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Effect of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Alpha Variants on Spontaneous Clearance and Fibrosis Progression during Hepatitis C Virus Infection in Moroccan Patients

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Virologica Sinica 2020年第5期35卷 566-574页

作者： Raouia ElFihry mohcine elmessaoudi-idrissi Fatima-Zahra Jadid Imane Zaidane Hajar Chihab Mohamed Tahiri Mostafa Kabine Wafaa Badre Isabelle Chemin Agnes Marchio Pascal Pineau Sayeh Ezzikouri Soumaya Benjelloun Virology Unit Viral Hepatitis LaboratoryInstitut Pasteur du Maroc20360 CasablancaMorocco Laboratoire Sante´et Environnement de´partement de BiologieFaculte´des Sciences Ain ChockUniversity Hassan II of Casablanca20360 CasablancaMorocco Service d’He´pato-Gastro-Ente´rologie CHU Ibn Rochd20360 CasablancaMorocco Centre de Recherche en Cance´rologie de Lyon UMR INSERM 1052CNRS 5286Lyon Cedex 03France Unite´"Organisation Nucle´aire et Oncogene`se" INSERM U993Institut Pasteur75015 ParisFrance

Hepatitis C virus(HCV)is still one of the main causes of liver disease *** disorders,including nonalcoholic fatty liver disease(NAFLD),induced by HCV have been shown to accelerate the progression of fibrosis to cirrhosis and to increase the risk of hepatocellular *** optimal peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPARGC1A)activity is crucial to prevent NAFLD *** present study aims to investigate the associations between two common PPARGC1A polymorphisms(rs8192678 and rs12640088)and the outcomes of HCV infection in a North African context.A series of 592 consecutive Moroccan subjects,including 292 patients with chronic hepatitis C(CHC),100 resolvers and 200 healthy controls were genotyped using a TaqMan allelic discrimination ***1A variations at rs8192678 and rs12640088 were not associated with spontaneous clearance of HCV infection(adjusted ORs=0.76 and 0.79 respectively,P[0.05,for both).Furthermore,multivariable logistic regression analysis showed that both SNPs were not associated with fibrosis progression(OR=0.71;95%CI 0.20–2.49;P=0.739;OR=1.28;95%CI 0.25–6.54;P=0.512,respectively).We conclude that,in the genetic context of South Mediterranean patients,rs8192678 and rs12640088 polymorphisms of PPARGC1 A are neither associated with spontaneous clearance nor with disease progression in individuals infected with HCV.

关键词： Chronic hepatitis C Peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPARGC1A) Polymorphisms Disease progression

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Kostmann’s Neutropenia: A Case Report

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Open Journal of Pediatrics 2024年第5期14卷 869-872页

作者： Khaoula Achir Ilham Tadmori Mounia Lakhdar idrissi Fatima Zahra Souilmi Mohamed Hbibi Moustapha Hida Pediatric Department of CHU Hassan II in Fez Fez Morocco

Kostmann syndrome, or severe congenital neutropenia, is a rare condition in children marked by a neutrophil count of less than 500/mm3. This congenital agranulocytosis, an autosomal recessive genetic disorder, is often first identified by a neonatal infectious syndrome. The deficiency in neutrophils increases susceptibility to bacterial and fungal infections. Prior to the availability of hematopoietic growth factors, the disease was associated with significant morbidity and early mortality. We present the case of a 17-month-old boy who was admitted to the pediatric emergency department at Hassan II University Hospital in Fes with skin abscesses.

关键词： Kostmann Syndrome Severe Congenital Neutropenia Skin Abscesses

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Electrical properties of ^(70)Ge:Ga near the metal–insulator transition

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Journal of Semiconductors 2015年第6期36卷 1-5页

作者： M Errai A El kaaouachi H El idrissi Laboratoire MSTI Ecole Supérieure de tecchnologie d'Agadir B.P: 33/S University Ibn ZohrFaculty of Sciences AgadirMorocco Laboratoire Electronique électrotechnique Automatique et Traitement de l'Information Département Génie Electrique Faculté des Sciences et Techniques de Mohammedia Université Hassan II Mohammedia CasablancaBP 146 Quartier YasminaMohammedia

The results of the metal-insulator transition （MIT） induced by impurity concentration are presented in the case of metallic and insulating samples 70Ge：Ga p-type. The eight samples studied have Ga concentrations N ranging from 1.848 × 1017 to 1.912 × 10^17 cm-3. The conductivity measurements were carried out at low temperature in the range 1 to 0.019 K. We provide physical explanations to explain the behaviors of the temperature dependence of the electrical conductivity in both sides of the MIT. The data are for a 70Ge：Ga sample prepared and reported by Itoh et aL in Ref. [Itoh K M, Watanabe M, Ootuka Y, et al. J Phys Soc Jpn, 2004, 73（1）： 173].

关键词： 70Ge: Ga semiconductor low temperature impurity concentration metal-insulator variable rangehopping conductivity transport properties

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Variable range hopping conduction in n-CdSe samples at very low temperature

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Journal of Semiconductors 2015年第12期36卷 14-17页

作者： M Errai A El Kaaouachi H El idrissi Physics Department Ibn Zohr University Faculty of Sciences Laboratoire Electronique électrotechnique Automatique et Traitement de l'Information Département Génie ElectriqueFaculté des Sciences et Techniques de Mohammedia Université Hassan Ⅱ Mohammedia Casablanca

We reanalyzed experimental data already published in Friedman J R, Zhang Y, Dai P, et al. Phys Rev B, 1996, 53（15）： 9528. Variable range hopping （VRH） conduction in the insulating three-dimensional n-CdSe samples has been studied over the entire temperature range from 0.03 to 1 K. In the absence of a magnetic field, the low temperature conductivity a of the three samples （A, B and C） obeys the Mott VRH conduction with an appropriate temperature dependence in the prefactor （a = σ0 exp [- （T0/T）]^p with p ≈ 0.25）. This behavior can be explained by a VRH model where the transport occurs by hopping between localized states in the vicinity of the Fermi level, EF, without creation of the Coulomb gap （CG）. On the contrary, no Efros-Shklovskii VRH is observed, suggesting that the density is constant in the vicinity of the EF.

关键词： n-CdSe samples low temperature variable range hopping density of state

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A direct power control of a DFIG based-WECS during symmetrical voltage dips

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Protection and Control of Modern Power Systems 2020年第1期5卷 36-47页

作者： Sara Mensou Ahmed Essadki Tamou Nasser Badr Bououlid idrissi Research Center of Engineering and Health Sciences and Technologies from ENSET Mohammed V UniversityRabatMorocco Research Center of Engineering and Health Sciences and Technologies from ENSIAS Mohammed V UniversityRabatMorocco Electromechanical Engineering Department of ENSAM Moulay Ismaïl UniversityMeknèsMorocco.

The Wind Energy Conversion System(WECS)based Doubly Fed Induction Generator(DFIG)has experienced a rapid development in the world,which leads to an increasing insertion of this source of energy in the electrical *** sudden and temporary drop of voltage at the network can affect the operation of the DFIG;the voltage dips produce high peak currents on the stator and rotor circuits,without protection,the rotor side converter(RSC)will suffer also from over-current limit,consequently,the RSC may even be destroyed and the generator be *** this paper a new Direct Power Control(DPC)method was developed,in order to control the stator powers and help the operation of the aero-generator during the faults grid;by injecting the reactive power into the network to contribute to the return of voltage,and set the active power to the optimum value to suppress the high peak *** DPC method was designed using the nonlinear Backstepping(BS)controller associated with the Lyapunov function to ensure the stability and robustness of the system.A comparison study was undertaken to verify the robustness and effectiveness of the DPC-BS to that of the classical vector control(VC)using Proportional-Integral(PI)*** were simulated under the Simulink®software.

关键词： Wind energy Doubly-fed induction aero-generator Voltage dips DPC strategy Backstepping technique Lyapunov function

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Comparative study of semiconductor power losses between CSI-based STATCOM and VSI-based STATCOM,both used for unbalance compensation

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Protection and Control of Modern Power Systems 2020年第1期5卷 56-69页

作者： Anas Benslimane Jamal Bouchnaif Mohammed Essoufi Bekkay Hajji Loukmane el idrissi Laboratory Renewable energy embedded system and information processingNational School of Applied SciencesUniversity of Mohammed IOujdaMorocco Laboratory of Electrical Engineering and Maintenance Higher School of TechnologyUniversity of Mohammed IOujdaMorocco

In this paper,we present a detailed procedure to determine the semiconductor losses for both structures of a shunt STATCOM(Static Compensator),STATCOM based on Current Source Inverter(CSI)and STATCOM based on Voltage Source Inverter(VSI),both used for voltage unbalance *** a first step,we study the VSI-based STATCOM and the CSI-based STATCOM used in high speed railway *** we analyze the design and the sizing of the unbalance compensator in order to obtain an unbalance factor that does not exceed the limits imposed by the standards or by the energy *** that,we compare the performances obtained with both structures VSI-STATCOM and CSI-STATCOM,after calculating the semiconductor power losses in the STATCOM ***,we validate our approach by simulation over real data of unbalance compensation caused by the new high-speed railway in *** use the tools MATLAB/Simulink/Simpowersys for performing our simulations.

关键词： Power losses VSI CSI STATCOM Unbalance compensation Railway

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Developing a multi-label tinyML machine learning model for an active and optimized greenhouse microclimate control from multivariate sensed data

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Artificial Intelligence in Agriculture 2022年第1期6卷 129-137页

作者： Ilham Ihoume Rachid Tadili Nora Arbaoui Mohamed Benchrifa Ahmed idrissi Mohamed Daoudi Solar Energy and Environment Laboratory Mohammed V University in RabatFaculty of SciencesB.P 1014RabatMorocco

In the uncertainties within which the worldwide food security lies nowadays,the agricultural industry is raising a crucial need for being equipped with the state-of-the-art technologies for a more efficient,climate-resilient and sustainable *** traditional production methods have to be revisited,and opportunities should be given for the innovative solutions henceforth brought by big data analytics,cloud computing and internet of things(IoT).In this context,we develop an optimized tinyML-oriented model for an active machine learningbased greenhouse microclimate management to be integrated in an on-field *** design an experimental strawberry greenhouse from which we collect multivariate climate data through installed *** obtained values'combinations are labeled according to a five-action multi-label control strategy,then used to prepare a machine learning-ready *** dataset is used to train and five-fold cross-validate 90 Multi-Layer Perceptrons(MLPs)with varied hyperparameters to select the most performant–yet optimized–model instance for the addressed *** multi-label control approach enables designing highly scalable models with reduced computational complexity,comprising only n control neurons instead of(1+∑n k=1Cn k)neurons(usually generated from a classic single-label approach from n input variables).Our final selected model incorporates 2 hidden layers with 7 and 8 neurons respectively and 151 parameters;it scored a mean accuracy of 97%during the cross-validation phase,then 96%on our supplementary test *** model enables an intelligent and autonomous greenhouse management with the less required *** can be efficiently deployed in microcontrollers within real world operating conditions.

关键词： Agricultural greenhouse Microclimate control Machine learning Optimization TinyML

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Liver resection and metabolic disorders: An undescribed mechanism leading to postoperative mortality

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World Journal of Gastroenterology 2014年第39期20卷 14455-14462页

作者： Alban Zarzavadjian Le Bian Renato Costi Mohamed Said Sbai-idrissi Claude Smadja Service de Chirurgie Digestive H?pital Antoine BéclèreClamart Assistance Publique-H?pitaux de ParisUniversité Paris Sud-XI 91400 Orsay France Laboratoire d’Ethique Médicale et de Médecine Légale Université Paris Descartes-V 75006 Paris France Service de Chirurgie Digestive H?pital Simone Veil95600 Eaubonne France Dipartimento di Scienze Chirurgiche Università degli Studi di Parma 43100 Parma Italy

AIM: To investigate the mechanism leading to perioperative mortality in patients undergoing major liver resection and presenting with metabolic disorders.

关键词： Metabolic syndrome Major hepatectomy Liver resection Postoperative mortality Hepatorenal syndrome

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Magnetic properties of La2CuMnO6 double perovskite ceramic investigated by Monte Carlo simulations

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Chinese Physics B 2020年第5期29卷 387-391页

作者： S Mtougui I EL Housni N EL Mekkaoui S Ziti S idrissi H Labrim R Khalladi L Bahmad Laboratoire de la Matière Condensée et des Sciences Interdisciplinaires (LaMCScI) Mohammed V University of RabatFaculty of SciencesB.P.1014 RabatMorocco Intelligent Processing and Security Systems Mohammed V University of RabatFaculty of SciencesB.P.1014 RabatMorocco USM/DERS/Centre National de l’Energie des Sciences et des Techniques Nucl´eaires(CNESTEN)RabatMorocco

We present a theoretical study of the magnetic properties of the lanthanum copper manganate double perovskite La2CuMnO6 ceramic,using Monte Carlo *** analyze and discuss the ground state phase diagrams in different planes to show the effect of every physical *** on the Monte Carlo simulations,which combine Metropolis algorithm and Ising model,we explore the thermal behavior of the total magnetization and *** also present and discuss the influence of physical parameters such as the external magnetic field,the exchange coupling interactions between magnetic atoms,and the exchange magnetic field on the magnetization of the ***,the critical temperature of the system is about Tc=70 K,in agreement with the experimental ***,the hysteresis loops of La2CuMnO6 are discussed.

关键词： double perovskite La2CuMnO6 Monte Carlo simulations Ising model hysteresis loops Metropolis algorithm critical temperature

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Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis

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World Journal of Gastroenterology 2010年第5期16卷 583-587页

作者： Harry Sokol Nadia Vasquez Nadia Hoyeau-idrissi Philippe Seksik Laurent Beaugerie Anne Lavergne-Slove Philippe Pochart Philippe Marteau Gastro-enterology and Nutrition Department Saint Antoine HospitalPierre et Marie Curie-Paris6 UniversityAP-HP184 rue du Faubourg Saint-Antoine75571ParisFrance Laboratoire de Biologie EA 3199 CNAM2 rue Conte75003ParisFrance Pathology Department Saint Antoine HospitalPierre et Marie Curie-Paris6 UniversityAP-HP184 rue du Faubourg Saint-Antoine75571ParisFrance Gastro-enterology and Nutrition Department Saint Antoine HospitalPierre et Marie Curie-Paris6 UniversityAP-HP184 rue duFaubourg Saint-Antoine75571ParisFrance Pathology Department Lariboisière Hospital&Paris 7 University2 rue Ambroise-Paré75475ParisFrance Medicosurgical Department of Digestive Diseases Lariboisière HospitalAP-HP&Paris 7 University2rue Ambroise-Paré75475ParisFrance

AIM:To evaluate whether crypt abscesses frominflammatory bowel disease(IBD)patients containbacteria and to establish their ***:We studied 17 ulcerative colitis patients,11 Crohn's disease patients,7 patients with acute selflimited colitis(ASLC)and normal colonic biopsies from5 subjects who underwent colonoscopy for colon cancer screening.A fluorescent in situ hybridization techniquewas applied to colonic biopsies to assess the microbiotacomposition of the crypts and crypt ***:Crypts colonized by bacteria were observedin 42.9%and 3.6%of ASLC and IBD patients,respectively(P=0.019).Crypt abscesses colonized bybacteria were observed in 28.6%and 0.0%of ASLCand IBD patients,respectively(P=0.035).CONCLUSION:These results do not support thehypothesis that crypt abscesses in IBD are the resultof localized dysbiosis arising from persistence of livingbacteria colonizing the crypts.

关键词： Inflammatory bowel diseases Crohn’sdisease Ulcerative colitis Crypt abscess Microbiota

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