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Effects of Matricaria chamomilla Extract on Growth and Maturation of Isolated Mouse Ovarian Follicles in a Three-dimensional Culture System

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Chinese Medical Journal 2018年第2期131卷 218-225页

作者： Hamed Shoorei Arash Khaki Nava Ainehchi mohammad mehdi hassanzadeh taheri Moloud Tahmasebi Giti Seyedghiasi Ziba Ghoreishi Majid Shokoohi Amir Afshin Khaki Sayed Haidar Abbas Raza Department of Anatomical Sciences Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran Department of Pathology Tabriz Branch Islamic Azad University Tabriz Iran Women's Rep oduciive Heaiih Rese'arch Center Ta'briz University of Medical Sciences Tabriz Iran Department of Anatomical Sciences Faculty of Medicine Birjand University of Medical Sciences Birjand Iran Department of Anatomical Sciences Faculty of Medicine Tarbiat Modares University Tehran Iran Department of Nursing Faculty of Paramedical Mashhad University of Medical Sciences Mashhad Iran Department of Biology College of Animal Science and Technology Northwest A&F University Yangling Shaanxi 712100 China

Background： The aim of this study was to design and assess the effects of hydroalcoholic extract of Matricaria chamomill^l （MC） on preantral follicle culture of mouse ovaries in a three-dimensional culture system. Methods： Isolated preantral follicles were randomly divided into three main groups： the control group containing 10% fetal bovine serum without MC extract （G1）, the first experimental group supplemented with 25 ktg/ml hydroalcoholic extract of chamomile （G2）, and the second experimental group supplemented with 50 p,g/ml hydroalcoholic extract of chamomile （G3）. Results： After 12 days of culture, the survival rate （P 〈 0.05）, antrum formation （P 〈 0.01）, metaphase two oocytes （P 〈 0.01）, and the expression ofPCNA （P 〈 0.05） and FSHR （P 〈 0.05） genes significantly decreased in G3 as compared with GI. On the other hand, at the last day of culture （day 12）, the mean diameter of follicles cultured in the medium which was supplemented with 50 lag/ml hydroalcoholic extract of chamomile significantly decreased as compared with the GI （P 〈 0.05）. In addition, the levels of progesterone and dehydroepiandrosterone hormones significantly increased in the medium of G3 relative to G I （P 〈 0.01）, while in the medium of G 1, the level of 17[3-estradiol was significantly higher than that of other groups （P 〈 0.01）. Reactive oxygen species levels of metaphase 11 oocytes were significantly decreased in G2 as compared with G1 （P 〈 0.01）. Conclusion： Adding chamomile extract to culture media appeared to decrease follicular function and development.

关键词： Follicular Development Follicular Maturation FSHR Gene PCNA Gene Steroid Hormones Toxicology

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Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

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Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat Goran Sedeeq Hama Faraj Fattma Abodi Ali Abbas Salihi Aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy Wojciech Branicki mohammad taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

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A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

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Animal Models and Experimental Medicine 2024年第5期 591-605页

作者： mohammad Yasin Zamanian Niloofar taheri Montather F.Ramadan Yasser Fakri Mustafa Safa Alkhayyat Klunko Nataliya Sergeevna Hashem O.Alsaab Ahmed Hjazi Farnoosh Molavi Vasei Siamak Daneshvar Department of Physiology School of Medicine Hamadan University of Medical Sciences Department of Pharmacology and Toxicology School of Pharmacy Hamadan University of Medical Sciences School of Medicine Shahroud University of Medical Sciences College of Dentistry Al-Ayen University Department of Pharmaceutical Chemistry College of Pharmacy University of Mosul College of Pharmacy The Islamic University Department of Training of Scientific and Scientific-Pedagogical Personnel Russian New University Department of Pharmaceutics and Pharmaceutical Technology Taif University Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Department of Clinical Biochemistry School of Medicine Rafsanjan University of Medical Sciences Department of Surgery School of Medicine Hamadan University of Medical Sciences

Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription *** results of this study demonstrate that fisetin induces colon cancer cell apoptosis through multiple mechanisms. It impacts the p53 pathway, leading to increased levels of p53 and decreased levels of murine double minute 2, contributing to apoptosis induction. Fisetin also triggers the release of important components in the apoptotic process, such as second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI and cytochrome c. Furthermore, fisetin inhibits the cyclooxygenase-2 and wingless-related integration site(Wnt)/epidermal growth factor receptor/nuclear factor kappa B signaling pathways, reducing Wnt target gene expression and hindering colony formation. It achieves this by regulating the activities of cyclin-dependent kinase 2 and cyclin-dependent kinase 4, reducing retinoblastoma protein phosphorylation, decreasing cyclin E levels, and increasing p21 levels, ultimately influencing E2 promoter binding factor 1 and cell division cycle 2(CDC2) protein levels. Additionally, fisetin exhibits various effects on CRC cells, including inhibiting the phosphorylation of Y-box binding protein 1 and ribosomal S6 kinase, promoting the phosphorylation of extracellular signal-regulated kinase 1/2, and disrupting the repair process of DNA double-strand breaks. Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α(PIK3CA)-mutant CRC, resulting in a reduction in phosphatidylinositol-3 kinase(PI3K) expressio

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Neuroprotective potential of traditional Ayurvedic Kadha:age-related neurological disorders:a comprehensive literature review

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Traditional Medicine Research 2024年第9期9卷 51-77页

作者： Sarvin Sadreddini mohammad Javad Emami Kazemabad Sogand Sheikholeslami Kosar Chitzan-Zadeh mohammad Taha Kouchaki Midia Rashidi Amir Abbas Ghayerin Shahin Sabaghi Ghazal Tavakoli Sepehr Nanbakhsh Tina Mansourian Arefeh Tabashiri Fariba Arbab Mojeni Mohammed Namiq Amin Zahra taheri Seyed Esmaeil Sedighi Taraneh Tarkashvand Parham Amirazodi Mobina Fathi Shirin Yaghoobpoor Niloofar Deravi School of Medicine Tabriz University of Medical SciencesTabriz ***Iran School of Medicine Qom University of Medical SciencesQom ***Iran School of Medicine Hamadan University of Medical SciencesHamadan ***Iran School of Medicine Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Faculty of Medicine Tabriz University of Medical SciencesTabriz ***Iran School of Medicine Iran University of Medical SciencesTehran ***Iran School of Medicine Shahid Beheshti University of Medical SciencesTehran ***Iran School of Medicine Mazandaran University of Medical SciencesSari ***Iran School of Medicine Kermanshah University of Medical SciencesKermanshah ***Iran Faculty of Pharmacy Pharmaceutical Sciences BranchIslamic Azad UniversityTehran ***Iran Department of Biology Faculty of SciencePayamNoor UniversityTehran ***Iran Faculty of Medicine Islamic Azad University of Medical ScienceTehran 193951495Iran International Campus Shahid Sadoughi University of Medical SciencesYazd ***Iran

Despite modern medicine’s advancements,age-related neurological diseases like Alzheimer’s disease and Parkinson’s disease remain challenging due to high costs,side effects,and limited ***,a traditional Indian medicine system,offers Kadha tea as a potential herbal *** review explores Kadha’s components(basil(Ocimum basilicum L.),black pepper(Piper nigrum L.),Cinnamon(Cinnamomum verum ***),ginger(Zingiber officinale Roscoe),and raisin(Vitis vinifera L.))and their interaction with various neurological *** suggest Kadha exhibits anti-inflammatory,antioxidant,and antiviral properties,potentially impacting Alzheimer’s disease,Parkinson’s disease,neurotoxicity,neuroinflammation,and brain *** focusing on specific disease mechanisms and Kadha’s intergrade effects,this review aims to elucidate its potential role in managing age-related neurological disorders.

关键词： Ayurveda Kadha neuroprotective neurological disorders traditional medicine

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The efficient synthesis of 14-alkyl or aryl 14H-dibenzo[a,j] xanthenes catalyzed by bismuth(Ⅲ)chloride under solvent-free conditions

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Chinese Chemical Letters 2011年第8期22卷 927-930页

作者： Ebrahim Soleimani mohammad mehdi Khodaei Afsaneh taheri Kal Koshvandi Department of Chemistry Razi UniversityKermanshah 67149Iran

An efficient method for the synthesis of 14-alkyl or aryl 14H-dibenzo[a,j]xanthene derivatives by the reaction of β-naphthol,and aldehydes in the presence of a catalytic amount of bismuth（Ⅲ） chloride（BiCl_3） under solvent-free conditions at 110℃is *** and aromatic aldehydes were used in the reaction and in all cases the desired products were synthesized *** reaction was studied under different temperatures;the maximum yield was obtained in a short reaction period at 110℃.The method offers the advantages of high yields,short reaction times,simplicity and easy workup compared to the conventional method of syntheses.

关键词： Bismuth(Ⅲ) chloride 14H-Dibenzo[a j]xanthenes β-Naphthol

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Microstructural evolution,mechanical properties,and corrosion resistance of a heat-treated Mg alloy for the bio-medical application

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Journal of Magnesium and Alloys 2019年第1期7卷 80-89页

作者： mohammad Janbozorgi Kimia Karimi taheri Ali Karimi taheri Department of Materials Science and Engineering Sharif University of TechnologyAzadi Ave.TehranIran School of Medicine Shahid Beheshti University of Medical ScienceTehranIran

During the recent years,some Mg based alloys have extensively been considered as a new generation of degradable and absorbable bio-medical *** this work,the Mg-2Zn-1Gd-1Ca(wt%)alloy as a new metallic bio-material was produced by the casting process followed by the heat *** samples of the alloy were solution treated at temperatures of 500,550,and 600°C and then quench aged at temperatures of 125,150,and 175°*** results of SEM-EDS examinations indicated that the alloy microstructure consists ofα-Mg matrix and the Ca_(2)Mg_(6)Zn_(3)and Mg_(3)Gd_(2)Zn_(3)secondary *** regard to the results of Vickers hardness test,the temperatures of 500°C and 150°C were selected as the optimum solutionizing and aging temperatures,***,the dissolution of casting precipitates and production of lattice distortion occurring after the solution treatment led to the reduction in ultimate shear strength up to 21%.But,the precipitation hardening and morphological changes taking place during the aging treatment improved the ultimate shear strength up to 32%.Furthermore,the results of electro-chemical and weight-loss measurements in a simulated body fluid indicated that the heat-treated alloy is a promising candidate for the Mg based alloys recently considered for the bio-medical applications.

关键词： Mg alloys Bio-medical applications Microstructural evolution Mechanical properties Corrosion resistance

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Quantitative study of poplar plantations in three Iranian provinces

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Forestry Studies in China 2013年第4期15卷 363-369页

作者： Majid AZIZI mohammad mehdi FAEZIPOUR Ali BAYATKASHKOOLI Fatemeh taheri Faculty of Natural Resources University of Tehran Faculty of Natural Resources Zabol University

Fast growing poplar species enjoy a highly favored position in Iran’s forest product industries. However, information on poplar plantations, such as areas, growing stock and harvest volumes, are largely obtained by non scientific means and poorly executed methods. A few studies have been conducted to obtain data on the capacity of poplar plantations, their extent, existing growing stock, distribution and species choice in three provinces, i.e., Western Azerbaijan, Kurdistan and Hamedan, with relatively well developed management systems. We opted for a cluster method, a standard sampling method for conducting similar investigations, consisting of two phases. In the first phase we collected library information and conducted half-open interviews with villagers. In the second phase field measurements in the villages of these three provinces were carried out. Information from field measurements on growing stock, cultivated areas, dominant species were used to estimate volumes by way of volume and weight tables. Results obtained from the present study indicate that the average annual volume of timber harvested in the three provinces was 697,723 m3, with an average sampling error of 22.7 per cent. This annual volume of poplar timber harvested from the three provinces was estimated to amount to about 25 per cent of overall harvest; at that rate, the overall annual utilization potential of poplar plantations will be 10 million m3, which constitutes a reliable resource of raw timber for use in wood and paper industries.

关键词： poplar plantations ,field measurements harvest volumes ,cluster sampling

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LC-Z-Source Inverter Design and Control

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Chinese Journal of Electronics 2020年第3期29卷 580-585页

作者： Asghar taheri Jamal Abbasi Bolaghi mohammad Hossein Babaei Department of Electrical Engineering University of Zanjan

The paper presents a new Z-source inverter with a low-stress reduction in the voltage of capacitors compared to the traditional Z-source inverter with the same boost factor. The proposed structure reduces costs and weight by reducing voltage *** main difference between this inverter and the traditional Z-source inverter lies in the arrangement of the components. In addition, the superiority of the proposed inverter over the L-Z-source inverter is related to the use of two capacitors instead of two diodes, which increases the boost power factor and obviates the need for the snubber circuit. Furthermore, another advantage of the proposed inverter can be extended to n cases in cascade form and the proposed inverter is continues current. The analysis,derivation of boost factor, capacitor voltages, voltages gain,and switch stress of the proposed inverter topology are carried out and are compared with the similar *** advantages of the proposed structure are verified by simulation and implementation.

关键词： Z-source inverter Voltage stress Boost factor Modulation index

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Effect of pyrite content of feed and configuration of locked particles on rougher flotation of copper in low and high pyritic ore types

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International Journal of Mining Science and Technology 2018年第2期28卷 167-176页

作者： Sahar Agheli Ahmad hassanzadeh Behzad Vaziri Hassas mohammad Hasanzadeh Mining Engineering Department Shahid Bahonar University of Kerman Faculty of Mines Mineral Processing Engineering Department Istanbul Technical University Department of Mineral Resources Engineering Montan University of Leoben College of Mines and Earth Science University of Utah Drug Applied Research Center Tabriz University of Medical Sciences

Misreported pyrite into copper concentrates dramatically declines copper grade and recovery. Copper flotation can be also more complicated if flotation feed comes from an elevated-pyritic copper ore. In this investigation, the effect of two different ore types(high pyritic and low pyritic feeds) was studied on rougher stage of industrial copper flotation circuit. Samples were taken from different streams and the structure of chalcopyrite within the pyrite and non-sulfide gangue minerals was examined in various size fractions for mentioned ore types. Results indicated that 72% and 56% of the total floated pyrite was transferred to concentrate in first four cells in the low and high pyritic feeds, respectively. Whereas, this proportion for floated SiO_2 in last ten cells was detected as 72% and 71%, respectively. A detailed interpretation of the effect of locked particles in different size fractions on rougher flotation cells is studied from industrial point of view.

关键词： Liberation degree High pyritic feed Pyrite Froth flotation Chalcopyrite

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Optimization of cement-based grouts using chemical additives

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第4期9卷 623-637页

作者： mohammad Reza Azadi Ali Taghichian Ali taheri Faculty of Science and Technology Federation University Australia Mewbourne School of Petroleum and Geological Engineering University of Oklahoma Department of Earth Science and Engineering Imperial College

Grout injection is used for sealing or strengthening the ground in order to prevent water entrance or any failure after *** are many methods of *** grouting is one of the most common types in which the grout material is injected to the pore spaces of the *** grouting operations,the grout quality is important to achieve the best *** are four main characteristics for a grout mixture including bleeding,setting time,strength,and *** this paper,we try to build some efficient grouting mixtures with different water to cement ratios considering these *** ingredients of grout mixtures built in this study are cement,water,bentonite,and some chemical additives such as sodium silicate,sodium carbonate,and triethanolamine(TEA).The grout mixtures are prepared for both of the sealing and strengthening purposes for a structural *** of each abovementioned ingredient is profoundly *** each ingredient may have positive or negative aspect,an optimization of appropriate amount of each ingredient is *** optimization is based on 200 grout mixture samples with different percentages of ***,some of these grout mixtures are chosen for the introduced *** should be mentioned that grouting operations depend on various factors such as pressure of injection,ground structure and grain size of ***,quality of a grout can be helpful to make an injection easier and *** example,during the injection,a wrong estimated setting time can destroy the injected grout by washing the grout or setting early which prevents *** paper tries to show some tests in easy way to achieve a desirable sample of grout.

关键词： Permeation grouting Bleeding Setting time Chemical additives Cement-based grout

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