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荷兰全科门诊1987年和2001年脓疱病的发病率和治疗——2项国家调查结果

世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 19-20页

作者： Koning s. mohammedamin r.s.a. Van Der Wouden J.C. 王琼 Department of General Practice Erasmus MC University Medical Centre Rotterdam PO Box 1738 3000 DR Rotterdam Netherlands

Background: Impetigo is a common skin infection in children. The epidemiology is relatively unknown, and the choice of treatment is subject to debate. Objective: The objective of our study was to determine the incidence and treatment of impetigo in Dutch general practice, and to assess trends between 1987 and 2001. Methods: We used data from the first (1987) and second (2001) Dutch national surveys of general practice. All diagnoses, prescriptions and referrals were registered by the participating general practitioners (GPs), 161 and 195, respectively. results: The incidence rate of impetigo increased from 16.5 (1987) to 20.6 (2001) per 1000 person years under 18 years old (P rs, the incidence was significantly higher in summer, in rural areas and in the southern region of the Netherlands, compared with winter, urban areas and northern region, respectively. socioeconomic status was not associated with the incidence rate. From 1987 to 2001, there was a trend towards treatment with a topical antibiotic (from 43%to 64%), especially fusidic acid cream and mupirocin cream. Treatment with oral antibiotics (from 31%to 14%) and antiseptics (from 11%to 3%) was prescribed less often. Conclusions: We have shown an increased incidence of impetigo in the past decade, which may be the result of an increased tendency to seek help, or increased antibiotic resistance and virulence of staphylococcus aureus. Further microbiological r.s.a.ch on the marked regional difference in incidence may contribute to understanding the factors that determine the spread of impetigo. Trends in prescribing for impetigo generally follow evidencebased knowledge on the effectiveness of different therapies, rather than the national practice guideline.

关键词：治疗情况全科门诊发病率脓疱病荷兰调查结果莫匹罗星软膏 18岁以下人群金黄色葡萄球菌口服抗生素

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