Health-related quality of life (HQOL) is poor in multiple sclerosis(MS) but t he clinical precipitants of the problem are not well understood. Previous correl ative studies demonstrated relationships between various c...
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Health-related quality of life (HQOL) is poor in multiple sclerosis(MS) but t he clinical precipitants of the problem are not well understood. Previous correl ative studies demonstrated relationships between various clinical parameters and diminished HQOL in MS. Unfortunately, these studies failed to account for multi ple predictors in the same analysis. We endeavored to determine what clinical pa rameters account for most variance in predicting HQOL, and employ ability, while accounting for disease course, physical disability, fatigue, cognition, mood di sorder,personality, and behavior disorder. In 120 MS patients,we measured HQOL ( MS Quality of Life-54) and vocational status (employed vs. disabled) and then c onducted detailed clinical testing. Data were analyzed by linear and logistic re gression methods. MS patients reported lower HQOL (p < 0.001) and were more like ly to be disabled (45%of patients vs. 0 controls).Physical HQOL was predicted b y fatigue, depression,and physical disability. Mental HQOL was associated with o nly depression and fatigue. In contrast, vocational status was predicted by thre e cognitive tests, conscientiousness, and disease duration (p < 0.05). Thus, for the first time, we predicted HQOL in MS while accounting for measures from thes e many clinical domains. We conclude that self-report HQOL indices are most str ongly predicted by measures of depression,whereas vocational status is predicted primarily by objective measures of cognitive function. The findings highlight c ore clinical problems that merit early identification and further research regar ding the development of effective treatment.
The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements ...
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The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.
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