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The potent osteo-inductive capacity of bioinspired brown seaweed-derived carbohydrate nanofibrous three-dimensional scaffolds

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Marine Life Science & Technology 2024年第3期6卷 515-534页

作者： Zahra Dadashi Ouranj Saadi Hosseini Atefeh Alipour Shahin Homaeigohar Shahram Azari Leila Ghazizadeh mohammadali.shokrgozar Sabu Thomas Saeed Irian Hosein Shahsavarani Department of Cell and Molecular Biology Faculty of Biological SciencesKharazmi UniversityTehran 15719-14911Iran Laboratory of Regenerative Medicine and Biomedical Innovations National Cell Bank of IranPasteur Institute of IranTehran 13169-43551Iran Department of Nanobiotechnology Pasteur Institute of IranTehran 13169-43551Iran School of Science and Engineering University of DundeeDundee DD14HNUK School of Chemical Sciences Mahatma Gandhi UniversityKottayamKeralaIndia Department of Cell and Molecular Biology Faculty of Life Sciences and BiotechnologyShahid Beheshti UniversityTehran 19839-69411Iran Iranian Biological Resource Center Academic Center for EducationCulture and Research(ACECR)Tehran ***Iran

This study aimed to investigate the osteo-inductive capacity of a fucoidan polysaccharide network derived from brown algae on human adipose-derived stem cells(HA-MSCs)for bone *** physiochemical properties of the scaffold including surface morphology,surface chemistry,hydrophilicity,mechanical stiffness,and porosity were thoroughly *** in vitro and in vivo measurements implied a superior cell viability,proliferation,adhesion,and osteo-inductive performance of obtained scaffolds compared to using specific osteogenic induction medium with increased irregular growth of calcium crystallites,which mimic the structure of natural *** scaffold was highly biocompatible and suitable for cell *** examinations,such as quantification of mineralization,alkaline phosphatase,gene expression,and immunocytochemical staining of pre-osteocyte and bone markers confirmed that HAD-MSCs differentiate into osteoblasts,even without an osteogenic induction *** study provides evidence for the positive relationship and synergistic effects between the physical properties of the decellularized seaweed scaffold and the chemical composition of fucoidan in promoting the osteogenic differentiation of ***,the natural matrices derived from brown seaweed offers a sustainable,cost-effective,non-toxic bioinspired scaffold and holds promise for future clinical applications in orthopedics.

关键词： Bone tissue engineering Seaweed-derived scaffold Fucoidans HA-MSCs differentiation Osteoblasts

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Molecular insights into oil detachment from hydrophobic quartz surfaces in clay-hosted nanopores during steam-surfactant co-injection

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Petroleum Science 2024年第4期21卷 2457-2468页

作者： Ben-Jie-Ming Liu Xuan-Tong Lei mohammadali Ahmadi Zhangxin Chen Department of Chemical and Petroleum Engineering University of Calgary Eastern Institute of Technology

Thermal recovery techniques for producing oil sands have substantial environmental impacts. Surfactants can efficiently improve thermal bitumen recovery and reduce the required amount of steam. Such a technique requires solid knowledge about the interaction mechanism between surfactants, bitumen,water, and rock at the nanoscale level. In particular, oil sands ores have extremely complex mineralogy as they contain many clay minerals(montmorillonite, illite, kaolinite). In this study, molecular dynamics simulation is carried out to elucidate the unclear mechanisms of clay minerals contributing to the bitumen recovery under a steam-anionic surfactant co-injection process. We found that the clay content significantly influenced an oil detachment process from hydrophobic quartz surfaces. Results reveal that the presence of montmorillonite, illite, and the siloxane surface of kaolinite in nanopores can enhance the oil detachment process from the hydrophobic surfaces because surfactant molecules have a stronger tendency to interact with bitumen and quartz. Conversely, the gibbsite surfaces of kaolinite curb the oil detachment process. Through interaction energy analysis, the siloxane surfaces of kaolinite result in the most straightforward oil detachment process. In addition, we found that the clay type presented in nanopores affected the wettability of the quartz surfaces. The quartz surfaces associated with the gibbsite surfaces of kaolinite show the strongest hydrophilicity. By comparing previous experimental findings with the results of molecular dynamics(MD) simulations, we observed consistent wetting characteristics. This alignment serves to validate the reliability of the simulation outcomes. The outcome of this paper makes up for the lack of knowledge of a surfactant-assisted bitumen recovery process and provides insights for further in-situ bitumen production engineering designs.

关键词： Clay minerals Bitumen Contact angle Interaction energy Surfactant Molecular dynamics

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Efficacy of tadalafil on improvement of men with erectile dysfunction caused by COVID-19:A randomized placebo-controlled trial

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Asian Journal of Urology 2024年第1期11卷 128-133页

作者： Iman Shamohammadi Seyedmohammad Kazemeyni mohammadali Sadighi Tara Hasanzadeh Alireza Dizavi Department of Urology Nemazee HospitalShiraz University of Medical ScienceShirazIran Department of Urology Shariati HospitalTehran University of Medical ScienceTehranIran

Objective: According to the high prevalence of COVID-19 and the subsequent risk of men's sexual health, we decided to investigate the efficacy of tadalafil on improvement of men with erectile dysfunction caused by ***: In this study, 70 outpatients who were recovered from COVID-19 without acute respiratory distress syndrome with negative polymerase chain reaction test and a complaint of erectile dysfunction were divided into two groups: 35 patients who received tadalafil 5 mg daily and 35 who received placebo. For each patient, basic assessment of sexual function was performed using the 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire. Then, treatment was started from 2 months after complete recovery of COVID-19 with negative polymerase chain reaction test for 3 months. At the end of the treatments, the patients were re-evaluated for sexual function using the complete version of IIEF questionnaire. Finally, the results before and after treatment in the intervention group were compared with those of the control ***: Treatment with both tadalafil and placebo improved the patients' sexual function criteria compared to the baseline. However, this improvement was significantly higher in the intervention group with tadalafil than the control group with placebo (p<0.05).Conclusion: Daily administration of tadalafil 5 mg seems to be effective and safe for improvement of erectile dysfunction caused by COVID-19.

关键词： Tadalafil Erectile dysfunction COVID-19 Sexual function

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Assessment of Agricultural Soil Quality Indices Using Mechanistic Models

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Open Journal of Soil Science 2024年第6期14卷 333-352页

作者： mohammadali Nikpey Javad Robatjazi Shahabeddin Garmehei Hendra Gonsalve W. Lasar Nguyen Khoi Nghia Benjamin Kwadwo Agyei Department of Soil Science Faculty of Agriculture Tarbiat Modarres University Tehran Iran Texas A&M AgriLife Research Department of Soil and Crop Sciences Texas A&M University College Station TX USA Faculty of Soil Sciences College of Agriculture Can Tho University Can Tho Vietnam Department of Plant Soil and Microbial Sciences Michigan State University East Lansing MI USA

Assessing soil quality is a critical strategy for diagnosing soil status and anticipating concerns in land use systems for agricultural sustainability. In this study, two soil quality assessment indices, the Integrated Quality Index (IQI) and Nemoro Quality Index (NQI), were employed using two indicator selection methods: Total Data Set (TDS) and Minimum Data Set (MDS), focusing on agricultural fields in Golestan province, Iran. A total of 89 soil samples were collected and analyzed for particle size distribution, organic carbon, calcium carbonate equivalent (CCE), electrical conductivity (EC), pH, and plant-essential nutrients, including nitrogen, phosphorus, potassium, zinc, copper, manganese, and iron. Principal component analysis (PCA) was used to extract MDS from TDS, and geostatistical adaptation and correlation analyses were performed to determine the optimal soil quality evaluation index. Our results show that the exponential model better suits the spatial structure of soil quality indicators (IQIMDS: 0.955). Conformity and correlation analyses indicate that the IQI index outperformed the NQI index in estimating soil quality. The superiority of the TDS technique over the MDS technique in terms of accuracy (IQITDSs kappa: 0.155). Linear relationships between different methods showed a higher correlation coefficient (R2 = 0.43) through the application of IQI. This study suggests the use of IQIMDS to provide a reliable measurement that is particularly useful in assessing the quality of agricultural soil.

关键词： Soil Quality Geographic Information System Integrated Quality Index Nemoro Quality Index

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Dual effects of 3,4-methylenedioxymethamphetamine (ecstasy) on survival and apoptosis of primary hippocampal neurons

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Neural Regeneration Research 2009年第12期4卷 1068-1072页

作者： Abolfazl Azami Parichehr Pasbakhsh Mohammad Akbari Mohammad Barbarestani Mohammadhosein Ghahremani mohammadali.shokrgozar Ali Mandegary Amir Kiani Gholamreza Hassanzadeh Department of Anatomy School of MedicineTehran University of Medical Sciences Department of Toxicology-Pharmacology Faculty of PharmacyTehran University of Medical Sciences National Cell Bank of Iran Pasteur Institute of Iran School of Pharmacy Kermanshah University of Medical Scences

BACKGROUND： 3, 4-methylenedioxymethamphetamine （MDMA, also known as ＂ecstasy＂） has been shown to exhibit neurotoxic effects on the hippocampus. However, exposure to sub-lethal insults of MDMA has been reported to result in neuroprotection. OBJECTIVE： To investigate the effects of MDMA on hippocampal neuronal viability, caspase-3 activity, and mRNA expression of the N-methyI-D-aspartate （NMDA） receptor 2B （NR2B） subunit. DESIGN, TIME AND SETTING： A cytological, in vitro experiment was performed at the Department of Anatomy, School of Medicine, and Department of Toxicology-Pharmacology, Faculty of Pharmacy Tehran University of Medical Sciences in 2008. MATERIALS： MDMA was extracted from ecstasy tablets, which were kindly supplied by the Pharmacology-Toxicology Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran. METHODS： Hippocampal neurons were isolated from Wistar rats at gestational day 18. Following primary culture, hippocampal neuronal viability was detected by MTT assay. Varying concentrations of MDMA （100-5 000 μmol/L） were used to determine lethal concentration 50 （LC50）, which was around 1 500 μmol/L. Five concentrations of MDMA below 1 500 μmol/L （100, 200, 400, 800, and 1 050 μmol/L） were used for the remaining experiments. After 24 hours of MDMA treatment, NR2B mRNA expression was detected by RT-PCR, and caspase-3 relative activity was determined by colorimetric assay. MAIN OUTCOME MEASURES： Hippocampal neuronal viability, caspase-3 activity, and NR2B mRNA expression. RESULTS： MDMA-induced neurotoxicity in hippocampal neuronal cultures was dose-dependent. In high concentrations （1 000-5 000μmol/L） of MDMA, neuronal viability was decreased. However, with a 500 μmol/L dose of MDMA, neuronal viability was significantly increased （P 〈 0.01）. Low concentrations of MDMA （200 and 400μmol/L） significantly decreased caspase-3 activity （P 〈 0.01）, whereas high concentrations of MDMA significantly increased caspase-3 activity （P 〈 0.01）. NR2B

关键词： 3, 4-methylenedioxymethamphetamine ecstasy apoptosis N-methyI-D-aspartate neuronal culture

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Clean synthesis of 1,8-dioxooctahydroxanthenes promoted by DABCO-bromine in aqueous media

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Chinese Chemical Letters 2010年第10期21卷 1180-1182页

作者： mohammadali Bigdeli Faculty of Chemistry Tarbiat Moallem University

An efficient procedure is reported for the synthesis of 3,3,6,6-tetramethyl-9-aryl-1,8-dioxooctahydroxanthenes using a one-pot condensation of arylaldehydes and 5,5-dimethyl-l,3-cyclohexandione in the presence of DABCO-bromine （TDB） as an acid catalyst. To the best of our knowledge this is the first time that DABCO-bromine is used as an acid catalyst in aqueous media for this type of reaction. This method provides several advantages such as use of water as solvent, easy and clean synthesis, simple work up and versatility.

关键词： 1,4-Diazabicyclooctane (DABCO)-bromine Octahydroxyxanthene Aqueous media Arylaldehyde Dimedone

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A new bracing system for improvement of seismic performance of steel jacket type offshore platforms with float-over-deck

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Petroleum Science 2013年第3期10卷 373-384页

作者： Behrouz Asgarian Hamed Rahman shokrgozar Department of Civil Engineering K. N. Toosi University of TechnologyNo. 1346 Valiasr Street Mirdamad Intersection 19967 P.O. Box. 15875-4416Tehran Iran

In this paper, the seismic response of a newly designed steel jacket offshore platform with a float over deck （FOD） system in the Persian Gulf was investigated through incremental dynamic analysis. Comparison of incremental dynamic analysis results for both directions of the platform shows that the lateral strength of the platform in the float over direction is less than its lateral strength in other direction. Dynamic characteristics measurement of a scale model of platform was also performed using forced vibration tests. From experimental measurement of the scaled model, it was observed that dynamic characteristic of the platform is different in the float over direction compared to the other direction. Therefore, a new offshore installed bracing system for the float over direction was proposed for improvement of seismic performance of this type of platform. Finally, the structure with the modified system was assessed using the probabilistic seismic assessment method as well as experimental measurement of its dynamic characteristics. It was observed that the proposed offshore installed bracing system improves the performance of platforms subjected to strong ground motion.

关键词： Steel jacket type offshore platform float-over deck mean annual frequency force vibration test seismic performance dynamic characteristics

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Studying distribution of rare earth elements by classifiers,Se-Chahun iron ore,Central Iran

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Acta Geochimica 2017年第2期36卷 232-239页

作者： mohammadali Sarparandeh Ardeshir Hezarkhani Department of Mining and Metallurgical Engineering Amirkabir University of Technology (Tehran Polytechnic) Tehran Iran

The increased production and price of rare earth elements(REEs) are indicative of their importance and of growing global attention. More accurate and practical exploration procedures are needed for REEs, and for other geochemical resources. One such procedure is a multivariate approach. In this study, five classifiers, including multilayer perceptron(MLP), Bayesian, k-Nearest Neighbors(KNN), Parzen, and support vector machine(SVM),were applied in supervised pattern classification of bulk geochemical samples based on REEs, P, and Fe in the Kiruna type magnetite-apatite deposit of Se-Chahun,Central Iran. This deposit is composed of four rock types:(1) High anomaly(phosphorus iron ore),(2) Low anomaly(metasomatized tuff),(3) Low anomaly(iron ore), and(4)Background(iron ore and others). The proposed methods help to predict the proper classes for new samples from the study area without the need for costly and time-consuming additional studies. In addition, this paper provides a performance comparison of the five models. Results show that all five classifiers have appropriate and acceptable performance. Therefore, pattern classification can be used for evaluation of REE distribution. However, MLP and KNN classifiers show the same results and have the highest CCRs in comparison to Bayesian, Parzen, and SVM classifiers. MLP is more generalizable than KNN and seems to be an applicable approach for classification and predictionof the classes. We hope the predictability of the proposed methods will encourage geochemists to expand the use of numerical models in future work.

关键词： Geochemical exploration of REEs Supervised pattern classification Geochemistry of Se-Chahun ~Central Iran

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Robust non-aggressive three-axis attitude control of spacecraft:dynamic sliding mode approach

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Control Theory and Technology 2023年第4期21卷 505-514页

作者： Javad Nikyar Farhad Bayat mohammadali Mohammadkhani Department of Electrical Engineering University of ZanjanUniversity Blvd.ZanjanZanjan***Iran Department of Electrical Engineering Technical and Vocational UniversityBrazil St.TehranTehran***Iran

Conventional sliding mode control(SMC)has been extensively applied in controlling spacecrafts because of its appealing characteristics such as robustness and a simple design *** methods such as second-order sliding modes and discontinuous controllers are applied for the SMC ***,the main problems of these methods are convergence and error tracking in a finite amount of *** paper combines an improved dynamic sliding mode controller and model predictive controller for spacecrafts to solve the chattering phenomenon in traditional sliding mode *** this aim,this paper develops dynamic sliding mode control for spacecraft’s applications to omit the chattering *** proposed approach shows robust attitude tracking by a set of reaction wheels and stabilizes the spacecraft subject to disturbances and *** proposed method improves the performance of the SMC for spacecraft by avoiding chattering.A set of simulation results are provided that show the advantages and improvements of this approach(in some sense)compared to SMC approaches.

关键词： Dynamic sliding mode control Attitude control Model predictive control Spacecrafts

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Investigation of Microstructure and Corrosion of TiNbTaZrMo High-Entropy Alloy in the Simulated Body Fluid

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Journal of Bionic Engineering 2021年第1期18卷 118-127页

作者： Arash shokrgozar Navi Shahram Etemadi Haghighi Mohammad Haghpanahi Amir Momeni Deparment of mechanical engineering Science and Research branchIslamic Azad UniversityTehran ***Oran Department of mechanical engineering Iran University of Science and TechnologyTehran 13114-16846Iran Materials Science and Engineering Department Hamedan University of TechnologyHlamedan ***Iran

Microstructures and corrosion of TiNbTaZrMo(Ti_(20)Nb_(20)Ta_(20)Zr_(20)Mo_(20))High-Entropy Alloy(HEA)were investigated in the Simu-lated Body Fluid(SBF).Microstructure of this alloy was investigated by X-Ray Difiraction(XRD)and Scanning Electron Microscopy(SEM)*** observations confirmed the presence of two bcc phases as the major matrix as well as another minor phase in themicrostructure of the *** of some elements,such as tantalum,niobium,and molybdenum in the dendritic branches and thepresence of zirconium and titanium in the inter-dendritic branches were clearly evidenced by Energy Dispersive X-ray(EDX)*** importance of corrosion of implant alloys in the human's body,elctrochemical impedance and cyclic polarization tests werepcerformed on the alloy in *** the corrosion tests,corrosion potential,current,and resistance were obtained as E_(corr)=-0.42 V,i_(corr)=0.34μA·cm^(-2),and R_(p)=27.44 k ohm·cm^(2),*** results revealed that the rate of corrosion in TiNbTaZrMo HEA is about 26 times better than that of Ti_(6)Al_(4)V ***,both alloys had no pitting corrosion in the SBF solution.

关键词： HEA SBF implant material electrochemical impedance test Nyquist polarization test

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