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Numerical Simulation on Oil Spilling of Submarine Pipeline and Its Evolution on Sea Surface

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Computer Modeling in Engineering & Sciences 2020年第9期124卷 885-914页

作者： Yi Wang mohan lin National Engineering Laboratory for Pipeline Safety MOE Key Laboratory of Petroleum EngineeringBeijing Key Laboratory of Urban Oil and Gas Distribution TechnologyChina University of PetroleumBeijing102249China

Due to the interaction and corrosion of the seawater,submarine pipelines are easy to be broken to spill *** special environment of subsea restricts the technical development of pipeline ***,the study on the oil spilling model of submarine pipeline is very important for predicting the movement and diffusion of spilled oil,so that oil spilling traces and relating strategies can be *** paper aims to establish an oil spilling model of a submarine pipeline,study the movement characteristics of spilled oil in seawater by numerical simulation,and determine the traces,diffusion range,time to sea surface,***,the maximum horizontal migration distance(MHMD)with corresponding time are analyzed under different oil densities,spilling speeds and seawater *** show that the MHMD decreases first and then increases while the time to achieve the MHMD increases along with increasing oil *** MHMD increases while the time to achieve the MHMD decreases,along with increasing spilling *** the MHMD and corresponding time increase along with increasing seawater *** on numerical results,a correlation of spilling distance and spilling time is proposed to give fast and accurate *** the oil reaches sea surface,oil expansion and transport are ***-Lagrange method is used in the *** and non-dynamic factors are *** show that wind velocity and water velocity are dominant in dynamic *** they are large,spilled oil moves very fast with variable directions in complex flow *** factors such as evaporation,emulsion and solution mainly reduce the volume of oil *** almost do not affect the direction and displacement of spilled *** response should be made for large wind and water velocities when the placement of oil boom is *** the correlation and simulation,emergency responses can be guided effectively to reduce the impact of submarine o

关键词： Computational fluid dynamics submarine pipeline oil spilling pollution control environmental protection

Nanoparticle delivery for central nervous system diseases and its clinical application

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Nano Research 2024年第7期17卷 6305-6322页

作者： lin Tang Rui Zhang Yusi Wang mohan Liu Die Hu Yuanda Wang Li Yang Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

In the treatment of central nervous system(CNS)diseases such as glioma,Alzheimer's disease(AD)and Parkinson's disease(PD),drugs are expected to reach specific areas of the brain to achieve the desired *** a growing number of therapeutic targets have been identified in preclinical studies,the ones that can ultimately be used in the clinic are ***,the research process and clinical application of drugs for treating CNS diseases are still large *** barriers such as the blood‒brain barrier(BBB)act as selective permeable membranes,allowing only certain molecules to enter the brain;this barrier is the major obstacle restricting the arrival of most drugs to brain ***,nanoparticles,including lipid-based,cell-derived biomimetic,polymeric and inorganic nanoparticles,have gained increasing attention because of their ability to cross physiological barriers,and could play an important role as delivery carriers and ***,clinical applications of nanoparticles in CNS diseases are *** review focuses on the progress of current research on the use of nanoparticles for the treatment of CNS diseases to provide additional insight into the treatment of CNS diseases.

关键词： nanoparticles central nervous system(CNS)diseases clinical applications delivery carriers immunomodulators

Effect of continuous positive airway pressure ventilation on nocturnal ST-segment changes in patients with sleep-disordered breathing

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Journal of Geriatric Cardiology 2007年第2期4卷 101-104页

作者： Wenli Zhang Shiwen Wang Rui Chen mohan Liu lin Wang Lei Gao Caiyi Lu Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Objective To determine whether sleep-disordered breathing (SDB) may lead to nocturnal myocardial ischemia and whether the severity of this ischemia may be relieved by nasal continuous positive airway pressure (CPAP). Methods Overnight polysomnogram examination and simultaneous 3-channel Holter monitoring were performed on 76 patients with moderate to severe SDB and no history of coronary heart disease. All the cases were treated with CPAP for one night. ST depression was defined as a ST segment decrease of more than 1 mm from baseline and lasting 1 min or more. The total duration (minutes) of ST depression was indexed to the total sleep time (minutes per hour of sleep). Results Twenty-eight patients (37%) showed ST segment depression during their sleep. Before CPAP treatment, the respiratory disturbance index (RDI) and arousal index were significantly higher during periods of ST depression than when ST segments were isoelectric, whereas no significant difference was found in blood oxygen saturation (SaO2). After the CPAP treatment of patients with ST depression, the duration of ST depression was significantly reduced from 36.8±18.9 to 11.4±13.2 min/h (P<0.05). ST depression-related indexes, including RDI, arousal index and the percentage of sleep time spent at SaO2 below 90% (TS90/ TST), were all significantly decreased, with RDI from 63.4±23.8 to 8.1±6.6 /h, arousal index from 51.2±18.9 to 9.6±5.4 /h, and TS90/ TST from 50.6±21.4 to 12.9±14.7% (P<0.05). Conclusion ST-segment depression is rather common in patients with moderate to severe SDB, and CPAP treatment can significantly reduce the duration of ST depression. ST depression in these patients may reflect the myocardial ischemia that really exists and the non-ischemic changes associated with recurrent SDB.

关键词： ST-segment depression myocardial ischemia sleep-disordered breathing continuous positive airway pressure

BioTreasury:a community-based repository enabling indexing and rating of bioinformatics tools

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Science China(Life Sciences) 2024年第2期67卷 221-229页

作者： Qi Zhao Xin Zhou Jingxing Wu Jieyi Cai Xiaoqiong Bao lin Tang Chaoye Wang Chunlei Liu Yukai Wang Yuyan Teng mohan Zheng Weiping Mu Zhixiang Zuo Yubin Xie Xiaotong Luo Jian Ren School of Life Sciences State Key Laboratory of Oncology in South ChinaCancer CenterGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou 510060China Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China

The exponential growth of bioinformatics tools in recent years has posed challenges for scientists in selecting the most suitable one for their data analysis ***,to aid scientists in making informed choices,a community-based platform that indexes and rates bioinformatics tools is urgently *** this study,we introduce Bio Treasury(http://***),an integrated communitybased repository that provides an interactive platform for users and developers to share their experiences in various bioinformatics *** Treasury offers a comprehensive collection of well-indexed bioinformatics software,tools,and databases,totaling over 10,000 *** the past two years,we have continuously improved and maintained Bio Treasury,adding several exciting features,including creating structured homepages for every tool and user,a hierarchical category of bioinformatics tools and classifying tools using large language model(LLM).Bio Treasury streamlines the tool submission process with intelligent ***,Bio Treasury provides a wide range of social features,for example,enabling users to participate in interactive discussions,rate tools,build and share tool collections for the *** believe Bio Treasury can be a valuable resource and knowledge-sharing platform for the biomedical *** empowers researchers to effectively discover and evaluate bioinformatics tools,fostering collaboration and advancing bioinformatics research.

关键词： bioinformatics tools index tool database rating system large language model tool collections shari

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上海花博会沉水植物水质净化效果分析

上海海洋大学学报 2023年第1期32卷 118-125页

作者：蔡晓男林墨翰赵辉莫亚思中交三航局第二工程有限公司上海200122

选取矮型苦草(Vallisneria natans)、改良型刺苦草(Vallisneria spinulosa)和龙须眼子菜(Potamogeton pectinatus)等3种沉水植物为研究对象,对由江苏昆山污水处理厂尾水配制的试验污水开展水质净化试验。试验设置5个种植密度梯度和无植... 详细信息

选取矮型苦草(Vallisneria natans)、改良型刺苦草(Vallisneria spinulosa)和龙须眼子菜(Potamogeton pectinatus)等3种沉水植物为研究对象,对由江苏昆山污水处理厂尾水配制的试验污水开展水质净化试验。试验设置5个种植密度梯度和无植物空白对照组,从去除效率和不稳指数两个方面,分析不同植物种类和种植密度对试验污水净化效果的影响。结果表明:创新性建立的去除效率和不稳指数两大指标具有较好的评价效果。两大指标分别用于评价水质净化试验前后期的水质变化趋势,相互结合可综合评价试验全周期的水生态修复效果。不同植物对试验污水中污染物的净化效果存在差异,且种植密度对净化效果也存在一定程度的影响。因此,水生态修复工程中,建议选择适宜的沉水植物种类与种植密度,并且注意监测植株生长状况,以避免植株恶性竞争对水体净化产生负面影响。

关键词：水生态修复沉水植物种植密度净水效果

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大跨径仿叶脉状钢结构快速安装工艺

建筑结构 2022年第S1期52卷 2967-2970页

作者：蔡晓男杨连佼林宇翔林墨翰中交三航局第二工程有限公司上海200122

花博会主入口大门采用仿叶脉状钢结构外挂PVDF张拉膜,高19.21m,跨度100m,由448根弧形钢管构件组成。施工采用落地支架与钢管拉索相结合的支撑体系,代替传统的满堂脚手架方案,减少落地支架的占地面积和大型吊装设备的使用。在此基础上,... 详细信息

花博会主入口大门采用仿叶脉状钢结构外挂PVDF张拉膜,高19.21m,跨度100m,由448根弧形钢管构件组成。施工采用落地支架与钢管拉索相结合的支撑体系,代替传统的满堂脚手架方案,减少落地支架的占地面积和大型吊装设备的使用。在此基础上,针对仿叶脉状钢结构悬臂构件多、难自稳等问题,优化构件安装顺序与节点连接方式,确保整个安装过程安全、高效,节约工期20d。

关键词：仿生钢结构悬臂构件支架体系安装工艺

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Ern1调控肿瘤免疫原性机制的初步探索

中国免疫学杂志 2024年第5期40卷 897-904页

作者：李莫寒夏琳马瑜婷南京医科大学肿瘤个体化医学协同创新中心中国医学科学院系统医学研究院/苏州系统医学研究所免疫与炎症全国重点实验室

目的：探讨内质网跨膜蛋白IRE1（由Ern1编码）对肿瘤细胞免疫原性和成瘤性的影响与机制。方法：挖掘肿瘤公共数据库中ERN1表达水平和患者生存的关联性。利用CRISPR-Cas9技术敲除小鼠肿瘤细胞系MCA205和TC-1的Ern1基因，借助CCK-8、流式... 详细信息

目的：探讨内质网跨膜蛋白IRE1（由Ern1编码）对肿瘤细胞免疫原性和成瘤性的影响与机制。方法：挖掘肿瘤公共数据库中ERN1表达水平和患者生存的关联性。利用CRISPR-Cas9技术敲除小鼠肿瘤细胞系MCA205和TC-1的Ern1基因，借助CCK-8、流式细胞术、ELISA、荧光素酶报告系统、皮下植瘤、预免疫-再刺激等实验分析Ern1对肿瘤细胞体外增殖和体内成瘤能力、浸润肿瘤的免疫细胞比例、衣霉素诱导免疫原性细胞死亡和抗肿瘤效应T细胞活化的影响，比较Ern1-/-肿瘤在正常小鼠和Ifnar-/-小鼠体内生长速度的差异。结果：对多个癌种而言，肿瘤组织ERN1的表达水平与患者总生存时间呈负相关。虽然敲除Ern1不影响肿瘤细胞的体外增殖能力，但其在正常小鼠皮下的成瘤能力大幅降低，甚至会自发消退。与野生型相比，Ern1-/-肿瘤内中性粒细胞显著增多，CD4+T细胞浸润减少。衣霉素诱导内质网应激后，Ern1-/-细胞死亡更多，虽然其HMGB1释放和钙网蛋白暴露有所减少，但IFN-α/β分泌增多，能更强地激活效应T细胞分泌IFN-γ。与正常小鼠相比，Ifnar-/-免疫缺陷小鼠体内Ern1-/-肿瘤生长速度显著加快。结论：Ern1缺失可促进内质网应激肿瘤细胞的Ⅰ型干扰素应答，增强其免疫原性，促进抗肿瘤T细胞分泌IFN-γ，阻碍肿瘤生长。

关键词：未折叠蛋白反应肿瘤免疫原性干扰素内质网应激

多指标-正交试验优化沙棘叶和沙棘籽中黄酮的提取工艺

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中国药房 2017年第34期28卷 4856-4859页

作者：惠人杰冯静蔺默含冯柏年江南大学药学院江苏无锡214122 江苏艾凡生物医药有限公司江苏无锡214122

目的:优化沙棘叶和沙棘籽中黄酮的提取工艺。方法:以6种黄酮苷元即儿茶素、芦丁、杨梅素、槲皮素、山柰酚、异鼠李素的提取率总和为指标,以乙醇体积分数、提取时间、提取次数、料液比为考察因素,采用L9(34)表设计正交试验,分别优化沙棘... 详细信息

目的:优化沙棘叶和沙棘籽中黄酮的提取工艺。方法:以6种黄酮苷元即儿茶素、芦丁、杨梅素、槲皮素、山柰酚、异鼠李素的提取率总和为指标,以乙醇体积分数、提取时间、提取次数、料液比为考察因素,采用L9(34)表设计正交试验,分别优化沙棘叶和沙棘籽中黄酮的提取工艺,并进行验证试验。结果:沙棘叶中黄酮的最优提取工艺为乙醇体积分数70%、提取3次、每次提取2.0 h、料液比1:16;沙棘籽中黄酮的最优提取工艺为乙醇体积分数50%、提取3次、每次提取1.5 h、料液比1:24;验证试验中,沙棘叶和沙棘籽中6种黄酮苷元的提取率总和分别为56.4、15.4 mg/g(RSD分别为1.4%、3.4%,n=3)。结论:优化后的提取工艺方法简便、稳定、可行,可用于沙棘叶和沙棘籽中黄酮成分的提取。

关键词：沙棘叶沙棘籽正交试验提取工艺黄酮苷元

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青奥会对南京城市空间发展影响研究

住宅科技 2014年第1期34卷 5-7页

作者：晋夜林陌涵南京工业大学建筑学院

2014年第二届青年奥林匹克运动会将在南京举办,这是南京首次举办全球性质的大型综合性体育赛事。从城市事件与城市空间形态入手,分析青奥会场馆选址、布局及其与南京城市空间规划的契合,着重探讨了青奥会对南京城市空间发展的三方面影响... 详细信息

2014年第二届青年奥林匹克运动会将在南京举办,这是南京首次举办全球性质的大型综合性体育赛事。从城市事件与城市空间形态入手,分析青奥会场馆选址、布局及其与南京城市空间规划的契合,着重探讨了青奥会对南京城市空间发展的三方面影响:助推南京实现城市总体发展战略;加快城市空间更新;优化城市空间结构,促进城市空间拓展。

关键词：青奥会城市事件城市空间