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Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats

Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 434-439页

作者： Chinnadurai Veeramani Khalid S Al-Numair Govindasamy Chandramohan mohammed a alsaif Kodukkur Viswanathan Pugalendi Department of Community Health Sciences College of Applied Medical SciencesKing Sand UniversityP.O.Box 10219Riyadh 11433Saudi Arabia Department of Biochemistry and Biotechnology Annamalai UniversityAnnamalainagar-608 002TamilnaduIndia

Objective:To investigate the antihyperlipidemic effect of crude ethanolic extract of Melothria maderaspatana(***) leaf(CEEM) on deoxycorticosterone acetate(DOCA)-salt hypertensive ***:A midscapular incision was made on each rat and the left kidney was excised after ligation of the renal *** surgical wound was closed using an absorbable *** one week recovery period,hypertension was induced by subcutaneous injection of DOCA-salt solution,twice a week,and the rats received a 1%sodium chloride solution as drinking water throughout the experimental *** or nifedipine was administered orally once a day for 6 ***:In DOCA-salt hypertensive rats,the level of plasma and tissues of total cholesterol(TC),triglycerides(TG),free fatty acids(FFA) and phospholipids (PL) significantly increased and administration of CEEM significantly reduced these parameters towards ***,the levels of low density lipoprotein-cholesterol(LDL-C) and very low density lipoprotein-cholesterol(VLDL-C) significantly increased while high density lipoprotein-cholesterol (HDL-C) decreased in hypertensive rats and administration of CEEM brought these parameters to normality which proved their antihyperlipidemic *** of liver, kidney and heart on DOCA-salt induced rats treated with CEEM showed reduced the damages towards normal ***:These findings provided evidence that CEEM was found to be protecting the liver,kidney and heart against DOCA-salt administration and the protective effect could attribute to its antihyperlipidemic activities.

关键词： DOCA-salt Hypertension CEEM Total cholesterol Triglycerides Free fatty acids Phospholipids

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Galangin ameliorates changes of membrane-bound enzymes in rats with streptozotocin-induced hyperglycemia

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Asian Pacific Journal of Tropical Biomedicine 2019年第7期9卷 284-290页

作者： Amal A.Aloud Chinnadurai Veeramani Chandramohan Govindasamy mohammed A.alsaif Khalid S.AlNumair Department of Food Sciences and Nutrition College of Food and Agriculture SciencesKing Saud UniversityP.O.Box 2460Riyadh11451Saudi Arabia Department of Community Health Sciences College of Applied Medical SciencesKing Saud UniversityP.O.Box 10219Riyadh 11433Saudi Arabia

Objective: To assess the protective effect of galangin on membrane bound enzymes in rats with streptozotocin-induced diabetes. Methods: A single low dose of streptozotocin was injected to adult male albino rats to induce hyperglycemia. Galangin(8 mg/kg) or glibenclamide 600 μg/kg as a standard drug was given orally once daily for 45 days by gavage. Membrane-bound adenosine triphosphatases were determined including total ATPase, sodium-potassium-ATPase, calcium-ATPase and magnesium-ATPase in erythrocytes and tissues(kidney, liver, and heart). Results: The levels of total ATPases, sodium-potassium-ATPase, calcium-ATPase and magnesium-ATPase in erythrocytes and tissues were significantly altered in diabetic rats as compared to that in normal rats. After 45 days of treatment with galangin or glibenclamide, the levels of these enzymes were similar to that of normal control rats. Conclusions: Oral administration of galangin or glibenclamide can improve activities of these membrane-bound ATPases towards normal levels. Mechanism of galangin needs to be further explored in future.

关键词： Streptozotocin Hyperglycemia Sodium-potassium-ATPase Calcium-ATPase Magnesium-ATPase Galangin

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Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 939-944页

作者： Chinnadurai Veeramani Khalid S Al-Numair mohammed a alsaif Govindasamy Chandramohan Nouf S Al-Numair Kodukkur Viswanathan Pugalendi Department of Community Health Sciences College of Applied Medical SciencesKing Saud University Department of Structural and Molecular Biology University College LondonDarwin BuildingCower StreetLondonWCIE 6BT Department of Biochemistry and Biotechnology Annamalai University

Objective:To investigate the protective role of Cardiospermum halicacabum(***) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic ***: Diabetes was induced in male albino Wistar rats by intraperitonial administration of *** *** leaf extract(CHE) was administered orally to normal and STZ-diabetic rats for 45 *** effects of *** leaf extract(CHE) on plasma and tissue glycoproteins (hexose,hexosamine,fucose and sialic acid) were ***:The levels of plasma and tissues glycoproteins containing hexose,hexosamine and fucose were significantly increased in STZ-induced diabetic *** addition,the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic *** administration of CHE to diabetic rats,the metabolic alteration of glycoprotein reverted towards normal levels. Conclusions:The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.

关键词： Streptozotocin Cardiospermum halicacabum leaf extract Hexose Hexosamine Fucose Sialic acid

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