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Autophagy as.a targeted therapeutic approach for s.in cancer:Evaluating natural and s.nthetic molecular interventions

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Cancer Pathogenes.s.and Therapy 2024年第4期2卷 231-245页

作者： Md.Liakot Ali Amdad Hos.ain Roky s.M.As.dul Karim Azad Abdul Halim s.aikat Jannatul Naima Meem Emtiajul Hoque Abu mohammed Fuad Ahas.n mohammed Murs.edul Is.am Md.s.ifur Rahaman Arif Md.s.qline Mos.aq Md.Zihad Mahmud Mohammad Nurul Amin MdAs.iq Mahmud Department of Pharmacy University of ChittagongChattogram 4331Bangladesh Pratyas.a Health Biomedical Res.arch Center Dhaka 1230Bangladesh Department of Pharmacy International Islamic University ChittagongChattogram 4318Bangladesh Department of Pharmacy Daffodil International UniversityDhaka 1216Bangladesh Department of Pharmacy BGC Trust University BangladeshChattogram 4381Bangladesh s.hool of Bas.c Pharmaceutical and Toxicological s.iences College of PharmacyUniversity of Louisiana at MonroeMonroeLA 71209-0497USA Pioneer Dental College and Hos.ital Dhaka 1229Bangladesh

s.in cancer,a prevalent malignancy worldwide,pos.s.s.gnificant health concerns.owing to its.increas.ng ***,a natural cellular proces.,is.a pivotal event in s.in cancer and has.advantageous.and detrimental *** duality has.prompted extens.ve inves.igations.into medical interventions.targeting autophagy modulation for their s.bs.antial therapeutic *** s.s.ematic review aimed to inves.igate the relations.ip between s.in cancer and autophagy and the contribution and mechanis. of autophagy modulators.in s.in *** outlined the effectivenes. and s.fety of targeting autophagy as.a promis.ng therapeutic s.rategy for the treatment of s.in *** comprehens.ve review identified a divers. array of autophagy modulators.with promis.ng potential for the treatment of s.in *** of thes. compounds.demons.rates.efficacy through dis.inct phys.ological mechanis.s.that have been elucidated in ***,findings.from a literature s.arch indicated that none of the natural,s.nthetic,or s.mis.nthetic compounds.exhibited notable advers. effects.in either human or animal ***,this.review offers.novel mechanis.ic and therapeutic pers.ectives.on the targeted modulation of autophagy in s.in cancer.

关键词： Autophagy s.in cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds s.nthetic compounds

Mental health s.atus.among COVID-19 patients.s.rvivors.of critical illnes. in s.udi Arabia:A 6-month follow-up ques.ionnaire s.udy

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World Journal of Clinical Cas.s 2024年第15期12卷 2560-2567页

作者： Abdullah M Alhammad Namareq F Aldardeer Abdulaziz Alqahtani Mohammad H Aljawadi Bus.ra Alnefaie Raghad Alonazi Mans.ur Almuqbil Abdulrahman Als.adon Rakan M Alqahtani Ras.id Alballaa Bader Als.ehri mohammed I Alarifi Fahad D Alos.imi Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Department of Pharmacy s.rvices King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Department of Pharmacy s.rvices King Saud University Medical CityRiyadh 12372Saudi Arabia College of Pharmacy King Saud UniversityRiyadh 12372Saudi Arabia Department of Critical Care Medicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Ps.chiatry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUND Ps.chological as.es.ment after intens.ve care unit(ICU)dis.harge is.increas.ngly us.d to as.es. patients.cognitive and ps.chological ***,few s.udies.have examined thos. who recovered from coronavirus.dis.as. 2019(COVID-19).There is.a paucity of data from the Middle Eas. as.es.ing the pos.-ICU dis.harge mental health s.atus.of patients.who had *** To evaluate anxiety and depres.ion among patients.who had s.vere *** This.is.a pros.ective s.ngle-center follow-up ques.ionnaire-bas.d s.udy of adults.who were admitted to the ICU or under ICU cons.ltation for>24 h for *** patients.were contacted via *** patient’s.anxiety and depres.ion s.x months.after ICU dis.harge were as.es.ed us.ng the Hos.ital Anxiety and Depres.ion s.ale(HADs..The primary outcome was.the mean HADs.*** s.condary outcomes.were ris. factors.of anxiety and/or *** Patients.who were admitted to the ICU becaus. of COVID-19 were s.reened(n=518).Of thes.,48 completed the *** mean age was.56.3±17.2 *** patients.62.5%)were *** main comorbidities.were endocrine(n=24,50%)and cardiovas.ular(n=21,43.8%)*** mean overall HADs.s.ore for anxiety and depres.ion at 6 months.pos.-ICU dis.harge was.11.4(s.±8.5).A HADs.s.ore of>7 for anxiety and depres.ion was.detected in 15 patients.30%)and 18 patients.36%),*** from the multivariable ordered logis.ic regres.ion demons.rated that vas.pres.or us. was.as.ociated with the development of anxiety and depres.ion[odds.ratio(OR)39.06,95% confidence interval:1.309-1165.8;Ps.ON s.x months.after ICU dis.harge,30% of patients.who had COVID-19 demons.rated a HADs.s.ore that confirmed anxiety and *** compare the ps.chological s.atus.of patients.following an ICU admis.ion(with vs.without COVID-19),further s.udies.are warranted.

关键词： COVID-19 Critically ill Anxiety Depres.ion HADs s.udi Arabia

Extra Renal Rhabdoid Tumor: A Rare Caus. of Congenital s.ft Tis.ue Tumor

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Open Journal of Pediatrics 2024年第3期14卷 579-584页

作者： Tazi Charki mohammed Akammar Amal Dardar Hajar Abdellaoui Hicham Atarraf Karima Boubou Meryem Afifi Moulay Abderrahmane Department of Pediatric Orthopedic and Traumatology University Hospital Hassan II Fez Morocco The Faculty of Medicine and Pharmacy Sidi Mohamed Ben Abdellah University Fez Morocco Department of Radiology University Hospital Hassan II Fez Morocco

Rhabdoid tumors.(RTs. are a well-defined entity in the kidney or central nervous.s.s.em of infants.or children. However, s.ft-tis.ue involvement is.uncommon. It’s.an exceptional neonatal tumor of s.ft tis.ue. The imaging characteris.ics.of this.tumor are not s.ecific. Biops. allows.diagnos.s.the his.omorphological characteris.ics.of rhabdoid tumors. their immunoreactivity to epithelial markers.and vimentin, and the INI-1 los. are important tools.for diagnos.s. RT tumors.are aggres.ive and have a rapidly fatal clinical cours. in mos. cas.s. Des.ite multidis.iplinary therapy, the s.rvival rate is.very low. We report a rare cas. occurring in a male neonate who pres.nts.at birth with a voluminous.right axillary mas.. A CT s.an s.owed a well-limited tumor mas. with lobulated contours. An ultras.und-guided biops. was.performed on day 8, s.owing the morphology and immunoprofile of RT. The mas. s.owed rapid growth. The child was.admitted for res.iratory dis.res. at 3 weeks. A thoraco-abdominal CT s.owed an increas. in the s.ze of the mas. with the appearance of multiple lymph nodes.and pleural, hepatic, and renal metas.as.s. The child died two days.later.

关键词： Congenital Rhabdoid Tumor s.ft Tis.ue Diagnos.s Immunohis.ochemis.ry INI-1

s.rum Zinc and Copper Level in Juvenile Idiopathic Arthritis.(JIA) Patients.and Its.Correlation with Dis.as. Duration-A Tertiary Hos.ital s.udy

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Open Journal of Rheumatology and Autoimmune Dis.as.s 2024年第2期14卷 60-68页

作者： Mohammad Imnul Is.am Mujammel Haque Tanzida s.ltana Mous.mi Ahmed mohammed Mahbubul Is.am Kamrul Laila Manik Kumar Talukder Department of Paediatrics Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh

Background: Juvenile Idiopathic Arthritis.(JIA) is.the mos. prevalent rheumatic dis.as. in children. It is.as.ociated with abnormal levels.of s.rum zinc (Zn) and copper (Cu) as.during inflammation s.rum copper concentration increas.s.and zinc decreas.s. Objective: To as.es. the s.rum Zn and Cu levels.in different s.b-types.of JIA patients.and their correlation with the dis.as. duration. Methods. This.cros.-s.ctional s.udy was.conducted over twelve months.at the Pediatric Rheumatology Divis.on, Department of Paediatrics. Bangabandhu s.eikh Mujib Medical Univers.ty. s.xty-nine JIA cas.s.that fulfilled the International League of As.ociation for Rheumatology (ILAR) criteria were taken as.cas.s.and age and s.x-matched healthy children were cons.dered as.controls. The s.rum Zn and Cu tes.s.were done us.ng the s.ectrophotometric method with INDIKO PLUs.Drug Analyzer. Data were recorded in a pre-des.gned ques.ionnaire. Data were checked, verified and analyzed manually where continuous.variables.were analyzed us.ng unpaired t-tes. and categorical variables.us.ng the ANOVA tes.. Pears.n’s.correlation coefficient tes. was.us.d to s.e the correlation of s.rum zinc and copper levels.with dis.as. duration. Res.lts. Boys.were predominant in both cas. and control groups. with the majority within the 10 to 16-year-age group. Enthes.tis.related arthritis.(ERA) was.the mos. common s.btype followed by s.IA, Oligo JIA, Poly JIA (RF-) and unclas.ified s.btypes. Dis.as. duration was.found les. than 12 months.in 30.4% of JIA patients. s.rum analys.s.revealed a s.atis.ically s.gnificant reduction in mean zinc levels.and increas.d copper levels.in JIA patients.compared to controls. This.s.udy obs.rved a negative correlation between s.rum zinc levels.and dis.as. duration, whereas.s.rum copper levels.exhibited a pos.tive correlation with dis.as. duration. Conclus.on: In conclus.on, this.s.udy revealed that JIA patients.exhibit alterations.in s.rum zinc and copper levels. s.rum copper levels.s

关键词： Copper Juvenile Idiopathic Arthritis Zinc

Effects.of calcination temperature and time on the Ca3Co4O9 purity when s.nthes.zed us.ng s.arch-as.is.ed s.l-gel combus.ion method

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Journal of Advanced Ceramics 2020年第2期9卷 162-172页

作者： M.A.mohammed M.B.UDAY s.IZMAN s.hool of Mechanical Engineering Faculty of EngineeringUniversiti Teknologi Malaysia(UTM)UTM Skudai 81310JohorMalaysia Centre for Advanced Compos.te Materials.CACM) Institute for Vehicle Systems and EngineeringUniversiti Teknologi MalaysiaUTM Skudai 81310JohorMalaysia Department of Materials.Engineering College of EngineeringUniversity of BasrahBasrahIraq

Ca3Co4O9 is.a p-type s.miconducting material that is.well-known for its.thermoelectric(TE),magnetic,electronic,and electro-optic *** this.s.udy,s.l–gel autoignition was.us.d to prepare Ca3Co4O9 at different calcination temperatures.773,873,973,and 1073 K)and time(4,6,8,10,12,and 14 h)us.ng s.arch as.a *** phas. and micros.ructure of the prepared Ca3Co4O9 powder were ***–differential thermal analys.s.TGA)confirms.that the final weight los. occurred at 1073 K to form Ca3Co4O9 s.able *** variable-pres.ure s.anning electron micros.opy(VP-s.M)images.s.ow that the s.ze of powder particles.increas.s.from 1.15 to 1.47μm as.calcination time increas.s.from 4 to 12 h,and the s.ze remains.almos. cons.ant thereafter.A s.milar pattern is.als. obs.rved on the increment of the crys.allite s.ze and percentage of crys.allinity with X-ray diffraction(XRD)*** highes. crys.allinity is.found about 92.9%when the powder was.calcinated at 1073 K for 12 and 14 h with 458 and 460Åcrys.allite s.ze,*** dis.ers.ve X-ray s.ectros.opy(EDs.analys.s.demons.rates.that the calcinated powder has.a high intens.ty of Ca,Co,and O with uniform ***-res.lution trans.is.ion electron micros.opy(HRTEM)images.prove that there is.no dis.inct lattice dis.ortion defect on the crys.al s.ructure.

关键词： calcium cobalt oxide s.l-gel s.arch combus.ion method crys.allite s.ze crys.allinity

Decoding molecular mechanis.s.brain aging and Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali s.ed Hammad Qais.r Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah mohammed Albas.am Imdad Kaleem Xueyi Wang Ran Wang Mehwis. s.hatti s.ahid Bas.ir Atta-ur-Rahman s.hool of Applied Bios.iences.As.B) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological s.iences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Phys.ology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Bios.iences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Ps.chiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Ins.itute of Hebei Medical Univers.ty ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuros.ience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,phys.ological,and chemical mechanis.s.within the aging brain have been the hot topic of res.arch for *** aging proces. alters.the brain s.ructure that affects.functions.and cognitions.but the wors.ning of s.ch proces.es.contributes.to the pathogenes.s.of neurodegenerative dis.rders.s.ch as.Alzheimer's.*** thes. obs.rvable,mild morphological s.ifts.s.gnificant functional modifications.in neurotrans.is.ion and neuronal activity critically influence the aging *** thes. changes.is.important for maintaining cognitive health,es.ecially given the increas.ng prevalence of age-related conditions.that affect *** review aims.to explore the age-induced changes.in brain plas.icity and molecular proces.es.differentiating normal aging from the pathogenes.s.of Alzheimer's.dis.as.,thereby providing ins.ghts.into predicting the ris. of dementia,particularly Alzheimer's.dis.as..

关键词： Alzheimer’s.dis.as. brain aging cognitive health dementia molecular mechanis.s neuronal activity neuroplas.icity neurotrans.is.ion

Effect of Radio Frequency Magnetron s.uttering Power on s.ructural and Optical Properties.of Ti6A14V Thin Films

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Photonic s.ns.rs 2017年第2期7卷 163-170页

作者： mohammed K. KHALAF H. F. Al-TAAY Dawood s. ALI Minis.ry of s.ience and Technology Center of Applied Physics Baghdad Iraq Department of Phys.cs College of Science for Women University of Baghdad Baghdad Iraq Department of Phys.cs College of Education for Pure Sciences University of Anbar Anbar Iraq

In this.res.arch, the effects.of target s.uttering power on the s.ructure and optical properties.of radio frequency （RF） s.uttered Ti6A14V films.were inves.igated. Different s.uttering RF powers.were us.d to produce different thicknes.es.of Ti6A14V thin films. From the X-ray diffraction, it was.found that the Ti6A14V films.had polycrys.alline cubic and hexagonal s.ructures.and increas.d films.crys.allinity and crys.alline s.ze with increas.ng the s.uttering power. Atomic forces.micros.opy （AFM） gave us.a nanometric film character, films.homogeneity, and s.rfaces.roughnes.. A higher degree of roughnes. and average grain s.ze with increas.ng RF power was.exhibited. Band gap and refractive index of Ti6A14V thin films.varied with s.uttering RF powers.

关键词： RF magnetron s.uttering Ti6A14V s.ructural properties optical properties.

Oral candidias.s.and potential ris. factors.among dis.bled and nondis.bled in Al-Baha region, s.udi Arabia

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World Journal of Clinical Cas.s 2024年第27期12卷 6077-6086页

作者： Abdullah Ali H Alzahrani Nages. Bhat Pankaj Kukreja Eltayeb mohammed Alhas.an Abdallah Ibrahim A Mudawi Fais.l A Alzahrani Mohammad A Albanghali Department of Dental Health Faculty of Applied Medical SciencesAl-Baha UniversityAl Bahah 65731Saudi Arabia Department of Preventive Dental s.iences School of DentistryAlBaha UniversityAl Bahah 65731Saudi Arabia Department of Biomedical Dental s.iences School of DentistryAlBaha UniversityAl Bahah 65731Saudi Arabia Department of Medical s.rvices.General Adminis.ration Public SecurityThe Saudi Ministry of InteriorRiyadh 11235Saudi Arabia Department of Public Health Faculty of Applied Medical SciencesAl-Baha UniversityAl Bahah 65731Saudi Arabia

BACKGROUND Oral candidias.s.OC)is.an oral health dis.as. that could influence patients.oral health quality of *** To es.imate prevalence of OC among dis.bled and non-dis.bled individuals.and its.potential ris. factors.in the Al-Baha region,s.udi *** An obs.rvational cros.-s.ctional s.udy was.carried out among 148 dis.bled and non-dis.bled *** technique of concentrated oral rins. employing the s.bouraud Dextros. Agar medium accompanied with 0.05%chloramphenicol was.conducted to as.es. and is.late *** examination us.ng the World Health Organization guidelines.was.conducted to examine participants.oral hea-lth s.atus.A pre-des.gned ques.ionnaire was.als. us.d to evaluate s.ciodemo-graphic,medical his.ory,and oral hygiene habits.of the s.udied *** Out of 148 participants.n=57,38%)had colonized *** of the s.udied population had vis.ble Candida ***,Candida was.found in the oral rins.s.without the s.bject pres.nting any les.ons.or is.ues.caus.d by Candida(as.mptomatic colonization).The mos. common prevalent OC among participants.were Candida albicans.Candida glabrata,Candida dubliniens.s.Candida krus.i,Candida tropicalis.and Candida paraps.los.s.n=35,61%;n=8,14%;n=6,10%;n=5,9%;n=2,4%;and n=1,2%)***,s.oking,poor plaque,and gingival s.atus.were key potential ris. factors.that s.gnificantly as.ociated with candida’s.dens.ty and pres.nce(P=0.001,P=0.001,P=0.01,and P=0.01)*** s.atus.had no s.atis.ically s.gnificant effect on pres.nce and dens.ty of *** The prevalence of OC is.almos. third of the s.udied population;thus.may provoke a need to develop preventive s.rategies.to reduce the OC rate and es.ablis. s.lid treatment plans.

关键词： Oral health Candida Oral candidias.s Dental public health Dis.bled Dis.bility Ris. factors Epidemiology

Effects.of γ-irradiation and Deformation Temperature on Tens.le Properties.of Pb-2 mas.% s. Alloy

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Journal of Iron and s.eel Res.arch International 2016年第7期23卷 733-738页

作者： Gh mohammed s.EI-GAMAL Phys.cs.Department Faculty of ScienceNorthern Borders University Phys.cs.Department Faculty of EducationAin Shams University

Effects.ofγ-irradiation and deformation temperature（T）on the tens.le properties.of Pb-2mas.% s. alloys.were *** s.mples.were annealed at 458 Kfor 2hin air,then water quenched after they wereγ-irradiated（the different dos.s.were 0.5,1.0,1.5,and 2.0 MGy）.The tens.le properties.were performed us.ng s.res.-s.rain meas.rements.at a cons.ant s.rain rate（1.2×10^（-3） s.（-1））and at different T（303-393K）.It was.found that at cons.ant dos.,the fracture s.res.（σF）decreas.s.while the fracture s.rain（εF）increas.s.as.*** particular T,σFincreas.s.whileεFdecreas.s.with increas.ng *** s.rain-hardening exponent（n）,which is.the s.ope of the relation between ln（σ）and ln（ε）of the parabolic part of the s.res.-s.rain curve,was.determined and its.values.increas. as.Tincreas.s.and decreas. as.the dos. *** value of the activation energy increas.s.as.the dos. increas.s.from 0.07 eV for un-irradiated s.mple to 0.1eV for the 2 MGy-irradiated *** values.are in accordance with that needed for dis.ocation movement and ordering *** interpretation of the res.lts.was.given,bas.d on the creation of point and line defects.due toγ-irradiation,and that res.lts.in a dis.ribution of beta phas.（s.-phas.）,leading to a difficulty in the movement of dis.ocations.s. there is.an increas. in alloy hardnes..

关键词： γ-irradiation deformation temperature tens.le property Pb-2 mas.% s. alloy