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The Impact of the FreeStyle Libre^TM Flash Glucose Monitoring System on Glycemic Control in Patients with Diabetes;Observational Multicenter 15-Months Study

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International Journal of Clinical Medicine 2022年第8期13卷 391-404页

作者： Saud Alsifri Abdulkarim Almalki Samar Alsifri naif Alsifri mohammed Moatism Sahar Alsifri Emad R. Issak Endocrinology & Diabetes Department Alhada Armed Forces Hospital Taif Saudi Arabia Medicine Department King Fahad Armed Forces Hospital Jeddah Saudi Arabia Medicine Department East Jeddah Hospital Jeddah Saudi Arabia King Abdulaziz University Hospital Jeddah Saudi Arabia Medicine Department Asalam Center Cairo Egypt

Objectives: The study was to determine the impact of using the FreeStyle LibreTM flash glucose monitoring system on glycemic control and the rate of events due to diabetes in people with diabetes from different types and age groups. Methods: a retrospective cohort chart review study was carried out at three centers in the Taif region in the Kingdom of Saudi Arabia: The study was approved by an accredited centralized institutional review board. Paper or electronic medical records were included for individuals of any age with diabetes (type 1, type 2, gestational diabetes) managed with diet, insulin therapy, or/and oral antihyperglycemic medication and/or non-insulin injection therapy. The primary outcome measure was the laboratory HbA1c level as well as reduction. Secondary outcome measures were frequency of severe hypoglycemia, admission to hospital or ER visit related to diabetes complications, and severe hyperglycemia (DKA or HHS). Results: Data was analyzed from 1695 patients. The average HbA1c before using the flash glucose monitoring system was 9.60% ± 1.44% and 3 months HbA1c after using the FreeStyle LibreTM flash glucose monitoring system was 8.70% + 1.45% for a difference of -0.90% ([95% CI -0.92: -0.88];p 65 years, (p-values Conclusion: The benefits of using the FreeStyle LibreTM flash glucose monitoring system are self-evident in reducing HbA1c and events due to hyperglycemia or hypoglycemia.

关键词： FreeStyle LibreTM Flash Glucose Monitoring System Diabetes HbA1C Hypoglycemia Diabetic Ketoacidosis Hyperglycemic Hyperosmolar State

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Assessment of Levels of Knowledge towards Hormonal Related Breast Cancer Risk Factors in Qurayyat, Northern Saudi Arabia

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Open Journal of Obstetrics and Gynecology 2019年第3期9卷 371-381页

作者： Abdelbaset Mohamed Elasbali Elyasa Mustafa Elfakia mohammed Ziad Alonzi Rania Abdeen Hussain Abdalla Azizah Mazi Aldaham Diem Fayez Aljubab naif Muflih Alsharari Hussain Gadelkarim Ahmed Department of Clinical Laboratory Sciences College of Applied Medical Sciences Jouf University Qurayyat KSA Department of Clinical Laboratory Sciences College of Applied Medical Science Jouf University Sakaka KSA Department of Obstetrics and Gynecology College of Medicine University of Hail Hail KSA College of Medicine University of Hail Hail KSA Department of Histopathology and Cytology FMLS University of Khartoum Khartoum Sudan

Background: Continued exposure to sex hormones such as estrogen is a critical risk for subsequent breast cancer. Thus the present study aimed to assess the levels of knowledge towards hormonal related breast cancer risk factors in Qurayyat, Northern Saudi Arabia. Methodology: This descriptive study included 737 Saudi volunteers living in the city of Qurayyat, Northern Saudi Arabia. For females, only those agreeing to participate in the breast self-examination workshop were included, and non-respondents were included in the questionnaire. Results: For the question apropos “Inheritance as a risk factor for BC,” 405/607 (66.7%) females signposted certainly “Yes,” as well as, 70/130 (54%) males signposted certainly “Yes.” The odds ratio (OR) and 95% confidence interval (95% CI) were not statistically significant, but the level of knowledge was relatively higher among females OR (95% CI) = 1.4321 (0.9597 to 2.1370), P = 0.0786. “Are early puberty and late menopause risk factors for breast cancer?” No statistical significant differences were eminent between males and females, OR (95% CI) = 0.8878 (0.5932 to 1.3287), P = 0.5629. Conclusion: Saudi women are enthusiastically willing to raise their knowledge and awareness of breast cancer prevention and control. Although women have greater knowledge about breast cancer risk factors compared to men, still some gaps need to be filled.

关键词： Breast Cancer Hormones Risk Factors Estrogen Saudi Arabia Alquriat

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The Safety and Efficacy of Combination Therapy of Dapagliflozin and Metformin in Patient with Type 2 Diabetes Mellitus: A Review Study

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Journal of Diabetes Mellitus 2022年第4期12卷 271-283页

作者： Saif K. Alkhanferi Khadeejah H. Alhuraiz Hussein S. Alyami Sultan L. Alenazi mohammed F. Aldhaban naif Alrowedann Yazeed Y. Albedaiwi Nawal Alnazawi Abrar Bokhamseen Fatimah A. Talaqof King Abdulaziz Medical City National Guard Health Affairs Riyadh Saudi Arabia King Abdullah International Medical Research Center Riyadh Saudi Arabia Imam Abdurrahman Bin Faisal Hospital National Guard Health Affairs Dammam Saudi Arabia Qassim Primary Health Care Center National Guard Health Affairs Qassim Saudi Arabia

Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors are a new class that approved by FDA for patient with type 2 DM. Dapagliflozin alone or in combination therapy with metformin provided effective glycemic control and HbA1c reduction, with minimal hypoglycemia and hypotension adverse effects. Objective: To evaluate the safety and efficacy of the combination therapy of dapagliflozin and metformin in type 2 diabetes mellitus patients. Methods: Research was conducted through MEDLINE and Embase databases in search of randomized controlled studies including dapagliflozin, sodium glucose co-transporter 2, metformin, and efficacy. Results: Forty seven articles were spotted, 3 randomized controlled studies were involved in this review. Dapagliflozin and metformin combination was found beneficial in HbA1c reduction equal to 20.7% - 31.5% from the baseline compared to patients on metformin alone. 40.6% of patients on combination therapy achieved the ADA recommended reduction in HbA1c to less than 7%. Moreover fasting plasma glucose level was reduced by 23.4 mg/dl from the baseline in the combination therapy compared to 5.9 mg/dl in metformin group. Body weight reduction was statistically significant (P Conclusion: The combination therapy of dapagliflozin and metformin found to be safe and effective in type 2 diabetes mellitus management with minimal adverse effects.

关键词： Dapagliflozin Sodium Glucose Co-Transporter 2 SGLT2 Metformin Efficacy

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Two polymorphisms in methylenetetrahydrofolate reductase gene(C677T and A1298C) frequently associated with recurrentspontaneous abortion show no association in Saudi women

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BIOCELL 2020年第4期44卷 613-621页

作者： AFRAH ALKHURIJI ATEKAH ABDULLAH mohammed ALRAQIBAH AMAAL AWAD ALHARBI ZENEB BABAY FATIMAH BASIL AL-MUKAYNIZI ARWA ALTHOMALI SONYA S.ABDEL-RAZEQ ARJUMAND S.WARSY Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Obs/Gyn College of MedicineKing Saud UniversityRiyadh11451Saudi Arabia Prince naif Bin AbdulAziz Health Research Center(PNHRC) King Saud UniversityRiyadh11451Saudi Arabia Division of Maternal-Fetal Medicine Department of ObstetricsGynecologyand Reproductive SciencesYale University School of MedicineNew Haven06501USA Central Laboratory Center for Science and Medical Studies for GirlsKing Saud UniversityRiyadh11451Saudi Arabia

Methylenetetrahydrofolate reductase(MTHFR)deficiency is the most common genetic cause of hyperhomocysteinemia,which has been implicated in the etiology of recurrent spontaneous abortion(RSA).This study was designed to investigate the association between two single nucleotide polymorphisms(SNP)(rs1801133[C677T]and rs1801131[A1298C])in the MTHFR gene and RSA,in *** two SNPs were selected as these polymorphisms have a different effect on the activity and stability of the enzyme,and significantly diverse effects have been reported in relation to the association with *** approval was acquired from the IRB at King Saud University(KKUH),Saudi Arabia,and written informed consent was obtained from each *** study group comprised of 100 Saudi women with unexplained RSA and 100 age-matched controls,both attending KKUH for a routine *** was drawn in EDTA tubes,and DNA was *** was conducted using TaqMan SNP genotyping assay *** frequency of the T allele of C677T was 0.165 in patients and 0.17 in *** frequencies for CC,CT and TT genotypes were 70%,27%and 3%,respectively in RSA,and 71%,24%and 5%,respectively,in the controls(p>0.05).For the A1298C polymorphism,the C allele frequencies were 0.345 in patients and 0.28 in controls,while genotype frequencies for AA,AC and CC genotypes were 44%,43%,and 13%,respectively,in patients,and 54%,36%,and 10%,respectively,in controls(p>0.05).The frequency of CC genotype and C allele of A1298C were higher in the patients with RSA,but not significantly,while C677T genotypes and allele frequencies did not differ between patients and *** results suggested that MTHFR gene polymorphisms are population-specific and may not associate with RSA in Saudi women.

关键词： MTHFR RSA Single nucleotide polymorphism Hyperhomocystenemia

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