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Journal of Chemistry and Chemical Engineering 2010年第9期4卷 34-43页

作者： mohammed saleh tawfek makki Abeer Nasser AI-Romaizan Reda Mohmmady Abdel-Rahman Chemistry Department Faculty of Science King Abdul Aziz University Jeddah 80203 Kingdom of Saudi Arabia

Some new 2-thioxo thiazole, 2-thioxo 1,3,4- thiadiazole and 3-thioxo-1,3,4-triazole derivatives （3-17） have been synthesized through ring closure reactions ofdithioic formic acid hydrazones 2 with functional reagents in different medium. Former structures of the products have been established by the help of elemental and spectral analysis. Most of the obtained targets showed a moderate activity towards some microbes in comparison with two antibiotics Pipercillin and Mycostatine.

关键词： Synthetic thioxo thiazoles biocidal.

Synthesis of Some More New Sulfur Compounds Bearing Heterocyclic Systems as Biocidal Agents - Part I ： Synthetic of 2-Thioxo Thiadiazinone Derivatives

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Journal of Chemistry and Chemical Engineering 2010年第10期4卷 41-49页

作者： mohammed saleh tawfek makki Abeer Nasser Al-Romaizan Reda Mohmmady Abdel-Rahman Chemistry Department Faculty of Science King A bdul Aziz University Jeddah 80203 Kingdom of Saudi Arabia

Some more new sulfur compounds bearing heterocyclic systems mainly 2-thioxo-1,3,4-thiadiazinone derivatives 2-7 and 3-thioxo-1,2,4-triazole derivatives 9 have been synthetic via alkylation, acylation and condensation of dithioic formic acid hydrazide 1 through ring closure reactions with α,β-bi functional groups compounds. Most of the obtained target showed a highly activity towards some microbial in compare with two references antibiotics, Pipercillin and Mycostatine. The structures of the products have been established from their elemental and spectral analysis.

关键词： Synthetic thioxo thiadiazinones biocidal.

Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone

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International Journal of Organic Chemistry 2015年第3期5卷 153-165页

作者： mohammed saleh tawfek makki Reda Mohammady Abdel Rahman Ola Ahmad Abu Ali Chemistry Department Faculty of Science King Abdul Aziz University Jeddah Kingdom of Saudi Arabia

Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)-1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.

关键词： Synthesis Fluorinated 1 2 4-Triazinothiadiazolones Anthelmintic Drugs

Synthesis of Fluorinated Heterobicyclic Nitrogen Systems Containing 1,2,4-Triazine Moiety as CDK2 Inhibition Agents

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International Journal of Organic Chemistry 2015年第3期5卷 200-211页

作者： mohammed saleh Tawfik makki Reda Mohammdy Abdel-Rahman Faisal mohammed Aqlan Department of Chemistry Faculty of Science King Abdulaziz University Jeddah Saudi Arabia

New fluorine substituted heterobicyclic nitrogen system as imidozolopyrimidines (2,3), pyrimido- 1,2,4-triazinones (4-7), 1,2,4-triazinyl-1,2,4-triazine (12-16), 1,2,4-triazinyl-1,2,4-triazinones (14-17) and substituted thiobarbituric acids (19-20), have been synthesized using the reaction of 3- amino-5,6-di (4'-fluorophenyl)-1,2,4-triazine (1) with α,β–bifunctional compounds. Structures of the title compounds were characterized by UV, IR, 1H/13C-NMR and mass spectrometric method. The studied compounds were tested for CDK2 inhibiting activity in DNA damage, as well as in vitro anti-tumor activity.

关键词： Synthesis Fluoroheterobicyclic Nitrogen CDK2 Inhibition Anti-Tumor Activity