检索结果-南通市图书馆

Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach

引用

Food Science and Human Wellness 2023年第4期12卷 1224-1231页

作者： mohan Li Qilong Li Haikun Yu Xiumin Zhang Dehao Li Wanying Song Yan Zheng Xiqing Yue College of Food Science Shenyang Agricultural UniversityShenyang 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyang 110866China Beijing Academy of Food Sciences Beijing 100068China The Fourth Affiliated Hospital of China Medical University Shenyang 110866China

This study aimed to analyze and compare the differentially expressed whey proteins(DEWPs)of donkey and bovine colostrum using high-performance liquid chromatography with tandem mass spectrometry-based proteomics.A total of 620 and 696 whey proteins were characterized in the donkey and bovine colostrum,respectively,including 383 common whey *** these common proteins,80 were identified as DEWPs,including 21 upregulated and 59 downregulated DEWPs in donkey colostrum compared to bovine *** Ontology analysis revealed that these DEWPs were mainly related to cellular components,such as extracellular exosome,plasma membrane,and mitochondrion;biological processes,such as oxidation-reduction process,cell-cell adhesion,and small guanosine triphosphate(GTP)ase-mediated signal transduction;and molecular functions,such as GTP binding,GTPase activity,and soluble N-ethylmaleimide-sensitive factor(NSF)attachment protein receptor *** pathway analysis suggested that the majority of the DEWPs were associated with soluble NSF factor attachment protein receptor interactions in vesicular transport,fatty acid biosynthesis,and estrogen signaling *** results provide a vital insight into the differences between donkey and bovine colostrum,along with important information on the significant components as nutritional and functional factors to be included in infant formula based on multiple milk sources.

关键词： Bovine colostrum Donkey colostrum Proteomics Whey protein Gene Ontology Kyoto Encyclopedia of Genes and Genomes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways

引用

Journal of Animal Science and Biotechnology 2023年第4期14卷 1551-1568页

作者： Kan Xiao mohan Zhou Qingqing Lv Pengwei He Xu Qin Dan Wang Jiangchao Zhao Yulan Liu Hubei Key Laboratory of Animal Nutrition and Feed Science Wuhan Polytechnic UniversityWuhan 430023People’s Republic of China Department of Animal Science Division of AgricultureUniversity of ArkansasFayettevilleAR 72701USA

Background:Necroptosis and pyroptosis are newly identified forms of programmed cell death,which play a vital role in development of many gastrointestinal *** plant polyphenols have been reported to protect intestinal health,it is still unclear whether there is a beneficial role of plant polyphenols in modulating necroptosis and pyroptosis in intestinal porcine epithelial cell line(IPEC-1)infected with enterotoxigenic Escherichia coli(ETEC)*** research was conducted to explore whether plant polyphenols including protocatechuic acid(PCA)and quercetin(Que),attenuated inflammation and injury of IPEC-1 caused by ETEC K88 through regulating necroptosis and pyroptosis signaling ***:IPEC-1 cells were treated with PCA(40μmol/L)or Que(10μmol/L)in the presence or absence of ETEC ***:PCA and Que decreased ETEC K88 adhesion and endotoxin level(P<0.05)in cell *** and Que increased cell number(P<0.001)and decreased lactate dehydrogenases(LDH)activity(P<0.05)in cell supernatant after ETEC *** and Que improved transepithelial electrical resistance(TEER)(P<0.001)and reduced fluorescein isothiocyanate-labeled dextran(FD4)flux(P<0.001),and enhanced membrane protein abundance of occludin,claudin-1 and ZO-1(P<0.05),and rescued distribution of these tight junction proteins(P<0.05)after ETEC *** and Que also declined cell necrosis ratio(P<0.05).PCA and Que reduced mRNA abundance and concentration of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-8(P<0.001),and down-regulated gene expression of toll-like receptors 4(TLR4)and its downstream signals(P<0.001)after ETEC *** and Que down-regulated protein abundance of total receptor interacting protein kinase 1(t-RIP1),phosphorylated-RIP1(p-RIP1),p-RIP1/t-RIP1,t-RIP3,p-RIP3,mixed lineage kinase domain-like protein(MLKL),p-MLKL,dynamin-related protein 1(DRP1),phosphoglycerate mutase 5(PGAM5)and high mobility group box 1(HMGB1)(P<0.05)after ETEC infection.M

关键词： Cell damage ETEC K88 Intestinal inflammation Necroptosis Protocatechuic acid Pyroptosis Quercetin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Holt-Winters Algorithm to Predict the Stock Value Using Recurrent Neural Network

引用

Intelligent Automation & Soft Computing 2023年第1期35卷 1151-1163页

作者： M.mohan P.C.Kishore Raja P.Velmurugan A.Kulothungan Department of Computer Science&Engineering SRM UniversitySonepatHaryanaIndia Department of Electronics&Communication Engineering SRM UniversitySonepatHaryanaIndia Department of Computing Technologies SRM Institute of Science and TechnologyChennaiIndia Department of Computer Science&Engineering SRM Institute of Science and TechnologyModinagarGhaziabadIndia

Prediction of stock market value is highly risky because it is based on the concept of Time Series forecasting system that can be used for investments in a safe environment with minimized chances of *** proposed model uses a real time dataset offifteen Stocks as input into the system and based on the data,predicts or forecast future stock prices of different companies belonging to different *** dataset includes approximatelyfifteen companies from different sectors and forecasts their results based on which the user can decide whether to invest in the particular company or not;the forecasting is done for the next *** model uses 3 main concepts for forecasting *** one is for stocks that show periodic change throughout the season,the‘Holt-Winters Triple Exponential Smoothing’.3 basic things taken into conclusion by this algorithm are Base Level,Trend Level and Seasoning *** value of all these are calculated by us and then decomposition of all these factors is done by the Holt-Winters *** second concept is‘Recurrent Neural Network’.The specific model of recurrent neural network that is being used is Long-Short Term Memory and it’s the same as the Normal Neural Network,the only difference is that each intermediate cell is a memory cell and retails its value till the next feedback *** third concept is Recommendation System whichfilters and predict the rating based on the different factors.

关键词： Stock market stock market prediction time series forecasting efficient market hypothesis National stock exchange India smoothing observation trend level seasonal factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于液冷技术的高性能计算系统助力实现“双碳”目标的研究与实践

引用

现代工业经济和信息化 2024年第5期14卷 71-72,84页

作者：沈学东王军张墨涵杨启东王琨北京临近空间飞行器系统工程研究所北京100076

碳达峰碳中和是我国实现可持续发展、高质量发展的内在要求,已多次被写入政府工作报告,报告中提及要促进新能源节能环保技术、装备和产品研发应用,培育壮大节能环保产业。高性能计算系统作为航天领域重要的科研生产研制工具,一直面临着... 详细信息

碳达峰碳中和是我国实现可持续发展、高质量发展的内在要求,已多次被写入政府工作报告,报告中提及要促进新能源节能环保技术、装备和产品研发应用,培育壮大节能环保产业。高性能计算系统作为航天领域重要的科研生产研制工具,一直面临着高能耗和高散热的挑战。通过对高性能计算系统冷却系统现状分析,提出基于液冷技术的高性能计算系统的解决方案,通过降低PUE值,推动高性能计算系统低碳运转,打造具备绿色节能特点的高性能计算中心,助力“双碳”目标实现。

关键词：液冷碳达峰碳中和高性能计算环保节能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highlighting novel genes associated with the classical Rett syndrome patient from India

引用

Genes & Diseases 2022年第6期9卷 1394-1396页

作者： Gomathi mohan Ranjan Jyoti Sarma Mahalaxmi Iyer Nachimuthu Senthil Kumar Balachandar Vellingiri UGC-RGNF Senior Research Fellow Human Molecular Cytogenetics and Stem Cell LaboratoryDepartment of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatore 641046Tamil NaduIndia Department of Biotechnology Mizoram University(A Central University)Aizawl 796004MizoramIndia Livestock Farming&Bioresource Technology Tamil NaduIndia Human Molecular Cytogenetics and Stem Cell Laboratory Department of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatore 641046Tamil NaduIndia

Rett syndrome(RTT)is a rare X-linked brain disorder predominantly in females,caused by mutations in Methyl-CpGBinding Protein2(MECP2)gene with the characteristic features of progressive developmental delay,severe intellectual disability,microcephaly,retarded growth,loss of communication abilities,loss of purposeful hand movements,abnormal walking or gait abnormalities,repetitive hand movements,abnormal breathing,irritability and abnormal behaviours.1 Over the last five years,more than eighty genes related to RTT were found using next generation sequencing.2 Here we presented a comprehensive clinical report of a 38-year-old RTT woman having de novo heterozygous Laminin Subunit Gamma 3 gene(LAMC3)mutation G>A(Chr9:133944387;p.C947Y)links with RTT neurological dysfunctions,brain malformations,reduced brain volume and hypoplasia of corpus *** new finding supports the possibility of targeting LAMC3 gene for rescuing the neuropathology of *** deleterious mutations found in genes such as,CACNA1B(rs4422842),CUBN(rs2271460),GPATCH3(rs779537923),TUBB1(rs463312),KCNJ5(rs768906222),VWA5A(rs551469534),DNAAF1(rs751148678),and PARP1(rs3219145)were unreported in RTT patients.

关键词： RTT lighting delay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

汽车人机交互设计体系研究

引用

汽车文摘 2024年第8期 30-34页

作者：赵默涵郑红丽张惠李志艳中国第一汽车股份有限公司研发总院长春130013 一汽-大众汽车有限公司长春130011

为了提高智能座舱用户体验满意度、产品设计质量与产品研发效率,保证智能座舱产品的吸引力和用户粘性,从创新、质量、迭代3个方面对汽车人机交互体系进行阐述,建立了以创新为引领、以用户为中心的汽车HMI设计体系,包含全员协同的创新设... 详细信息

为了提高智能座舱用户体验满意度、产品设计质量与产品研发效率,保证智能座舱产品的吸引力和用户粘性,从创新、质量、迭代3个方面对汽车人机交互体系进行阐述,建立了以创新为引领、以用户为中心的汽车HMI设计体系,包含全员协同的创新设计体系,设计自查、一致性测试、问题管理等质量机制,以及HMI自进化体系,从而实现与用户共生共长。

关键词：人机交互设计体系人机交互设计模型用户体验测评协同创新设计质量

来源：

维普期刊数据库博看期刊

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intrusion Detection Using Ensemble Wrapper Filter Based Feature Selection with Stacking Model

引用

Intelligent Automation & Soft Computing 2023年第1期35卷 645-659页

作者： D.Karthikeyan V.mohan Raj J.Senthilkumar Y.Suresh Department of ECE KongunaduCollege of Engineering and TechnologyTrichy621215India Department of IT Sona College of TechnologySalem636005India

The number of attacks is growing tremendously in tandem with the growth of internet *** a result,protecting the private data from prying eyes has become a critical and tough *** intrusion detection solutions have been offered by researchers in order to decrease the effect of these *** attack detection,the prior system has created an SMSRPF(Stacking Model Significant Rule Power Factor)*** provide creative instance detection,the SMSRPF combines the detection of trained classifiers such as DT(Decision Tree)and RF(Random Forest).Nevertheless,it does not generate any accuratefindings that are *** suggested system has built an EWF(Ensemble Wrapper Filter)feature selection with SMSRPF classifier for attack detection so as to overcome this *** UNSW-NB15 dataset is used as an input in this proposed research ***,min–max normalization approach is used to pre-process the incoming *** feature selection is then carried out using *** on the selected features,SMSRPF classifiers are utilized to detect the *** SMSRPF is integrated with the trained classi-fiers such as DT and RF to create creative instance *** that,the testing data is classified using MCAR(Multi-Class Classification based on Association Rules).The SRPF judges the rules correctly even when the confidence and the lift measures *** accuracy,precision,recall,f-measure,computation time,and error,the experimental findings suggest that the new system outperforms the prior systems.

关键词： Intrusion detection system(IDS) ensemble wrapperfilter(EWF) stacking model with significant rule power factor(SMSRPF) classifier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

芪归紫草油促进难愈性创面愈合30例

引用

中医研究 2019年第6期32卷 7-10页

作者：程红屈帅勇吕黙晗高红吴仪刘亚南李彦杰张志鑫马纯政河南省中医院河南郑州450002 河南省中医药研究院附属医院河南郑州450004

目的:观察芪归紫草油在促进难愈性创面愈合方面的临床疗效。方法:选择创面超过1个月不愈合、临床分期为Ⅲ~Ⅳ期的患者69例,其中脱落2例、退出4例、剔除3例,最后纳入60例,采用随机数字表法随机分为两组。两组患者均于入院当天采用常规外... 详细信息

目的:观察芪归紫草油在促进难愈性创面愈合方面的临床疗效。方法:选择创面超过1个月不愈合、临床分期为Ⅲ~Ⅳ期的患者69例,其中脱落2例、退出4例、剔除3例,最后纳入60例,采用随机数字表法随机分为两组。两组患者均于入院当天采用常规外科消毒清创换药处理,同时积极治疗原发病。治疗组30例在常规外科消毒清创换药处理后给予芪归紫草油(黄芪、当归、紫草、大黄、珍珠粉)覆盖包扎;对照组30例采用无菌剪祛除坏死组织或痂皮后,外用龙珠软膏加压包扎。两组均以15d为1个疗程,治疗2个疗程后判定疗效。结果:治疗组治愈12例,有效17例,无效1例,有效率为96.67%;对照组治愈6例,有效14例,无效10例,有效率为66.67%。两组对比,差别有统计学意义(P<0.05)。治疗后,治疗组腐肉脱落时间、新生肉芽出现时间、创面愈合时间均少于对照组(P<0.05)。结论:芪归紫草油在促进难愈性创面愈合方面较龙珠软膏疗效更好,可加速创面愈合,值得临床推广运用。

关键词：难愈性创面/中医药疗法芪归紫草油/治疗应用白糖/治疗应用龙珠软膏/治疗应用临床观察

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pattern Recognition of Modulation Signal Classification Using Deep Neural Networks

引用

Computer Systems Science & Engineering 2022年第11期43卷 545-558页

作者： D.Venugopal V.mohan S.Ramesh S.Janupriya Sangsoon Lim Seifedine Kadry Department of Electronics and Communication Engineering KPR Institute of Engineering and TechnologyCoimbatore641048India Department of Electronics and Communication Engineering Saranathan College of EngineeringTrichy620012India Department of Computer Science and Engineering Krishnasamy College of Engineering&TechnologyCuddalore607109India Department of Electronics and Communication Engineering K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Computer Engineering Sungkyul UniversityAnyangKorea Department of Applied Data Science Noroff University CollegeKristiansandNorway

In recent times,pattern recognition of communication modulation signals has gained significant attention in several application areas such as military,civilian field,*** becomes essential to design a safe and robust feature extraction(FE)approach to efficiently identify the various signal modulation types in a complex *** works have derived new techniques to extract the feature parameters namely instant features,fractal features,and so *** addition,machine learning(ML)and deep learning(DL)approaches can be commonly employed for modulation signal *** this view,this paper designs pattern recognition of communication signal modulation using fractal features with deep neural networks(CSM-FFDNN).The goal of the CSM-FFDNN model is to classify the different types of digitally modulated *** proposed CSM-FFDNN model involves two major processes namely FE and *** proposed model uses Sevcik Fractal Dimension(SFD)technique to extract the fractal features from the digital modulated ***,the extracted features are fed into the DNN model for modulation signal *** improve the classification performance of the DNN model,a barnacles mating optimizer(BMO)is used for the hyperparameter tuning of the DNN model in such a way that the DNN performance can be raised.A wide range of simulations takes place to highlight the enhanced performance of the CSM-FFDNN *** experimental outcomes pointed out the superior recognition rate of the CSM-FFDNN model over the recent state of art methods interms of different evaluation parameters.

关键词： Pattern recognition signal modulation communication signals deep learning feature extraction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A comprehensive review of DC fault protection methods in HVDC transmission systems

引用

Protection and Control of Modern Power Systems 2021年第1期6卷 1-20页

作者： mohan Muniappan Senior Research Specialist Center for Future Energy Systems(CFES)Rensselaer Polytechnic Institute(RPI)TroyNew YorkUSA

High voltage direct current (HVDC) transmission is an economical option for transmitting a large amount of power over long distances. Initially, HVDC was developed using thyristor-based current source converters (CSC). With the development of semiconductor devices, a voltage source converter (VSC)-based HVDC system was introduced, and has been widely applied to integrate large-scale renewables and network interconnection. However, the VSC-based HVDC system is vulnerable to DC faults and its protection becomes ever more important with the fast growth in number of installations. In this paper, detailed characteristics of DC faults in the VSC-HVDC system are presented. The DC fault current has a large peak and steady values within a few milliseconds and thus high-speed fault detection and isolation methods are required in an HVDC grid. Therefore, development of the protection scheme for a multi-terminal VSC-based HVDC system is challenging. Various methods have been developed and this paper presents a comprehensive review of the different techniques for DC fault detection, location and isolation in both CSC and VSC-based HVDC transmission systems in two-terminal and multi-terminal network configurations.

关键词： HVDC VSC Multi-terminal DC grid DC fault Fault detection and location Fault isolation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：