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Increasing secondary bacterial infections with Enterobacteriaceae harboring bla_(CTX-M-15) and bla_(CMY-6) in patients with bronchogenic carcinoma:an emerging point of concern

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Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 5-12页

作者： mohammed shahid Abida Malik Rakesh Bhargava Section of Bacteriology & Molecular Biology Department of Medical MicrobiologyJN Medical College & HospitalAligarh Muslim UniversityAligarh-202 002U.P.India T.B.& Chest Diseases Jawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002Uttar PradeshIndia

Objective:To look for secondary bacterial infections in bronchogenic carcinoma（BCA） with resistant organisms harboring bla genes considering the paucity of relevant ***: A total of 137 confirmed cases of BCA and 34 healthy volunteers were studied for the occurrence and prevalence of blaCTX-M and and blaAmpC harboring-enterobacteriaceae.A subset of these patients（n=69） was previously reported for the secondary infection with the Aspergillus species. Bronchoalveolar lavages（BAL） were subjected for bacterial and fungal cultures and the bacterial isolates were screened by multiplex PCRs for the presence of blaCTX-M and blaAmpC.The isolates were also screened for the association of insertion sequence（IS26） by PCR and characterized by RAPD for any clonal ***:A total of 143 bacterial isolates were obtained from 137 BAL specimens of BC,*** Enterobacteriaceae-isolates were multidrug-resistant showing concomitant resistance to fluoroquinolones and *** blaCTX-M and blaAmpC of CIT family were detected in 77.4%and 27.4%isolates,*** revealed the presence of blaCTX-M-15 and blaCMY-6.Twenty one percent of the isolates were simultaneously harboring blaampC and blaCTX-M-15.IS26 PCR and RAPD typing revealed the presence of diverse bacterial population but no predominant clone was *** present study also suggests strong association of aspergillosis with lung cancer and further strengthens the potential use of non-validated serological tests suggested ***:We emphasize that all patients of bronchogenic carcinoma should also be screened for secondary bacterial infections,along with secondary fungal infections,so as to introduce early and specific antimicrobial therapy and to prevent unwanted deaths.

关键词： Bronchogenic carcinoma Secondary bacterial infections CTX-M AmpC Enterobacteriaceae

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bla_(CTX-M),bla_(TEM),and bla_(SHV) in Enterobacteriaceae from North-Indian tertiary hospital:high occurrence of combination genes

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Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 101-105页

作者： mohammed shahid Anuradha Singh Farrukh Sobia Mohammad Rashid Abida Malik Indu Shukla Haris Manzoor Khan Section of Antimicrobial Agents & Drug Resistance Research and Molecular Biology Department of Medical MicrobiologyJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002Uttar PradeshIndia

Objective:To delineate the frequency of occurrence of bla_(CTX-M),bla_(TEM),and bla_(SHV) in Enterobacteriaceae from North-Indian tertiary ***:A random collection of a subset of 45 Escherichia coli(***) and 28 Klebsiella pneumoniae(***) that was resistant to a third generation cephalosporin and obtained during 2007-2008 was selected for detailed screening for bla_(CTX-M),bla_(TEM),and bla_(SHV) by monoplex *** isolates demonstrating the presence of bla_(CTX-M) alleles were characterized for the specific CTX-M-genogroup by using a multiplex ***:Resistance to cefoperazone,ceftazidime,ceftriaxone,cefotaxime, cefoxitin and piperacillin was 100%each in *** isolates,whereas these resistancerates for *** isolates were 93.1%,83.8%,91.9%,93.6%,97.3%and 97.1%,respectively. Concomitant resistance to aminoglycosides,quinolones and aztreonam was also *** of any of the bla genes(bla_(CTX-M),bla_(TEM),and bla_(SHV)) was noticed in a total of 28(38.4%) isolates of the 73 isolates *** isolates demonstrated occurrence of these genes in various ***_(CTX-M),bla_(TEM),and bla_(SHV) were noticed in 28.8%,10.9%and 13.7%isolates, *** PCR in bla_(CTX-M) harboring isolates demonstrated the presence of CTX-MGenogroup -1 and sequencing for the specific CTX-M-type revealed presence of CTX-M-15 type. RAPD typing showed wide diversity in ***:This is amongst the premier report describing the simultaneous occurrence of blo_(TEM),bla_(SHV),and bla_(ampC) in Indian Enterobacteriaceae and that wider dissemination of these genes,as demonstrated by diversity of isolates,raises concern and emphasizes a need for extensive search for the presence of these gene pools in Indian subcontinent.

关键词： Resistance genes bla_(CTX-M-15) bla_(TEM) bla_(SHV) Concomitant-occurrence Enterobacteriaceae

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Impact of metal polluted sewage water on soil nematode assemblages in agricultural settings of Aligarh,India

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Soil Ecology Letters 2024年第1期6卷 61-75页

作者： mohammed F.S.A.Ghanem shahid Afzal Humira Nesar Zarrin Imran Wasim Ahmad Nematode Biodiversity Research Lab Department of ZoologyAligarh Muslim UniversityAligarh 202002India

Sewage water in agriculture threatens human health and soil ecosystems through metal *** show promise as bioindicators of soil health due to their abundance and position in soil food ***-polluted water decreased abundance of certain nematode groups and Sigma Maturity *** pollution positively affected nematode groups with r-selected life *** water has been inappropriately used in agriculture,posing possible threats to human health and the soil ecosystems by its constituent pollutants,especially heavy *** evaluation of its influences on soil biomes needs to consider the response of soil *** soil organisms,nematodes are seen as the best promising candidates for bioindicators of soil *** in,we collected soil samples from fresh water irrigated field from three sites(S1,S2 and S3)and sewage water irrigated distance gradient(5 m-40 m),to assess the influence of metal(Cu,Zn,Cd,Mn,Pb)polluted water on various characteristics of nematode *** results indicated that the heavy metals decreased the abundance of C-p3 nematodes,herbivores,and predatory nematodes as well as sigma maturity index,whereas,C-p1,C-p2,bacterivore and fungivore nematodes abundance and diversity positively responded to the metal ***,nematode genera with r-selected life cycle were positively affected and those with K-selected life cycle were negatively affected by metal *** nematode community has potential to be used as indicator of pollution stress in agricultural soils to check soil health and sustainability.

关键词： heavy metals sewage irigation agriculture nematodes bioindicators

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A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

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Oncology Research 2024年第5期32卷 817-830页

作者： shahid KARIM ALANOUD NAHER ALGHANMI MAHA JAMAL HUDA ALKREATHY ALAM JAMAL HIND A.ALKHATABI mohammed BAZUHAIR AFTAB AHMAD Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Health Information Technology Department The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia Pharmacovigilance and Medication Safety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Cancer frequently develops resistance to the majority of chemotherapy *** study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapagliflozin(DAP),Empagliflozin(EMP),and Doxorubicin(DOX),using in vitro *** precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their ***,when these medications were combined with DOX,there was a considerable inhibition of glucose consumption,as well as reductions in intracellular ATP and lactate ***,this effect was found to be dependent on the dosages of the *** addition to effectively inhibiting the cell cycle,the combination of CAN+DOX induces substantial modifications in both cell cycle and apoptotic gene *** work represents the initial report on the beneficial impact of SGLT2 inhibitor medications,namely CAN,DAP,and EMP,on the responsiveness to the anticancer properties of *** underlying molecular mechanisms potentially involve the suppression of the function of SGLT2.

关键词： SGLT2 Cancer Cytotoxicity ATP Cell cycle

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Smartphone-Based Wi-Fi Analysis for Bus Passenger Counting

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Computers, Materials & Continua 2024年第4期79卷 875-907页

作者： mohammed Alatiyyah Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia

In the contemporary era of technological advancement,smartphones have become an indispensable part of individuals’daily lives,exerting a pervasive *** paper presents an innovative approach to passenger countingonbuses throughthe analysis ofWi-Fi signals emanating frompassengers’mobile *** study seeks to scrutinize the reliability of digital Wi-Fi environments in predicting bus occupancy levels,thereby addressing a crucial aspect of public *** proposed system comprises three crucial elements:Signal capture,data filtration,and the calculation and estimation of passenger *** pivotal findings reveal that the system demonstrates commendable accuracy in estimating passenger counts undermoderate-crowding conditions,with an average deviation of 20%from the ground truth and an accuracy rate ranging from 90%to 100%.This underscores its efficacy in scenarios characterized by moderate levels of ***,in densely crowded conditions,the system exhibits a tendency to overestimate passenger numbers,occasionally doubling the actual *** acknowledging the need for further research to enhance accuracy in crowded conditions,this study presents a pioneering avenue to address a significant concern in public *** implications of the findings are poised to contribute substantially to the enhancement of bus operations and service quality.

关键词： Public transportation digital environment passenger estimation signal capturing Wi-Fi

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EECLP: AWireless Sensor Networks Energy Efficient Cross-Layer Protocol

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Computers, Materials & Continua 2024年第8期80卷 2611-2631页

作者： mohammed Kaddi mohammed Omari Moamen Alnatoor LDDI Laboratory University of AdrarAdrar01000Algeria Computer Science and Engineering Department School of EngineeringAmerican University of Ras Al KhaimahRas Al Khaimah72603United Arab Emirates

Recent advancements in wireless communications have allowed the birth of novel wireless sensor networks(WSN).A sensor network comprises several micro-sensors deployed randomly in an area of interest.A micro-sensor is provided with an energy resource to supply electricity to all of its ***,the disposed energy resource is limited and battery replacement is generally *** this restriction,the sensors must conserve energy to prolong their *** energy conservation strategies for WSNs have been presented in the literature,from the application to the physical *** of these solutions focus only on optimizing a single layer in terms of energy *** this research,a novel cross-layer technique for WSNs’effective energy usage is *** most energy consumption factors exist in the Medium Access Control(MAC)layer and network layer,our EECLP protocol(Energy Efficient Cross-Layer Protocol for Wireless Sensor Networks)integrates these two layers to satisfy energy efficiency *** gain access to the transmission channel,we implement a communication regime at the MAC layer based on CSMA/CA(Carrier Sense Multiple Access/Collision Avoidance)***,depending on the activity and a standby period,we employ the RTS/CTS(Request to Send/Clear to Send)method to prevent collisions and resolve hidden node concerns by utilizing the network allocation vector(NAV)to calculate the transmission *** a greedy strategy,we establish chains amongst cluster members to mitigate the issue of high energy consumption in routing *** objective function was utilized to determine the optimal cross-chain path based on the distances to the base station(BS)and residual energy(RE).The simulation,testing,and comparison of the proposed protocol to peer protocols have shown superior outcomes and a prolonged network *** the suggested protocol,the network lifetime increases by 10%compared to FAMACO(Fuzzy and Ant Col

关键词： WSN energy consumption MAC layer network layer EECLP energy-efficient lifespan

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Numerical investigation of the effects of soil-structure and granular material-structure interaction on the seismic response of a flat-bottom reinforced concrete silo

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 609-623页

作者： Sonia Benkhellat mohammed Kadri Abdelghani Seghir Laboratory of Solid Mechanics and Systems University of M’Hamed BougaraBoumerdes 35000Algeria Laboratory of Geomaterials Environment and DevelopmentUniversity of M’Hamed BougaraBoumerdes 35000Algeria Research Laboratory of Applied Hydraulics and Environment Faculty of TechnologyUniversity of BejaiaBejaia 06000Algeria

In this work,a numerical study of the effects of soil-structure interaction(SSI)and granular material-structure interaction(GSI)on the nonlinear response and seismic capacity of flat-bottomed storage silos is conducted.A series of incremental dynamic analyses(IDA)are performed on a case of large reinforced concrete silo using 10 seismic *** IDA results are given by two average IDA capacity curves,which are represented,as well as the seismic capacity of the studied structure,with and without a consideration of the SSI while accounting for the effect of *** curves are used to quantify and evaluate the damage of the studied silo by utilizing two damage indices,one based on dissipated energy and the other on displacement and dissipated *** cumulative energy dissipation curves obtained by the average IDA capacity curves with and without SSI are presented as a function of the base shear,and these curves allow one to obtain the two critical points and the different limit states of the *** is observed that the SSI and GSI significantly influence the seismic response and capacity of the studied structure,particularly at higher levels of ***,the effect of the SSI reduces the damage index of the studied structure by 4%.

关键词： reinforced concrete silo perfectly matched layers soil-structure interaction granular material-structure interaction effective seismic input method damage index

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Improved Dwarf Mongoose Optimization Algorithm for Feature Selection:Application in Software Fault Prediction Datasets

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Journal of Bionic Engineering 2024年第4期21卷 2000-2033页

作者： Abdelaziz I.Hammouri mohammed A.Awadallah Malik ShBraik mohammed Azmi Al-Betar Majdi Beseiso Department of Computer Science Al-Balqa Applied UniversityAl-Salt19117Jordan Department of Scientific Research and Graduate Studies University of Prince Mugrin42241MedinaSaudi Arabia Department of Computer Science Al-Aqsa UniversityGaza4051Palestine Artificial Intelligence Research Center(AIRC) Ajman UniversityAjmanUnited Arab Emirates Department of Information Technology Al-Huson University CollegeAl-Balqa Applied UniversityAl-HusonIrbid21110Jordan

Feature selection(FS)plays a crucial role in pre-processing machine learning datasets,as it eliminates redundant features to improve classification accuracy and reduce computational *** paper presents an enhanced approach to FS for software fault prediction,specifically by enhancing the binary dwarf mongoose optimization(BDMO)algorithm with a crossover mechanism and a modified positioning updating *** proposed approach,termed iBDMOcr,aims to fortify exploration capability,promote population diversity,and lastly improve the wrapper-based FS process for software fault prediction *** gained superb performance compared to other well-esteemed optimization methods across 17 benchmark *** ranked first in 11 out of 17 datasets in terms of average classification ***,iBDMOcr outperformed other methods in terms of average fitness values and number of selected features across all *** findings demonstrate the effectiveness of iBDMOcr in addressing FS problems in software fault prediction,leading to more accurate and efficient models.

关键词： Dwarf mongoose optimization algorithm Optimization Feature selection Classification

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Integrated photonic fractional convolution accelerator

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Photonics Research 2024年第8期12卷 1828-1839页

作者： KEVIN ZELAYA mohammed-ALI MIRI Department of Physics Queens College of the City University of New York Physics Program The Graduate Center of the City University of New York

An integrated photonic circuit architecture to perform a modified-convolution operation based on the discrete fractional Fourier transform(DFrFT) is introduced. This is accomplished by utilizing two nonuniformly coupled waveguide lattices with equally spaced eigenmode spectra, the lengths of which are chosen so that the DFrFT and its inverse operations are achieved. A programmable modulator array is interlaced so that the required fractional convolution operation is performed. Numerical simulations demonstrate that the proposed architecture can effectively perform smoothing and edge detection tasks even for noisy input signals, which is further verified by electromagnetic wave simulations. Notably, mild lattice defects do not jeopardize the architecture performance, showing its resilience to manufacturing errors. ? 2024 Chinese Laser Press

关键词： Array waveguide devices Edge detection Fourier transforms Free space optics Numerical simulation Optical elements

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Kaoline-based catalyst for a high stability desulfurization of sour heavy naphtha in a three-phase oscillatory baffled reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan M.Hmood Saba A.Gheni Safaa M.R.Ahmed Mudheher M.Ali Hamid Yonis Saleh mohammed H.mohammed Awad E.mohammed Marwan A.Mahomood Hiba R.mohammed Ahmed A.Hassan Adam Harvey North Refineries Company Ministry of OilIraq Chemical Engineering Department Tikrit UniversityIraq Ministry of Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of Engineering Newcastle UniversityUK

To meet the rapidly increasing demand for energy and the dramatic depletion of conventional crude oil,it is imperative to utilize sour *** no coke being produced,oxidative desulfurization(ODS)of naphtha lowers its sulfur content and average molecular *** this article,we outline a method for heavy naphtha non-extractive ODS using a very stable *** technique involves the use of a solid catalyst with oxygen gas as the *** necessitated relatively high mixing intensities;hence a three-phase Oscillatory Baffled Reactor(OBR)was *** catalyst was based on the zeolite ZSM-5,prepared from natural kaolin by a series of delamination and activation steps and impregnated with Fe.A TiO2 nanolayer was applied,using the sol-gel method,to prevent rapid *** reactor performance was evaluated to minimize the sulfur content in the naphtha *** to the protective coating,the sulfur conversion stabilized at 90%.The results of this work establish the use of natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term *** also showed that modest ODS can be achieved using an environmentally friendly oxidant,at mild operating conditions,whilst maintaining stability.

关键词： Natural kaoline Desulfurization Three-phase Oscillatory baffled reactor

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