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Isoimperatorin alleviates acetic acid-induced colitis in rats

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied Goodarzi Amir hossein Abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi Maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

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Special Column on Recent Advances in PCMs as Thermal Energy Storage in Energy Systems

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Journal of Thermal Science 2024年第2期33卷 395-395页

作者： mohammad hossein AHMADI Tingzhen MING Marc A.ROSEN S.A.SHERIF mohammad Mehdi RASHIDI Shahrood University of Technology Iran Wuhan University of Technology China University of Ontario Institute of Technology Canada University of Florida USA University of Electronic Science and Technology of China China

Thermal energy storage technology has the advantages of high energy storage density,small size,and high energy conversion *** is one of the key energy storage technologies and an important way to achieve carbon peaking and carbon neutrality *** change materials (PCMs) offer this opportunity to store high amount of energy and release it in the form of latent heat when needed,and therefore have the advantage of being capable to alleviate the intrinsic intermittency of renewable power production,especially in wind and solar farms.

关键词： efficiency store latent

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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi mohammad-Mahdi Salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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Etiology of Pancytopenia in Tabriz Shahid Ghazi Hospital:A Cross-sectional Study in Iran

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Proceedings of Anticancer Research 2024年第4期8卷 104-115页

作者： hossein Azari Bostanabad Safa Mousavi mohammad hossein hosseini Sadra Sarandili Ali Esfahani Babak Nejati Department of Hematology and Oncology Faculty of MedicineTabriz University of Medical SciencesTabrizIran Liqvan Health Center Tabriz University of Medical SciencesTabrizIran Hematology and Oncology Research Center Tabriz University of Medical SciencesTabrizIran Department of Health Sciences Curtin Medical SchoolCurtin UniversityPerthWAAustralia

Objective:Pancytopenia is characterized by a reduction in all three types of blood cells:erythrocytes,leukocytes,and *** is caused by a wide range of diseases,leading to diagnostic *** causes can range from drug reactions to life-threatening diseases such as aplastic anemia and *** study aims to investigate the causes of pancytopenia,specifically focusing on age and gender differences among ***:This cross-sectional study includes patients of all ages diagnosed with pancytopenia,as indicated by a CBC/H1 showing a WBC count less than 4,000/μL,platelet count less than 150,000/μL,and hemoglobin levels below 12 g/dL in women and less than 13 g/dL in *** study only included patients with pancytopenia who underwent bone marrow examination and were not subjected to chemotherapy or radiation ***:A total of 133 patients with pancytopenia were included in the *** average age was 47.35±17.62 years old,with 66%of the participants being male and 34%being *** leukemia,specifically acute myeloid leukemia(AML)and acute lymphoid leukemia(ALL),was identified as the primary cause of pancytopenia,accounting for 31.5%of *** anemia was the second most common cause,accounting for 30%of cases,followed by aplastic anemia at 7.5%.Conclusion:Pancytopenia,a condition marked by the decrease in both erythrocytes and leukocytes as well as thrombocytes,can arise from a myriad of *** main findings of this study revealed that megaloblastic anemia,acute myeloid leukemia(AML),and acute lymphoid leukemia(ALL)were the most common ***,a considerable proportion of cases of pancytopenia can be attributed to acute ***,expeditious and accurate diagnosis is imperative and has the potential to save lives in such cases.

关键词： Pancytopenia Leukemia Anemia Bone marrow Blood cells

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Enhanced Sensitivity and Stability in Gelatin-Based Fricke gel Dosimeters:Impact of Benzoic Acid on Low-Dose Radiation Measurements

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Instrumentation 2024年 23-29页

作者： Seyed Amir Saeedi-Sini Sedigheh Sina mohammad hossein Sadeghi Ebrahim Farajzadeh Nuclear Engineering Department School of Mechanical EngineeringShiraz University Radiation Research Center School of Mechanical EngineeringShiraz University Secondary Standard Dosimetry Laboratory(SSDL) Pars Isotope Co.

Fricke gel dosimetry is a critical technique for accurate radiation dose measurement,leveraging the radiation-induced oxidation of ferrous to ferric ions within a hydrogel *** study aimed to advance the field by preparing and evaluating seventy-one Fricke gel dosimeter (FGD) samples with varying chemical compositions,focusing on the incorporation of benzoic *** gelatin-based samples demonstrated superior sensitivity,particularly for low-dose *** findings indicated that the sample without benzoic acid exhibited a 1.75 times higher sensitivity compared to the sample containing benzoic acid,with lower limits of detection at 0.04 Gy and 0.1 Gy,*** tests revealed temperature-dependent responses,with better performance observed under refrigerated *** was confirmed through consistent calibration curves across multiple ***,the dosimeters'responses varied with different radiation types,underscoring the need for specific *** study concludes that while benzoic acid slightly reduces sensitivity,it provides consistent responses across various radiation energies,suggesting its potential as a beneficial additive in diverse clinical *** research contributes to the ongoing optimization of FGDs for precise radiation dose assessment.

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富里酸驱动发酵梭菌砷甲基化的代谢机制解析

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环境科学学报 2024年第6期44卷 404-413页

作者：梁永美陈冠虹朱潇方利平李晓敏 Hemmat-Jou mohammad hossein 李芳柏华南师范大学环境研究院广东省化学品污染与环境安全重点实验室环境理论化学教育部重点实验室广州510006 广东省科学院生态环境与土壤研究所广东省农业环境综合治理重点实验室广州510650 华南师范大学环境学院广州510006 中国科学院广州地球化学研究所广州510640

微生物介导砷甲基化是砷生物地球化学循环中的重要过程.已有研究表明,腐殖质添加能促进稻田土壤厌氧微生物砷甲基化,但其关键机制尚不明确.本研究以砷污染稻田土壤中分离的一株砷甲基化功能厌氧发酵梭菌Clostridium sporogenes LHA6为对... 详细信息

微生物介导砷甲基化是砷生物地球化学循环中的重要过程.已有研究表明,腐殖质添加能促进稻田土壤厌氧微生物砷甲基化,但其关键机制尚不明确.本研究以砷污染稻田土壤中分离的一株砷甲基化功能厌氧发酵梭菌Clostridium sporogenes LHA6为对象,探究富里酸对梭菌细胞代谢活性的影响,并解析其与砷甲基化效率的内在关系.结果表明,相比对照处理,特定浓度(0.5~2 g·L^(-1))富里酸处理中菌株LHA6的水溶态和细胞结合态甲基砷生成量分别增加25.7%~84.4%和39.8%~60.4%,挥发性甲基砷产物增加0.68~1.86倍,主要产物形态为二甲基砷及其氢化物.综合电化学、代谢物和基因表达定量等方法证实:富里酸可作为胞外电子受体,抑制梭菌胞内发酵产氢活性,增加NADH/NAD+比率;同时,富里酸存在时梭菌显著上调S-腺苷甲硫氨酸(SAM)合成相关基因转录活性,增强SAM合成代谢通量,很可能是富里酸促进梭菌产生甲基砷及其氢化物的关键机制.本研究系统揭示了富里酸调控梭菌细胞代谢,进而强化其砷甲基化及挥发的砷解毒机制,获得了对砷的生物地球化学循环的新认知,有望为土壤砷污染控制提供新思路.

关键词：砷甲基化砷挥发发酵梭菌富里酸产氢

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电子穿梭体介导土壤锑还原成矿的微生物机制

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生态环境学报 2024年第2期33卷 272-281页

作者：蓝浚陈冠虹张俊涛 Hemmat-Jou mohammad hossein 舒小华方利平李芳柏桂林理工大学环境科学与工程学院广西桂林541000 广东省科学院生态环境与土壤研究所/广东省农业环境综合治理重点实验室广东广州510650 广州市林业和园林科学研究院广东广州510405

微生物锑还原成矿有助于降低土壤锑的生物有效性和移动性,是土壤锑污染修复的重要策略之一。电子穿梭体AQDS能够加速土壤富集菌群锑还原速率,可能与其促进微生物呼吸及细胞生长有关。理解电子穿梭体(ES)介导微生物锑还原过程与机制可为... 详细信息

微生物锑还原成矿有助于降低土壤锑的生物有效性和移动性,是土壤锑污染修复的重要策略之一。电子穿梭体AQDS能够加速土壤富集菌群锑还原速率,可能与其促进微生物呼吸及细胞生长有关。理解电子穿梭体(ES)介导微生物锑还原过程与机制可为土壤锑污染控制提供关键理论支撑。醌类和黄素类电子穿梭体(AQDS和FMN)存在时可能改变微生物呼吸代谢中的电子传递过程,然而ES介导下的微生物锑还原过程及转录响应机制尚不清楚。利用锑污染稻田土壤分离的兼性厌氧锑还原细菌Mesobacillus jeotgali PS1作为研究对象,探究醌类和黄素类电子穿梭体(AQDS和FMN)对菌株PS1锑还原过程及关键功能基因转录活性的影响。结果表明,菌株PS1驱动Sb(Ⅴ)还原为Sb(Ⅲ)过程中水溶态Sb(Ⅲ)随培养时间先累积后下降,培养72 h后水溶态锑去除率为64%,生成十四面体方锑矿,表明菌株PS1驱动锑还原成矿有助于锑的钝化。两种ES能够加速细菌锑还原反应,而对胞外生成的方锑矿晶型没有影响。通过定量分析菌株PS1潜在功能基因转录表达活性,结果表明AQDS相比FMN更能促进菌株PS1细胞膜二甲基亚砜还原酶(DMSOR)基因和胞内解毒型砷还原基因(arsC)转录活性,有助于增加菌株PS1呼吸代谢活性和胞内锑解毒从而加速锑还原,所以AQDS可能在强化微生物锑还原钝化中更具有优势。该研究揭示了不同电子穿梭体介导锑还原的微生物机制,为锑污染土壤生物修复提供重要理论支撑。

关键词：锑还原细菌电子穿梭体方锑矿锑解毒转录响应二甲基亚砜还原酶

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ON THE STABILITY OF A FUNCTIONALLY GRADED RECTANGULAR MICRO-PLATE SUBJECTED TO HYDROSTATIC AND NONLINEAR ELECTROSTATIC PRESSURES

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Acta Mechanica Solida Sinica 2013年第2期26卷 205-220页

作者： Adel nabian Ghader Rezazadeh Morteza Almassi Ali-mohammad Borgheei Department of Agricultural Machinery Engineering Science and Research BranchIslamic Azad UniversityTehranIran Department of Mechanical Engineering Urmia UniversityUrmiaIran

This article studies the stability of a functionally graded clamped-clamped micro- plate subjected to hydrostatic and electrostatic pressures. Equilibrium positions of the micro-plate are determined and shown in the state control space. To study the stability of the equilibrium positions, the motion trajectories are given for different initial conditions in the phase plane. Effects of the electrostatic and hydrostatic pressure changes on the deflection and stability of the micro-plate for some sample value of k are studied and values of the applied voltage and hydrostatic pressure leading system to unstable conditions by undergoing a saddle node and homoclinic bifurcations are determined.

关键词： MEMS FGM stability micro-plate electrostatic hydrostatic pressure

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Resilience-oriented intentional islanding of reconfigurable distribution power systems

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Journal of Modern Power Systems and Clean Energy 2019年第4期7卷 741-752页

作者： mohammad hossein OBOUDI mohammad mohammadI mohammad RASTEGAR Department of Power and Control Engineering School of Electrical and Computer EngineeringShiraz UniversityShirazIran

The participation of distributed energy resources in the load restoration procedure,known as intentional islanding,can significantly improve the distribution system *** system reconfiguration can effectively alter islanding procedure and thus provide an opportunity to supply more demanded energy and reduce distribution system *** addition,high-impact events such as hurricanes and earthquakes may complicate the procedure of load restoration,due to the disconnection of the distribution system from the upstream grid or concurrent component *** paper presents a two-level method for intentional islanding of a reconfigurable distribution system,considering high-impact *** thefirst level,optimal islands are selected according to the graph model of the distribution *** the second level,an optimal power flow(OPF)problem is solved to meet the operation constraints of the islands by reactive power control and demand side *** proposed problem in the first level is solved by a combination of depth first search and particle swarm optimization *** OPF problem in the second level is solved in DIgSILENT *** proposed method is implemented in the IEEE 69-bus test system,and the results show the validity and effectiveness of the proposed algorithm.

关键词： Intentional islanding Active distribution system Distributed energy resource Distribution system reconfiguration Distribution system resilience

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Efficient Wind Turbine Generation Planning for Decreasing Distribution System Company Payments in Real Applications

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 81-90页

作者： mohammad Hasan Hemmatpour mohammad hossein Rezaeian Koochi Electrical Engineering Department Faculty of EngineeringJahrom UniversityJahromIran Department of Electrical Engineering Shahid Bahonar University of KermanKermanIran

Wind energy has posed new challenges in both transmission and distribution systems owing to its uncertain nature. The effect of wind turbines (WTs) on the actual payments charged by upstream networks to distribution system companies (DISCOs) is one challenge. Moreover, when the grid-connected inverters of WT operate in the lead or lag modes, WTs absorb or inject reactive power from the system. This paper proposes an approach to assess the importance of operation modes of WTs to minimize the costs by DISCOs in the presence of system uncertainties. Accordingly, an optimization problem is formulated to minimize the costs to DISCO by determining the optimal locations and sizes of WTs in optimally reconfigured distribution systems. In addition, an improved vector-based swarm optimization (IVBSO) algorithm is proposed because it is highly suitable for vector-based problems. Two distribution systems are used in the simulations to evaluate the proposed algorithm. Firstly, the capabilities of the IVBSO algorithm to determine better solutions over other heuristic algorithms are confirmed using the IEEE 33-bus test system. Secondly, the BijanAbad distribution system (BDS) is used to demonstrate the effectiveness of the proposed optimization problem. Accordingly, the distribution system model, cumulative distribution function of wind speed, and load profile are all extracted from the actual data of the BijanAbad region. Finally, the optimization problem is applied to BDS in both the lead and lag modes of WTs. Results indicate that the total costs of DISCO are lower when WTs operate in the lag mode than in the lead mode.

关键词： Distribution system companies(DISCOs) improved vector-based swarm optimization(IVBSO) reconfiguration wind turbine operation mode

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