检索结果-南通市图书馆

Double aortic arch and nasogastric tubes: A fatal combination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第16期14卷 2590-2592页

作者： julia massaad Kelly Crawford Emory University School of Medicine Division of Digestive Diseases

Double aortic arch is a common form of complete vascular ring that encircles both the trachea and the esophagus, and presents with various respiratory and esophageal symptoms, usually in the pediatric population. We present a case of double aortic arch in an adult patient that manifested as massive upper gastrointestinal bleeding after prolonged nasogastric intubation.

关键词： Nasogastric tubes Aortoesophageal fistula Gastrointestinal bleeding Double aortic arch Vasculardngs

Outcomes of a single-step endoscopic ultrasound-guided drainage of pancreatic-fluid collections using an electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent with and without fluoroscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2020年第6期8卷 425-430,I0001页

作者： Babatunde Olaiya Parit Mekaroonkamol Bai-Wen Li julia massaad Cicily TVachaparambil Jennifer Xu Vladamir Lamm Hui Luo Shan-Shan Shen Hui-Min Chen Steve Keilin Field FWillingham Qiang Cai Department of Internal Medicine Marshfield ClinicMarshfieldWIUSA Division of Digestive Diseases Emory University School of MedicineAtlantaGAUSA Division of Gastroenterology King Chulalongkorn Memorial HospitalChulalongkorn University and Thai Red CrossBangkokThailand Department of Gastroenterology Shanghai General HospitalShanghai Jiaotong UniversityShanghaiP.R.China Department of Gastroenterology Xijing HospitalXi’anShaanxiP.R.China Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangshuP.R.China Department of Gastroenterology Renji HospitalShanghai Jiaotong UniversityShanghaiP.R.China

Background:Fluoroscopy is often used during the endoscopic drainage of pancreatic-fluid collections(PFCs).An electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent(ELAMS)facilitates a single-step procedure and may avoid the need for *** study compares the treatment outcomes using ELAMS with and without ***:Patients with PFCs who had cystogastrostomy from January 2014 to February 2017 were *** groups were studied based on fluoroscopy *** success was defined as uneventful insertion of ELAMS at time of *** success was defined as(i)clinical resolution of symptoms after the procedure and(ii)>75%reduction in cyst size on computed tomography 8 weeks after stent *** events including bleeding,stent migration,and infection were ***:A total of 21 patients(13 males)had PFCs drainage with ELAMS in the study *** mean age was 51.6614.2 *** patients had walled-off necrosis while eight had a pancreatic *** mean size of the PFCs was 11.363.3 *** was used in seven cases(33%)and was associated with a longer procedure time compared to non-fluoroscopy(43.1610.4 vs 33.3610.5 min,P=0.025).This association was independent of the size,location,or type of *** had no effect on the technical success *** fluoroless procedures,the clinical resolution was 91%as compared to 71%in fluoroscopy procedures(P=0.52)and the radiologic resolution was 57%as compared to 71%in fluoroscopy procedures(P=0.65).Three cases of stent migration/displacement occurred in the fluoroless ***:ELAMS may avoid the need for fluoroscopy during *** without fluoroscopy were significantly shorter and fluoroscopy use had no impact on the technical or clinical success rates.

关键词： pancreatic-fluid collections electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent(ELAMS) fluoroscopy endoscopic ultrasound

A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver Research 2021年第4期5卷 239-242页

作者： Satyanarayana R Pondugula julia M Salamat Kodye L Abbott Patrick C Flannery mohammed Majrashi mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy Moore Muralikrishnan Dhanasekaran Department of Anatomy Physiology and PharmacologyCollege of Veterinary MedicineAuburn UniversityAuburnALUSA Department of Pharmacology Faculty of MedicineUniversity of JeddahJeddahSaudi Arabia Department of Drug Discovery and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pathobiology College of Veterinary MedicineAuburn UniversityAuburnALUSA Animal Biochemistry Division National Dairy Research InstituteICAR-National Dairy Research InstituteKarnalHaryanaIndia Department of Clinical Science College of Veterinary MedicineAuburn UniversityAuburnALUSA

Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast *** is not well understood whether a combination therapy with DOX and CPS can induce *** therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in ***:Male C57BL/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 *** the treatment period,liver histology and various serum bio-markers of hepatotoxicity were ***:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total ***,co-administration of DOX and CPS did not result in a noticeable change in liver ***,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and ***:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice.

关键词： Cyclophosphamide(CPS) Doxorubicin(DOX) Hepatotoxicity Liver injury Muscle injury

A dahlia flower extract has antidiabetic properties by improving insulin function in the brain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Life Metabolism 2023年第4期2卷 39-50页

作者： Dominik Pretz Philip M.Heyward Jeremy Krebs Joel Gruchot Charles Barter Pat Silcock Nerida Downes mohammed Zubair Rizwan Alisa Boucsein julia Bender Elaine J.Burgess Geke Aline Boer Pramuk Keerthisinghe Nigel B.Perry Alexander Tups Centre for Neuroendocrinology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Department of Physiology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Maurice Wilkins Centre for Molecular Biodiscovery University of AucklandAuckland 1010New Zealand Department of Medicine University of OtagoWellingtonWellington South 6242New Zealand Centre for Endocrine Diabetes and Obesity Research Wellington Regional HospitalNewtownWellington 6021New Zealand Product Development Research Centre University of OtagoDunedin 9054New Zealand Department of Chemistry The New Zealand Institute for Plant and Food ResearchUniversity of OtagoDunedin 9054New Zealand

Butein,a rare chalcone found in the toxic plant Toxicodendron vernicifluum,has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta(IKKβ)/nuclear factor kappa B(NF-κB)pathway in the ***,we investigated whether the nonpoisonous plant Dahlia pinnata could be a source of butein as a potential treatment for type 2 diabetes(T2D).In mice fed a high-fat diet(HFD)to induce glucose intolerance,an oral *** petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body ***,this effect was not mediated by butein alone but by butein combined with the closely related flavonoids,sulfuretin and/or ***,the extract improved systemic insulin *** of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered *** extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed *** NF-κB reporter zebrafish to determine IKKβ/NF-κB activity,a potent anti-inflammatory action of the extract was found.A randomized controlled crossover clinical trial on participants with predia-betes or T2D confirmed the safety and efficacy of the extract in *** conclusion,we identified an extract from the flower petals of *** as a novel treatment option for T2D,potentially targeting the central regulation of glucose homeostasis as a root cause of the disease.

关键词： inflammation hypothalamus signal transduction neuroendocrine arcuate nucleus