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Efﬁciency and safety of sofosbuvir in Bangladeshi children with chronic hepatitis C virus

iLIVER 2023年第3期2卷 146-150页

作者： Salahuddin Mahmud Jahida Gulshan MdBelayet Hossain Madhabi Baidya Rafia Rashid Farhana Tasneem Ahmed Rashidul Hasan Tanzila Farhana mohammed reaz mobarak MdJahangir Alam Syed Shafi Ahmed Department of Pediatric Gastroenterology Hepatology&NutritionBangladesh Shishu Hospital&InstituteDhakaBangladesh Institute of Statistical Research and Training(ISRT) University of DhakaDhakaBangladesh Department of Pediatric Hematology&Oncology Bangladesh Shishu Hospital&InstituteDhakaBangladesh Department of Pediatric Gastroenterology Dr.M R Khan Shishu Hospital&Institute of Child HealthDhakaBangladesh Department of Pediatrics BIHS General HospitalDiabetic Association of BangladeshDhakaBangladesh Department of Epidemiology&Research Bangladesh Shishu Hospital&InstituteDhakaBangladesh Bangladesh Shishu Hospital&Institute DhakaBangladesh

Background and aims:Currently,treatment with oral direct-acting antivirals is recommended for all hepatitis C virus(HCV)-infected pediatric *** aim of this study was to evaluate the efficacy and safety of sofosbuvir and ribavirin combination ther apy for children and adolescents in Bangladesh who are living with chronic HCV in ***:An experimental study was performed from January 2021 to December *** polymerase chain reaction(PCR)-positive thalassemic children,who were 6–18 years of age,were enrolled by consecutive non-probability *** features were recorded,and investigations were *** patients were initially treated with sofosbuvir(200 mg for 6-to 11-year-olds and 400 mg for 12-to 18-year-olds)and ribavirin(10–15 mg/kg/day)and were assessed clinically on a four-weekly basis,along with liver-function *** total duration of therapy was 24 *** PCR was done at the end of treatment and 12 weeks after the completion of treatment to see the sustained virological ***:There were 26 cases in total,with a mean age of 9.26?2.82 years;14 were males(53.8%),and 12 females(46.2%).Twenty-five(96.15%)patients achieved a sustained virological response,and the end-of-treatment PCR was *** patient(3.85%)was a nonresponder even after 24 weeks of *** medication was well received,with only four patients(15.3%)reporting headaches that were reported ***:The combination of sofosbuvir and ribavirin is effective in treating chronic HCV infection and is not accompanied by any major negative side effects.

关键词： Hepatitis C virus Direct-acting antivirals Sofosbuvir Ribavirin

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Study on Comparison between Enzyme Wash and Bleach Wash (Traditional vs. Sustainable Washing Machine) the Physical and Color Fastness to Rubbing Properties of Denim Garments

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Journal of Textile Science and Technology 2020年第3期6卷 123-129页

作者： Shohidul Islam Shamim Md. Iusuf Khan Shaukat Hossan mohammed reaz Uddin Department of Textile Engineering Port City International University Chattogram Bangladesh

This study focuses on comparison between Enzyme Wash and Bleach Wash (Traditional vs. Sustainable Washing Machine) the physical and color fastness to rubbing properties of denim garments. For this experiment indigo dyed cotton denim garments (trousers) were chosen which were 98% cotton and 2% spandex and processed by enzyme with the concentration of 2 g/l, and the temperature of 45°C. In another work, enzyme treated denim garments were used for bleach wash with the concentration of 2 g/l, temperature 45°C and those samples have been processed by traditional and sustainable washing machine. After completing process, the sample properties have been compared like rubbing, tearing and tensile properties. After comparing result the color fastness to rubbing of enzyme wash was poor in traditional and sustainable machine an

关键词： Denim Garments Enzyme Wash Bleach Wash Sustainability Tensile and Tearing Strength C.F to Rubbing

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