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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi mohammad-mahdi salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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An Electrical Impedance Imaging System Towards Edge Intelligence for Non-Destructive Testing of Concrete

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Tsinghua Science and Technology 2024年第3期29卷 883-896页

作者： Abolfazl Roshanpanah mahdi Abbasi Hani Attar Ayman Amer mohammad R.Khosravi Ahmed A.Solyman Department of Electrical Engineering Islamic Azad UniversityScience and Research BranceTehran ***Iran Department of Computer Engineering Bu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Department of Computer Engineering Persian Gulf UniversityBushehr ***Iran Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNişantaşıUniversityIstanbul 34398Turkey

In the construction industry,to prevent accidents,non-destructive tests are necessary and *** impedance tomography is a new technology in non-invasive imaging in which the image of the inner part of conductive bodies is reconstructed by the arrays of external electrodes that are connected on the periphery of the *** equipment is cheap,fast,and edge *** this imaging method,the image of electrical conductivity distribution(or its opposite;electrical impedance)of the internal parts of the target object is *** image reconstruction process is performed by injecting a precise electric current to the peripheral boundaries of the object,measuring the peripheral voltages induced from it and processing the collected *** an electrical impedance tomography system,the voltages measured in the peripheral boundaries have a non-linear equation with the electrical conductivity *** paper presents a cheap Electrical Impedance Tomography(EIT)instrument for detecting impurities in the concrete.A voltage-controlled current source,a micro-controller,a set of multiplexers,a set of electrodes,and a personal computer constitute the structure of the *** conducted tests on concrete with impurities show that the designed EIT system can reveal impurities with a good accuracy in a reasonable time.

关键词： non-destructive testing system concrete electrical impedance tomography

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Kink-band Kinematic Analysis and its Implications for Late-stage Deformation in the Internal Parts of the Zagros Collision(Sanandaj–Sirjan Zone) in West Iran

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 921-935页

作者： Maryam HEYDARI mahdi BEHYARI Department of Geology Faculty of SciencesUrmia University57153165 UrmiaIran

In the internal parts of the Zagros collision zone, several deformation phases have been superimposed. The early deformation phase caused the development of a penetrative foliation. The late-stage deformation phase was preferentially accommodated within shear zones and caused the generation of shear bands, implying a non-coaxial component of deformation, the end of this stage deformation was marked by the development of kink-bands. In the vicinity of Zagros suture zone, the kink angle increased from 40° to 60°, and the kink-bands was converted to chevron folds. In this region, the external(α) and internal(β) angular ratio is α/β ≠ 1 and kink angle increased, and deformation occurred with 10% to 30% volume loss. Farther from the suture zone in the east, α/β = 1;and total volume was constant or increased by 5% to 10%. Kink-bands kinematic analysis in the study area revealed this structures were sensitive to deformation conditions and components such that, with decreasing distance to the Zagros suture zone, shearing and rotation increased, a high kinematic vorticity dominated, and volume loss occurred during deformation.

关键词： kink-band shear zone strain vorticity Zagros Iran

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High-Performance Flow Classification of Big Data Using Hybrid CPU-GPU Clusters of Cloud Environments

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Tsinghua Science and Technology 2024年第4期29卷 1118-1137页

作者： Azam Fazel-Najafabadi mahdi Abbasi Hani H.Attar Ayman Amer Amir Taherkordi Azad Shokrollahi mohammad R.Khosravi Ahmed A.Solyman Department of Computer Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13132Jordan Department of Informatics University of OsloOslo 0316Norway Department of Computer Science MalmöUniversityMalmö20506Sweden Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 261100China Department of Electrical and Electronics Engineering NişantaşıUniversityIstanbul 34481742Türkiye

The network switches in the data plane of Software Defined Networking (SDN) are empowered by an elementary process, in which enormous number of packets which resemble big volumes of data are classified into specific flows by matching them against a set of dynamic rules. This basic process accelerates the processing of data, so that instead of processing singular packets repeatedly, corresponding actions are performed on corresponding flows of packets. In this paper, first, we address limitations on a typical packet classification algorithm like Tuple Space Search (TSS). Then, we present a set of different scenarios to parallelize it on different parallel processing platforms, including Graphics Processing Units (GPUs), clusters of Central Processing Units (CPUs), and hybrid clusters. Experimental results show that the hybrid cluster provides the best platform for parallelizing packet classification algorithms, which promises the average throughput rate of 4.2 Million packets per second (Mpps). That is, the hybrid cluster produced by the integration of Compute Unified Device Architecture (CUDA), Message Passing Interface (MPI), and OpenMP programming model could classify 0.24 million packets per second more than the GPU cluster scheme. Such a packet classifier satisfies the required processing speed in the programmable network systems that would be used to communicate big medical data.

关键词： OpenMP Compute Unified Device Architecture(CUDA) Message Passing Interface(MPI) packet classification medical data tuple space algorithm Graphics Processing Unit(GPU)cluster

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Optimal monitoring and attack detection of networks modeled by Bayesian attack graphs

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Cybersecurity 2024年第1期7卷 1-15页

作者： Armita Kazeminajafabadi mahdi Imani Department of Electrical and Computer Engineering Northeastern UniversityBostonMAUSA

Early attack detection is essential to ensure the security of complex networks,especially those in critical *** is particularly crucial in networks with multi-stage attacks,where multiple nodes are connected to external sources,through which attacks could enter and quickly spread to other network *** attack graphs(BAGs)are powerful models for security risk assessment and mitigation in complex networks,which provide the probabilistic model of attackers’behavior and attack progression in the *** attack detection techniques developed for BAGs rely on the assumption that network compromises will be detected through routine monitoring,which is unrealistic given the ever-growing complexity of *** paper derives the optimal minimum mean square error(MMSE)attack detection and monitoring policy for the most general form of *** exploiting the structure of BAGs and their partial and imperfect monitoring capacity,the proposed detection policy achieves the MMSE optimality possible only for linear-Gaussian state space models using Kalman *** adaptive resource monitoring policy is also introduced for monitoring nodes if the expected predictive error exceeds a user-defined *** and efficient matrix-form computations of the proposed policies are provided,and their high performance is demonstrated in terms of the accuracy of attack detection and the most efficient use of available resources using synthetic Bayesian attack graphs with different topologies.

关键词： Multi-stage attacks Bayesian attack graph Attack detection Optimal monitoring

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Toward a comprehensive hypothesis of oxygen-evolution reaction in the presence of iron and gold

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Journal of Energy Chemistry 2024年第2期89卷 172-183,I0005页

作者： Negah Hashemi Jafar Hussain Shah Cejun Hu Subhajit Nandy Pavlo Aleshkevych Sumbal Farid Keun Hwa Chae Wei Xie Taifeng Liu Junhu Wang mohammad mahdi Najafpour Department of Chemistry Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Center for Advanced Mössbauer Spectroscopy Mössbauer Effect Data CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Key Lab of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Institute of Physics Polish Academy of SciencesWarsaw 02-668Poland National and Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan UniversityKaifeng 475004HenanChina Center of Climate Change and Global Warming Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Research Center for Basic Sciences&Modern Technologies(RBST) Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran

This study investigates the effects of Fe on the oxygen-evolution reaction(OER)in the presence of *** distinct areas of OER were identified:the first associated with Fe sites at low overpotential(~330 mV),and the second with Au sites at high overpotential(~870 mV).Various factors such as surface Fe concentration,electrochemical method,scan rate,potential range,concentration,method of adding K_(2)Fe O_(4),nature of Fe,and temperature were varied to observe diverse behaviors during OER for Fe O_(x)H_(y)/*** amounts of Fe ions had a significant impact on OER,reaching a saturation point where the activity did not increase *** electronic interaction between Fe and Au ions was indicated by X-ray photoelectron spectroscopy(XPS)and electron paramagnetic resonance(EPR)*** situ visible spectroscopy confirmed the formation of Fe O_(4)^(2-)during *** situ Mossbauer and surfaceenhanced Raman spectroscopy(SERS)analyses suggest the involvement of Fe-based species as intermediates during the rate-determining step of OER.A lattice OER mechanism based on Fe O_(x)H_(y)was proposed for operation at low *** functional theory(DFT)calculations revealed that Fe oxide,Fe-oxide clusters,and Fe doping on the Au foil exhibited different activities and stabilities during *** study provides insights into the interplay between Fe and Au in OER,advancing the understanding of OER mechanisms and offering implications for the design of efficient electrocatalytic systems.

关键词： DFT calculation Fe/Au electrocatalysis Mechanism Oxygen evolution Water oxidation

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Auto-tuning PVT data using multi-objective optimization: Application of NSGA-Ⅱ algorithm

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Petroleum 2024年第1期10卷 135-149页

作者： Abdolhadi Zarifi mohammad Madani mohammad Jafarzadegan Reservoir Engineering Systems Petroleum Engineering Department Main Office Building of National Iranian South Oil Company (NISOC) Combined Planning Management National Iranian Oil Company (NIOC) Reservoir Engineering Division Petroleum Engineering Department Petroleum Engineering and Development Company (PEDEC)

Reservoir simulation is known as perhaps the most widely used, accurate, and reliable method for field development in the petroleum industry. An integral part of a reliable reservoir simulation process is to consider robust and rigorous tuned EOS models. Traditionally, EOS models are tuned iteratively through arduous workflows against experimental PVT data. However, this comes with a number of drawbacks such as forcingly using weight factors, which upon alteration adversely affects the optimization *** objective of the current work is thus to introduce an auto-tune PVT matching tool using NSGA-II multi-objective optimization. In order to illustrate the robustness of the presented technique, three different PVT samples are used, including two black-oil and one gas condensate sample. We utilize PengRobinson EOS during all the manual and auto-tuning processes. Comparison of auto-tuned EOS-generated results with those of experimental and computed statistical error values for these samples clearly show that the proposed method is robust. In addition, the proposed method, contrary to the manual matching process, provides the engineer with several matched solutions, which allows them to select a match based on the engineering background to be best amenable to the problem at hand. In addition, the proposed technique is fast, and can output several solutions within less time compared to the traditional manual matching method.

关键词： Auto-tuning PVT Equation of state NSGA-II Multi-objective optimization

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Improving mobile mass monitoring in the IoT environment based on Fog computing using an improved forest optimization algorithm

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Journal of Control and Decision 2024年第1期11卷 36-49页

作者： Tahere Motedayen mahdi Yaghoobi Maryam Kheirabadi Department of Computer Engineering Neyshabur BranchIslamic Azad UniversityNeyshaburIran

In the IoT-based users monitor tasks in the network environment by participating in the data collection process by smart *** monitor their data in the form of fog computing(mobile mass monitoring).Service providers are required to pay user rewards without increasing platform *** of the NP-Hard methods to maximise the coverage rate and reduce the platform costs(reward)is the Cooperative Based Method for Smart Sensing Tasks(CMST).This article uses chaos theory and fuzzy parameter setting in the forest optimisation *** proposed method is implemented with *** average findings show that the network coverage rate is 31%and the monitoring cost is 11%optimised compared to the CMST scheme and the mapping of the mobile mass monitoring problem to meta-heuristic *** using the improved forest optimisation algorithm can reduce the costs of the mobile crowd monitoring platform and has a better coverage rate.

关键词： Internet of Things mobile mass monitoring forest optimization algorithm chaos theory fuzzy system

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Delayed Pseudoaneurysms of Vertebral Artery Post Penetrating Trauma: A Case Report

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Case Reports in Clinical Medicine 2024年第4期13卷 95-100页

作者： Ahmad Rezaee Azandariani Leili Ebrahimi Farsangi mohammad mahdi Talimkhani Department of Radiology School of Medicine Besat Hospital Hamadan Iran Cardiology Department Albirz University of Medical Science Karaj Iran School of Medicine Hamadan University of Medical Sciences Hamadan Iran

Objective: Vascular injuries usually present immediately after the penetration, but the delayed onset of vascular symptoms caused by vessel dissection or aneurysm after a traumatic event is extremely rare. Vertebral artery injury is a low-frequency but high-mortality injury. We aim to report evidence of delayed onset of vascular symptoms following penetrating trauma in the neck. Materials and Methods: A case report. Results: A 19-year-old boy was referred to our hospital and complained of a mass in the right part of his neck (right mandibular angle). He gave a history of penetrating trauma to his neck 2 months ago. The mass was expanding during these 2 months and doesn’t respond to antibiotic therapy. In the examination, 3 × 3 cm, firm, nonmobile, and without tenderness and pain mass was palpated in the second level of his neck. Doctors ordered a Doppler sonography in the hospital where a yin-yang pattern was reported. A 36 × 43 × 40 mm heterogeneous, solid, and hypodense area close to C1-C2-C3 with vascular flow was discovered in the right submandibular area after computed tomography (CT)-angiography. The patient was referred to an interventional neurologist for angiography and due to the lack of flow at the distal of the V3 segment, he decided to sacrifice this artery by two coils. Conclusion: Penetrating neck injuries are usually asymptomatic, but these injuries are often accompanied by hemorrhage, neurological symptoms, dysphagia, odynophagia, and windpipe. Penetrating lesions of the vertebral artery are rare and very difficult to diagnose. Also, these lesions are challenging for surgeons due to complex anatomy and difficult surgical exposure. So, endovascular treatment was used to treat the patient.

关键词： Penetrating Trauma Delayed Pseudoaneurysms Vertebral Artery

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Investigation of material composition,design,and performance of open-graded asphalt mixtures for semi-flexible pavement:A comprehensive experimental study

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 92-116页

作者： mohammad Taghipoor Abolfazl Hassani mohammad M.Karimi Department of Civil and Environmental Engineering Tarbiat Modares UniversityTehranIran

The primary goal of this study is the design and construction of semi-flexible pavement(SFP)mixture in accordance with the engineering and mechanical *** study involves the use of a range of gradation curves,air void contents,cellulose and synthesized fibers,and neat and modified asphalt binders to prepare the open-graded asphalt(OGA)*** analyze the characteristics of these mixtures,a variety of test,namely binder drainage,semi-circular bending(SCB),Cantabro,wheel tracking,indirect tensile strength(ITS),and permeability tests were ***,to analyze the prepared grouting material,flexural strength,compressive strength,and fluidity tests were *** the final stage,SFP was compared to HMA in terms of engineering characteristics and *** to the results,SFP was more resistant to skid,rutting,fire,and moisture damage,while HMA had a better performance in fracture tests,including SCB *** to the results of the mechanical performance tests conducted on OGA mixtures,the highest and lowest values for air void content to achieve the highest mechanical performance level were 30%-35%and 25%,***,based on the laboratory results,it was determined that the required void ratio for constructing OGA mixtures was 24%-26%based on the bitumen type and fibers amount in the ***,SFP mixture can be regarded as a viable alternative to common pavements thanks to its high resistance to rutting and moisture damage,long freezing-thawing fatigue life,and adequate fire and skid resistance.

关键词： Semi-flexible pavement mixture Open-graded asphalt mixture Engineering properties Cantabro test Hot mix asphalt

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