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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Energy Optimised Security against Wormhole Attack in IoT-Based Wireless Sensor Networks

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Computers, Materials & Continua 2021年第8期68卷 1967-1981页

作者： Hafsa Shahid Humaira Ashraf Hafsa javed Mamoona Humayun Nz Jhanjhi mohammed A.AlZain Department of Computer Science and Software Engineering International Islamic University IslamabadIslamabadPakistan Department of Information Systems College of Computer and Information ScienceJouf UniversityAl-JoufSaudi Arabia School of Computer Science and Engineering(SCE) Taylor’s UniversitySelangorMalaysia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

An IoT-based wireless sensor network(WSN)comprises many small sensors to collect the data and share it with the central *** sensors are battery-driven and resource-restrained devices that consume most of the energy in sensing or collecting the data and transmitting *** data sharing,security is an important concern in such networks as they are prone to many threats,of which the deadliest is the wormhole *** attacks are launched without acquiring the vital information of the network and they highly compromise the communication,security,and performance of the *** the IoT-based network environment,its mitigation becomes more challenging because of the low resource availability in the sensing *** have performed an extensive literature study of the existing techniques against the wormhole attack and categorised them according to their *** analysis of literature has motivated our *** this paper,we developed the ESWI technique for detecting the wormhole attack while improving the performance and *** algorithm has been designed to be simple and less complicated to avoid the overheads and the drainage of energy in its *** simulation results of our technique show competitive results for the detection rate and packet delivery *** also gives an increased throughput,a decreased end-to-end delay,and a much-reduced consumption of energy.

关键词： IoT Internet of Things energy wormhole WSN wireless sensor networks

Recent progress in flexible Zn-ion hybrid supercapacitors: Fundamentals, fabrication designs, and applications

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Carbon Energy 2023年第1期5卷 82-122页

作者： Muhammad Sufyan javed Sumreen Asim Tayyaba Najam Muhammad Khalid Iftikhar Hussain Awais Ahmad mohammed A.Assiri Weihua Han School of Physical Science and Technology Lanzhou UniversityLanzhouGansuChina Institute of Chemistry Khwaja Fareed University of Engineering and Information TechnologyPunjabPakistan College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdongChina Department of Mechanical Engineering City University of Hong KongKowloonHong KongChina Departamento de Quimica Organica Universidad de CordobaCordobaSpain Department of Chemistry Faculty of ScienceKing Khalid UniversityAbhaSaudi Arabia

One of the most exciting new developments in energy storage technology is flexible Zn-ion hybrid supercapacitors(f-ZIHSCs),which combine the high energy of Zn-ion batteries with high-power supercapacitors to satisfy the needs of portable flexible ***,the development of f-ZHSCs is still in its infancy,and there are numerous barriers to overcome before they can be widely implemented for practical *** review gives an up-to-date description of recent achievements and underlying concepts in energy storage mechanisms of f-ZIHSCs and emphasizes the critical role of cathode,anode,and electrolyte materials systems in speeding the prosperity of *** innovative nanostructured-based cathode materials for f-ZIHSCs include carbon(e.g.,porous carbon,heteroatom-doped carbon,biomass-derived porous carbon,graphene,etc.),metal-oxides,MXenes,and metal/covalentorganic frameworks,and other materials(e.g.,activated carbon,phosphorene,etc.)are mainly ***,the latest developments in flexible anode and electrolyte frameworks and impacts of electrolyte compositions on the electrochemical properties of f-ZIHSC are ***,the advancements based on fabrication designs,including quasi-solid-state,micro,fiber-shaped,and all climate-changed f-ZIHSCs,are discussed in ***,a summary of current challenges and recommendations for the future progress of advanced f-ZIHSC are *** review article is anticipated to further understand the viable strategies and achievable approaches for assembling high-performance f-ZIHSCs and boost the technical revolutions on cathode,anode,and electrolytes for f-ZIHSC devices.

关键词： electrode electrolyte flexible MOFs MXenes Zn-ion hybrid supercapacitor

Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou Huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

Classification and Categorization of COVID-19 Outbreak in Pakistan

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Computers, Materials & Continua 2021年第10期69卷 1253-1269页

作者： Amber Ayoub Kainaat Mahboob Abdul Rehman javed Muhammad Rizwan Thippa Reddy Gadekallu Mustufa Haider Abidi mohammed Alkahtani Department of Computer Science Kinnaird College for WomenLahore54000Pakistan Department of Cyber Security Air UniversityIslamabadPakistan School of Information Technology and Engineering Vellore Institute of TechnologyTamil NaduIndia Raytheon Chair for Systems Engineering Advanced Manufacturing InstituteKing Saud UniversityRiyadh11421Saudi Arabia Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

Coronavirus is a potentially fatal disease that normally occurs in mammals and ***,in humans,the virus spreads through aerial droplets of any type of fluid secreted from the body of an infected *** is a family of viruses that is more lethal than other unpremeditated *** December 2019,a new variant,i.e.,a novel coronavirus(COVID-19)developed in Wuhan province,*** January 23,2020,the number of infected individuals has increased rapidly,affecting the health and economies of many countries,including *** objective of this research is to provide a system to classify and categorize the COVID-19 outbreak in Pakistan based on the data collected every day from different regions of *** research also compares the performance of machine learning classifiers(i.e.,Decision Tree(DT),Naive Bayes(NB),Support Vector Machine,and Logistic Regression)on the COVID-19 dataset collected in *** to the experimental results,DT and NB classifiers outperformed the other *** addition,the classified data is categorized by implementing a Bayesian Regularization Artificial Neural Network(BRANN)*** results demonstrate that the BRANN classifier outperforms state-of-the-art classifiers.

关键词： COVID-19 pandemic neural network BRANN machine learning

An Efficient Mechanism for Product Data Extraction from E-Commerce Websites

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Computers, Materials & Continua 2020年第12期65卷 2639-2663页

作者： Malik javed Akhtar Zahur Ahmad Rashid Amin Sultan H.Almotiri mohammed A.Al Ghamdi Hamza Aldabbas University of Engineering and Technology TaxilaPakistan Computer Science Department Umm Al-Qura UniversityMakkah CitySaudi Arabia Al-Balqa Applied University Al-SaltJordan

A large amount of data is present on the web which can be used for useful purposes like a product recommendation,price comparison and demand forecasting for a particular *** are designed for human understanding and not for ***,to make data machine-readable,it requires techniques to grab data from web *** have addressed the problem using two approaches,i.e.,knowledge engineering and machine *** of the art knowledge engineering approaches use the structure of documents,visual cues,clustering of attributes of data records and text processing techniques to identify data records on a web *** learning approaches use annotated pages to learn *** rules are used to extract data from unseen web *** structure of web documents is continuously ***,new techniques are needed to handle the emerging requirements of web data *** this paper,we have presented a novel,simple and efficient technique to extract data from web pages using visual styles and structure of *** proposed technique detects Rich Data Region(RDR)using query and correlative words of the *** is then divided into data records using style *** elements are removed using a Common Tag Sequence(CTS)and formatting *** system is implemented using JAVA and runs on the dataset of real-world working *** effectiveness of results is evaluated using precision,recall,and F-measure and compared with five existing systems.A comparison of the proposed technique to existing systems has shown encouraging results.

关键词： Document object model rich data region common tag sequence web data extraction deep web mining

Animal- and Human-Inspired Nanostructures as Supercapacitor Electrode Materials: A Review

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Nano-Micro Letters 2022年第12期14卷 151-175页

作者： Iftikhar Hussain Charmaine Lamiel Sumanta Sahoo Muhammad Sufyan javed Muhammad Ahmad Xi Chen Shuai Gu Ning Qin mohammed AAssiri Kaili Zhang Department of Mechanical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongPeople’s Republic of China Department of Chemical Engineering University of WyomingLaramieWY 82071USA Department of Chemistry Madanapalle Institute of Technology and ScienceMadanapalleAndhra Pradesh 517325India School of Physical Science and Technology Lanzhou UniversityLanzhou 730000People’s Republic of China Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

Human civilization has been relentlessly inspired by the nurturing lessons;nature is teaching *** birds to airplanes and bullet trains,nature gave us a lot of perspective in aiding the progress and development of countless industries,inventions,transportation,and many *** only that nature inspired us in such technological advances but also,nature stimulated the advancement of micro-and ***-inspired nanoarchitectures have been consid-ered a favorable structure in electrode materials for a wide range of *** offers various positive attributes,especially in energy storage applications,such as the formation of hierarchical two-dimen-sional and three-dimensional interconnected networked structures that benefit the electrodes in terms of high surface area,high porosity and rich surface textural features,and eventually,delivering high capacity and outstanding overall material *** this review,we compre-hensively assessed and compiled the recent advances in various nature-inspired based on animal-and human-inspired nanostructures used for *** comprehensive review will help researchers to accommodate nature-inspired nanostructures in industrializing energy storage and many other applications.

关键词： Nature-inspired nanostructure Supercapacitors Energy storage Animal-inspired and human-inspired nanostructures

Is intra-operative cholangiography necessary during laparoscopic cholecystectomy? A multicentre rural experience from a developing world country

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World Journal of Gastroenterology 2007年第33期13卷 4493-4497页

作者： Iqbal Saleem Mir Mir Mohsin Omar Kirmani Tafazul Majid Khurshid Wani Mehmood-ul Hassan javed Naqshbandi mohammed Maqbool Minimal Access Surgery Unit Government Gousia Hospital Khanyar Kashmir 190010 India Department of Radiology Government Gousia Hospital Khanyar Kashmir 190010 India Anaesthesia Unit Government Gousia Hospital Khanyar Kashmir 190010 India

AIM: To evaluate the feasibility and safety of performing laparoscopic cholecystectomy (LC) in nonteaching rural hospitals of a developing country without intra-operative cholangiography (IOC). To evaluate the possibility of reduction of costs and hospital stay for patients undergoing ***: A prospective analysis of patients with symptomatic benign diseases of gall bladder undergoing LC in three non-teaching rural hospitals of Kashmir Valley from Jan 2001 to Jan 2007. The cohort represented a sample of patients requiring LC, aged 13 to 78 (mean 47.2) years. Main outcome parameters included mortality, complications, re-operation, conversion to open procedure without resorting to IOC, reduction in costs borne by the hospital, and the duration of hospital ***: Twelve hundred and sixty-seven patients (976 females/291 males) underwent laparoscopic cholecystectomy. Twenty-three cases were converted to open procedures; 12 patients developed port site infection, nobody died because of the procedure. One patient had common bile duct (CBD) injury, 4 patients had biliary leak, and 4 patients had subcutaneous emphysema. One cholecystohepatic duct was detected and managed intraoperatively, 1 patient had retained CBD stones, while 1 patient had retained cystic duct stones. Incidental gallbladder malignancy was detected in 2 cases. No long-term complications were detected up to ***: LC can be performed safely even in non-teaching rural hospitals of a developing country provided proper equipment is available and the surgeons and other team members are well trained in the procedure. It is stressed that IOC is not essential to prevent biliary tract injuries and missed CBD stones. The costs to the patient and the hospital can be minimized by using reusable instruments, intracorporeal sutures, and condoms instead of titanium clips and endobags.

关键词： Laparoscopic cholecystectomy Intraoperative cholangiography

An Optimized Offloaded Task Execution for Smart Cities Applications

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Computers, Materials & Continua 2023年第3期74卷 6321-6334页

作者： Ahmad Naseem Alvi Muhammad Awais javed Mozaherul Hoque Abul Hasanat Muhammad Badruddin Khan Abdul Khader Jilani Saudagar mohammed Alkhathami Department of Electrical and Computer Engineering COMSATS University Islamabad45550Pakistan Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

Wireless nodes are one of the main components in different applications that are offered in a smart *** wireless nodes are responsible to execute multiple tasks with different priority *** the wireless nodes have limited processing capacity,they offload their tasks to cloud servers if the number of tasks exceeds their task processing *** these tasks from remotely placed cloud servers causes a significant delay which is not required in sensitive task *** execution delay is reduced by placing fog computing nodes near these application nodes.A fog node has limited processing capacity and is sometimes unable to execute all the requested *** this work,an optimal task offloading scheme that comprises two algorithms is proposed for the fog nodes to optimally execute the time-sensitive offloaded *** first algorithm describes the task processing criteria for local computation of tasks at the fog nodes and remote computation at the cloud *** second algorithm allows fog nodes to optimally scrutinize the most sensitive tasks within their task *** results show that the proposed task execution scheme significantly reduces the execution time and most of the time-sensitive tasks are executed.

关键词： Smart cities fog computing task offloading knapsack