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Journal of Cancer Therapy 2023年第3期14卷 117-126页

作者： Oumaima Siyouri mohammed ismaili Khaoula Alaoui ismaili Imane Stitou Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas Hospital Center University Hassan II Fez Morocco

Introduction: Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation can range from asymptomatic to bleeding or manifestations of mass effect. Cancer surgery followed by adjuvant treatment with imatinib is the standard of care. However, in special circumstances, a cytoreductive approach may represent a therapeutic option. We describe here the case of two patients who presented with a painful and protruding epigastric mass, the first case was a localized E-GIST candidate for neoadjuvant treatment with imatinib with complete resection surgery thereafter with very good evolution, and the second is that of an E-GIST of the liver at an advanced stage with an evolution very quick to death. Conclusion: Primary liver E-GIST is a rare condition. Treatment is based on systemic therapy and total resection surgery. However, cytoreductive surgery will be required when complete resection is not possible.

关键词： Extra GIST Foie Imatinib

Pre-Sacral Chordomas, about Two Cases and Review of the Literature

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Journal of Cancer Therapy 2023年第4期14卷 152-160页

作者： Oumaima Siyouri Khaoula Alaoui ismaili Imane Stitou mohammed ismaili Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas Department of Oncology University Hospital Center Fes Morocco

The World Health Organization (WHO) defines chordoma as a malignant tumor of intermediate or low grade, developing at the expense of embryonic remnants of the notochord. These tumors represent 8.4% of all malignant bone tumors. We report 2 cases collected in the medical oncology department at the CHU Hassan II in Fes. In whom the clinical examination revealed a mass and/or signs of loco-regional compression. The tumor was located in the sacrum in both patients. The diagnosis was based on the data of the anatomopathological examination showing the association of a lobulated architecture with classic physaliphore cells and a mucoid intercellular substance. Immunohistochemistry was performed for both patients. The principle of therapeutic management was based on radiotherapy and targeted therapy since surgery was difficult given the local tumor extension.

关键词： Chordomas Imatinib Radiotherapy

Colonic schistosomiasis:A case report

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World Journal of Gastrointestinal Endoscopy 2022年第12期14卷 789-794页

作者： Hajar Koulali Abdelkrim Zazour Wafaa Khannoussi Ghizlane Kharrasse Zahi ismaili Department of Gastro-enterology Mohammed VI University HospitalOujda 60050Morocco

BACKGROUND Schistosomiasis is a chronic parasitic infection endemic in many *** schistosomiasis is a rare entity with no specific clinical manifestations or endoscopic aspects,which delays the *** is primarily dependent on histopathological analysis,and treatment with antihelminthics typically resolves the *** SUMMARY We present the case of a 21-year-old male who suffered from chronic diarrhea and abdominal *** examination found no abnormalities,blood tests were normal,and stool examination was negative.A colonoscopy revealed a nodular terminal ileal mucosa,two cecal polypoid lesions with no particular surface pattern,and millimetric erosions in the *** presence of Schistosoma eggs with thick peripheral capsules and viable embryos inside and numerous eosinophils surrounding the egg capsule were observed on histopathological *** patient received praziquantel,and his symptoms were *** Colonic schistosomiasis should be considered as a differential diagnosis,especially in endemic *** and histopathological examination can confirm the diagnosis,and antihelminthics are an effective treatment.

关键词： Schistosoma Colon Polyps Colonoscopy Histopathology Ova

Compound Heterozygous C282Y/H63D Mutation in Hemochromatosis: A Case Report

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Open Journal of Clinical Diagnostics 2016年第3期6卷 30-35页

作者： Zazour Abdelkrim Wafaa Khannoussi Amine El Mekkaoui Ghizlane Kharrasse Zahi ismaili Hepato-Gastro-Enterology Unit Mohammed VI University Hospital Oujda Oujda Morocco

Hereditary hemochromatosis is a condition characterized by iron overload, which is both treatable and preventable. It’s mainly related to hepcidin deficiency related to mutations in genes involved in hepcidin regulation. Iron overload increases the risk of disease such as liver cirrhosis, heart disease and diabetes. Two HFE genotypes have been commonly described in cases of iron overload, C282Y homozygosity and C282Y/H63D compound heterozygoty. The diagnosis of this rare disease now can be explored by biological and imaging tools. We report a case of compound heterozygous C282Y/H63D discovered by family screening for elevated serum ferritin.

关键词： Iron Overload Compound Heterozygoty Phlebotomy

Crizotinib in non-small cell lung cancer

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Modern Chemotherapy 2014年第1期3卷 5-9页

作者： Nawfel Mellas Fatimzahra Hijri Zineb Benbrahim Omar El Mesbahi Nabil ismaili Department of Medical Oncology Hassan II University Hospital Fez Morocco Oncology Center Medical Oncology University Hospital Mohammed VI Marrakech Morocco

Chemotherapy and targeted therapy remain the cornerstone of treatment of locally advanced and metastatic non-small cells lung cancer (NSCLC). Given the intrinsic chemoresistance of tumor cells, new treatment options have been developped. The knowledge of the molecular mechanisms of tumor biology, and signal transduction pathways activating cancer cells led to the identification of a new targeted therapy such as Crizotinib. The small molecule Crizotinib is a selective inhibitor of the receptor tyrosine kinase ALK (anaplastic lymphoma kinase) and its oncogenic variants (ALK fusion gene and some mutations of ALK). Phases I and II trials showed the efficacy of Crizotinib in the treatment of locally advanced and metastatic NSCLC expressing ALK. Thereafter, randomized Phase III trial confirmed the significant superiority of Crizotinib versus standard chemotherapy in terms of progression free survival and objective response with good tolerance;therefore, it has been approved by the Food and Drug Administration (FDA) as the standard treatment for locally advanced and metastatic ALK-positive NSCLC.

关键词： NSCLC Crizotinib Metastatic NSCLC ALK Chemotherapy

Epidemiology of Pemphigus: A Single Center Experience in Morocco

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International Journal of Dermatology and Venereology 2022年第1期5卷 20-26页

作者： Farah El Hadadi Line Mezni Karima Senouci Laila Benzekri Nadia ismaili Mariame Meziane Department of Dermatology-Venereology Ibn Sina University HospitalMohammed V UniversityRabat 10100Morocco

Objective:Pemphigus is a life threatening autoimmune bullous disease which involves the skin and mucous membranes of the stratified squamous *** global distribution of Pemphigus varies according to genetic,ethnic,socioeconomic,and cultural *** purpose of our study is to evaluate the epidemiological features of pemphigus a single center in Morocco and compare our results with those reported ***:A retrospective analysis was conducted of 302 pemphigus patients seen between 1990 and 2020 in the Dermatology Department of Ibn Sina Hospital(Rabat,Morocco).We further collected all the Moroccan scientific researches published by now to ***:The average annual incidence was 0.32/100,000 *** incidence doubled to 0.72 in *** most common variant was pemphigus vulgaris(125 cases)followed by pemphigus erythematosus(99 cases),pemphigus foliaceous(40 cases),and vegetans(27 cases).The female to male ratio was 0.75,the average age at onset was 53 years old and the mean duration of the disease before diagnosis was ***:This study joins the main characteristics of pemphigus in the Maghreb and around the world(pemphigus vulgaris most frequent subtype).In 2020,an epidemiological peak occurred during the coronavirus disease 2019 pandemic;probably related to stress and delayed time consultation for fear of contracting the severe acute respiratory syndrome coronavirus 2.

关键词： pemphigus epidemiology Rabat Morocco autoimmune bullous disease desmoglein

SARS-COV-2 Infection and Anti-Tuberculosis Immunity: Temporal Association or Real Protective Role?

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Advances in Infectious Diseases 2022年第4期12卷 656-667页

作者： Sanaa Hammi Myriem Bourkia Adil Najdi Rajae Chahboune Karima Rissoul Jamal Eddine Bourkadi Jouda Benamor Fatema El Bouzouiki Soumiya El Bachiri mohammed Moumkin Rachid ismaili Nadira Mourabait Ouafae Kaissi Asmae Zerrouki Adil Grourinda Fadila Bousgheiri Hassana Belafki Mhamed Harif Mohamed Ahalat Faculty of Medicine and Pharmacy of Tangier FMPT Abd Elmalek Essadi University (AEU) Tangier Morocco Faculty of Medicine and Pharmacy of Rabat Mouhamed V University Rabat Morocco Faculty of Science and Technology of Al Hoceima Abd Elmalek Essadi University (AEU) Tangier Morocco Faculty of Science and Technology of Tangier Abd Elmalek Essadi University (AEU) Tangier Morocco

Introduction: According to the literature consulted to date, there is epidemiological heterogeneity of Covid-19 between countries depending on their vaccination policy, in particular BCG vaccination. These findings have led to several hypotheses, including the protective role of immunity induced by the BCG tuberculosis vaccine against Covid-19 infection. The immunity induced by the BCG vaccine significantly increases the secretion of pro-inflammatory cytokines, in particular IL-1B, which has been shown to play an essential role in antiviral immunity. This cross-immunity, although not specific, if highlighted, is a real providence that must be taken advantage of in the face of this pandemic. The main objective of this study is to rule out or confirm that anti-tuberculosis immunity protects against SARS-COV-2 in our context. Material and Methods: Two groups will be compared: cases infected with the virus and controls who have never been infected with the virus. Both case and control groups will undergo a tuberculin skin test: the intra dermal tuberculin reaction (IDR). Results: We found that our control group had a high IDR immunity value, with an IDR tuberculin positive percentage of 67.2%. This suggests that immunity to IDR is a protective factor against coronavirus disease. Conclusion: The hypothesis of nonspecific anti-tuberculosis protection deserves further verification studies;it would have large positive repercussions for developing countries.

关键词： BCG Nonspecific Anti-Tuberculosis Immunity Covid-19

Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature

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World Journal of Gastrointestinal Endoscopy 2022年第7期14卷 455-466页

作者： Kaouthar Rais Oumayma El Eulj Najoua El Moutaoukil Imane Kamaoui Amal Bennani Ghizlane Kharrasse Abdelkrim Zazour Wafaa Khannoussi Zahi ismaili Department of Hepatogastroenterology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco Department of Radiology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco Department of Anatomo-Pathology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco

BACKGROUND Pancreatic metastases from squamous cell lung carcinoma(SCLC)are *** lesions are often asymptomatic and detected incidentally or during followup investigations,occasionally several years after removal of the primary *** SUMMARY A 56-year-old male with SCLC developed jaundice 1 mo after the cancer *** abdominal computed tomography(CT)scan showed a mass in the pancreatic head with distention of both intra-and extrahepatic biliary *** retrograde cholangiopancreatography and sphincterotomy were performed first,culminating with plastic biliary stent *** examination of the pancreatic mass sample collected by fine-needle aspiration(FNA)under endoscopic ultrasound(EUS)guidance revealed the presence of malignant cells compatible with well-differentiated squamous cell *** liver function normalized,chemotherapy was initiated with carboplatin and paclitaxel;however,4 d later,the patient presented ***-thoracoabdominal CT showed tracheoesophageal fistula and stent *** replacement with a 10 cm/10 mm uncovered metallic biliary stent and treatment of the tracheoesophageal fistula with a fully covered esophageal stent,the patient was able to start oral feeding *** died 9 mo after the initial *** The diagnosis of pancreatic metastasis from SCLC is challenging for ***-FNA is the primary exam for confirmatory diagnosis.

关键词： Squamous cell lung carcinoma Pancreatic metastasis Jaundice Esotracheal fistula Ultrasound endoscopy Case report