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Hippo-YAP/TAZ signaling in breast cancer:Reciprocal regulation of microRNAs and implications in precision medicine

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Genes & Diseases 2024年第2期11卷 760-771页

作者： Farzad Sadri Seyede fatemeh Hosseini Zohreh rezaei mohammad Fereidouni Student Research Committee Birjand University of Medical SciencesBirjand ***Iran Tabas School of Nursing Birjand University of Medical SciencesBirjand ***Iran Department of Biology University of Sistan and BaluchestanZahedan ***Iran Cellular and Molecular Research Center Birjand University of Medical SciencesBirjand ***Iran

Breast cancer is a molecularly heterogeneous disease and the most common female *** recent years,therapy approaches have evolved to accommodate molecular diversity,with a focus on more biologically based therapies to minimize negative *** regulate cell fate in human breast cells,the Hippo signaling pathway has been associated with the alpha subtype of estrogen *** pathway regulates tissue size,regeneration,and healing,as well as the survival of tissue-specific stem cells,proliferation,and apoptosis in a variety of organs,allowing for cell *** signaling is mediated by the kinases MST1,MST2,LATS1,and LATS2,as well as the adaptor proteins SAV1 and *** kinases phosphorylate the downstream effectors of the Hippo pathway,yes-associated protein(YAP),and transcriptional coactivator with PDZ-binding motif(TAZ),suppressing the expression of their downstream target *** Hippo signaling pathway kinase cascade plays a significant role in all *** the principles of this kinase cascade would prevent the occurrence of breast *** recent years,small noncoding RNAs,or microRNAs,have been implicated in the development of several malignancies,including breast *** interconnections between miRNAs and Hippo signaling pathway core proteins in the breast,on the other hand,remain poorly *** this review,we focused on highlighting the Hippo signaling system,its key parts,its importance in breast cancer,and its regulation by miRNAs and other related pathways.

关键词： Breast cancer Hippo signaling Large tumor suppressor kinase 1 microRNAs PDZ-binding motif Yes-associated protein

Platform Evolution in an Oligo-Miocene Back-arc Basin:An Example from the Central Iran Basin

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 185-206页

作者： Masoud SHARIFI-YAZDI Amirhossein ENAYATI Jamal SALEHI AGHDAM mohammad BAHREHVAR Seyed Mustafa rezaei Department of Geology Faculty of Earth SciencesGeography and AstronomyUniversity of Vienna1090 Vienna.Austria Geology and Geophysics Department Tehran Energy Consultants(TEC Co.)TehranIran School of Geology College of ScienceUniversity of TehranTehranIran Department of Geology Tarbiat Modares UniversityTehranIran

The Qom Formation is the most important hydrocarbon reservoir target in Central *** Qom platform developed in a back-arc basin during the Oligo-Miocene due to the closing of the Tethyan *** formation consists of a variety of carbonate and non-carbonate facies deposited on a platform ranging from supratidal to basin.A combination of tectonic and eustatic events led to some lateral and vertical facies variations in the study *** third-order depositional sequences and related surfaces were identified regarding vertical facies changes in the studied sections of this Oligo-Miocene *** to all results and data,this succession was initially deposited during the Chattian upon a distally steepened ramp of siliciclastic-carbonate composition,including the Bouma ***,from the late Chattian to the Aquitanian,the platform changed into a homoclinal carbonate ramp with a gentle *** respect to tectonic activity,this phase was a calm period during the deposition of the Qom ***,a drowned carbonate platform and a rimmed shelf emerged during the Burdigalian,terminated by the continental deposits of the Upper Red *** all geological characteristics,three main tectono-eustatic evolutionary phases have been recognized in the Qom back-arcbasin.

关键词： carbonate ramp depositional facies submarine fan eustasy basement faults back-arc basin

Prediction of representative deformation modulus of longwall panel roof rock strata using Mamdani fuzzy system

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International Journal of Mining Science and Technology 2015年第1期25卷 23-30页

作者： mohammad rezaei Mostafa Asadizadeh Abbas Majdi mohammad Farouq Hossaini School of Mining Engineering College of Engineering University of Tehran

Deformation modulus is the important parameter in stability analysis of tunnels, dams and mining structures. In this paper, two predictive models including Mamdani fuzzy system(MFS) and multivariable regression analysis(MVRA) were developed to predict deformation modulus based on data obtained from dilatometer tests carried out in Bakhtiary dam site and additional data collected from longwall coal mines. Models inputs were considered to be rock quality designation, overburden height, weathering,unconfined compressive strength, bedding inclination to core axis, joint roughness coefficient and fill thickness. To control the models performance, calculating indices such as root mean square error(RMSE),variance account for(VAF) and determination coefficient(R2) were used. The MFS results show the significant prediction accuracy along with high performance compared to MVRA results. Finally, the sensitivity analysis of MFS results shows that the most and the least effective parameters on deformation modulus are weathering and overburden height, respectively.

关键词： Mamdani模糊系统预测模型变形模量顶板岩层无侧限抗压强度面板稳定性分析均方根误差

Development of a time-dependent energy model to calculate the mining-induced stress over gates and pillars

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第3期7卷 306-317页

作者： mohammad rezaei mohammad Farouq Hossaini Abbas Majdi School of Mining Engineering College of Engineering University of Tehran

Generally, longwall mining-induced stress results from the stress relaxation due to destressed zone that occurs above the mined panel. Knowledge of induced stress is very important for accurate design of adjacent gateroads and intervening pillars which helps to raise the safety and productivity of longwall mining operations. This study presents a novel time-dependent analytical model for determination of the longwall mining-induced stress and investigates the coefficient of stress concentration over adjacent gates and pillars. The model is developed based on the strain energy balance in longwall mining incorporated to a rheological constitutive model of caved materials with time-varying parameters. The study site is the Tabas coal mine of Iran. In the proposed model, height of destressed zone above the mined panel, total longwall mining-induced stress, abutment angle, induced vertical stress, and coefficient of stress concentration over neighboring gates and intervening pillars are calculated. To evaluate the effect of proposed model parameters on the coefficient of stress concentration due to longwall mining, sensitivity analysis is performed based on the field data and experimental constants. Also, the results of the proposed model are compared with those of existing models. The comparative results confirm a good agreement between the proposed model and the in situ measurements. According to the obtained results, it is concluded that the proposed model can be successfully used to calculate the longwall mining-induced stress. Therefore, the optimum design of gate supports and pillar dimensions would be attainable which helps to increase the mining efficiency.

关键词： Longwall mining Strain energy Time-dependent model Destressed zone Mining-induced stress

Annual growth of Fagus orientalis is limited by spring drought conditions in Iran’s Golestan Province

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Journal of Forestry Research 2024年第1期35卷 128-142页

作者： Khalil Ghorbani Jahangir mohammadi Laleh rezaei Ghaleh Department of Water Engineering Faculty of Water and Soil EngineeringGorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Forestry Gorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Water Engineering Faculty of AgricultureUrmia UniversityUrmiaIran

Due to the lack of a uniform and accurate defi-nition of‘drought’,several indicators have been introduced based on different variables and methods,and the efficiency of each of these is determined according to their relationship with *** relationship between two drought indices,SPI(standardized precipitation index)and SPEI(standard-ized precipitation-evapotranspiration index)in different sea-sons was investigated using annual rings of 15 tree samples to determine the effect of drought on the growth of oriental beech(Fagus orientalis Lipsky)in the Hyrcanian forests of northern *** different evapotranspiration calcula-tion methods were evaluated on SPEI efficiency based on Hargreaves-Samani,Thornthwaite,and Penman-Monteith methods using the step-by-step M5 decision tree regression *** results show that SPEI based on the Penman-Monteith in a three-month time scale(spring)had similar temporal changes and a better relationship with annual tree rings(R^(2)=0.81)at a 0.05 significant *** change and a decreasing trend in the time series of annual tree rings are similar to the variation in the SPEI based on the Penman-Monteith *** affecting evapotranspiration,temperature,wind speed,and sunshine hours(used in the Penman-Monteith method),increased but precipitation *** non-linear modeling methods,SPEI based on Penman-Monteith best illustrated climate changes affecting tree growth.

关键词： Climate change Drought index Hyrcanian forests SPEI'Annual growth rings Fagus orientalis

A two-stage DEA model to evaluate sustainability and energy efficiency of tomato production

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Information Processing in Agriculture 2017年第4期4卷 342-350页

作者： Hossein Raheli Rassul mohammad rezaei Mehri Raei Jadidi Hassan Ghasemi Mobtaker Department of Agricultural Economics Faculty of AgricultureUniversity of TabrizTabrizIran Department of Biosystems Engineering Faculty of AgricultureUniversity of TabrizTabrizIran

The aims of this study were to evaluate the sustainability and efficiency of tomato production and to investigate the determinants of inefficiency of tomato farming in Marand region of East Azerbaijan province,*** these purposes,a two-stage methodology was applied,in which for the first time a fractional regression model(FRM)was employed in the second stage of analysis,so that,in the first stage a nonparametric Data Envelopment Analysis(DEA)was used to analyze the efficiencies of tomato production and in the second stage,farm specific variables such as education level,farmers’age,total land size and use of manure were used in a fractional regression model to explain how these factors influenced efficiency of tomato *** results of the first stage showed that there are considerable differences between efficient and inefficient farmers in the studied area,so that the main differences were in the use of chemical fertilizers,biocides and water for ***,the results of second stage revealed that farmers’age,education level and total land size positively affected efficiency in tomato ***,better use of land,chemical fertilizers,water for irrigation and improving the farmers’educational levels through literacy campaign and land consolidation would probably increase the efficiency in the long term.

关键词： Data envelopment analysis Energy efficiency Fractional regression model Tomato

Potentially Toxic Element Concentration in Fruits Collected from Markazi Province(Iran): A Probabilistic Health Risk Assessment

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Biomedical and Environmental Sciences 2019年第11期32卷 839-853页

作者： mohammad rezaei Bahareh Ghasemidehkordi Babak Peykarestan Nabi Shariatifar Maryam Jafari Yadolah Fakhri Maryam Jabbari Amin Mousavi Khaneghah Department of Food Hygiene Faculty of Veterinary MedicineUniversity of TehranTehranIran Department of Food Safety and Hygiene School of Public HealthTehran University of Medical SciencesTehranTran Department of Biochemistry Payame Noor UniversityIsfahanIran Department of Agriculture Payame Noor UniversityTehranTran Department of Environmental Health Engineering School of Public Health and SafetyStudent Research CommitteeShahid Beheshti University of Medical SciencesTehranTran Department of Public Health School of Paramedical and HealthZanjan University of Medical SciencesZanjaniran Department of Food Science Faculty of Food EngineeringUniversity of Campinas(UNICAMP)Rua Monteiro Lobato80.Caixa Postal:6121.CEP:13083-862.Campinas.Sao Paulo.Brazil

Objective This study was conducted to evaluate the concentration of potentially toxic elements(PTEs)such as arsenic(As),cadmium(Cd),mercury(Hg),and lead(Pb)in fruit samples collected from Markazi Province,Iran.A probabilistic health risk assessment due to ingestion of PTEs through the consumption of these fruits was also *** The concentration of PTEs in 90 samples of five types of fruits(n=3)collected from six geographic regions in Markazi Province was *** potential health risk was evaluated using a Monte Carlo simulation *** A significant difference was observed in the concentration of PTEs between fruits as well as soil and water samples collected from different regions in Markazi *** order of PTE concentration in the soil and water samples was as follows:Pb>As>Hg>***,the highest level of transfer factor for Cd and Hg correlated with the *** estimated daily intake for adults and children was lower than the recommended tolerable daily *** The population in Markazi Province,Iran,is not at considerable noncarcinogenic or carcinogenic risk due to the ingestion of PTEs through the consumption of the examined fruits.

关键词： Fruits Soil Water Toxic elements Target Hazard Quotient(THQ) Estimated Hazard Index(HI)

Multi-millijoule terahertz emission from laser- wakefield-accelerated electrons

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Light(Science & Applications) 2023年第2期12卷 248-258页

作者： Taegyu Pak mohammad rezaei-Pandari Sang Beom Kim Geonwoo Lee Dae Hee Wi Calin loan Hojbota mohammad Mirzaie Hyeongmun Kim Jae Hee Sung Seong Ku Lee Chul Kang Ki-Yong Kim Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Korea Department of Physics and Photon Science Gwangju Institute of Science and Technology(GIST)Gwangju 61005Korea Laser and Plasma Research Institute Shahid Beheshti UniversityTehranIran Advanced Photonics Research Institute GISTGwangju 61005Korea Institute for Research in Electronics and Applied Physics and Department of Physics University of MarylandCollege ParkMaryland 20742USA

High-power terahertz radiation was observed to be emitted from a gas jet irradiated by 100-terawatt-class laser pulses in the laser-wakefield acceleration of *** emitted terahertz radiation was characterized in terms of its spectrum,polarization,and energy dependence on the accompanying electron bunch energy and charge under various gas target *** a nitrogen target,more than 4 mJ of energy Was produced at<10 THz with a laser-to-terahertz conversion efficiency of~0.15%.Such strong terahertz radiation is hypothesized to be produced from plasma electrons accelerated by the ponderomotive force of the laser and the plasma wakefelds on the time scale of the laser pulse duration and plasma *** model is examined with analytic calculations and particle-in-cell simulations to better understand the generation mechanism of high-energy terahertz radiation in laser-wakefield acceleration.

关键词： laser polarization acceleration

AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS

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Acta Mathematica Scientia 2024年第1期44卷 311-338页

作者： Safoura rezaei ADERYANI Azam AHADI Reza SAADATI Hari M.SRIVASTAVA School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Mathematics and Statistics Universtity of VictoriaVictoriaCanada Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402China Department of Mathematics and Informatics Azerbaijan University71 Jeyhun Hajibeyli StreetAZ1007BakuAzerbaijan Section of Mathematics International TelematicUniversity UninettunoI-00186RomeItaly

In this paper,we define a new class of control functions through aggregate special *** class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.

关键词： permuting tri-homomorphism in Banach algebra permuting tri-derivation on C*-algebra fixed point theorem Ulam-Hyers-Rassias stability aggregate special functions tri-additiveψ-functional inequality