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Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies

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World Journal of Gastroenterology 2006年第44期12卷 7136-7142页

作者： mohammed Ibrahim Aleem A Khan Santosh K Tiwari mohammed aejaz habeeb MN Khaja CM Habibullah Centre for Liver Research and Diagnostics Deccan college of Medical Sciences and Allied Hospitals Kanchanbagh Hyderabad India

AIM: To evaluate the antibacterial activity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi). METHODS: Powders of S. mukorossi and R. emodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. The disk diffusion method was used for in vitro studies and in vivo studies were performed on male Wister rats. Thirty resistant clinical isolates of H pylori, as determined by their antibiotic sensitivity patterns by E-test, along with two Gram +ve (S. aureus, B. subtilis) and two Gram -ve (E. coli, P. vugaris) organisms were screened for their susceptibility patterns against these extracts. RESULTS: In our screening, all 30 resistant isolates and the other four organisms (two Gram +ve S. aureus, B. subtilis and two Gram -ve, E. coli, P. vugaris) were sensitive to the test compounds. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited H pylori at very low concentrations. In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations (10 μg/mL) for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi (2.5 mg/mL) and R. emodi (3.0 mg/mL) given orally for seven days. CONCLUSION: We can conclude from this study that the extracts of S. mukorossi and R. emodi inhibited the growth of pylori in vitro and, in in vivo studies, the H pylori infection cleared within seven days at very low concentrations. We also found that H pylori did not acquire resistance against these herbal extracts even after 10 consecutive passages.

关键词：抗菌剂活性幽门感冒病毒

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Characterization of hepatic progenitors from human fetal liver during second trimester

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World Journal of Gastroenterology 2008年第37期14卷 5730-5737页

作者： Mekala Subba Rao Aleem Ahmed Khan Nyamath Parveen mohammed aejaz habeeb Chittoor mohammed Habibullah Gopal Pande Centre for Cellular and Molecular Biology Uppal Road Hyderabad 500007 India Centre for Liver Research and Diagnostics Kanchanbagh Hyderabad 500058 India

AIM: To enrich hepatic progenitors using epithelial cell adhesion molecule (EpCAM) as a marker from human fetal liver and investigate the expression of human leukocyte antigen (HLA) and their markers associated with hepatic progenitor cells. METHODS: EpCAM +ve cells were isolated using magnetic cell sorting (MACS) from human fetuses (n = 10) at 15-25 wk gestation. Expression of markers for hepatic progenitors such as albumin, alpha-fetoprotein (AFP), CD29 (integrin β1), CD49f (integrin α6) and CD90 (Thy 1) was studied by using flow cytometry, immunocytochemistry and RT-PCR; HLA class Ⅰ (A, B, C) and class Ⅱ (DR) expression was studied by flow cytometry only. RESULTS: FACS analysis indicated that EpCAM +ve cells were positive for CD29, CD49f, CD90, CD34, HLA class Ⅰ, albumin and AFP but negative for HLA class Ⅱ (DR) and CD45. RT PCR showed that EpCAM +ve cells expressed liver epithelial markers (CK18), biliary specific marker (CK19) and hepatic markers (albumin, AFP). On immunocytochemical staining, EpCAM +ve cells were shown positive signals for CK18 and albumin. CONCLUSION: Our study suggests that these EpCAM +ve cells can be used as hepatic progenitors for cell transplantation with a minimum risk of alloreactivity and these cells may serve as a potential source for enrichment of hepatic progenitor.

关键词：妊娠中三个月胎儿肝脏上皮细胞粘附分子白细胞抗原

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Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies

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World Journal of Gastroenterology 2008年第16期14卷 2566-2571页

作者： mohammed Ibrahim mohammed Nane Khaja Anjum Aara Aleem Ahmed Khan mohammed aejaz habeeb Yalavarthy Prameela Devi Mangamoori Lakshmi Narasu Chitoor mohammed Habibullah Centre for Liver Research and Diagnostics Deccan college of Medical Sciences and Allied Hospitals Kanchanbagh Nizam Institute of Pharmacy Deshmukhi pochampally (Mandal) Near Ramoji Film City Centre for Biotechnology Jawaharlal Nehru Technological University Kukatpally

AIM: To study the hepatoprotective capacity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi) extracts in CCl4 treated male rats. METHODS: The dried powder of S. mukorossi and R. emodi was extracted successively with petroleum ether, benzene, chloroform, and ethanol and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extract of the fruit pericarp of S. mukorossi and the rhizomes of R. emodi was analyzed in liver injured CCl4-treated male rats. RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with CCl4 and extracts of S. mukorossi & R. emodi. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo : extracts of the fruit pericarp of S. mukorossi (2.5 mg/mL) and rhizomes of R. emodi (3.0 mg/mL) were found to have protective properties in rats with CCl4 induced liver damage as judged from serum marker enzyme activities. CONCLUSION: The extracts of S. mukorossi and R. emodi do have a protective capacity both in vitro on primary hepatocytes cultures and in in vivo in a rat model of CCl4 mediated liver injury.

关键词：大黄素感冒肝损伤临床医学

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A study on the transmission of <i>helicobacter pylori</i>from food prepared and consumed under hygienic and unhygienic conditions: A first study using biopsy samples

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Health 2014年第4期6卷 274-283页

作者： Khawaja Shakeel Ahmed Basheer Madompoyil Janak Dulari Ahi Aleem Ahmed Khan Santosh Kumar Tiwari mohammed aejaz habeeb Asmara College of Health Sciences Department of Clinical Laboratory Sciences Microbiology Unit Asmara Eritrea Centre for Liver Research and Diagnostics Deccan College of Medical Sciences Hyderabad India Dr. Hari Singh Gour University Sagar Madhya Pradesh India Orotta School of Medicine and Dentistry Asmara Eritrea

Objective: A comparative analysis on transmission of Helicobacter pylori in people who consumed food prepared in both hygienic and unhygienic conditions. Method: The study was carried out in 1000 people across India. The Ratio of Male: female was 700: 300 with age group ranging from 20 - 39. Three gastric biopsies were collected for identification of Helicobacter pylori. PCR (Polymerase Chain Reaction) amplification was done by using 16srRNA primers. Result: The analysis showed the prevalence of H. pylori as 70.8% in individuals frequently consuming food prepared under less hygienic condition (street vendor’s food) whereas 60% (less prevalence) in individuals consuming food prepared under hygienic conditions. Conclusion: The results showed that most of the food that we consume daily is not involved much in the transmission of Helicobacter pylori. The study also showed that the street vendor’s food is not directly involved in the transmission of this bacterium. The unhygienic preparation of food and poor personal hygiene play a vital role in the transmission of these bacteria.

关键词： Helicobacter pylori Hygiene PCR 16SrRNA Food Biopsy

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The epidemiology and prevalence of Ulcerative colitis in the South of India

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Open Journal of Immunology 2012年第4期2卷 144-148页

作者： Sivaram Gunisetty Santosh Kumar Tiwari Avinash Bardia Meka Phanibhushan Vishnupriya Satti mohammed aejaz habeeb Aleem Ahmed Khan Centre for Liver Research and Diagnostics Deccan College of Medical Sciences Hyderabad India Department of Genetics Osmania University Hyderabad India Society for Translational and Regenerative Medicine Secunderabad India

Ulcerative colitis is considered frequent in majority of European and North American population and exceptional in most of the developing Asian countries. There is a dearth of reported data from South India on the incidence of the disease and its prevalence. Hence the present study was designed to estimate the prevalence of ulcerative colitis in a tertiary care hospital of Hyderabad, South India. The study population consisted of 157 Ulcerative colitis and 204 healthy subjects. All subjects were interviewed by means of a questionnaire for general demographical details and socioeconomic conditions, health related quality of life and history of UC. Patients were categorized based on disease severity;moderate: 95, and severe: 62 and disease manifestation: 73 (46.5%) pancolitis, 60 (38.2%) left-sided colitis and 24 (15.3%) had proctosigmoiditits. Disease prevalence was high in patients

关键词： Ulcerative Colitis Epidemiology Prevalence South India

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PNPLA3 as a Genetic Determinant of Risk for and Severity of Non-alcoholic Fatty Liver Disease Spectrum

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Journal of Clinical and Translational Hepatology 2016年第3期4卷 175-191页

作者： habeeb Salameh Muhannad Al Hanayneh Maen Masadeh mohammed Naseemuddin Tasnia Matin Angelika Erwin Ashwani K.Singal Division of Gastroenterology and Hepatology Department of Internal Medicine University of Texas Medical Branch GalvestonTX USA Division of Gastroenterology and Hepatology Department of Internal Medicine University of Iowa Iowa City IA USA Department of Internal Medicine University of Alabama Birmingham AL USA Genomic Medicine Institute Cleveland Clinic Foundation Cleveland OH USA Division of Gastroenterology and Hepatology University of Alabama Birmingham AL USA

Background and Aims:Patatin-like phospholipase domain protein 3 (PNPLA3) polymorphisms (rs738409 C>G) are associated with non-alcoholic fatty liver disease (NAFLD).We performed a systematic review and meta-analysis to examine the association of PNPLA3 polymorphisms with the spectrum and severity of this disease.Methods:Studies evaluating the association between the PNPLA3 polymorphism spectrum (fatty liver,steatohepatitis,cirrhosis,and hepatocellular carcinoma) and NAFLD were included.Pooled data are reported as odds ratios (ORs) with 95% confidence intervals.Results:Of 393 potentially relevant studies,35 on NAFLD were included in the analysis.Compared to healthy controls,the pooled ORs for rs738409 CG and GG compared to CC among patients with non-alcoholic fatty liver (NAFL)were 1.46 (1.16-1.85) and 2.76 (2.30-3.13),and were 1.75 (1.24-2.46) and 4.44 (2.92-6.76) among patients with non-alcoholic steatohepatitis respectively.The respective ORs for CG and GG compared to the CC genotype were 2.35 (0.90-6.13) and 5.05 (1.47-17.29) when comparing nonalcoholic hepatocellular carcinoma to NAFL patients.Among the NAFLD patients,the ORs for G allele frequency when comparing steatosis grade 2-3 to grade 0-1 NAFL,when comparing the NAFLD activity score of ≥ 4 to score ≤ 3,when comparing NASH to NAFLD,when comparing the presence of lobular inflammation to absence,and when comparing the presence of hepatocyte ballooning to absence were 2.33 (1.43-3.80),1.80 (1.36-2.37),1.66 (1.42-1.94),1.58 (1.19-2.10),and 2.63 (1.87-3.69) respectively.Subgroup analysis based on ethnicity showed similar results.Conclusions:PNPLA3 polymorphisms have strong association with the risk for and severity of NAFLDs.PNPLA3 polymorphism plays an evolving role in diagnosis and treatment decisions in patients with NAFLD.

关键词： PNPLA3 Polymorphisms Non-alcoholic liver disease rs738409 C>G

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Ovarian Vein Thrombosis, Critical Diagnosis at Al-Hasahisa Obstetrics & Gynecology Teaching Hospital in Geziera State, Sudan

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1020-1024页

作者： Mohamed ElAmin M. A. Elkhazein Atif B. E. Fazari Mohamed Bakry habeeb Parveen B. mohammed Elrasheed H. A. mohammed Al-Hasahisa Obstetrics & Gynecology Teaching Hospital Rufaa Sudan Faculty of Medicine Albutana University Rufaa Sudan Latifa Hospital DHA Dubai UAE Faculty of Medicine University of Medical Sciences & Technology Khartoum Sudan

Ovarian vein thrombosis (OVT) is a rare thrombotic condition commonly attributed to the puerperium. The complications of OVT can be significant, and diagnosis relies on a high clinical index of suspicion. It can occur with lower quadrant pain that may mimic a surgical abdomen, especially in the setting of recent pregnancy, abdominal surgery, inflammatory disease, or malignancy. Diagnosis can be made with confidence using ultrasound, computed tomography, or magnetic resonance imaging. Management of OVT is particularly important in postpartum patients, with anticoagulation therapy being the treatment of choice.

关键词： Ovarian Vein Thrombosis Puerperium Pregnancy

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Fluorescent Superlattices of Gold Nanoparticles:A New Class of Functional Materials

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Nano Research 2009年第3期2卷 220-234页

作者： Edakkattuparambil Sidharth Shibu Madathumpady Abubaker habeeb Muhammed Keisaku Kimura Thalappil Pradeep DST Unit on Nanoscience(DST UNS) Department of Chemistry and Sophisticated Analytical Instrument FacilityIndian Institute of TechnologyMadrasChennai 600036India Graduate School of Material Science University of Hyogo3-2-1 KotoKamigori-choAko-gun Hyogo 678-1297Japan

Fluorescent three-dimensional(3-D)superlattices of dansyl glutathione protected gold nanoparticles,with potential applications in molecular detection,have been synthesized at an air/water interface by controlling the pH of the nanoparticle suspension.The number of fluorophores per nanoparticle was calculated to be~127.Morphologies of the superlattice crystals were examined using scanning electron microscopy(SEM).Most of the crystals observed were triangular in shape.High-resolution transmission electron microscopy(HRTEM)and small angle X-ray scattering(SAXS)were used to study the packing of nanoparticles in these crystals.Both these studies showed that the nanoparticles were arranged in a face-centered cubic(fcc)pattern with a particle-particle distance(center-center)of~10.5 nm.Evolution of the crystal morphologies with time was also examined.The fluorescence properties of these triangles were studied using confocal fluorescence imaging and confocal Raman mapping,which were in good agreement with the morphologies observed by SEM.The superlattice exhibits near-infrared(NIR)absorption in the range 1100-2500 nm.Easy synthesis of such functional nanoparticle-based solids makes it possible to use them in novel applications.We utilized the fluorescence of dansyl glutathione gold superlattice crystals for the selective detection of bovine serum albumin(BSA),the major protein constituent of blood plasma,based on the selective binding of the naphthalene ring of the dansyl moiety with site I of BSA.

关键词： Periodic self-assembly dansyl glutathione fluorescent superlattice confocal fluorescence imaging selective binding

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Application of Scale Relativity (ScR) Theory to the Problem of a Particle in a Finite One-Dimensional Square Well (FODSW) Potential

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Journal of Quantum Information Science 2011年第1期1卷 7-17页

作者： Saeed N. T Al-Rashid mohammed A. Z habeeb Khalid A Ahmad Physics Department College of Science Al-Anbar University Anbar Iraq

In the present work, and along the lines of Hermann, ScR theory is applied to a finite one-dimensional square well potential problem. The aim is to show that scale relativity theory can reproduce quantum mechanical results without employing the Schr?dinger equation. Some mathematical difficulties that arise when obtaining the solution to this problem were overcome by utilizing a novel mathematical connection between ScR theory and the well-known Riccati equation. Computer programs were written using the standard MATLAB 7 code to numerically simulate the behavior of the quantum particle in the above potential utilizing the solutions of the fractal equations of motion obtained from ScR theory. Several attempts were made to fix some of the parameters in the numerical simulations to obtain the best possible results in a practical computer CPU time within limited local computer facilities [1,2]. Comparison of the present results with the corresponding results obtained from conventional quantum mechanics by solving the Schr?dinger equation, shows very good agreement. This agreement was improved further by optimizing the parameters used in the numerical simulations [1,3]. This represents a new example where scale relativity theory, based on a fractal space-time concept, can accurately reproduce quantum mechanical results without invoking the Schr?dinger equation.

关键词： Square Well ScR Theory Numerical Simulations Fractal Space-Time

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Qualitative Interpretation of Gravity and Aeromagnetic Data in West of Tikrit City and Surroundings, Iraq

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International Journal of Geosciences 2017年第2期8卷 151-166页

作者： Emad mohammed Salah Al-Heety Mahmoud Abdullah Al-Mufarji Losyan habeeb Al Esho Department of Applied Geology University of Anbar Rammadi Iraq Department of Geology University of Kirkuk KirKuk Iraq Department of Geology University of Mosul Mosul Iraq

The qualitative interpretation of anomalies of the gravity and the magnetic fields at the west of Tikrit City and surroundings, Iraq, was carried out. According to the tectonic framework of Iraq, the study area is classified as a part of the stable shelf unit. The polynomial technique was employed to separate the residual-regional anomalies as a first step in the qualitative interpretation. Bouguer gravity anomaly map did not exhibit any clear closures. The magnetic maps showed remarkable high closure in the central eastern part of the study area. The regional gravity and magnetic fields values decline towards the eastern parts of the maps (Mesopotamian Basin) in consistent with the increase in the sedimentary cover (basement depth). The residual gravity and magnetic maps displayed several positive and negative closures. The gravity and magnetic lineaments were depicted and superimposed on the tectonic map of the study area. The rose diagram showed that the dominant orientation of the gravity and magnetic lineaments was toward NE-SW.

关键词： Qualitative Interpretation Residual Gravity Residual Magnetic Gravity Lineaments Iraq

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