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Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study

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Neural Regeneration Research 2019年第4期14卷 666-672页

作者： mohammed benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari Ismail Rammouz Mustapha Maaroufi Rabia Magoul Driss Boussaoud Laboratory of Clinical Neuroscience Faculty of Medicine Department of Neurosurgery University Hospital of Fez Laboratory of Neuroendocrinology and Nutritional and Climatic Environment Faculty of Sciences Dhar El Mahraz Department of Biophysics and Clinical MRI Methods Faculty of Medicine Department of Radiology and Clinical Imaging University Hospital of Fez Department of Psychiatry University Hospital of Fez Aix Marseille Université INSERM INS Institut de Neurosciences des Systèmes

Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease.

关键词： Parkinson’s disease emotion processing Blood oxygenation level-dependent functional magnetic resonance imaging brain activation dopamine neural regeneration

Pachymeningeal en Plaque Tuberculoma in Children: A Case Report

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Open Journal of Modern Neurosurgery 2020年第1期10卷 63-69页

作者： Ibrahima Berete Alpha Boubacar Bah Seylan Diawara mohammed benzagmout Khalid Chakour mohammed Faiz Chaoui Service de Neurochirurgie CHU Hassan II Fès Morocco Service de Neurochirurgie CHU Donka Conakry Guinea

Pachymeningeal en plaque tuberculoma is a rare manifestation of tuberculosis and has a poor prognosis if not diagnosed early and treated adequately. The aim of the present paper is to collect the reported clinical and radiological signs in the literature and compare it with a personal observation to evaluate the possibility of a presumptive diagnosis. A 4-year-old boy presented at the pediatric emergency department with 7 days history of severe headache, vomiting blurred vision and had one partial seizure. His neurologic examination was notable for decreased visual acuity with bilateral papilledema and intact extra-ocular muscles. His neck was rigid. Neuroimaging revealed a multifocal dural-based mass on the fronto-parietal convexity with dense heterogeneous contrast enhancement and hydrocephalus. He has undergone a Ventriculoperitoneal shunt and surgical excision of the mass the next day. Outcome was favorable with antituberculosis therapy and corticosteroids. The clinical presentation and outcome were similar to the reported cases in the literature.

关键词： Tuberculoma Pachymeningeal Intracranial Tuberculosis MRI CT Scan

Lipomatous Medulloblastoma: A Case Report

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Open Journal of Modern Neurosurgery 2019年第4期9卷 452-456页

作者： Ibrahima Berete Alpha Boubacar Bah Seylan Diawara Hammas Nawal mohammed benzagmout Khalid Chakour mohammed Faiz Chaoui Department of Neurosurgery University Hospital Donka Conakry Guinea Department of Pathology University Hospital Hassan II Fez Morocco Department of Neurosurgery University Hospital Hassan II Fez Morocco

Lipomatous medulloblastoma is not a separate entity but apparently distinct variant of medulloblastoma. Since the first case report in 1978 by Bechtel et al. [1], few cases have been published. We report an additional case of a 52-year-old right-handed man presented to the emergency department with evaluation of progressive severe intracranial hypertension and ataxia. His past medical history was unremarkable. His physical examination showed cerebellar syndromes. He underwent magnetic resonance imaging (MRI) which revealed a unique mass in the posterior fossa, lying within a cerebellar hemisphere. The patient underwent a suboccipital craniotomy for with a complete resection and samples were sent for histologic examination, showing closely packed, and round to oval cells. The nuclei had an irregular shape with clumps of heterochromatin. Lipid accumulation was a prominent feature of neoplastic cells. Postoperatively the patient did not receive fractionated radiotherapy. He is alive without deficit and with no evidence of recurrence on neuroimaging.

关键词： Medulloblastoma Lipomatous Liponeurocytoma Posterior Fossa Tumor Suboccipital Craniotomy

Lumbar Artery Pseudo-Aneurysm after Spinal Trauma and Transpedicular Fixation: A Case Report

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Open Journal of Modern Neurosurgery 2021年第2期11卷 65-72页

作者： Armel Junior Tokpo Guelord Metre Mpambia Fayçal Lakhdar Hassan Amadou Ali Oualid mohammed Hmamouche mohammed benzagmout Khalid Chakour mohammed El Faiz Chaoui Teaching Hospital of Hassan 2 Fès Morocco

Introduction: A case of lumbar artery pseudo-aneurysm after surgery for lumbar vertebra burst fracture is presented. Only two cases secondary to spinal trauma and revealed after surgery have been described in the literature. A review of literature was conducted and a possible relationship with burst fracture or reduction maneuvers was discussed. Case Presentation: Here, we report a post traumatic lumbar burst facture with incomplete motor deficit of lower limbs after a fall. Surgical reduction and stabilization via posterior approach were performed. Post-operatively, a hemorrhage through surgical wound had been noticed. Pseudo-aneurysm of the lumbar artery at L3 level was diagnosed and embolisation was performed. Conclusion: This is a rare case of pseudo-aneurysm occurring in the setting of surgical stabilisation after a trauma. It was revealed by a hemorrhage discovered as a late complication. We should be aware of such potential complication as a delayed post surgery event in order to adapt the care.

关键词： Pseudo-Aneurysm Lumbar Spine Burst Fracture Embolisation

Adult Posterior Cranial Fossa Arachnoid Cyst: A Case Report

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Open Journal of Modern Neurosurgery 2019年第4期9卷 436-440页

作者： Ibrahima Berete Alpha Boubacar Bah Hammas Nawal mohammed benzagmout Khalid Chakour Faiz Chaoui Department of Neurosurgery CHU de Donka Conakry Guinea Department of Pathology Hassan II Teaching Hospial Fez Morocco Department of Neurosurgery Hassan II Teaching Hospital Fez Morocco

Adult posterior fossa arachnoid cysts are rare lesions that are considered to be mostly congenital in origin. We present 49-year-old man admitted with a chief complaint of tremor and balance problems for the past 2 months. He had ataxia on examination. Magnetic resonance imaging revealed a well circumscribed midline cystic lesion of the posterior fossa sharing the same signal characteristics as cerebrospinal fluid and non-communicating to the fourth ventricle. He underwent surgical treatment for his symptomatic posterior fossa arachnoid cyst with a good outcome at 2 years follow up.

关键词： Posterior Fossa Arachnoid Cyst Subocciptal Craniotomy Cerebellar Ataxia