid-beta 1-40 brain-derived neurotrophic factor Fluoro-Gold neuroprotection retinal ganglion cells(RGC) retinal toxicity tropomyosin receptor kinase B(TrkB)

Wavelet Based Detection of Outliers in Volatility Time Series Models

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Computers, Materials & Continua 2022年第8期72卷 3835-3847页

作者： Khudhayr A.Rashedi mohd Tahir ismail Abdeslam Serroukh SAl wadi School of Mathematical Sciences University Sains MalaysiaMindenPenang11800Malaysia Faculty of Science University of Ha’ilHail81451Kingdom of Saudi Arabia Polydisciplinary Faculty of Larache University Abdelmalek EssaadiTetouanMorocco Department of Risk Management and Insurance Faculty of BusinessThe University of JordanAqabaJordan

We introduce a new wavelet based procedure for detecting outliers in financial discrete time *** procedure focuses on the analysis of residuals obtained from a model fit,and applied to the Generalized Autoregressive Conditional Heteroskedasticity(GARCH)like model,but not limited to these *** apply the Maximal-Overlap Discrete Wavelet Transform(MODWT)to the residuals and compare their wavelet coefficients against quantile thresholds to detect *** methodology has several advantages over existing methods that make use of the standard Discrete Wavelet Transform(DWT).The series sample size does not need to be a power of 2 and the transform can explore any wavelet filter and be run up to the desired *** wavelet quantiles from a Normal and Student t-distribution are used as threshold for the maximum of the absolute value of wavelet *** performance of the procedure is illustrated and applied to two real series:the closed price of the Saudi Stock market and the S&P 500 index *** efficiency of the proposed method is demonstrated and can be considered as a distinct important addition to the existing methods.

关键词： GARCH models MODWT wavelet transform outlier detections quantile threshold

Polarization Insensitive Broadband Zero Indexed Nano-Meta Absorber for Optical Region Applications

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Computers, Materials & Continua 2022年第4期71卷 993-1009页

作者： ismail Hossain Md Samsuzzaman Ahasanul Hoque mohd Hafiz Baharuddin Norsuzlin Binti mohd Sahar Mohammad Tariqul Islam Space Science Center(ANGKASA) Universiti Kebangsaan Malaysia43600UKM BangiSelangorMalaysia Department of Computer and Communication Engineering Faculty of Computer Science and EngineeringPatuakhali Science and Technology UniversityDumki8602PatuakhaliBangladesh Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600UKM BangiSelangorMalaysia

Broadband response metamaterial absorber(MMA)remains a challenge among researchers.A nanostructured new zero-indexed metamaterial(ZIM)absorber is presented in this study,constructed with a hexagonal shape resonator for optical region *** design consists of a resonator and dielectric layers made with tungsten and quartz(Fused).The proposed absorbent exhibits average absorption of more than 0.8972(89.72%)within the visible wavelength of 450–600 nm and nearly perfect absorption of 0.99(99%)at 461.61 *** on computational analysis,the proposed absorber can be characterized as *** developments of ZIM absorbers have demonstrated plasmonic resonance characteristics and a perfect impedance *** incidence obliquity in typically the range of 0◦–90◦both in TE and TM mode with maximum absorbance is more than 0.8972(∼89.72%),and up to 45◦angular stability is suitable for solar cell applications,like exploiting solar *** proposed structure prototype is designed and simulated by studying microwave technology numerical computer simulation(CST)*** finite integration technique(FIT)based simulator CST and finite element method(FEM)based simulator HFSS also helps validate the numerical data of the proposed ZIM *** proposed MMA design is appropriate for substantial absorption,wide-angle stability,absolute invisible layers,magnetic resonance imaging(MRI),color images,and thermal imaging applications.

关键词： Hexagonal resonator loaded star shaped polarization insensitive compact broadband metamaterial absorber optical region applications

Computational Investigation of Multiband EMNZ Metamaterial Absorber for Terahertz Applications

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Computers, Materials & Continua 2022年第5期71卷 3905-3920页

作者： ismail Hossain Md Samsuzzaman mohd Hafiz Baharuddin Norsuzlin Binti mohd Sahar Mandeep Singh Jit Singh Mohammad Tariqul Islam Space Science Center Universiti Kebangsaan Malaysia43600UKM BangiSelangorMalaysia Department of Computer and Communication Engineering Faculty of Computer Science and EngineeringPatuakhali Science and Technology UniversityBangladesh Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaMalaysia

This study presents an Epsilon Mu near-zero(EMNZ)nanostructured metamaterial absorber(NMMA)for visible regime *** resonator and dielectric layers are made of tungsten(W)and quartz(fused),where the working band is expanded by changing the resonator layer’s *** to perfect impedance matching with plasmonic resonance characteristics,the proposed NMMA structure is achieved an excellent absorption of 99.99%at 571 THz,99.50%at 488.26 THz,and 99.32%at 598 THz *** absorption mechanism is demonstrated by the theory of impedance,electric field,and power loss density distributions,*** geometric parameters are explored and analyzed to show the structure’s performance,and a near-field pattern is used to explain the absorption mechanism at the resonance frequency *** numerical analysis method describes that the proposed structure exhibited more than 80%absorbability between 550 and 900 *** Computer Simulation Technology(CST Microwave Studio 2019)software is used to design the proposed ***,CSTHFSS interference is validated by the simulation data with the help of the finite element method(FEM).The proposed NMMA structure is also exhibits glucose concentration sensing capability as *** the proposed broadband absorber may have a potential application in THz sensing,imaging(MRI,thermal,color),solar energy harvesting,light modulators,and optoelectronic devices.

关键词： Metamaterial absorber terahertz applications multiband EM near zero nanostructured visible regime applications

Diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects

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World Journal of Clinical Cases 2022年第24期10卷 8450-8462页

作者： Amanina Ahmad Safri Che mohd Nasril Che mohd Nassir ismail Nurul Iman Nur Hartini mohd Taib Anusha Achuthan Muzaimi Mustapha Department of Neurosciences School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia Department of Radiology School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia School of Computer Sciences Universiti Sains Malaysia11800 USMPenangMalaysia Department of Neurosciences Hospital Universiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia

Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of *** a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain *** relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in *** tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter ***,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical *** this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals.

关键词： Diffusion tensor imaging White matter Cerebral small vessel disease Pipeline processing Tractography

Optimized Gated Recurrent Unit for Mid-Term Electricity Price Forecasting

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Computer Systems Science & Engineering 2022年第11期43卷 817-832页

作者： Rashed Iqbal Hazlie Mokhlis Anis Salwa mohd Khairuddin Syafiqah ismail Munir Azam Muhammad Department of Electrical Engineering Faculty of EngineeringUniversiti Malaya50603Malaysia Department of Electrical Engineering Main CampusIqra UniversityKarachi75300Pakistan

Electricity price forecasting(EPF)is important for energy system operations and management which include strategic bidding,generation scheduling,optimum storage reserves scheduling and systems ***,accurate EPF is crucial for the purpose of bidding strategies and minimizing the risk for market participants in the competitive electricity ***,accurate time-series prediction of electricity price is very challenging due to complex nonlinearity in the trend of electricity *** work proposes a mid-term forecasting model based on the demand and price data,renewable and non-renewable energy supplies,the seasonality and peak and off-peak hours of working and nonworking *** optimized Gated Recurrent Unit(GRU)which incorporates Bagged Regression Tree(BTE)is developed in the Recurrent Neural Network(RNN)architecture for the mid-term *** layer is employed to optimize the hyperparameters of the heterogeneous GRU with the aim to improve the model’s performance,error reduction and predict the *** this work,the proposed framework is assessed using electricity market data of five major economical states in Australia by using electricity market data from August 2020 to May *** results showed significant improvement when adopting the proposed prediction framework compared to previous works in forecasting the electricity price.

关键词： Deep learning energy management machine learning prediction

Generation of OAM Waves and Analysis of Mode Purity for 5G Sub-6 GHz Applications

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Computers, Materials & Continua 2023年第1期74卷 2239-2259页

作者： Shehab Khan Noor Arif Mawardi ismail mohd Najib mohd Yasin Mohamed Nasrun Osman Nurulazlina Ramli Ali H.Rambe J.Iqbal Advanced Communication Engineering(ACE) Centre of ExcellenceFaculty of Electronic Engineering TechnologyUniversiti Malaysia PerlisKangarPerlisMalaysia Centre for Advanced Electrical&Electronic System(CAEES)Faculty of Engineering Built Environment and Information TechnologySEGi University Petaling JayaSelangorMalaysia Department of Electrical Engineering Universitas Sumatera UtaraMedan20155Indonesia School of Electrical and Electronic Engineering Engineering CampusUniversiti Sains MalaysiaNibong Tebal14300PenangMalaysia Faculty of Engineering&Technology Gomal University29050 kpkPakistan

This article presents the generation of Orbital AngularMomentum(OAM)vortex waves with mode 1 using Uniform Circular Array(UCA)*** different designs,namely,UCA-1(4-element array antenna)and UCA-2(8-element array antenna),were designed and fabricated using FR-4 substrate to generate OAM mode 1 at 3.5 GHz(5G mid-band).The proposed antenna arrays comprised rectangular microstrip patch elements with inset fed *** elements were excited by a carefully designed feeding phase shift network to provide similar output energy at output ports with desired phase shift *** generated OAM waves were confirmed by measuring the null in the bore sight of their 2D radiation patterns,simulated phase distribution and intensity *** measurement results agree well with the simulation ***,a detailed mode purity analysis of the generated OAM waves was carried out considering different *** investigation found that the greater the number of elements,the higher the purity of the generated OAM *** with other previous works,the proposed antenna design of this paper is very simple to design and *** addition,the proposed antennas are compact in design even at lower frequency band with very wide bandwidth to meet the requirements of 5G mid-band applications.

关键词： Orbital angular momentum vortex waves fifth generation wireless communications uniform circular array antenna patch antenna

Energy Emissions Profile and Floating Solar Mitigation Potential for a Malaysia’s State

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地球与环境科学(英文) 2023年第2期5卷 50-60页

作者： Suraya Nabilah Zaini Azlin mohd Azmi Annie Syazrin ismail School of Mechanical Engineering College of EngineeringUniversiti Teknologi Mara(UiTM)Shah Alam Selangor40450Malaysia Solar Research Institute(SRI) Universiti Teknologi MARA(UiTM)Shah AlamSelangor40450Malaysia Jabatan Perancangan Majlis Bandaraya Shah AlamWisma MBSAPersiaran PerbandaranShah AlamSelangor40000Malaysia

The establishment of the National Low Carbon City Master Plan(NLCCM)by Malaysia’s government presents a significant opportunity to minimize carbon emissions at the subnational or local scales,while simultaneously fostering remarkable economic ***,the lack of data management and understanding of emissions at the subnational level are hindering effective climate policies and planning to achieve the nationally determined contribution and carbon neutrality *** is an urgent need for a subnational emission inventory to understand and manage subnational emissions,particularly that of the energy sector which contribute the biggest to Malaysia’s *** research aims to estimate carbon emissions for Selangor state in accordance with the Global Protocol for Community-Scale Greenhouse Gas Emission Inventories(GPC),for stationary energy *** study also evaluates the mitigation potential of Floating Solar Photovoltaic(FSPV)proposed for *** was found that the total stationary energy emission for Selangor for the year 2019 was 18,070.16 ktCO2e,contributed the most by the Manufacturing sub-sector(40%),followed by the Commercial and Institutional sub-sector;with 82%contribution coming from the Scope 2 *** highest sub-sector of Scope 1 emissions was contributed by Manufacturing while Scope 2 emissions from the Commercial and ***,the highest fuel consumed was natural gas,which amounted to 1404.32 ktCO2e(44%)of total *** FSPV assessment showed the potential generation of 2.213 TWh per year,by only utilizing 10%of the identified available ponds and dams in Selangor,equivalent to an emission reduction of 1726.02 ktCO2e,offsetting 11.6%Scope 2 electricity *** results from the study can be used to better evaluate existing policies at the sub-national level,discover mitigation opportunities,and guide the creation of future policies.

关键词： Greenhouse gas emission Floating solar GPC protocol Stationary energy Low carbon state