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miRNA表达谱和靶基因分析在糖尿病轻瘫发病机制中的作用

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中国实验诊断学 2024年第6期28卷 714-721页

作者：孙嘉咛张默函延边大学医学院临床医学系吉林延吉133000 延边大学医学院组织学与胚胎学教研室吉林延吉133000

目的本研究旨在通过分析微小RNA(miRNAs)在糖尿病胃轻瘫(Diabetic Gastroparesis,DGP)中的表达变化,揭示其在疾病发病机制中的潜在作用。方法通过基因表达综合数据库(Gene Expression Omnibus,GEO)获取糖尿病胃轻瘫患者和健康对照者的血... 详细信息

目的本研究旨在通过分析微小RNA(miRNAs)在糖尿病胃轻瘫(Diabetic Gastroparesis,DGP)中的表达变化,揭示其在疾病发病机制中的潜在作用。方法通过基因表达综合数据库(Gene Expression Omnibus,GEO)获取糖尿病胃轻瘫患者和健康对照者的血浆miRNA测序数据,使用limma软件包鉴定差异表达miRNAs,并预测其靶基因。结合Gene Cards数据库获取糖尿病胃轻瘫的潜在靶点,进行功能富集分析和蛋白质-蛋白质相互作用网络构建。结果研究共筛选出43个在糖尿病胃轻瘫患者中差异表达的miRNAs,并预测了其对应的171个靶基因。功能富集分析显示这些靶基因涉及多种生物学过程、细胞组分和分子功能,与糖尿病胃轻瘫的发病机制密切相关。蛋白质-蛋白质相互作用网络构建和枢纽基因筛选揭示了一批关键基因,如PRKN、SNCA、PINK1等,可能在疾病发展中发挥重要调控作用。结论本研究通过深入探索miRNAs在糖尿病胃轻瘫中的表达变化及其靶基因情况,揭示了该疾病的潜在分子机制。发现的关键基因可能成为治疗靶点,为糖尿病胃轻瘫的治疗提供新的思路和策略。

关键词：糖尿病胃轻瘫微小RNA 靶基因蛋白质-蛋白质相互作用治疗靶点

A novel reusable anti-COVID-19 transparent face respirator with optimized airflow

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Bio-Design and Manufacturing 2021年第1期4卷 1-9页

作者： Hussain Alenezi Muhammet Emin Cam mohan Edirisinghe Department of Mechanical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUK Department of Manufacturing Engineering College of Technological StudiesPAAET13092 Kuwait CityKuwait Center for Nanotechnology and Biomaterials Application and Research Marmara University34722 IstanbulTurkey

This novel face mask is designed to be a reusable respirator with a small and highly efficient disposable fabric *** material requirements are reduced by 75%compared to traditional designs and allow repeated cleaning or *** probability of virus particle inhalation is reduced using novel air filtration pathways,through square-waveform design to increase filter *** enters the mask from right and left side filters,while the area in front of the mouth is *** epoxy is used for a transparent frame,allowing lip-reading,and mask edges contain a silicone seal preventing bypass of the *** mask is manufactured using silicone molds,eliminating electricity requirements making it economical and viable in developing *** fluid dynamics numerical studies and Fluent ANSYS software were used to simulate airflow through the filter to optimize filter air path geometry and validate mask design with realistic human *** breathing cycle was represented as a transient function,and N95 filter specifications were selected as a porous *** novel design achieved 1.2×10^(−3) kg s^(−1),20%higher than human requirements,with air streamlines velocity indicating local high speed,forcing and trapping virus particles against filter walls through centrifugal forces.

关键词： COVID-19 Mask Prototype Flow Pressure Temperature

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基于特征融合和混合注意力的小目标检测

郑州大学学报（工学版） 2024年第3期45卷 72-79页

作者：魏明军王镆涵刘亚志李辉华北理工大学人工智能学院河北唐山063210 华北理工大学河北省工业智能感知重点实验室河北唐山063210

针对目标检测任务中小目标特征信息不足、检测率较低,且错、漏检率较高等缺点,提出一种基于多尺度特征融合以及混合注意力机制的Tr-SSD算法。首先,使用Resnet50残差网络作为SSD算法的骨干网络,增强SSD算法的特征提取能力;其次,设计了一... 详细信息

针对目标检测任务中小目标特征信息不足、检测率较低,且错、漏检率较高等缺点,提出一种基于多尺度特征融合以及混合注意力机制的Tr-SSD算法。首先,使用Resnet50残差网络作为SSD算法的骨干网络,增强SSD算法的特征提取能力;其次,设计了一种混合注意力机制并将其应用于网络的中尺度特征图中以增强特征图中的有效信息,并建立信息间的远距离依赖;最后,使用以Transformer为核心的网络层与替换骨干网络后的SSD算法形成FPN结构,融合不同尺度的特征信息,以更准确地对小目标进行定位。实验结果表明:Tr-SSD算法在PASCAL VOC数据集、HRSID数据集和RSOD遥感数据集上检测的mAP值分别达到81.9%、87.5%和88.4%,比SSD算法分别提高了4.7百分点、6.8百分点和9.2百分点,且检测速度均满足实时检测的要求。

关键词：小目标检测注意力机制特征融合深度学习实时检测

Recent advances in catalytic combustion of AP-based composite solid propellants

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Defence Technology（防务技术） 2021年第3期17卷 1013-1031页

作者： Narendra Yadav Prem Kumar Srivastava mohan Varma Department of Space Engineering&Rocketry India Department of Chemistry Birla Institute of TechnologyMesraRanchiIndia

Composite solid propellants(CSPs) have widely been used as main energy source for propelling the rockets in both space and military applications. Internal ballistic parameters of rockets like characteristic exhaust velocity, specific impulse, thrust, burning rate etc., are measured to assess and control the performance of rocket motors. The burn rate of solid propellants has been considered as most vital parameter for design of solid rocket motors to meet specific mission requirements. The burning rate of solid propellants can be tailored by using different constituents, extent of oxidizer loading and its particle size and more commonly by incorporating suitable combustion catalysts. Various metal oxides(MOs),complexes, metal powders and metal alloys have shown positive catalytic behaviour during the combustion of CSPs. These are usually solid-state catalysts that play multiple roles in combustion of CSPs such as reduction in activation energy, enhancement of rate of reaction, modification of sequences in reaction-phase, influence on condensed-phase combustion and participation in combustion process in gas-phase reactions. The application of nanoscale catalysts in CSPs has increased considerably in recent past due to their superior catalytic properties as compared to their bulk-sized counterparts. A large surface-to-volume ratio and quantum size effect of nanocatalysts are considered to be plausible reasons for improving the combustion characteristics of propellants. Several efforts have been made to produce nanoscale combustion catalysts for advanced propellant formulations to improve their energetics. The work done so far is largely scattered. In this review, an effort has been made to introduce various combustion catalysts having at least a metallic entity. Recent developments of nanoscale combustion catalysts with their specific merits are discussed. The combustion chemistry of a typical CSP is briefly discussed for providing a better understanding on role of co

关键词： Composite solid propellants Burn rate modifier Metallic nano-catalysts Catalytic combustion Thermal decomposition

Co-axial depth sensor with an extended depth range for AR/VR applications

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Virtual Reality & Intelligent Hardware 2020年第1期2卷 1-11页

作者： mohan XU Hong HUA 3D Visualization and Imaging Systems Laboratory College of Optical SciencesUniversity of Arizona1630 East University BoulevardTucsonAZ 85721USA

Background Depth sensor is an essential element in virtual and augmented reality devices to digitalize users'environment in real *** current popular technologies include the stereo,structured light,and Time-of-Flight(ToF).The stereo and structured light method require a baseline separation between multiple sensors for depth sensing,and both suffer from a limited measurement *** ToF depth sensors have the largest depth range but the lowest depth map *** overcome these problems,we propose a co-axial depth map sensor which is potentially more compact and cost-effective than conventional structured light depth ***,it can extend the depth range while maintaining a high depth map ***,it provides a high-resolution 2 D image along with the 3 D depth *** This depth sensor is constructed with a projection path and an imaging *** two paths are combined by a beamsplitter for a co-axial *** the projection path,a cylindrical lens is inserted to add extra power in one direction which creates an astigmatic *** depth measurement,the astigmatic pattern is projected onto the test scene,and then the depth information can be calculated from the contrast change of the reflected pattern image in two orthogonal *** extend the depth measurement range,we use an electronically focus tunable lens at the system stop and tune the power to implement an extended depth range without compromising depth *** In the depth measurement simulation,we project a resolution target onto a white screen which is moving along the optical axis and then tune the focus tunable lens power for three depth measurement subranges,namely,near,middle and *** each sub-range,as the test screen moves away from the depth sensor,the horizontal contrast keeps increasing while the vertical contrast keeps decreasing in the reflected ***,the depth information can be obtained by computing the contrast ratio between fe

关键词： Depth map sensor 3 D camera Controlled aberration

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned

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Biosafety and Health 2024年第2期6卷 125-132页

作者： Reuben Kiggundu J.P.Waswa Niranjan Konduri Hassan Kasuja Marion Murungi Patrick Vudriko Harriet Akello Eric Lugada Cecilia Muiva Esther Were Dinah Tjipura Henry Kajumbula Kate Kikule Emmanuel Nfor mohan P.Joshi USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthArlingtonVA 22203USA College of Veterinary Medicine Animal Resources and BiosecurityMakerere UniversityKampala 256Uganda Ministry of Health Uganda Kampala 256Uganda USAID Strengthening Supply Chain Systems Activity Management Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthNairobi 254Kenya Department of Microbiology College of Health SciencesMakerere UniversityKampala 256Uganda

Uganda has been implementing the Global Health Security Agenda(GHSA)since 2015 to build its capacity according to World Health Organization(WHO)Benchmarks on International Health Regulations *** country remains prone to outbreaks,with more than 20 disease outbreaks reported in the past five years,including Ebola virus disease,Crimean-Congo haemorrhagic fever,Marburg haemorrhagic fever,measles,yellow fever,coronavirus disease 2019(COVID-19),and *** resistance(AMR)is an ongoing *** scored capacity level 3 on infection prevention and control(IPC)and antimicrobial stewardship(AMS)in the 2017 Joint External Evaluation(JEE)*** gaps were being addressed after a self-assessment in *** paper describes the technical assistance approaches provided to Uganda by the Medicines,Technologies,and Pharmaceutical Services Program,funded by the United States(U.S.)Agency for International Development,and implemented by Management Sciences for *** program,through a One Health approach,supported systematic capacity strengthening based on the JEE's capacity advancement framework for global health security,specifically relating to *** program's interventions impacted 32 WHO benchmark actions(7 for AMR multisectoral coordination,16 for IPC,and 9 for AMS),contributing to Uganda's strengthened GHSA *** success built on the AMR platform,the program trained 745 health workers in IPC for the Ebola virus and provided support for simulation exercises by eight district IPC *** program also worked with the Ministry of Health to coordinate IPC for the COVID-19 response in five health regions,covering 45 districts and reaching 5,452 health workers at 858 health facilities.

关键词： One health Antimicrobial resistance Antibiotic resistance Jointexternal evaluation Global health security Uganda Africa WHO Benchmarks for International Health Regulations Capacities

Sammon Quadratic Recurrent Multilayer Deep Classifier for Legal Document Analytics

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Computers, Materials & Continua 2022年第8期72卷 3039-3053页

作者： Divya mohan Latha Ravindran Nair School of Engineering Cochin University of Science and TechnologyKeralaIndia

In recent years,machine learning algorithms and in particular deep learning has shown promising results when used in the field of legal *** legal field is strongly affected by the problem of information overload,due to the large amount of legal material stored in textual *** text processing is essential in the legal domain to analyze the texts of the court events to automatically predict smart *** an increasing number of digitally available documents,legal text processing is essential to analyze documents which helps to automate various legal domain *** document classification is a valuable tool in legal services for enhancing the quality and efficiency of legal document *** this paper,we propose Sammon Keyword Mapping-based Quadratic Discriminant Recurrent Multilayer Perceptive Deep Neural Classifier(SKM-QDRMPDNC),a system that applies deep neural methods to the problem of legal document *** SKM-QDRMPDNC technique consists of many layers to perform the keyword extraction and ***,the set of legal documents are collected from the *** the keyword extraction is performed using SammonMapping technique based on the distance *** the extracted features,Quadratic Discriminant analysis is applied to performthe document classification based on the likelihood ratio ***,the classified legal documents are obtained at the output *** process is repeated until minimum error is *** experimental assessment is carried out using various performance metrics such as accuracy,precision,recall,F-measure,and computational time based on several legal documents collected from the *** observed results validated that the proposed SKM-QDRMPDNC technique provides improved performance in terms of achieving higher accuracy,precision,recall,and F-measure with minimum computation time when compared to existing methods.

关键词： Legal document data analytics recurrent multilayer perceptive deep neural network sammon mapping quadratic discriminant analysis likelihood ratio test

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基于数据集蜜点的抗损毁数据标识技术

计算机研究与发展 2024年第10期61卷 2417-2432页

作者：李浩波李默涵陈鹏孙彦斌田志宏广州大学网络空间安全学院广州510006 广东省工业控制系统攻防对抗重点实验室广州510006

数据标识是实现数据精准监管的前提条件,有效地保证了数据要素在跨域流转过程中的安全.当前已有针对单一数据的标识生成方法,但是随着数据规模的不断扩大,数据层面的数据标识无法直接应用到数据集层面,并且会带来标识“易损毁”和标识... 详细信息

数据标识是实现数据精准监管的前提条件,有效地保证了数据要素在跨域流转过程中的安全.当前已有针对单一数据的标识生成方法,但是随着数据规模的不断扩大,数据层面的数据标识无法直接应用到数据集层面,并且会带来标识“易损毁”和标识“难嵌入”的问题.为有效解决上述问题,通过沿用方滨兴院士提出的“护卫”模式中网络蜜点的设计理念,借助欺骗防御的思想提出数据跨域流转场景下基于数据集蜜点的抗损毁数据标识技术,设计并形成一套完整的数据集蜜点生成和嵌入方法.首先,针对数据跨域流转场景设计了数据集蜜点,并通过增强数据集蜜点的隐蔽性和增加数据集蜜点冗余的方式解决标识“易损毁”的问题.其次,通过保证数据集蜜点形态与真实数据密不可分,解决标识“难嵌入”的问题.最后,通过在图像和加密文本2个数据模态下进行实验,验证了数据集蜜点具备高抗损毁、高鲁棒和低性能开销的特性.

关键词：数据跨域流转数据标识数据集蜜点欺骗防御抗损毁嵌入

WETLAND TYPES AND ASSOCIATE VEGETATION IN NEPAL:AN OVERVIEW

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湿地科学 2007年第3期5卷 193-200页

作者： mohan Siwakoti Natural History Museum Tribhuvan University

Wetland is the transitional zone between the permanently wet and dry environment and shares the charac-teristics of the environment. Wetland is not yet to be classified unambiguously as either aquatic or terrestrial. However,the Ramsar Convention adopts an extremely broad approach in determining the wetland; as a result, several varieties ofhabitat types are included under the wetland definition. Wetlands are among the world’s most productive ecosystems andprovide a wide variety of goods and services. Nepal lies on the southern slopes of central Himalayas and occupies a totalarea of 147 181 km2between the latitudes 26°22′N and 30°27′N and the longitudes 80°40′E and 88°12′E. The di-verse landscape (60 -8 848 m) and bioclimatic conditions (alpine to tropical) of the country provide a unique niche fordifferent types of wetlands. These are distributed from high altitudinal glacial lakes to hot springs, ponds, ox-bowlakesto river floodplains, marshes and swamps. The country has 15 types of inland freshwater natural wetlands as classified bythe Ramsar Convention. These wetlands house several species of rare and endangered flora and fauna. The present paperattempts to highlight the various types of wetlands in Nepal with associate vegetation.

关键词：湿地类型植被尼泊尔