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Bio-Design and Manufacturing 2019年第3期2卷 181-186页

作者： Ghazal Shineh Soheila S.Kordestani mohammadreza tahriri Lobat Tayebi Biomaterials Department Faculty of Biomedical EngineeringAmirkabir University of TechnologyTehranIran Marquette University School of Dentistry MilwaukeeWI 53233USA

Wounds heal through a complex process including four *** interruption or interference in healing process can prevent wound *** is one of the most common complications preventing wounds from *** this study,we investigated the fibroblast cell morphology and behavior of a gelatin-based hydrogel containing anthocyanin to determine whether it can be used for early detection of *** experimental results ascertained that 6 h after culturing the fibroblasts,they could be well attached to the surface of the hydrogel,and 48 h after seeding,they were spread over the surface and connected with each *** the addition of a low dose of anthocyanin,the vitality of the cell increased,and the results of the ATR-FTIR analysis showed that anthocyanin could eliminate remaining glutaraldehyde free *** also could change its color after the addition of bacterial ***,hydrogels containing black carrot anthocyanin may be a potential therapeutic and diagnostic strategy to promote wound healing and early detection of infection.

关键词： Wound healing Hydrogel Gelatin Infection Anthocyanin pH

UV irradiation-H2O2 system as an effective combined depolymerization technique to produce oligosaccharides from chitosan

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Bio-Design and Manufacturing 2018年第1期1卷 62-68页

作者： Seyed Ahmad Ayati Najafabadi Hengameh Honarkar Majid Moghadam Valiollah Mirkhani mohammadreza tahriri Lobat Tayebi Biomaterials Group Faculty of Biomedical Engineering Amirkabir University of Technology Tehran Iran Polyurethane and Advanced polymers Faculty of Science Iran Polymer and Petrochemical Institute Tehran Iran Catalysis Divisions Department of Chemistry University of Isfahan Isfahan Iran Marquette University School of Dentistry Milwaukee WI 53233 USA Department of Engineering Science University of Oxford Oxford OX13PJ UK

UV irradiation hydrogen peroxide （H202） system is used as an effective, easy and low-cost combined depolymerization technique to produce oligosaccharides from chitosan. UV-Vis spectroscopic studies explained that with increasing treatment time, the absorption of the depolymerized chitosan solution has increased, indicating the increase in the carbonyl and amino groups in their structure. Fourier transform infrared spectroscopy and nuclear magnetic resonance （1H NMR） analysis showed that the 1,4-β-D-glucoside linkages of chitosan are degraded without important changes in chemical structure of decomposed samples. X-ray diffraction patterns verified the polymerization of chitosan to produce oligomers, changing in structure from crystalline to amorphous. Viscosity-average molecular weight measurements of fragmented chitosan samples and MarkHouwink equation are used to demonstrate the efficiency of this depolymerization method. Finally, the obtained results ascertained that this combined method could produce water soluble chitosan with significant efficiency and no essential change in its chemical *** irradiation hydrogen peroxide （H202） system is used as an effective, easy and low-cost combined depolymerization technique to produce oligosaccharides from chitosan. UV-Vis spectroscopic studies explained that with increasing treatment time, the absorption of the depolymerized chitosan solution has increased, indicating the increase in the carbonyl and amino groups in their structure. Fourier transform infrared spectroscopy and nuclear magnetic resonance （1H NMR） analysis showed that the 1,4-β-D-glucoside linkages of chitosan are degraded without important changes in chemical structure of decomposed samples. X-ray diffraction patterns verified the polymerization of chitosan to produce oligomers, changing in structure from crystalline to amorphous. Viscosity-average molecular weight measurements of fragmented chitosan samples and MarkHouwink equation are used to dem

关键词： Chitosan Depolymerization Ultraviolet irradiation Hydrogen peroxide Oligosaccharides

Cartilage and facial muscle tissue engineering and regeneration： a mini review

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Bio-Design and Manufacturing 2018年第2期1卷 115-122页

作者： Michael Del Monico mohammadreza tahriri Mina D. Fahmy Hamed Ghassemi Daryoosh Vashaee Lobat Tayebi Marquette University School of Dentistry Milwaukee WI 53233 USA Eye Research Center Farabi Eye Hospital Tehran University of Medical Sciences Tehran Iran Department of Electrical and Computer Engineering North Carolina State University Raleigh NC 27606 USA

Cartilage and facial muscle tissue provide basic yet vital functions for homeostasis throughout the body, making human survival and function highly dependent upon these somatic components. When cartilage and facial muscle tissues are harmed or completely destroyed due to disease, trauma, or any other degenerative process, homeostasis and basic body functions consequently become negatively affected. Although most cartilage and cells can regenerate themselves after any form of the aforementioned degenerative disease or trauma, the highly specific characteristics of facial muscles and the specific structures of the cells and tissues required for the proper function cannot be exactly replicated by the body itself. Thus, some form of cartilage and bone tissue engineering is necessary for proper regeneration and function. The use of progenitor cells for this purpose would be very beneficial due to their highly adaptable capabilities, as well as their ability to utilize a high diffusion rate, making them ideal for the specific nature and functions of cartilage and facial muscle tissue. Going along with this, once the progenitor cells are obtained, applying them to a scaffold within the oral cavity in the affected location allows them to adapt to the environment and create cartilage or facial muscle tissue that is specific to the form and function of the area. The principal function of the cartilage and tissue is vascularization, which requires a specific form that allows them to aid the proper flow of bodily functions related to the oral cavity such as oxygen flow and removal of waste. Facial muscle is also very thin, making its reproduction much more possible. Taking all these into consideration, this review aims to highlight and expand upon the primary benefits of the cartilage and facial muscle tissue engineering and regeneration, focusing on how these processes are performed outside of and within the body.

关键词： Soft tissue regeneration Cartilage tissue engineering Muscle tissue engineering Facial regeneration

Mathematical modeling of drug release from biodegradable polymeric microneedles

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Bio-Design and Manufacturing 2019年第2期2卷 96-107页

作者： Sarvenaz Chavoshi Mohammad Rabiee Mehdi Rafizadeh Navid Rabiee Alireza Shahin Shamsabadi Mojtaba Bagherzadeh Reza Salarian mohammadreza tahriri Lobat Tayebi Biomaterials Group Faculty of Biomedical EngineeringAmirkabir University of TechnologyTehranIran Polymer&Color Engineering Department Amirkabir University of TechnologyTehranIran Department of Chemistry Sharif University of TechnologyTehranIran Tissue Engineering Group Faculty of Biomedical EngineeringAmirkabir University of TechnologyTehranIran Biomedical Engineering Department Maziar UniversityP.O.Box 511NoorMazandaranIran Marquette University School of Dentistry MilwaukeeWI 53233USA Department of Engineering Science University of OxfordOxford OX1 3PJUK

Transdermal drug delivery systems have overcome many limitations of other drug administration routes,such as injection pain and first-pass metabolism following oral route,although transdermal drug delivery systems are limited to drugs with low molecular ***,new emerging technology allowing high molecular weight drug delivery across the skin—known as‘microneedles’—has been developed,which creates microchannels that facilitate drug *** this report,drug-loaded degradable conic microneedles are modeled to characterize the degradation rate and drug release *** a lot of data are available for polylactic acid-co-glycolic acid(PLGA)degradation in the literature,PLGA of various molecular weights-as a biodegradable polymer in the polyester family-is used for modeling and verification of the drug delivery in *** main reaction occurring during polyester degradation is hydrolysis of steric bonds,leading to molecular weight *** acid produced in the degradation has a catalytic effect on the *** in water,acid and steric bond concentrations over time and for different radii of microneedles are *** solve the partial and ordinary differential equations simultaneously,finite difference and Runge–Kutta methods are employed,respectively,with the aid of *** of the polymer degradation rate with its molecular weight and molecular weight changes versus time are ***,drug diffusivity is related to matrix molecular *** molecular weight reduction and accumulative drug release within the system are *** order to validate and assess the proposed model,data series of the hydrolytic degradation of aspirin(180.16 Da)-and albumin(66,000 Da)-loaded PLGA(1:1 molar ratio)are used for *** proposed model is in good agreement with experimental data from the *** diffusion as themain phenomena and autocatalytic effects in the reaction,the drug release profile i

关键词： Mathematical modeling Microneedle Polymer degradation Drug release Poly(lactic-co-glycolic acid) Autocatalytic effect