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<i>In Vivo</i>and <i>In Vitro</i>Survival Rates of Protoscoleces Kept at Different Constant Temperature

Open Journal of Epidemiology 2017年第2期7卷 124-130页

作者： Ekram Ismail Fagiree Ismail mohammed bahaa eldeen ahmed saad Department of Biology Alzaem Alazhari University Khartoum Sudan Alahlia University Khartoum Sudan

An experiment was conducted on the survival rate of protoscoleces derived from hydatid cyst brought from infected camels in Tambool area (North Eastern Sudan). The survival rate was studied in vivo and in vitro through exposure to different constant temperatures to measure their viability. The results revealed that the protoscoleces remained viable in vitro for 20 days at 4°C, 7 and 5 days at 25°C and 37°C, respectively, while at 45°C the protoscoleces were immediately dead. This means that the infection rate of hydatid cyst becomes high in relatively cold seasons (winter and autumn). In the in vivo study, each mouse (five groups, four mice in each) was inoculated intraperitoneally with 2000 protoscoleces exposed to the same different constant temperature, as previously used. 6 months later, the mice in different groups were sacrificed and necropsied to study the development of hydatid cyst inside. The results showed that the rate of development inside the mice was clear in the first and the second groups (4°C and 25°C), however, in the other 2 groups (37°C and 45°C), no sign of development of the cyst was observed, with the presence of few number of hooks compared to the control group, which showed significant difference in the development of hydatid cyst.

关键词： Echinococcus granulosus Hydatid Cyst Protoscoleces Temprature Mice

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Effect of Albendazole and Mebendazole on Hydatid Cyst of Mice

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Open Journal of Epidemiology 2017年第4期7卷 307-316页

作者： Ekram Ismail Fagiree Ismail mohammed bahaa eldeen ahmed saad Aisha Abass Elsadig Department of Biology Alzaem Alazhari University Khartoum Sudan Alahlia University Khartoum Sudan Department of Radioisotopes of the Veterinary Research Center Khartoum Sudan

In the current study, hydatid cysts from livers and lungs of camels were obtained from Tambool slaughter house and protoscoleces were separated aseptically. 36-weeks-old Swiss mice (25 - 30 gram body weight males and females) were divided into two groups of 6 each: a prophylactic group dosed with 150 ml/kg of albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for 10 consecutive days. The treated group was given a dose of 300 ml/kg of albendazole and mebendazole for 24 days with 4 days interval separated by 2 days and after 6 months of inoculation with protoscoleces, the two groups in addition to the control group were sacrificed and necropsied. The results revealed a significant difference in the development of hydatid cyst (p < 0.01). Inside the mice, small number of cysts was noticed in the group treated with albendazole and mebendazole compared to the control group, however, albendazole was highly efficacious than the mebendazole where the efficiency of albendazole reached 97% while the mebendazole efficiency rate was almost 50% which indicates that albendazole could be considered the drug of choice in the treatment of hydatid cyst.

关键词： Hydatid Cyst Mebendazole Albendazole

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